The advent of telemedicine has significantly transformed the healthcare landscape, offering enhanced accessibility to specialised wound care. By integrating digital health solutions, complementary to face-to-face care, in a personalised care pathway telemedicine facilitates timely interventions, reduces unnecessary hospital visits and optimises medical resources. Developing recommendations on the effective use of telemedicine in wound care can encourage good practice. The model proposed by the...
Ras signalling is an important regulator of cell proliferation, survival, differentiation, and immune responses. Although Ras pathways have been extensively studied in cancer biology, increasing evidence suggests that many pathogens also manipulate Ras-associated signalling networks to support infection, persistence, and immune evasion. Viruses, bacteria, and parasites can alter Ras activity either directly or indirectly through downstream pathways such as MAPK/ERK and PI3K/AKT. However,...
CONCLUSION: Our study indicates, resurgence of gonorrhea in post-COVID-19 period and emergence of cases with lack of adequate treatment response, thereby, emphasizing the need for increased surveillance.
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2025 annual meeting featured a new "Soapbox: Rapid fire presentations" session, highlighting various topics and emerging work across diverse areas of psoriatic disease (PsD). Three presentations are summarized here. The first provided the first national epidemiologic analysis of PsD in Peru, demonstrating marked age, sex, and geographic disparities, as well as shifts in healthcare utilization following the...
The primary route of SARS-CoV-2 entry is via respiratory epithelium. However, many COVID-19 patients developed dermatological lesions, and SARS-CoV-2 RNA has been detected in the patients' skin. Inflammatory skin diseases, psoriasis and atopic dermatitis (AD), significantly increased the risk of COVID-19. To evaluate the potential role of skin in SARS-CoV-2 host interactions, we utilized 3D human skin organoids (HSO) generated from human epidermal keratinocytes, as well as neonatal skin...
Background: The increasing incidence and improved survival rates of multiple myeloma (MM) have led to a growing healthcare burden, particularly in terms of hospitalizations. In addition, infection-related complications remain a major cause of morbidity and mortality in these patients. The impact of infection control measures implemented during the COVID-19 pandemic on hospitalization patterns in MM is not well-established. Methods: We conducted a retrospective observational study including all...
Background/Objectives: SARS-CoV-2 infection and COVID-19 vaccination have both been linked to post-acute alopecia, yet prevalence, patterns, and correlates remain poorly defined. We aimed to determine the prevalence and patterns of alopecia after SARS-CoV-2 infection and COVID-19 vaccination, and to identify independent correlates among Saudi adults. Methods: A cross-sectional study of 1261 Saudi adults (≥18 years) was conducted nationwide between March and July 2025 using a structured,...
CONCLUSIONS: Long COVID was associated with profound impairment in HRQoL compared with recovered controls. Depressive symptoms, post-COVID comorbidity burden, and lower active employment were the strongest independent correlates of poorer HRQoL; fatigue severity showed a borderline association in the same direction. These findings support multidisciplinary long COVID care models that integrate symptom control, mental health assessment, and social and occupational reintegration. Routine...
COVID-19, caused by the SARS-CoV-2 virus, has become a global public health crisis with diverse clinical manifestations affecting multiple organ systems, including the integumentary system. One notable cutaneous manifestation, referred to as "COVID toes," involves the development of pernio-like chilblains, characterized by red-to-violet macules, plaques, or nodules, primarily on toes and fingers. This characteristic clinical feature gained significant attention due to its apparent association...
CONCLUSIONS: To improve vaccination rates among pregnant women, it is essential to provide clear, evidence-based information through healthcare professionals, particularly those directly caring for pregnant women. Educational campaigns should address concerns calmly and without judgment, emphasizing the safety and benefits of vaccinations. Enhanced access to healthcare and vaccinations, along with strategic information dissemination, can significantly improve vaccine acceptance during pregnancy....
Dupilumab-associated erythema multiforme and lichenoid eruptions have been previously reported as rare dermatological adverse events. We present an atypical paediatric case of a dupilumab-associated erythema multiforme-like eruption in a 5-year-old male eczema patient, who developed erythematous targetoid papules and plaques over the upper and lower limbs, with a biopsy suggestive of a lichenoid interface reaction. Dupilumab was discontinued, and the side effect was managed with topical...
Superficial fungal infections and eczematous dermatitis frequently present with overlapping clinical features, such as erythema, scale, and pruritus, which often lead to empiric treatment and delayed diagnosis. Existing confirmatory tests, such as potassium hydroxide microscopy, fungal culture, and polymerase chain reaction, can be limited by operator dependence, turnaround time, availability, and cost. These challenges create a need for a rapid, non-invasive method to distinguish fungal...
CONCLUSION: Patients with SSD showed distinct sensitization patterns associated with clinical characteristics, barrier dysfunction, and scalp microbiota alterations. These findings suggest that patch test reactivity in SSD should be interpreted in the broader context of allergen exposure, skin barrier status, and microbial imbalance.
CONCLUSION: Autistic females in early childhood face greater cardiometabolic and neurological burdens, while males are more prone to respiratory and metabolic conditions. These sex- and cognition-specific risk profiles support tailored screening-cardiovascular/metabolic monitoring for females and respiratory disease prevention for males-to inform clinical care and health policy.
Despite the success of COVID-19 mRNA vaccines, they still face challenges with high costs, complex manufacturing, off-target biodistribution, and systemic reactogenicity stemming from their inflammatory carriers: lipid nanoparticles (LNPs). While "naked" RNA delivery could in principle solve these issues, studies have suggested that it is infeasible due to rapid degradation by RNases and poor cellular entry, thereby necessitating formulations that enhance intracellular delivery and RNA...
Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common inflammatory skin diseases influenced by environmental factors, but disease-specific environmental pathways remain poorly defined. This study developed a machine learning model to predict monthly disease prevalence and characterize distinct environmental conditions associated with each disease. We analyzed nationwide health insurance claims data for AD, ACD, and corns (control) from six major South Korean cities from 2012 to...
Real-world evidence on clinical and molecular outcomes of systemic therapy for pediatric atopic dermatitis remains limited. Within the prospective TREATkids registry, we conducted an observational analysis of children and adolescents treated with Dupilumab in routine care. Baseline data from 200 and follow-up data from 124 patients were evaluated for clinician- and patient-/caregiver-reported outcomes, alongside with epidermal proteomic profiling using tape strips and the Olink® Explore...
CONCLUSION: Dupilumab treatment in children with AD was associated with height and BALP level improvements.
CONCLUSION: These findings identify an AMPK-mTOR-redox metabolic checkpoint that governs regulatory B cell function and restrains AD inflammation, linking metabolic control to immune regulation.
CONCLUSIONS AND CLINICAL RELEVANCE: In dogs, aFEPs present distinctive histopathological characteristics and should be differentiated from other aural masses. Identification and removal of aFEPs might be critical for the resolution of chronic-recurrent otitis in dogs.