Bacterial coinfection following a respiratory viral infection is one of the main causes of morbidity and mortality during viral pandemics. However, the specific interaction between S. pneumoniae and SARS-CoV-2 remains scattered and poorly understood. In this narrative review, current evidence regarding the pathogenesis, synergistic effects, and clinical impact of this coinfection was collected and reviewed. Peer-reviewed literature published between January 2020 and January 2026 was retrieved...
CONCLUSIONS: COVID-19 mRNA vaccines produced a broadly consistent humoral immune response across participants, regardless of zinc, copper, magnesium, and ceruloplasmin levels. There were no significant associations between trace element status, RA treatment, and long-term antibody durability; suggesting that humoral immunity may be maintained across different nutritional and therapeutic profiles.
Background Repeated COVID-19 vaccination is widely used in long-term care facilities, yet SARS-CoV-2 infection and reinfection continue to occur in frail older populations. Resident-level longitudinal data linking vaccination records with first and recurrent infections remain limited in Japanese long-term care settings. Materials and methods We conducted a retrospective descriptive study in a 134-bed long-term care facility in Okinawa, Japan. We linked 976 valid, dated vaccination records for...
Ageism is widespread and intensified during the COVID-19 pandemic, with resource shortages contributing to healthcare guidelines that systematically deprioritised older adults. Whilst the ethical considerations of these guidelines are well documented, perceptions of age and ageism in healthcare allocation remain underexplored. This study examined younger and older adults' perceptions of age and ageism in healthcare during COVID-19 through a social identity approach. Using a story completion...
CONCLUSIONS: Older decedents with advanced COPD experienced substantial multimorbidity and hospital-centered acute-care use, while documented palliative care exposure was uncommon. Survival analyses by palliative care exposure were excluded because exposure timing was unavailable and fixed retrospective classification would be vulnerable to immortal-time bias.
Despite growing evidence linking sleep duration to chronic kidney disease (CKD), long-term trend analyses specific to the Korean population remain limited, and most previous studies have relied on broad intermediate sleep categories. This study analyzed trends in CKD prevalence by self-reported sleep duration among Korean adults. We included 87,246 Korean adults aged ≥19 years from the Korea National Health and Nutrition Examination Survey, 2007 to 2022. CKD was defined as an estimated...
CONCLUSIONS: Older adults recovering from COVID-19 showed coexisting physical and emotional impairments. Physical function and emotional status, particularly depression, functional mobility, and ADLs independence, appear interrelated. Rehabilitation and nursing care should address both physical and psychosocial needs to support functional independence and reintegration into daily life after COVID-19 or similar acute health events.
CONCLUSIONS: These findings support the potential of a DCI program for older adults with PASC-Neuro.
CONCLUSIONS: The incidence of PIs in patients on invasive mechanical ventilation in an ICU exclusively dedicated to treating patients with COVID-19 was high. The risk of developing a PI in these conditions rose significantly for each day on mechanical ventilation. Ventilation in the prone position was associated with development of PIs in less common areas.
CONCLUSIONS: Perceived respect for human rights and job satisfaction among MHWs showed a sustained improvement after the COVID-19 pandemic, supporting the resilience of Italy's community psychiatry model. Ongoing concerns regarding resources underscore the need for renewed investment in human capital.
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Integration of screening for health-related social needs into clinical care represents an important advance. But most screening tools haven’t been developed or validated with older adults in mind.
Author: Mark A. Unruh, Joshua R. Vest
Posted: October 10, 2026, 12:00 am
Older adults are vulnerable to firearm-related harms. Medicare’s annual wellness visit presents an opportunity to engage older adults and their families or caregivers in conversations about firearms.
Author: Lena K. Makaroun, Timothy W. Farrell, Marian E. Betz
Posted: October 10, 2026, 12:00 am
For decades, one of the most important unresolved questions in preventive cardiovascular medicine has been whether statin therapy should be initiated for primary prevention in healthy older adults. Although age is among the strongest determinants of absolute risk, the benefits of statin therapy beyond 70 to 75 years of age...
Author: Martin Bødtker Mortensen
Posted: October 1, 2026, 12:00 am
In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival.
Author: Sophia Zoungas, Rory Wolfe, Chris Moran, Stephen J. Nicholls, Geoffrey C. Cloud, Christopher M. Reid, Andrew M. Τonkin, Lawrence Beilin, Anthony S. Wierzbicki, Trevor T.-J. Chong, Jonathan C. Broder, Andrea J. Curtis, Zachary Flanagan, Ingrid Hopper, Joanne Ryan, Simone Spark, John J. McNeil, Mark R. Nelson, the STAREE Investigators
Posted: October 1, 2026, 12:00 am
A 65-year-old man was admitted to this hospital because of fever, intermittent abdominal pain, and rash. The fever began 5 weeks earlier, and palpable purpura developed 1 week before admission. A diagnosis was made.
Author: Jacqueline T. Chu, Robert G. Rasmussen, Jacquelyn M. Nestor, Mack Y. Su
Posted: September 10, 2026, 12:00 am
A dying patient in a state psychiatric hospital has no access to a DNR order that would make the process as peaceful as possible — as the notorious Bedlam casts a shadow over mental health care to this day.
Author: Richard Elledge
Posted: September 10, 2026, 12:00 am
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.
Author: James T. Rosenbaum
Posted: August 13, 2026, 12:00 am
Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rheumatica and giant-cell arteritis (GCA), owing to...
Author: Yoshiya Tanaka
Posted: August 13, 2026, 12:00 am
Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone.
Author: John H. Stone, Frank Buttgereit, Alain Saraux, Wolfgang A. Schmidt, Christian Dejaco, Robert Spiera, Bhaskar Dasgupta, Edit Drescher, Andrew Jordan, Libor Novosad, Daiki Nakagomi, Yoshinobu Koyama, Sergio Duran-Barragan, Gerald Tracey, Adeline Ruyssen-Witrand, Andrea Rubbert Roth, Juanzhi Fang, Jennifer Ng, Renuka Hiremath, Roselyne Raffner, Ruvie Martin, Silvia Napoletano, Songqiao Huang, Julian Storim, Manmath Patekar, the REPLENISH Investigators*
Posted: August 13, 2026, 12:00 am
This review summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.
Author: Rose Anne Kenny
Posted: August 6, 2026, 12:00 am
As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.
Author: Mara Buchbinder
Posted: July 30, 2026, 12:00 am
As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline.
Author: Steven McGaughey
Posted: July 16, 2026, 12:00 am
Growing acceptance of voluntary euthanasia, which opens the door to death by organ donation, warrants a recontextualization of the dead donor rule and assessment of the ethical principles involved.
Author: Carter Winberg, Ian Ball, Robert D. Truog
Posted: July 9, 2026, 12:00 am
The United States faces a projected shortage of millions of long-term–care workers by 2040. Yet in each area where progress could help address this gap, federal policy is moving in the wrong direction.
Author: Andrew R. Olenski, David C. Grabowski
Posted: July 9, 2026, 12:00 am
An ICU physician believed letting her father die at home meant comfort, dignity, control, family close by, and the quiet reassurance of hospice. But she didn’t realize what it would require of her family.
Author: Danielle D. DeCourcey
Posted: July 9, 2026, 12:00 am
A rapid growth in the population of older Americans has long been anticipated. But projections didn’t anticipate that this transition would coincide with a sustained reduction in nursing-home services.
Author: Mark A. Unruh, Vincent Mor, Hye-Young Jung
Posted: July 9, 2026, 12:00 am
Patients with shrinking cognitive bandwidth may feel their disability keenly in daily life, even if they can pass a controlled test of cognitive capacity. How should clinicians approach and care for them?
Author: Jan Stubberud
Posted: July 2, 2026, 12:00 am
This review summarizes advances in the treatment of multiple sclerosis, with emphasis on effective disease-modifying therapies for relapsing disease and the need for better treatments to prevent progression and rebuild myelin.
Author: Stephen L. Hauser
Posted: July 2, 2026, 12:00 am
Post-thrombotic syndrome is the most common chronic complication of deep-vein thrombosis (DVT), affecting 20 to 50% of patients with DVT and causing debilitating symptoms involving the limbs — including pain, swelling, skin changes, and venous ulcers — that substantially reduce quality of life and impose considerable socioeconomic burden.1 ...
Author: Ronald Luiz Gomes Flumignan, Luís Carlos Uta Nakano
Posted: June 18, 2026, 12:00 am
Among patients with moderate or severe PTS, the addition of endovascular therapy to standard care resulted in less severe PTS and better quality of life at 6 months than standard care alone but with a higher risk of bleeding.
Author: Suresh Vedantham, Susan R. Kahn, William A. Marston, Ido Weinberg, Akhilesh K. Sista, Elizabeth A. Magnuson, David J. Cohen, Suman M. Wasan, Mahmood K. Razavi, Samuel Z. Goldhaber, Kristen M. Sanfilippo, Anthony J. Comerota, Ezana M. Azene, Cassius Iyad Ochoa Chaar, Daniel A. Leung, K. Pallav Kolli, Sanjeeva P. Kalva, Nassir Rostambeigi, Ajinkya Desai, Kush R. Desai, Alfonso J. Tafur, Bhavraj Khalsa, Elaine Majerus, Borong Wang, Yang Wang, Patricia Nieters, Mary Clare Derfler, Angela Oliver, Cassandra Hardy, Riyaz Bashir, Ronald Winokur, Natalie Weger, Minhaj S. Khaja, Aditya Sharma, Naganathan Mani, Pavan Kavali, Siddhant Thukral, Leslie L. Lake, Kathryn Mikkelsen, Sameer Parpia, the C-TRACT Trial Investigators*
Posted: June 18, 2026, 12:00 am