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The manosphere, a diffuse commercial ecosystem and loose collection of online communities united by shared beliefs about masculinity, misogyny, and male victimisation, is an under-recognised determinant of health harms. This network has been implicated in considerable health harms: widespread mental health impacts, especially in young people; violence against women, girls, and gender minorities; and delegitimising help-seeking in boys and men. In this Viewpoint, we argue that the manosphere is best understood and addressed as a public health problem.
Posted: October 31, 2026, 12:00 am
Many men are failing to thrive. Shorter life expectancies for men than for woman first emerged in the 19th century and the gap has continued to widen (albeit with geographical variations). Men have a higher burden of illness: global disability-adjusted life-years are 16% greater among men than women. The primary drivers of these differences include non-communicable diseases (cardiovascular disease, cancer, and diabetes), external causes (suicide, road traffic injuries, falls, and interpersonal violence), communicable diseases (respiratory infections, tuberculosis, HIV/AIDS, and hepatitis), and substance use (alcohol-related and drug-related harms).
Posted: October 31, 2026, 12:00 am
On my tenth visit, it took me two attempts to find the care and treatment centre (CTC) for people living with HIV/AIDS in Miono, Tanzania. The one-storey white building, where patients used to sit along wooden benches waiting to be called, was now filled with motorbikes and a few people milling outside doctors’ offices off to the side. There used to be two buildings in the complex, one for people living with HIV/AIDS and another a maternity clinic, both full of people and babies. Now there are six buildings and fewer patients, no boda bodas (motorcycle taxis) hanging around for a fare, or family members waiting in the shaded area outside.
Posted: October 31, 2026, 12:00 am
Men occupy a privileged position within gender power relations: the male body has been the default reference point for biomedical research and therapeutic development (with the historical exclusion of women from medical trials), and men dominate health services leadership and exercise well documented medical misogyny. Yet despite their privileged position, many aspects of men's health outcomes are neglected and undertheorised because they are not examined through an intersectional gender lens. Although consideration of gender and masculinity is important for understanding men's health, research thus far has focused predominantly on men's harmful health behaviours, overemphasising individual determinants of health, and a deficit-based approach.
Posted: October 31, 2026, 12:00 am
Jim Catto, co-leading author of the Lancet Series on men's health, was reluctant to be the subject of a profile, insisting it is more important to highlight what he is trying to accomplish: tackling the inequalities in men's health. The patients he cares for come mainly from South Yorkshire, where he also lives; the area includes places that are among the most deprived parts of the UK.
Posted: October 31, 2026, 12:00 am
Despite long-standing evidence of poor health and life expectancy outcomes among men, particularly among men who are socially or structurally marginalised, men's health has generally received little and uneven attention in health policy and practice. Its gendered and intersectional aspects have been especially overlooked. This third paper in the Lancet Men's Health Series examines why men's health has received so little policy attention and proposes strategies to raise men's health on national and global agendas.
Posted: October 31, 2026, 12:00 am
A patient in France has died from the infection, which normally affects cattle. Virologists say the wider risk to public health is low. Marianne Guenot reports.
Posted: October 31, 2026, 12:00 am
“We know a lot about male health. We don’t know a lot about men's health”, says Derek Griffith, who is one of the authors of a new Lancet Series on men's health. “Male health is about male bodies and hormones. Men's health is more holistic and comprehensive and should consider psychological, social, and structural factors like race, ethnicity, country of origin, and colonisation, which a biomedical approach has largely missed.”
Posted: October 31, 2026, 12:00 am
With an opportunity to overturn Republican control of Congress, Democrats hope to win voters’ support by focusing on cuts to health-care programmes. Susan Jaffe reports from Washington, DC.
Posted: October 31, 2026, 12:00 am
Afghanistan has reported twice as many polio cases than in 2025, prompting concern over the Taliban's vaccination policies. Samaan Lateef reports.
Posted: October 31, 2026, 12:00 am
The Lancet Countdown on health and climate change celebrated its tenth anniversary this week. The Countdown was preceded by two Lancet Commissions that sought to mobilise multiple disciplines within universities to address the climate crisis. The first Commission, in 2009, identified climate change as the greatest threat to global health this century. The second Commission, in 2025, took a different approach, describing climate change as the greatest opportunity for global health in the 21st century.
Posted: October 31, 2026, 12:00 am
The authors of The Lancet's Series on men's health1–3 provide a genuinely world-scale picture of the issues. Their approach links biological with social process, and emphasises intersectional perspectives. The Series papers offer valuable case studies, and a suite of proposals to move health policy in new directions.
Posted: October 31, 2026, 12:00 am
Non-invasive tests (NITs) are central to clinical decision making in metabolic dysfunction-associated steatotic liver disease, including risk stratification, treatment decisions, referral pathways, and recruitment into clinical trials.1 As pharmacological treatments for metabolic dysfunction-associated steatohepatitis (MASH) become more widely available, the importance of accurately identifying fibrosis stage has grown considerably. In clinical drug trials on MASH, the objective is usually to identify patients with substantial (≥F2) or advanced fibrosis (≥F3) who are most likely to benefit from pharmacological therapy.
Posted: October 31, 2026, 12:00 am
Paediatric acute respiratory distress syndrome (PARDS) is a common, severe manifestation of direct or indirect lung injury in children. Management focuses on the careful implementation of lung protective strategies with high-frequency oscillatory ventilation (HFOV) and prone positioning often deployed in the most severe cases. As such, we read the Prone positioning and high-frequency oscillatory ventilation in early paediatric acute respiratory distress syndrome (PROSpect) trial by Martha A Q Curley and colleagues published in The Lancet with great interest.
Posted: October 31, 2026, 12:00 am
Pioneer of paediatric stem cell transplantation and Director of the Bone Marrow Transplant Unit at Great Ormond Street Hospital for Children, UK. Born in Dar es Salaam, Tanzania, on Aug 7, 1960, he died of metastatic cholangiocarcinoma on July 18, 2026, in Winchelsea, UK, aged 65 years.
Posted: October 31, 2026, 12:00 am
Although single markers resulted in variable and limited performance when compared to histology for detecting at-risk MASH, multimarker panels showed great potential, with a proteomic panel showing strong diagnostic performance. These findings could support the selection and implementation of non-invasive testing strategies in MASLD and inform future clinical guidelines, regulatory evaluation, and clinical trial design.
Posted: October 31, 2026, 12:00 am
Saima Wazed, the Regional Director for WHO's South-East Asia Regional Office, resigned in September, 2026.1 Wazed's appointment drew considerable public attention and controversy, particularly when her qualifications were compared with those of other candidates.2,3
Posted: October 31, 2026, 12:00 am
Males have lower life expectancies and greater disability-adjusted life-years (DALYs) than females, and particularly poor outcomes are seen among males in marginalised contexts. In this paper, we provide an epidemiological overview and highlight the intersectional nature of men's health. We analyse mortality and DALYs data from the 1990–2023 Global Burden of Diseases, Injuries, and Risk Factors Studies to illustrate our intersectional framework and draw attention to how health varies in men and to show key themes.
Posted: October 31, 2026, 12:00 am
We found no evidence to support prone positioning or HFOV as first-line strategies to improve ventilator-free days in patients with early, moderate-to-severe PARDS. Thus, the routine use of these strategies in this population is not recommended.
Posted: October 31, 2026, 12:00 am
In 2027, WHO will be embarking on a process to elect its next Director-General. It is clear that the new Director-General will have to continue dealing with important health issues globally, such as the health impacts of climate change, continuously evolving pathogens, pandemic preparedness, resurgence of diseases linked to low vaccination rates and anti-vaccine sentiments, and the task of guiding and assisting WHO's member states to reach the wide-ranging health objectives within the Sustainable Development Goals by 2030.
Posted: October 31, 2026, 12:00 am
In his recent Offline on the upcoming elections for the new Director-General of WHO,1 Richard Horton mentions several of the previous Director-Generals, starting with Hiroshi Nakajima (1988–98); however, I believe the achievements of Halfdan Mahler (1973–88) should also be highlighted.2,3
Posted: October 31, 2026, 12:00 am
Having worked for WHO for 5 years at the end of a career as an academic in global health, I was keen to read Richard Horton's Offline on the tragic fallacy of global health reform.1 Although the Offline summarised the reasons why current efforts might fail, I was disappointed that Horton did not make any suggestions for what he thought should be done instead, as well as the inference that WHO might not include voices from Latin America, Asia, the Middle East, or civil society in their deliberations related to reform.
Posted: October 31, 2026, 12:00 am
The Lancet Editorial1 on skin diseases rightly argues that vitiligo trials such as Viti-Up, in which more than 70% of participants were White, should enrol patients who reflect the population affected and measure what lies beyond the visible: stigma, comorbidity, and quality of life. The same oversight, however, occurs throughout observational literature, shaping how we judge health care.
Posted: October 31, 2026, 12:00 am
In patients with locally advanced dMMR colon cancer, treatment with ipilimumab and nivolumab before surgery resulted in a 3-year disease-free survival and 5-year overall survival of 100%. These findings support neoadjuvant nivolumab plus ipilimumab as a potential standard of care for patients with locally advanced dMMR colon cancer.
Posted: October 21, 2026, 10:30 pm
For decades, the standard of care for patients with resected stage II and III colon cancer has centred on surgery with consideration of postoperative adjuvant systemic therapy to reduce risk of recurrence. Mismatch repair deficiency is seen in 10–15% of non-metastatic colon cancers and is predictive of response to immune checkpoint inhibition. The initial report of the single-arm, phase 2 NICHE-2 study of one dose of ipilimumab (1 mg per kg) and two doses of nivolumab (3 mg per kg) before surgery with clinical stage II and III colon cancer generated considerable interest after demonstrating a remarkable 98% pathologic response rate, including a pathologic complete response rate of 68%.
Posted: October 21, 2026, 10:30 pm
The combination of endometrial ablation and LNG-IUS significantly reduced the incidence of hysterectomy compared with endometrial ablation alone. The combined treatment appears to be a safe adjunctive strategy for heavy menstrual bleeding that does not increase the risk of complications.
Posted: October 21, 2026, 10:30 pm
Heavy menstrual bleeding is a challenging condition that, when refractory to conventional treatment, frequently culminates in hysterectomy. Endometrial ablation offers an effective, uterus-sparing alternative for women who do not desire future childbearing, with lower perioperative morbidity and faster recovery than hysterectomy.1–3 However, the durability of this procedure can be variable. Residual endometrium can result in recurrent bleeding or cyclical pelvic pain requiring further treatment, with approximately one in ten women undergoing hysterectomy within 2 years.
Posted: October 21, 2026, 10:30 pm
The Thirlwall Inquiry1 was set up to examine events at the Countess of Chester Hospital (Chester, UK) and their implications following convictions for murder and attempted murder of babies by nurse Lucy Letby. The inquiry's terms of reference are mainly about the needs of bereaved parents and hospital safety;1 both are important, but are secondary to the prevention of the murders that led to such needs. When babies continue to die unexpectedly and clinical and postmortem explanations are uncertain, police involvement should follow and questions must begin with diagnosis.
Posted: October 16, 2026, 10:30 pm
Mocking RJT, Klírová M, Opel N, et al. Underuse of neuromodulation in depression care. Lancet 2026; 408: 1552–53—In this Correspondence, author Maria Semkovska's name has been corrected. This correction has been made to the online version as of Oct 16, 2026.
Posted: October 16, 2026, 10:41 am
The Victorian painter Richard Dadd was born in 1817. By the time of his death in 1886 he had been detained in psychiatric hospitals for 42 years. Dadd's life trajectory once promised to be very different. He began to draw seriously at the age of 13 years and was admitted to London's prestigious Royal Academy Schools when he was 19 years old. There he excelled, winning prizes in drawing and painting. But any possibility of a distinguished career evaporated in 1843 when, experiencing delusions, he tragically murdered his father and was later admitted to London's Bethlem Hospital.
Posted: October 15, 2026, 10:30 pm
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