Among patients with stroke due to medium-vessel occlusion, thrombectomy led to functional independence at 90 days (in 58.6% of patients, vs. 46.6% with medical management) but also to a higher risk of intracranial hemorrhage.
Author: Wei Hu, Xiaozhong Jing, Zhongjun Chen, Jin Zheng, Tingyu Yi, Tuanyuan Zheng, Zhide Li, Junzhong Liu, Tao Cui, Jianshang Wen, Ganghua Feng, Cunfeng Song, Lei Yang, Shunfu Jiang, Lin Tong, Changchun Jiang, Zhongfan Ruan, ˒Peiyang Zhou, Shouchun Wang, Tao Wang, Zhiming Zhou, Youquan Ren, Tao Qiu, Chong Zheng, Hao Wang, Yong Liu, Yun Luo, Jing Wang, Zhengfei Ma, Bin Mei, Yong Liang, Yuyou Zhu, Rui Li, Jun Sun, Li Wang, Chao Zhang, Tianlong Liu, Jianlong Song, Chunrong Tao, Anmo Wang, Jinjing Wang, Pengfei Xu, Xiaofan Guo, Liqi Shu, Adnan I. Qureshi, Thanh N. Nguyen, Mohamad AbdalKader, Jeffrey L. Saver, Wenhuo Chen, Raul G. Nogueira
Posted: May 14, 2026, 12:00 am
One way to classify acute ischemic stroke is by the anatomy of vessel occlusion. Initial randomized trials of endovascular thrombectomy focused on large-vessel occlusions.1-5 These proximal occlusions of the intracranial carotid artery or the stem of the middle cerebral artery (MCA) represent the most severe form of anterior...
Author: Johanna M. Ospel, Michael D. Hill
Posted: May 14, 2026, 12:00 am
An 86-year-old man presented to the neurology clinic with 2 years of progressive memory loss and difficulty walking. An MRI showed microbleeds that appeared as hypointense foci throughout the lobar regions.
Author: Sihui Chen, Xueping Chen
Posted: May 7, 2026, 12:00 am
Cerebral amyloid angiopathy, caused by beta-amyloid deposition in brain blood vessels, leads to lobar cerebral hemorrhage, microbleeds, and white-matter lesions and contributes to cognitive decline.
Author: Steven M. Greenberg
Posted: May 7, 2026, 12:00 am
Among adults 50 years of age or older, fewer cases of confirmed influenza-like illness were observed with an mRNA influenza vaccine than with standard vaccines. Reactogenicity was higher with the mRNA vaccine.
Author: Isabel Leroux-Roels, Grace Huang, Murdo Ferguson, Anita Kohli, Rebecca Clark, Markus Bickel, Mieke Soens, Evelyn Du, Alicia Pucci, Bryony Hicks, Colbie Eschen, Rituparna Das, Eleanor Wilson, the Fluent Trial Investigators*
Posted: May 7, 2026, 12:00 am
This article summarizes the pathogenesis, diagnosis, and management of Barrett’s esophagus, a reflux-related condition with increased adenocarcinoma risk, highlighting endoscopic diagnosis, surveillance, and early curative therapy.
Author: Rebecca C. Fitzgerald
Posted: April 30, 2026, 12:00 am
Effective blood-pressure control is the cornerstone of management after intracerebral hemorrhage; it is both the primary determinant of risk and the most vital intervention for reducing the threat of a second vascular event.1 Yet, despite the availability of effective treatments, blood pressure remains poorly controlled in survivors of...
Author: Ayush Batra, Farzaneh Sorond
Posted: April 23, 2026, 12:00 am
Jack, a retired teacher whose 91 years hadn’t been easy, wanted to leave the hospital forever. With a hospice nurse who was Polish like his cherished grandmother, he could finally take comfort in his care.
Author: Mark Earnest
Posted: April 23, 2026, 12:00 am
Among survivors of intracerebral hemorrhage, a single pill with three low-dose antihypertensive agents added to standard care was associated with a lower incidence of stroke and major cardiovascular events than placebo.
Author: The Trident Research Group, Craig S. Anderson, Clara K. Chow, H. Asita de Silva, Bimsara Senanayake, Kolawole Wahab, Rustam Al-Shahi Salman, Catharina J.M. Klijn, Sheila Ouriques Martins, Natalie Espinosa, Lauren Kuhles, Laurent Billot, Hisatomi Arima, Cheryl Carcel, Xia Wang, Qiang Li, Sana Shan, Mathangi Shanthakumar, Huy Thang Nguyen, Dilum Palliyaguruge, Janaka Peiris, Udaya K. Ranawaka, Senaka Bandusena, Thambipillai Rajendiran, Darshana Wijegunasinghe, Harsha Gunasekera, Indunil Wijeweera, Athula Dissanayake, Ajantha Keshavaraj, Reginald O. Obiako, Rufus Akinyemi, Luiz Nasi, Rodrigo Bazan, Carla Heloisa Cabral Moro, Mariana Battaglini, Viviane Zétola, Wan Chung Law, Yuen Kang Chia, Dennis Cordato, Rohan Grimley, Anuradha Dahanayaka, Sonali Liyanagamage, Nilukshi Fernando, Nihara Abdul Rasheed, Nodar Kakabadze, Maia Beridze, Mythily Aravinthan, Vithoosan Sahathevan, Devasmitha Wijesundara, Pramith Ruwanpathirana, Wan Asyraf Wan Zaidi, Tinatin Kherkheulidze, Urs Fischer, Ana Cláudia de Souza, Tsong-Hai Lee, Christopher Chen, Octavio Pontes-Neto, Thompson Robinson, Jiguang Wang, Sharon L. Naismith, Michael Barnett, Carlos Delfino, Shoujiang You, Feifeng Liu, Candice Delcourt, Tom J. Moullaali, Tim Wilkinson, Neil Watson, Karla Santo, Qiao Han, Mariana Almudi Souza, Wilmar M.T. Jolink, Anderson Berni Cristofari, Zien Zhou, Floris H. Schreuder, Richard I. Lindley, Manuela Armenis, Mark Woodward, Ruth Freed, Lili Song, John Chalmers, Anthony Rodgers
Posted: April 23, 2026, 12:00 am
In a placebo-controlled trial involving patients with noncardioembolic ischemic stroke or high-risk TIA, asundexian added to antiplatelet therapy led to a lower risk of ischemic stroke without increasing major bleeding.
Author: Mukul Sharma, Qiang Dong, Teruyuki Hirano, Scott E. Kasner, Jeffrey L. Saver, Jaime Masjuan, Andrew M. Demchuk, Charlotte Cordonnier, Daniel Bereczki, Georgios Tsivgoulis, Roland Veltkamp, Ivan Staikov, Hee-Joon Bae, Bruce C.V. Campbell, Andrea Zini, I-Hui Lee, Martin Kovar, Robert Mikulik, Robin Lemmens, José M. Ferro, Thompson Robinson, Hanne Christensen, Serefnur Ozturk, Ronen R. Leker, Peter Turcani, Agnieszka Slowik, Pablo Amaya, Fan Kee Hoo, Gian Marco De Marchis, Michael Knoflach, P.N. Sylaja, Jukka Putaala, Jonathan M. Coutinho, H. Bart van der Worp, Evija Miglane, Vaidas Matijošaitis, Arne G. Lindgren, Gisele Sampaio Silva, Else Charlotte Sandset, Saule T. Turuspekova, Pierre Amarenco, Kevin N. Sheth, Eric E. Smith, John W. Eikelboom, Raed A. Joundi, Karleen Schulze, Lizhen Xu, Laura Heenan, Pablo Colorado, Lars Keller, Eva Muehlhofer, Christoph Neumann, Hardi Mundl, Ashkan Shoamanesh, the OCEANIC-STROKE Investigators*
Posted: April 16, 2026, 12:00 am
Despite the implementation of efficacious interventions for secondary prevention, patients with ischemic stroke or transient ischemic attack (TIA) remain at substantial residual risk for short- and long-term recurrent ischemic stroke and coronary events.1,2 Approximately three quarters of ischemic strokes or TIAs are noncardioembolic and may be attributable to...
Author: Marion Boulanger
Posted: April 16, 2026, 12:00 am
This Double Take video reviews the differential diagnosis for a woman with night sweats and unintentional weight loss and how it evolves as new clinical findings are presented.
Author: Sarah Gorey, Alison E. Burke, Natalie Koscal, Emily Ling, Nadine Tan, Caren G. Solomon
Posted: April 16, 2026, 12:00 am
Post-thrombotic syndrome is the most common chronic complication of deep-vein thrombosis (DVT), affecting 20 to 50% of patients with DVT and causing debilitating symptoms involving the limbs — including pain, swelling, skin changes, and venous ulcers — that substantially reduce quality of life and impose considerable socioeconomic burden.1 ...
Author: Ronald Luiz Gomes Flumignan, Luís Carlos Uta Nakano
Posted: April 13, 2026, 12:00 am
Among patients with moderate or severe PTS, the addition of endovascular therapy to standard care resulted in less severe PTS and better quality of life at 6 months than standard care alone but with a higher risk of bleeding.
Author: Suresh Vedantham, Susan R. Kahn, William A. Marston, Ido Weinberg, Akhilesh K. Sista, Elizabeth A. Magnuson, David J. Cohen, Suman M. Wasan, Mahmood K. Razavi, Samuel Z. Goldhaber, Kristen M. Sanfilippo, Anthony J. Comerota, Ezana M. Azene, Cassius Iyad Ochoa Chaar, Daniel A. Leung, K. Pallav Kolli, Sanjeeva P. Kalva, Nassir Rostambeigi, Ajinkya Desai, Kush R. Desai, Alfonso J. Tafur, Bhavraj Khalsa, Elaine Majerus, Borong Wang, Yang Wang, Patricia Nieters, Mary Clare Derfler, Angela Oliver, Cassandra Hardy, Riyaz Bashir, Ronald Winokur, Natalie Weger, Minhaj S. Khaja, Aditya Sharma, Naganathan Mani, Pavan Kavali, Siddhant Thukral, Leslie L. Lake, Kathryn Mikkelsen, Sameer Parpia, the C-TRACT Trial Investigators*
Posted: April 13, 2026, 12:00 am
This Double Take video explores how a comprehensive patient-centered approach can provide high-value care for older patients.
Author: Daniel Pound, Ishani Ganguli, Debra Malina
Posted: April 9, 2026, 12:00 am
A 68-year-old man who had undergone intubation 25 days earlier had difficulty swallowing after extubation. A swallowing study showed fluid penetrating into the trachea without triggering a cough reflex (shown in a video).
Author: Shuo-Ting Jian, Hsiu-Nien Shen
Posted: April 9, 2026, 12:00 am
Chronologic age plays an outsized role in various aspects of medicine. Yet people of the same age can differ dramatically when it comes to aging-related risk factors.
Author: Martin G. Lee
Posted: April 2, 2026, 12:00 am
If the future of primary care lies in teams, what makes a team and how should it function? NOS host Lisa Rosenbaum and her guests consider the possibilities of team-based care.
Posted: March 12, 2026, 12:00 am
This review summarizes the diagnosis and management of polymyalgia rheumatica in adults older than 50 years of age, emphasizing clinical diagnosis, glucocorticoids as first-line therapy, relapses, and glucocorticoid-sparing options.
Author: Christian Dejaco, Eric L. Matteson
Posted: March 12, 2026, 12:00 am
This feature about blood-pressure targets to manage hypertension offers a case vignette accompanied by two essays, one recommending a systolic blood-pressure target of less than 120 mm Hg and the other supporting a target of less than 140 mm Hg.
Author: Christos P. Kotanidis, Paul K. Whelton, Clinton B. Wright
Posted: March 5, 2026, 12:00 am