An 80-year-old woman was admitted to the hospital because of cough and hypoxemia (oxygen saturation, 83%). CT of the chest showed diffuse ground-glass opacities in both lungs. A diagnosis was made.
Author: Shreya Shrestha, Tyler Brown, Jacqueline T. Chu, M. Lauren Donnelly-Morell
Posted: January 29, 2026, 12:00 am
The retina is a specialized patch of central nervous system tissue located at the back of the eye. When the principal source of oxygen and metabolic substrates to the retina — the central retinal artery — is occluded, rapid retinal cell death and loss of visual function ensue. This acute...
Author: Matthew Schrag, Brian Mac Grory
Posted: January 29, 2026, 12:00 am
The U.S. government can combat chronic disease among Medicare patients by strengthening primary care, expanding access to preventive care, making care more affordable, and modernizing Medicare benefits.
Author: David Blumenthal, Elizabeth Fowler, Gretchen Jacobson
Posted: January 29, 2026, 12:00 am
Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization.
Author: Mary M. McDermott
Posted: January 29, 2026, 12:00 am
In acute central retinal artery occlusion treated within 4.5 hours after onset, intravenous tenecteplase did not result in greater recovery of vision at 30 days than aspirin and was associated with serious safety concerns.
Author: Stephen J. Ryan, Øystein Kalsnes Jørstad, Mona Skjelland, Maiju Pesonen, Claus Z. Simonsen, Toke Bek, Rolf Ankerlund Blauenfeldt, Petra Ijäs, Arja Laitinen, Andrej Khanevski, Jørgen Krohn, Eyvind Rødahl, Robin Lemmens, Jelle Demeestere, Catherine Cassiman, Ingvild Nakstad, Kristin Evensen, Tiril Sandell, Steffen Hamann, Thomas C. Truelsen, Louisa M. Christensen, Sverre Rosenbaum, Vaidas Matijošaitis, Reda Žemaitienė, Hanne Ellekjær, Erlend Almaas, Dordi Austeng, Michael V. Mazya, Frank Traïsk, Pauli Ylikotila, Ulpu Salmi, Kristian N. Jenssen, Håvard Lisether, Cathrine Breivik, Kristina Devik, Lasse-Marius Elden Honningsvåg, Jurgita Valaikienė, Andrius Cimbalas, Vetle Nilsen Malmberg, Espen Anderson, Ansar Roy, Thor Håkon Skattør, Kristian Lundsgaard Kraglund, Christina Kefaloykos, Inge Christoffer Olsen, Peter Vanacker, Daniel Strbian, Morten C. Moe, Anne Hege Aamodt, the TenCRAOS Investigators*
Posted: January 29, 2026, 12:00 am
How can health care organizations balance physicians’ interests with patient safety in designing programs to ensure that cognitive and physical decline in older physicians doesn’t harm patients?
Author: Daniel B. Kramer, Thomas H. Gallagher, Paulina H. Osinska, Andrew A. White, Kelly Davis Garrett, Michelle M. Mello
Posted: January 22, 2026, 12:00 am
A key barrier to effective government oversight and optimal allocation of health care resources is the use of “related-party transactions” between health care organizations and affiliated entities.
Author: Erin C. Fuse Brown, Andrew R. Olenski, Ashvin D. Gandhi
Posted: January 22, 2026, 12:00 am
The author describes the scientific foundations of restoring vision through the implantation of a retinal prosthetic chip in persons with geographic atrophy.
Author: Jacque Duncan
Posted: January 15, 2026, 12:00 am
In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit.
Author: Thomas G. Brott, George Howard, Brajesh K. Lal, Jenifer H. Voeks, Tanya N. Turan, Gary S. Roubin, Ronald M. Lazar, Robert D. Brown Jr., John Huston III, Lloyd J. Edwards, Michael Jones, Wayne M. Clark, Ángel Chamorro, Laura Llull, Carlos Mena-Hurtado, Donald Heck, Randolph S. Marshall, Virginia J. Howard, Wesley S. Moore, Kevin M. Barrett, Bart M. Demaerschalk, Navdeep Sangha, Herbert Aronow, Malcolm Foster, W. Charles Sternbergh III, Fayaz Shawl, Giuseppe Lanzino, Joseph Rapp, Hoang S. Tran, Robert Ecker, Ariane Mackey, Vaqar Ali, Curtis Given II, Philip Teal, Vikram S. Kashyap, Dipankar Mukherjee, Mark Harrigan, Scott Silverman, Matthew Koopmann, Virginia G. Wadley, Yu Zhang, J. David Rhodes, Seemant Chaturvedi, James F. Meschia, the CREST-2 Investigators*
Posted: January 15, 2026, 12:00 am
In persons with geographic atrophy due to age-related macular degeneration, a neurostimulation system composed of glasses, a processor, and a subretinal implant restored central vision and significantly improved visual acuity.
Author: Frank G. Holz, Yannick Le Mer, Mahiul M.K. Muqit, Lars-Olof Hattenbach, Andrea Cusumano, Salvatore Grisanti, Laurent Kodjikian, Marco Andrea Pileri, Frederic Matonti, Eric Souied, Boris V. Stanzel, Peter Szurman, Michel Weber, Karl Ulrich Bartz-Schmidt, Nicole Eter, Marie Noelle Delyfer, Jean François Girmens, Koen A. van Overdam, Armin Wolf, Ralf Hornig, Martina Corazzol, Frank Brodie, Lisa Olmos de Koo, Daniel Palanker, José-Alain Sahel
Posted: January 15, 2026, 12:00 am
The management of carotid-artery stenosis that has not caused recent symptoms — asymptomatic carotid stenosis — has been controversial. Clinical trials that began more than 30 years ago showed a small benefit of carotid endarterectomy as compared with medical treatment, but improvements in medical prevention of stroke call into question...
Author: Martin M. Brown, Leo H. Bonati
Posted: January 15, 2026, 12:00 am
In this open-label, randomized trial, the RSV vaccine reduced the incidence of hospitalization for RSV-related respiratory tract disease as compared with no vaccine among adults 60 years of age or older.
Author: Mats C. Højbjerg Lassen, Niklas Dyrby Johansen, Sine H. Christensen, Negar Aliabadi, Kristoffer G. Skaarup, Daniel Modin, Brian L. Claggett, Carsten S. Larsen, Lykke Larsen, Lothar Wiese, Michael Dalager-Pedersen, Matias G. Lindholm, Anne Marie R. Jensen, Maria Dons, Katrine F. Bernholm, Filip S. Davidovski, Lisa S. Duus, Camilla I. Ottosen, Anne B. Nielsen, Julie H. Borchsenius, Caroline Espersen, Güldas Köse, Frederik H. Fussing, Lars Køber, Scott D. Solomon, Jens Ulrik Stæhr Jensen, Cyril Jean-Marie Martel, Bradford D. Gessner, Claudia Schwarz, Elisa Gonzalez, Mette Skovdal, Lawrence H. Moulton, Pingping Zhang, Elizabeth Begier, Tor Biering-Sørensen
Posted: January 8, 2026, 12:00 am
Twelve former commissioners of the FDA express concern that the agency’s recent moves will undermine a regulatory model designed to ensure vaccine safety, effectiveness, and availability.
Author: Robert M. Califf, Andrew C. von Eschenbach, Michael A. Friedman, Brett P. Giroir, Scott Gottlieb, Margaret A. Hamburg, Jane E. Henney, David A. Kessler, Mark B. McClellan, Stephen M. Ostroff, Norman E. Sharpless, Janet Woodcock
Posted: January 1, 2026, 12:00 am
Grieving over a beloved patient who’d invited her into the private, sacred space of her planned day of death, a palliative care physician finds it hard to switch gears as she sits in a PTA meeting.
Author: Danielle Chammas
Posted: January 1, 2026, 12:00 am
Randomized, placebo-controlled trials are widely accepted as the scientific reference standard to determine a causal association between an intervention and an outcome. They are pivotal for product licensure. Although such trials establish safety and efficacy with the assumption that bias has been eliminated, limitations remain. For vaccines, establishing the duration...
Author: Kathleen M. Neuzil
Posted: December 11, 2025, 12:00 am
Among adults 65 years of age or older, a high-dose influenza vaccine did not result in a significantly lower incidence of hospitalization for influenza or pneumonia than a standard-dose vaccine.
Author: Niklas Dyrby Johansen, Daniel Modin, Matthew M. Loiacono, Rebecca C. Harris, Marine Dufournet, Carsten Schade Larsen, Lykke Larsen, Lothar Wiese, Michael Dalager-Pedersen, Brian L. Claggett, Kira Hyldekær Janstrup, Katja Vu Bartholdy, Katrine Feldballe Bernholm, Julie Inge-Marie Helene Borchsenius, Filip Soeskov Davidovski, Lise Witten Davodian, Maria Dons, Lisa Steen Duus, Caroline Espersen, Frederik Holme Fussing, Anne Marie Reimer Jensen, Nino Emanuel Landler, Adam Cadovius Femerling Langhoff, Mats Christian Højbjerg Lassen, Anne Bjerg Nielsen, Camilla Ikast Ottosen, Morten Sengeløv, Kristoffer Grundtvig Skaarup, Scott D. Solomon, Martin J. Landray, Gunnar H. Gislason, Lars Køber, Line Ralfkiaer, Joshua Nealon, Pradeesh Sivapalan, Cyril Jean-Marie Martel, Jens Ulrik Stæhr Jensen, Tor Biering-Sørensen
Posted: December 11, 2025, 12:00 am
In adults 65 to 79 years of age, there appeared to be fewer hospitalizations for influenza or pneumonia with high-dose influenza vaccine than with the standard dose, with a similar incidence of serious adverse events.
Author: Jacobo Pardo-Seco, Carmen Rodríguez-Tenreiro-Sánchez, Iago Giné-Vázquez, Narmeen Mallah, Susana Mirás-Carballal, Marta Piñeiro-Sotelo, Martín Cribeiro-González, Mónica Conde-Pájaro, Juan-Manuel González-Pérez, Irene Rivero-Calle, Xabier Bello, Josefina Lorena Razzini, Ana Dacosta-Urbieta, Antonio Salas, Rebecca C. Harris, Matthew M. Loiacono, Robertus van Aalst, Joan Manel Farre, Marine Dufournet, Niklas Dyrby Johansen, Daniel Modin, Tor Biering-Sørensen, Carmen Durán-Parrondo, Federico Martinón-Torres, the GALFLU Trial Team*
Posted: December 11, 2025, 12:00 am
Idiopathic normal-pressure hydrocephalus typically causes gait, cognitive, and urinary impairment. The diagnosis is aided by a medical evaluation, imaging findings, and tests that predict improvement with CSF shunting.
Author: Mark D. Johnson, Michael A. Williams
Posted: December 4, 2025, 12:00 am
Results from recently published, peer-reviewed studies support the safety and effectiveness of immunizations against Covid-19, RSV, and influenza.
Author: Jake Scott, Michael S. Abers, Harleen K. Marwah, Nicole C. McCann, Eric A. Meyerowitz, Aaron Richterman, Derek F. Fleming, Elise J. Holmes, Leah E. Moat, Sydney G. Redepenning, Emily A. Smith, Clare J. Stoddart, Maria E. Sundaram, Angela K. Ulrich, Christopher Alba, Cory J. Anderson, Meredith K. Arpey, Ethan Borre, Joseph Ladines-Lim, Angela J. Mehr, Katherine Rich, Corey Watts, Nicole E. Basta, Jana Jarolimova, Rochelle P. Walensky, Caitlin M. Dugdale
Posted: December 4, 2025, 12:00 am
In patients with idiopathic normal-pressure hydrocephalus responsive to CSF drainage, shunting improved gait and balance at 3 months, but not cognition or incontinence, and was associated with some procedure-related risks.
Author: Mark G. Luciano, Michael A. Williams, Mark G. Hamilton, Heather L. Katzen, Nickolas A. Dasher, Abhay Moghekar, Jun Hua, Jan Malm, Anders Eklund, Naomi Alpert Abel, Ahmed M. Raslan, Benjamin D. Elder, Jesse J. Savage, Daniel L. Barrow, Kiarash Shahlaie, Hailey Jensen, Thomas J. Zwimpfer, Jessica Wollett, Daniel F. Hanley, Richard Holubkov, the PENS Trial Investigators and the Adult Hydrocephalus Clinical Research Network*
Posted: December 4, 2025, 12:00 am