Gastroenterology

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COVID-19 – PubMed search results

Introduction: The expression dynamics of Toll-like receptors (TLRs) in response to SARS-CoV-2, particularly regarding disease severity, remain poorly understood. This study aimed to investigate the gene expression of TLR3, TLR4, and TLR7 in COVID-19 patients and correlate them with disease severity and gender.

Methods: This case-control study enrolled 470 COVID-19 patients (categorized as moderate, severe, and critical) and 100 healthy controls. The mRNA expression levels of these...

CONCLUSION: CMR strain imaging provides fast, reliable, and reproducible measurements. However, strain values are not directly interchangeable even between similar post-processing methods or when compared with dedicated sequences, highlighting the need for standardization and method-specific reference values.
Extracorporeal liver cross-circulation (ELC) using genetically modified pig livers may address an unmet need for temporary liver support in patients with acute or acute-on-chronic liver failure. This study used the ELC platform to evaluate early immune responses and assess xenogeneic liver physiological support in a human decedent model. Four human decedents underwent ELC using pig livers with a triple glycan knockout; insertion of seven human transgenes and inactivation of pig endogenous...
Background Transmission of the delta variant resulted in a surge of SARS-CoV-2 cases in New Delhi, India, during the early half of the year 2021. Healthcare workers (HCWs) received vaccines on priority for the prevention of infection. We estimated the effectiveness of the BBV152 vaccine among HCWs against SARS-CoV-2 infection, hospitalization, or death. Methods This retrospective cohort study was done at a multi-speciality tertiary care public-funded hospital in New Delhi, India. 12 237 HCWs...
Remote patient monitoring (RPM) has emerged as a valuable complement to traditional in-person clinical assessments, particularly since the COVID-19 pandemic. RPM encompasses a wide range of tools and technologies that enable the longitudinal collection of biometric, behavioral, and biochemical data outside the conventional clinic setting. These programs have been successfully integrated across several medical subspecialties, such as cardiology, endocrinology, and psychiatry, where the...
Post-acute sequelae of SARS-CoV-2 infection (PASC), also referred to as long COVID, encompasses a constellation of persistent symptoms lasting for at least three months after acute SARS-CoV-2 infection and not explained by alternative diagnoses. The multifactorial pathophysiology underlying PASC remains incompletely understood, limiting the development of effective management strategies. Increasing evidence suggests that both immune dysregulation and hemostatic imbalance play central roles in...
Viral infections, particularly those triggered by emerging pathogens like severe acute respiratory syndrome coronavirus 2, are increasingly recognized for their profound impact on the gut microbiota, causing dysbiosis, a condition characterized by an imbalance in microbial communities. Recent studies suggest that alterations in gut microbiota can influence disease progression, immune responses, and clinical outcomes. The bidirectional relationship between the gut microbiota and the host immune...
CONCLUSION: These findings, supported by related literature, demonstrate that clinical epidemiology played vital roles in monitoring infection trends, evaluating diagnostic and preventive measures, establishing treatment strategies, optimizing healthcare resources, and guiding policy. Its continued application will be essential for preparedness against future emerging infectious diseases.
Coronavirus disease 2019 (COVID-19) is known to induce gastrointestinal symptoms as well as respiratory symptoms. There have been instances where diarrhea persists after the acute phase of COVID-19, suggesting an extension of the disease's symptoms. It is not typical to recall the onset of inflammatory bowel disease (IBD) with such symptoms, much less with reports on Crohn's disease (CD). It is important to collect such cases in order to lead to appropriate diagnosis and treatment. This report...

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