Effective blood-pressure control is the cornerstone of management after intracerebral hemorrhage; it is both the primary determinant of risk and the most vital intervention for reducing the threat of a second vascular event.1 Yet, despite the availability of effective treatments, blood pressure remains poorly controlled in survivors of...
Author: Ayush Batra, Farzaneh Sorond
Posted: April 23, 2026, 12:00 am
Jack, a retired teacher whose 91 years hadn’t been easy, wanted to leave the hospital forever. With a hospice nurse who was Polish like his cherished grandmother, he could finally take comfort in his care.
Author: Mark Earnest
Posted: April 23, 2026, 12:00 am
Among survivors of intracerebral hemorrhage, a single pill with three low-dose antihypertensive agents added to standard care was associated with a lower incidence of stroke and major cardiovascular events than placebo.
Author: The Trident Research Group, Craig S. Anderson, Clara K. Chow, H. Asita de Silva, Bimsara Senanayake, Kolawole Wahab, Rustam Al-Shahi Salman, Catharina J.M. Klijn, Sheila Ouriques Martins, Natalie Espinosa, Lauren Kuhles, Laurent Billot, Hisatomi Arima, Cheryl Carcel, Xia Wang, Qiang Li, Sana Shan, Mathangi Shanthakumar, Huy Thang Nguyen, Dilum Palliyaguruge, Janaka Peiris, Udaya K. Ranawaka, Senaka Bandusena, Thambipillai Rajendiran, Darshana Wijegunasinghe, Harsha Gunasekera, Indunil Wijeweera, Athula Dissanayake, Ajantha Keshavaraj, Reginald O. Obiako, Rufus Akinyemi, Luiz Nasi, Rodrigo Bazan, Carla Heloisa Cabral Moro, Mariana Battaglini, Viviane Zétola, Wan Chung Law, Yuen Kang Chia, Dennis Cordato, Rohan Grimley, Anuradha Dahanayaka, Sonali Liyanagamage, Nilukshi Fernando, Nihara Abdul Rasheed, Nodar Kakabadze, Maia Beridze, Mythily Aravinthan, Vithoosan Sahathevan, Devasmitha Wijesundara, Pramith Ruwanpathirana, Wan Asyraf Wan Zaidi, Tinatin Kherkheulidze, Urs Fischer, Ana Cláudia de Souza, Tsong-Hai Lee, Christopher Chen, Octavio Pontes-Neto, Thompson Robinson, Jiguang Wang, Sharon L. Naismith, Michael Barnett, Carlos Delfino, Shoujiang You, Feifeng Liu, Candice Delcourt, Tom J. Moullaali, Tim Wilkinson, Neil Watson, Karla Santo, Qiao Han, Mariana Almudi Souza, Wilmar M.T. Jolink, Anderson Berni Cristofari, Zien Zhou, Floris H. Schreuder, Richard I. Lindley, Manuela Armenis, Mark Woodward, Ruth Freed, Lili Song, John Chalmers, Anthony Rodgers
Posted: April 23, 2026, 12:00 am
Despite the implementation of efficacious interventions for secondary prevention, patients with ischemic stroke or transient ischemic attack (TIA) remain at substantial residual risk for short- and long-term recurrent ischemic stroke and coronary events.1,2 Approximately three quarters of ischemic strokes or TIAs are noncardioembolic and may be attributable to...
Author: Marion Boulanger
Posted: April 16, 2026, 12:00 am
This Double Take video reviews the differential diagnosis for a woman with night sweats and unintentional weight loss and how it evolves as new clinical findings are presented.
Author: Sarah Gorey, Alison E. Burke, Natalie Koscal, Emily Ling, Nadine Tan, Caren G. Solomon
Posted: April 16, 2026, 12:00 am
In a placebo-controlled trial involving patients with noncardioembolic ischemic stroke or high-risk TIA, asundexian added to antiplatelet therapy led to a lower risk of ischemic stroke without increasing major bleeding.
Author: Mukul Sharma, Qiang Dong, Teruyuki Hirano, Scott E. Kasner, Jeffrey L. Saver, Jaime Masjuan, Andrew M. Demchuk, Charlotte Cordonnier, Daniel Bereczki, Georgios Tsivgoulis, Roland Veltkamp, Ivan Staikov, Hee-Joon Bae, Bruce C.V. Campbell, Andrea Zini, I-Hui Lee, Martin Kovar, Robert Mikulik, Robin Lemmens, José M. Ferro, Thompson Robinson, Hanne Christensen, Serefnur Ozturk, Ronen R. Leker, Peter Turcani, Agnieszka Slowik, Pablo Amaya, Fan Kee Hoo, Gian Marco De Marchis, Michael Knoflach, P.N. Sylaja, Jukka Putaala, Jonathan M. Coutinho, H. Bart van der Worp, Evija Miglane, Vaidas Matijošaitis, Arne G. Lindgren, Gisele Sampaio Silva, Else Charlotte Sandset, Saule T. Turuspekova, Pierre Amarenco, Kevin N. Sheth, Eric E. Smith, John W. Eikelboom, Raed A. Joundi, Karleen Schulze, Lizhen Xu, Laura Heenan, Pablo Colorado, Lars Keller, Eva Muehlhofer, Christoph Neumann, Hardi Mundl, Ashkan Shoamanesh, the OCEANIC-STROKE Investigators*
Posted: April 16, 2026, 12:00 am
Post-thrombotic syndrome is the most common chronic complication of deep-vein thrombosis (DVT), affecting 20 to 50% of patients with DVT and causing debilitating symptoms involving the limbs — including pain, swelling, skin changes, and venous ulcers — that substantially reduce quality of life and impose considerable socioeconomic burden.1 ...
Author: Ronald Luiz Gomes Flumignan, Luís Carlos Uta Nakano
Posted: April 13, 2026, 12:00 am
Among patients with moderate or severe PTS, the addition of endovascular therapy to standard care resulted in less severe PTS and better quality of life at 6 months than standard care alone but with a higher risk of bleeding.
Author: Suresh Vedantham, Susan R. Kahn, William A. Marston, Ido Weinberg, Akhilesh K. Sista, Elizabeth A. Magnuson, David J. Cohen, Suman M. Wasan, Mahmood K. Razavi, Samuel Z. Goldhaber, Kristen M. Sanfilippo, Anthony J. Comerota, Ezana M. Azene, Cassius Iyad Ochoa Chaar, Daniel A. Leung, K. Pallav Kolli, Sanjeeva P. Kalva, Nassir Rostambeigi, Ajinkya Desai, Kush R. Desai, Alfonso J. Tafur, Bhavraj Khalsa, Elaine Majerus, Borong Wang, Yang Wang, Patricia Nieters, Mary Clare Derfler, Angela Oliver, Cassandra Hardy, Riyaz Bashir, Ronald Winokur, Natalie Weger, Minhaj S. Khaja, Aditya Sharma, Naganathan Mani, Pavan Kavali, Siddhant Thukral, Leslie L. Lake, Kathryn Mikkelsen, Sameer Parpia, the C-TRACT Trial Investigators*
Posted: April 13, 2026, 12:00 am
This Double Take video explores how a comprehensive patient-centered approach can provide high-value care for older patients.
Author: Daniel Pound, Ishani Ganguli, Debra Malina
Posted: April 9, 2026, 12:00 am
A 68-year-old man who had undergone intubation 25 days earlier had difficulty swallowing after extubation. A swallowing study showed fluid penetrating into the trachea without triggering a cough reflex (shown in a video).
Author: Shuo-Ting Jian, Hsiu-Nien Shen
Posted: April 9, 2026, 12:00 am
Chronologic age plays an outsized role in various aspects of medicine. Yet people of the same age can differ dramatically when it comes to aging-related risk factors.
Author: Martin G. Lee
Posted: April 2, 2026, 12:00 am
If the future of primary care lies in teams, what makes a team and how should it function? NOS host Lisa Rosenbaum and her guests consider the possibilities of team-based care.
Posted: March 12, 2026, 12:00 am
This review summarizes the diagnosis and management of polymyalgia rheumatica in adults older than 50 years of age, emphasizing clinical diagnosis, glucocorticoids as first-line therapy, relapses, and glucocorticoid-sparing options.
Author: Christian Dejaco, Eric L. Matteson
Posted: March 12, 2026, 12:00 am
This feature about blood-pressure targets to manage hypertension offers a case vignette accompanied by two essays, one recommending a systolic blood-pressure target of less than 120 mm Hg and the other supporting a target of less than 140 mm Hg.
Author: Christos P. Kotanidis, Paul K. Whelton, Clinton B. Wright
Posted: March 5, 2026, 12:00 am
A 91-year-old man with a history of bladder carcinoma and left total knee arthroplasty was evaluated because of left knee pain. A culture of synovial fluid showed no growth. A diagnosis was made.
Author: Sandra B. Nelson, Tina Shiang, Erik T. Newman, Barbra M. Blair, Sarah M. Schrader
Posted: February 26, 2026, 12:00 am
Group B streptococcal infection mostly affects newborns, infants, pregnant persons, and older adults. Perinatal prevention is successful but contributes to antibiotic exposure. Multivalent glycoconjugate vaccines are in development.
Author: Karen M. Puopolo
Posted: February 26, 2026, 12:00 am
After ischemic stroke, recurrence risk is reduced by identifying the stroke mechanism and targeting modifiable risk factors. Early diagnostic evaluation, prompt preventive therapy, and ongoing monitoring are central to care.
Author: Karen L. Furie, Peter J. Kelly
Posted: February 19, 2026, 12:00 am
The U.S. government can combat chronic disease among Medicare patients by strengthening primary care, expanding access to preventive care, making care more affordable, and modernizing Medicare benefits.
Author: David Blumenthal, Elizabeth Fowler, Gretchen Jacobson
Posted: January 29, 2026, 12:00 am
Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization.
Author: Mary M. McDermott
Posted: January 29, 2026, 12:00 am
In acute central retinal artery occlusion treated within 4.5 hours after onset, intravenous tenecteplase did not result in greater recovery of vision at 30 days than aspirin and was associated with serious safety concerns.
Author: Stephen J. Ryan, Øystein Kalsnes Jørstad, Mona Skjelland, Maiju Pesonen, Claus Z. Simonsen, Toke Bek, Rolf Ankerlund Blauenfeldt, Petra Ijäs, Arja Laitinen, Andrej Khanevski, Jørgen Krohn, Eyvind Rødahl, Robin Lemmens, Jelle Demeestere, Catherine Cassiman, Ingvild Nakstad, Kristin Evensen, Tiril Sandell, Steffen Hamann, Thomas C. Truelsen, Louisa M. Christensen, Sverre Rosenbaum, Vaidas Matijošaitis, Reda Žemaitienė, Hanne Ellekjær, Erlend Almaas, Dordi Austeng, Michael V. Mazya, Frank Traïsk, Pauli Ylikotila, Ulpu Salmi, Kristian N. Jenssen, Håvard Lisether, Cathrine Breivik, Kristina Devik, Lasse-Marius Elden Honningsvåg, Jurgita Valaikienė, Andrius Cimbalas, Vetle Nilsen Malmberg, Espen Anderson, Ansar Roy, Thor Håkon Skattør, Kristian Lundsgaard Kraglund, Christina Kefaloykos, Inge Christoffer Olsen, Peter Vanacker, Daniel Strbian, Morten C. Moe, Anne Hege Aamodt, the TenCRAOS Investigators*
Posted: January 29, 2026, 12:00 am