Pulmonary embolism is the third leading cardiovascular cause of complications and death after myocardial infarction and stroke, with a rising incidence globally.1 The approach to management of acute pulmonary embolism as a condition to be treated nonsurgically with systemic heparin anticoagulation was established more than 60 years ago.
Posted: May 28, 2026, 12:00 am
A 51-year-old man presented with a 2-hour history of coffee-ground emesis and difficulty swallowing. Upper endoscopy showed black discoloration and friability of the mucosa from the midesophagus to the gastroesophageal junction.
Posted: May 28, 2026, 12:00 am
A 57-year-old woman presented with left wrist pain after slipping on ice and falling on her palm. On examination, there was dorsal angulation of the distal forearm proximal to the wrist.
Posted: May 28, 2026, 12:00 am
In patients with pulmonary embolism, ultrasound-facilitated, catheter-directed fibrinolysis led to a lower risk of a composite of major adverse outcomes than anticoagulation alone.
Posted: May 28, 2026, 12:00 am
Among patients with traumatic hemorrhage, prehospital transfusion of whole blood did not result in lower 30-day mortality than transfusion of plasma or red cells. Outcomes did not differ according to the storage age of blood.
Posted: May 18, 2026, 12:00 am
Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the emergency department with wheezing, regardless of whether they tested positive for pathogenic bacteria.
Posted: May 18, 2026, 12:00 am
One way to classify acute ischemic stroke is by the anatomy of vessel occlusion. Initial randomized trials of endovascular thrombectomy focused on large-vessel occlusions.1-5 These proximal occlusions of the intracranial carotid artery or the stem of the middle cerebral artery (MCA) represent the most severe form of anterior...
Posted: May 14, 2026, 12:00 am
A 65-year-old woman with cardiovascular risk factors presented with a 14-hour history of painless, worsening, blurry vision in the right eye (visual acuity, 20/400). Funduscopy showed diffuse retinal hemorrhages and venous dilatation.
Posted: May 14, 2026, 12:00 am
A 55-year-old man presented with cough, chest pain, and worsening dyspnea after being trapped in a burning house for 10 minutes. Bronchoscopy revealed carbonaceous deposits that extended along the airway (shown in a video).
Posted: May 14, 2026, 12:00 am
Among patients with stroke due to medium-vessel occlusion, thrombectomy led to functional independence at 90 days (in 58.6% of patients, vs. 46.6% with medical management) but also to a higher risk of intracranial hemorrhage.
Posted: May 14, 2026, 12:00 am
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