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Agencies have long relied on civil monetary penalties to address violations of health care and public health regulations. But rules governing federal fines are now in flux.
Author: Anjali D. Deshmukh, Joan H. Krause
Posted: October 29, 2026, 12:00 am
In 2015, pivotal randomized, controlled trials established the benefit of endovascular treatment for acute ischemic stroke due to a large-vessel occlusion.1,2 The trials showed a major clinical benefit in patients presenting with relatively standard stroke features: large-vessel occlusion in the anterior circulation; relevant clinical neurologic deficit; short time...
Author: Gaultier Marnat
Posted: October 23, 2026, 12:00 am
Among patients with mild stroke from large-vessel occlusion, 69.4% had a favorable functional outcome at 90 days with endovascular therapy plus medical management, as compared with 50.0% with medical management alone.
Author: Jianmin Liu, Tingyu Yi, Pengfei Xing, Meihua Wu, Liyong Zhang, Tuanyuan Zheng, Mingzhu Huang, Yanmin Wu, Hao Wang, Guoyong Zeng, Jinglun Li, Ya Peng, Yueqi Zhu, Yibin Fang, Xueli Cai, Jun Luo, Yuanbiao Lei, Hao Qin, Pu Fang, Yamei Tang, Guangxiong Yuan, En Wang, Xiongjun He, Xiongwei Lu, Zhentao Li, Bo Lei, Hua Cao, Xinguang Yang, Chenghua Xu, Meixia Shang, Craig S. Anderson, Zeguang Ren, Pengfei Yang, Wenhuo Chen, the MILD-MT Investigators*
Posted: October 23, 2026, 12:00 am
Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle.
Author: Robert B. Shpiner
Posted: October 22, 2026, 12:00 am
In two trials involving participants with OSA and obesity or overweight with or without type 2 diabetes, treatment with retatrutide was found to result in greater decreases in the apnea–hypopnea index than placebo.
Author: Ronald R. Grunstein, Virend K. Somers, Ali Azarbarzin, Atul Malhotra, Scott A. Sands, Brendan P. Lucey, Sheryl E. Allen, Kathryn Giblin, Beverly L. Falcon, So Young Park, Jitong Lou, Kathryn Krueger, the TRIUMPH-1-OSA and TRIUMPH-2-OSA Investigators*
Posted: October 21, 2026, 12:00 am
Integration of screening for health-related social needs into clinical care represents an important advance. But most screening tools haven’t been developed or validated with older adults in mind.
Author: Mark A. Unruh, Joshua R. Vest
Posted: October 15, 2026, 12:00 am
Older adults are vulnerable to firearm-related harms. Medicare’s annual wellness visit presents an opportunity to engage older adults and their families or caregivers in conversations about firearms.
Author: Lena K. Makaroun, Timothy W. Farrell, Marian E. Betz
Posted: October 15, 2026, 12:00 am
For decades, one of the most important unresolved questions in preventive cardiovascular medicine has been whether statin therapy should be initiated for primary prevention in healthy older adults. Although age is among the strongest determinants of absolute risk, the benefits of statin therapy beyond 70 to 75 years of age...
Author: Martin Bødtker Mortensen
Posted: October 1, 2026, 12:00 am
In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival.
Author: Sophia Zoungas, Rory Wolfe, Chris Moran, Stephen J. Nicholls, Geoffrey C. Cloud, Christopher M. Reid, Andrew M. Τonkin, Lawrence Beilin, Anthony S. Wierzbicki, Trevor T.-J. Chong, Jonathan C. Broder, Andrea J. Curtis, Zachary Flanagan, Ingrid Hopper, Joanne Ryan, Simone Spark, John J. McNeil, Mark R. Nelson, the STAREE Investigators
Posted: October 1, 2026, 12:00 am
A dying patient in a state psychiatric hospital has no access to a DNR order that would make the process as peaceful as possible — as the notorious Bedlam casts a shadow over mental health care to this day.
Author: Richard Elledge
Posted: September 10, 2026, 12:00 am
A 65-year-old man was admitted to this hospital because of fever, intermittent abdominal pain, and rash. The fever began 5 weeks earlier, and palpable purpura developed 1 week before admission. A diagnosis was made.
Author: Jacqueline T. Chu, Robert G. Rasmussen, Jacquelyn M. Nestor, Mack Y. Su
Posted: September 10, 2026, 12:00 am
As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward.
Author: James T. Rosenbaum
Posted: August 13, 2026, 12:00 am
Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rheumatica and giant-cell arteritis (GCA), owing to...
Author: Yoshiya Tanaka
Posted: August 13, 2026, 12:00 am
Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone.
Author: John H. Stone, Frank Buttgereit, Alain Saraux, Wolfgang A. Schmidt, Christian Dejaco, Robert Spiera, Bhaskar Dasgupta, Edit Drescher, Andrew Jordan, Libor Novosad, Daiki Nakagomi, Yoshinobu Koyama, Sergio Duran-Barragan, Gerald Tracey, Adeline Ruyssen-Witrand, Andrea Rubbert Roth, Juanzhi Fang, Jennifer Ng, Renuka Hiremath, Roselyne Raffner, Ruvie Martin, Silvia Napoletano, Songqiao Huang, Julian Storim, Manmath Patekar, the REPLENISH Investigators*
Posted: August 13, 2026, 12:00 am
This review summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.
Author: Rose Anne Kenny
Posted: August 6, 2026, 12:00 am
As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity.
Author: Mara Buchbinder
Posted: July 30, 2026, 12:00 am
As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline.
Author: Steven McGaughey
Posted: July 16, 2026, 12:00 am
The United States faces a projected shortage of millions of long-term–care workers by 2040. Yet in each area where progress could help address this gap, federal policy is moving in the wrong direction.
Author: Andrew R. Olenski, David C. Grabowski
Posted: July 9, 2026, 12:00 am
An ICU physician believed letting her father die at home meant comfort, dignity, control, family close by, and the quiet reassurance of hospice. But she didn’t realize what it would require of her family.
Author: Danielle D. DeCourcey
Posted: July 9, 2026, 12:00 am
A rapid growth in the population of older Americans has long been anticipated. But projections didn’t anticipate that this transition would coincide with a sustained reduction in nursing-home services.
Author: Mark A. Unruh, Vincent Mor, Hye-Young Jung
Posted: July 9, 2026, 12:00 am