Gastroenterology

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Clinical Knowledge Summaries- Gastrointestinal Topics

COVID-19 – PubMed search results

Factors affecting loneliness in pregnant women: A scoping review

CONCLUSIONS: Current generic instruments fail to capture the unique transitional nature of prenatal loneliness. Addressing this issue requires developing pregnancy-specific assessment tools and implementing multi-level interventions targeting multi-level socio-ecological factors.

Pentoxifylline in patients with COVID-19 and with liver cirrhosis or metabolic dysfunction-associated steatotic liver disease: Emerging insights

Coronavirus (CoV) disease 2019 (COVID-19) deteriorates existing hepatopathies, such as liver cirrhosis and metabolic-associated syndrome liver disease (MASLD), which in turn increases the risk of serious complications. The pathophysiology of COVID-19 includes inflammation, proinflammatory cytokine storms, oxidative stress and fibrosis. Notably, pentoxifylline (PTX) blocks nuclear factor-κB activity, thus inhibiting the secretion of proinflammatory cytokines, and is an antioxidant and...

Global inequities in biologic and targeted DMARD use in rheumatoid arthritis: cross-sectional data from the international COVAD-2 cohort

CONCLUSION: Marked continent- and HDI-based inequities in biologic and targeted DMARD use persist globally, demanding coordinated action from the rheumatology community to ensure equitable RA care across resource settings.

Widening Colon Cancer Disparities Post-Pandemic in Disaggregated Asian American and Pacific Islander Populations (2004-2021)

Colon cancer stage at diagnosis strongly predicts survival, yet racial disparities remain underexplored for Asian American, Native Hawaiian, and Pacific Islander (AANHPI) subpopulations. In light of COVID-19 and rising anti-Asian hate, we examined temporal changes in colon cancer stage at diagnosis among disaggregated AANHPI populations before and during the pandemic. Using the National Cancer Database, we examined colon cancer stage at presentation (0-IV) among AANHPI subgroups in pre-pandemic...

Real-World Infectious Outcomes with Dupilumab Compared with Proton Pump Inhibitors and Topical Steroids in Eosinophilic Esophagitis: A Multi-cohort Propensity Matched Analysis

CONCLUSIONS: In large real-world matched cohorts, dupilumab was not associated with increased infectious risk compared with standard EoE therapies. These findings provide reassurance regarding the infectious safety of dupilumab in routine clinical practice.

Increased in-hospital mortality in immunocompromised individuals hospitalized with COVID-19 during the global pandemic, a multinational cohort study in the EuCARE project

BACKGROUND: Although COVID-19 is no longer a public health emergency, it remains the most prevalent circulating infectious-like-illness in Europe. Whether immunocompromising conditions (ICCs) still carry increased mortality risk during the Omicron era is unclear.

Significant Increase in Clostridioides difficile Mortality During the COVID-19 Pandemic: A Nationwide Study

CONCLUSION: Significantly increased risks of mortality were observed in CDI-associated hospitalizations with concomitant COVID-19 and vice versa.

Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome

Understanding the genetic regulation of circulating protein levels can provide new insights into disease mechanisms. Here, we present the largest proteogenomic study to date (n = 78,664 participants across 38 studies), identifying >24,000 protein quantitative trait loci (QTLs) associated with 1,116 proteins, acting near to (n = 5,040) or distant (n = 19,698) from the cognate gene. Using machine learning-guided effector gene assignment, we provide genetic evidence for pathways, cell types, and...

Risk of interstitial lung disease following COVID-19 infection in patients with autoimmune diseases: a retrospective cohort study

CONCLUSIONS: COVID-19 infection was identified as a risk factor for the development of ILD in patients with autoimmune diseases, highlighting the importance of vigilant pulmonary surveillance in this population. Nevertheless, these findings should be interpreted with caution due to potential residual confounding, diagnostic misclassification, and the heterogeneity of autoimmune diseases, which may mask disease-specific risk variations and lead to potential misattribution of ILD risk across...

Multi-Strain Probiotic Intervention Modestly Modulates Microbial Composition and Inflammatory Profile in Individuals with Long COVID

Probiotics are widely used to support host health by modulating microbial communities and immune-metabolic homeostasis. Such interventions may be particularly relevant in long COVID syndrome, a condition characterized by persistent symptoms, low-grade inflammation, and microbiota alterations following SARS-CoV-2 infection. This study investigated the effects of a multi-strain probiotic on gut microbiota composition and predicted functional potential and biochemical parameters in individuals with...

Journal Table of Contents (Current Issues)

American Journal of Gastroenterology (Full-text Available via OpenAthens)
BMJ Open Gastroenterology (Open Access)
Current Opinion in Gastroenterology (Full-text not Available)
Gastroenterology (Full-text not Available)
Gastrointestinal Endoscopy (Full-text not available)
Gut (Full-text available via NHS Athens)
Hepatology (Full-text not Available)
Inflammatory Bowel Disease (Full-text available via NHS Athens)
Seminars in Liver Disease (Full-text not Available)

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Other Sources

New England Journal Of Medicine – Search Results for Gastroenterology
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