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Gastroenterology

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COVID-19 – PubMed search results

SARS-CoV-2-specific monoclonal antibody AER002 in Long COVID: an exploratory randomized phase 2a mechanistic trial
Persistence of SARS-CoV-2 has been proposed as a biological driver of Long COVID, a disabling chronic illness with no proven treatments. We conducted an exploratory, placebo-controlled, double-blind, 2:1 randomized mechanistic trial (NCT05877508) of the SARS-CoV-2-specific monoclonal antibody AER002 in 36 participants who met the World Health Organization case definition of Long COVID. After baseline characterization, participants received a single infusion and were followed for 360 days. The...
Cross-reactive T cell immunity against novel coronaviruses with pandemic potential, predictable from spike sequence conservation
Widespread SARS-CoV-2 infection and vaccination have reshaped global immunity to coronaviruses. Whether this immunity extends to animal sarbecoviruses with spillover potential remains unknown. We assessed cross-reactive memory T-cell responses to spike proteins from five relevant human angiotensin-converting enzyme 2 (hACE2)-dependent sarbecoviruses and MERS-CoV in healthcare workers in the UK and Vietnam. Limited SARS-CoV-2 specific or cross-reactive responses were seen in pre-pandemic samples....
Incidence of Intensive Care Unit Delirium After Heart Surgery: A Feasibility Study of a Forest Environment Intervention
CONCLUSIONS: Chronotherapeutic environmental interventions were feasible and safe in ICU care. Feasibility results highlighted challenges related to ICU logistics, sedation-related assessment limitations and pandemic-related disruptions. The unexpectedly low delirium incidence limited conclusions regarding intervention efficacy. Future trials should include larger high-risk populations and prospectively defined feasibility outcomes.
Pregnancy and iron deficiency anemia are associated with COVID-19 severity: a retrospective cohort study from Gaza
CONCLUSION: This study suggests that among young, otherwise healthy, unvaccinated women with COVID-19, pregnancy and IDA are associated with increased COVID-19 severity. However, interpretation requires caution considering the small number of events, particularly deaths, and the assessment of iron status during acute infection using transferrin saturation alone without ferritin measurements, which limits the ability to distinguish preexisting iron deficiency from inflammation-related changes in...
Upper respiratory virome signatures reflect COVID-19 severity and post-recovery shifts
INTRODUCTION: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection profoundly affects the upper respiratory tract, yet the dynamics of the resident virome across different stages of Coronavirus Disease 2019 (COVID-19) and recovery remain poorly understood.
Iron Status in Patients with SARS-CoV-2 Infection
This study evaluated the iron status and diagnostic usefulness of iron-related parameters in patients with SARS-CoV-2 infection upon admission to the hospital and during hospitalization. The study group included 87 patients with COVID-19 and 45 healthy subjects. Serum iron, ferritin, transferrin, transferrin saturation (TSAT), soluble transferrin receptor (sTfR), and hepcidin concentrations were measured using routine laboratory methods. Serum iron, transferrin concentrations, and TSAT were...
Oxidative Stress and Alveolar-Capillary Barrier Failure in Sepsis- and Severe Acute Pancreatitis-Associated ARDS
Acute respiratory distress syndrome (ARDS) is the final common phenotype of diverse insults, but the route to alveolar-capillary barrier failure matters. Sepsis and severe acute pancreatitis provide an informative contrast: sepsis begins with infection and pathogen-associated molecular patterns, whereas pancreatitis is initially driven by sterile acinar-cell injury, necrosis and damage-associated molecular patterns, before infected necrosis can superimpose sepsis biology. These differences are...
Liver Cirrhosis and Septic Shock Attenuate the Increase in Plasma Endostatin Concentrations That Is Associated with Acute Kidney Injury Requiring Dialysis
Background/Objectives: Sepsis is a life-threatening syndrome characterized by a dysregulated host response to infection. Alterations in pro- and anti-angiogenic mediators have been associated with disease severity and clinical outcomes. Endostatin, a potent endogenous inhibitor of angiogenesis, has been linked to renal dysfunction through elevated circulating concentrations. This study investigated whether plasma endostatin levels could serve as a biomarker of acute kidney injury requiring...
Lower Plasma Brain-Derived Neurotrophic Factor Levels During Critical Illness Are Associated with Subsequent Dialysis Requirement
Background and Objectives: Brain-derived neurotrophic factor (BDNF), best known for its role in cognitive function, is an anti-inflammatory protein proposed as a potential therapeutic target and diagnostic biomarker in sepsis. However, studies investigating circulating BDNF levels in patients with sepsis have yielded conflicting results, reporting both increased and decreased concentrations. Comorbid conditions, particularly liver cirrhosis, pancreatitis, and kidney failure, may contribute to...
Multi-Virus Surveillance Across Diverse Freshwater Systems in Tehran, Iran
Environmental surveillance of viral contaminants in water systems is an essential tool for assessing exposure risk and supporting early-warning frameworks for emerging infectious diseases. In this study, a comprehensive one-year surveillance of SARS-CoV-2 and six enteric viruses was conducted across diverse freshwater systems in Tehran, Iran - including rivers, wells, and traditional qanat (underground aqueduct) infrastructures. Water quality parameters (turbidity, pH, Total Dissolved Solids,...

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