Menopause Pubmed Results

CONCLUSION: The combination of CA therapy and CHM shows high safety and efficacy, and a low CPP recurrence rate in women.

The menopausal transition, defined by declining estradiol, disrupts neurotrophic and anti-inflammatory pathways, contributing to hippocampal and cognitive decline. In this longitudinal study, we examined 150 perimenopausal women and 80 premenopausal controls over 12 months, assessing estradiol levels, neurotrophic and inflammatory biomarkers, cognitive performance, and structural and functional hippocampal changes. This study assessed estradiol using LC-MS/MS, BDNF and cytokines (IL-6, TNF-α)...

INTRODUCTION: Women carrying the apolipoprotein E4 (APOE4) allele have a greater risk of Alzheimer's disease (AD) from ages 65-75 years compared to men, yet the effects of APOE4 on cognitive and neuroimaging outcomes among midlife women remain poorly understood. We investigated APOE4-related differences in memory-based functional neuroimaging outcomes in cognitively normal, midlife postmenopausal women.

CONCLUSIONS: Each incremental disease was significantly associated with impaired work productivity. After adjusting for other comorbidities, work productivity impairment was associated with psychiatric disorders and migraines. These findings underscore the importance of optimal management of preexisting conditions and prevention of comorbidities.

Background: An early menopause (by definition, menopause that occurs at a woman's age 40 through 45) is often associated with certain changes in the body that can result in risks for health-related conditions, an extended period later. Thus, scientists have begun examining how vitamin D has been suggested to be associated with endocrine function regulating both hormones and reproductive function during this time. However, it is not yet clear as to whether or not vitamin D provides any benefit to...

In the modern day, despite advances in medicine and the prolongation of life expectancy, the age of menopause and male late-onset hypogonadism remains the same. This narrative review describes the physiology of the human reproductive system in females and males based on clinical and experimental studies. It explores the impact of gonadal aging and reproductive hormone withdrawal on the development of insulin resistance and diabetes and summarizes the use of antioxidants for the prevention of...

Background: Menopause is associated with hormonal changes that may influence cognitive function, psychological health, and quality of life, but data on Middle Eastern populations remain scarce. Methods: A cross-sectional study was conducted among 220 Saudi women (110 perimenopausal, 110 postmenopausal) in Riyadh. Cognitive function was assessed with the MMSE-2; quality of life with SF-36 and MENQOL; and psychological distress with PHQ-4 and PSS-10. Group comparisons used the Mann-Whitney U test;...

Background: Hypertension (HTN) is a multifactorial condition involving alterations in vascular signaling, inflammation, and oxidative stress. Women during the menopausal transition may experience increased cardiovascular risk due to hormonal fluctuations, highlighting the need for circulating biomarkers that may assist in identifying HTN-related biological changes. This study aimed to evaluate circulating biomarkers reflecting estrogen signaling, inflammation, and oxidative stress, and to assess...

Background/Objectives: Pelvic organ prolapse (POP) management requires precise patient selection for surgical techniques to balance clinical efficacy and safety. The primary aim of this study was to evaluate the role of preoperative 3D/4D transperineal ultrasound in the risk stratification of POP recurrence. We analyzed the impact of levator ani muscle (LAM) injuries, specifically avulsion and ballooning, as identified by ultrasound, on both anatomical and subjective success rates, comparing...

Background and Objectives: Younger and middle-aged women may continue to describe psychological and psychosocial burden years after myocardial infarction (MI), yet multicenter real-world data remain limited on what women retrospectively report during long-term follow-up. This study examined such reports in younger and middle-aged women with prior MI while explicitly accounting for delayed, heterogeneous follow-up timing and the non-standardized nature of symptom ascertainment. Materials and...

CONCLUSION: The incidence of intravenous leiomyomatosis is low in postmenopausal women, although it is commonly misdiagnosed. Most patients have a history of uterine fibroids before menopause. Intravenous leiomyomatosis is treated via surgical resection, and it has a low postoperative recurrence rate.

CONCLUSIONS: Vitrified zygote banking yielded clinical pregnancy and live birth outcomes comparable to conventional fresh embryo transfer, though differences in study design limit direct comparison. While associated with higher treatment costs, zygote banking may provide additional flexibility in embryo selection and transfer timing. Further prospective studies are needed to validate its clinical and economic utility.

CONCLUSIONS: Urinary succinate was higher in women with symptom-defined probable OAB even after adjustment for major demographic covariates, while the association with malate was weaker. These findings are hypothesis-generating and require confirmation in adequately powered, prospectively phenotyped cohorts with standardized metabolic, dietary, and urinary microbiome assessment.

CONCLUSIONS: SI and LO were associated with EM and premature mortality. Women with EM are especially vulnerable to the negative effects of social adversity. Integrating psychological and social support into menopause care is essential, and reducing SI and LO may promote healthier aging.

Female fertility declines dramatically with age, primarily due to the loss of oocyte number and quality. This physiological event leads to ovarian dysfunction and infertility, irregular cycles and ultimately menopause. Despite its significance, the factors that underlie the natural process of age-related follicle loss, or those that promote premature ovarian aging, remain unknown. Here we show that low levels of chronic inflammation in mice lacking the nuclear factor kappa B transcription factor...

CONCLUSIONS: VLCKD significantly reduced UA levels and UA-defined CV risk, supporting its role as a potentially effective lifestyle intervention in this population.

Circulating sex hormone levels decrease in aging, influencing cerebrovascular health. Estradiol has been shown to support female vascular and brain health, though its effects across the menopausal transition remain unknown. Similarly, the influence of testosterone and other hormones in females is not clear. In males, testosterone is associated with positive health outcomes, but the effects of estradiol and other hormones are undetermined. Here, 187 females were categorized as premenopausal,...

Purpose: Vasomotor, sexual, and musculoskeletal symptoms are common adverse effects of adjuvant endocrine therapy in breast cancer survivors. Social media use has not been investigated with altered symptom perception in patients receiving adjuvant endocrine therapy. This study aimed to investigate whether social media use or addiction independently predicts endocrine therapy-related symptom burden in breast cancer survivors. Methods: A cross-sectional survey study was conducted among 153 breast...

CONCLUSION: Vaginal estrogen use was not associated with worse overall survival or breast cancer-specific survival in this cohort SEER-MHOS cohort of patients older than 65 years. Loss of significance in time-dependent models suggests that initial associations may reflect immortal time or selection bias. These findings support growing evidence that local vaginal estrogen is not associated with adverse survival outcomes and may be considered for symptom management in appropriately selected...

Background/Objectives: Insomnia is one of the most prevalent and persistent symptoms among patients with breast cancer, yet it remains under-recognized and undertreated in routine clinical practice. Beyond its impact on sleep quality, insomnia is increasingly understood as a multidimensional condition involving neurobiological, psychological, and behavioral mechanisms, closely intertwined with cancer-related stress and psychiatric comorbidities. This narrative review aims to provide a...

CONCLUSIONS: Thyroid function before diagnosis does not appear to play a major role in bc survival. Although subgroup-specific associations were identified, these findings should be interpreted with caution due to limited statistical power and warrant confirmation in independent populations.

Background: Osteoporosis/osteoporotic fractures are identified in both hypercalcemic (HC-HPT) and normocalcemic variant (NC-HPT) of primary hyperparathyroidism (HPT) at various rates. Objective: Noting the need of modern society to easily assess the osteoporotic fracture risk amid the diagnosis of HPT, we aimed to address this gap by analyzing the 10-year fracture risk assessment based on traditional FRAX (Fracture Risk Assessment Tool) model in comparison to the novel algorithm (FRAXplus),...

CONCLUSION: Individualized, patient-selected supportive interventions may help maintain key aspects of quality of life and support adherence to endocrine therapy in premenopausal women with early-stage breast cancer. These findings support further evaluation in larger, controlled trials.

The absence of a culturally adapted instrument to assess menopause-specific quality of life in Vietnamese women limits both clinical practice and research in this population. This study aimed to translate, culturally adapt, and psychometrically validate the Vietnamese version of the Utian Quality of Life (VN-UQOL) Scale. A cross-sectional design was employed with 384 community-dwelling postmenopausal women aged 46-65 years. The UQOL was translated and adapted following established guidelines,...

Hypertension, or high blood pressure, is a major risk factor for cardiovascular disease, the leading cause of mortality worldwide. The incidence and the severity of hypertension is higher in middle-aged men than women. The hallmark of hypertension is an increased sympathetic nerve activity to the cardiovascular organs. One mechanism that regulates sympathetic nerve activity is the homeostatic baroreflex which maintains blood pressure at optimal levels for survival. Baroreceptive nerve endings...

Background: Cervical cancer is primarily caused by the human papillomavirus (HPV), with persistent infections progressing to low- (LGSIL) and high-grade (HGSIL) lesions. Emerging evidence indicates that the cervicovaginal microbiota influences HPV persistence and disease progression, although the underlying metabolic mechanisms remain unclear. Therefore, we assessed the relationship between the cervicovaginal microbiota and the metabolic milieu in women with cervical dysplasia and HPV...

CONCLUSION: IMPC shows favorable OS but requires progression risk monitoring. PFS varied by molecular subtype, while OS did not. Molecular typing, clinical stage, and inflammatory/biochemical markers aid prognosis and personalized treatment.

Background/Objectives: Obesity and menopause are major determinants of skeletal deterioration; however, their combined effects on bone remodeling and associated cellular bioenergetics remain incompletely understood. This study aimed to determine whether obesity induces osteoporotic alterations under both estrogen-replete and estrogen-deficient conditions and to evaluate the therapeutic potential of dental tissue-derived mesenchymal stem cells (D-MSCs). Methods: Female mice were subjected to...

CONCLUSION: Night shift work, particularly with cumulative and long-term exposure, is associated with sleep disruption, reduced well-being, and early cardiometabolic alterations in female healthcare workers. Sleep impairment emerges as a robust exposure-related marker, while metabolic risk reflects combined occupational and individual susceptibility. These findings support life-course exposure assessment and suggests the use of early subclinical indicators for implementation of precision...

Background/Objectives: Standard mechanical compression applied during screening mammography is a primary barrier that reduces patient compliance. Current guidelines attempt to standardize compression based solely on the one-dimensional "breast thickness" measured by the device. This study aimed to investigate the effects of three-axis anatomical breast dimensions, applied compression force, menstrual cycle phases, and BI-RADS breast density patterns on pain scores during mammography within a...

CONCLUSION: Optimizing dietary intake of vitamins, antioxidants, and mitochondrial cofactors is a cost-effective, accessible strategy to support mitochondrial health and reduce age-related disease risk in women.

CONCLUSIONS: Current evidence suggests that hormonal factors may influence TMD risk and symptom presentation in women. However, heterogeneity in definitions of hormonal exposure and diagnostic criteria limits definitive conclusions. Further prospective studies using standardized diagnostic protocols and real-time biochemically validated hormonal assessments correlated with clinical symptoms are needed.

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CONCLUSIONS: This study showed male and female factors impacting female sexual function. There is a need for a couple's approach.

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CONCLUSIONS: These findings suggest that, in the context of a soybean-supplemented vegan diet, replacing the consumption of both unprocessed or minimally processed and ultra-processed animal foods with plant foods (regardless of the level of processing), was associated with significant weight loss and a reduction in severe hot flashes.

CONCLUSION: The burden of MS among postmenopausal women in East Asia is substantial and rising, exhibiting divergent patterns across countries. These findings underscore the urgent need for tailored, gender-sensitive healthcare policies and resource allocation to address the growing challenge of MS in aging female populations across the region.

CONCLUSION: The long-term side effects of breast cancer treatments highlight the need for comprehensive survivorship care, including routine monitoring, personalized rehabilitation programs, lifestyle modifications, and psychosocial support. Future research should focus on identifying risk factors, developing targeted interventions, and optimizing treatment strategies to minimize adverse effects and improve the quality of life for breast cancer survivors.

Chronic opioid use disrupts the female endocrine system, affecting the hypothalamic-pituitary-gonadal (HPG), hypothalamic-pituitary-adrenal (HPA), and hypothalamic-pituitary-thyroid (HPT) axes. In women, these disruptions manifest as menstrual irregularity, infertility, early menopause, reduced bone mineral density, adrenal insufficiency, and altered mood and sexual function. Despite the magnitude of the opioid epidemic and its impact on women of reproductive age, the existing evidence base is...

CONCLUSIONS: Phytoestrogens have numerous positive effects on the human body across various stages of life. Their overall impact and potency, however, seem to be influenced by factors such as intake level, individual genetic variability, and the specific phytoestrogen class consumed.

Menopausal hormone therapy (MHT) remains the most effective treatment for vasomotor symptoms (VMS) and other manifestations of menopause; however, its use is limited in women with contraindications to oestrogen. Progestogen monotherapy, though historically underutilized, represents a viable alternative in this population. This narrative review summarizes the indications, efficacy, and limitations of progestogen monotherapy as MHT. A structured literature search identified systematic reviews,...

CONCLUSIONS: MHT should not be used for cardiovascular disease prevention. Current evidence suggests that younger women in the early postmenopausal period may derive the greatest benefit with the lowest risk from individualized hormone therapy regimens, particularly those using transdermal estrogen. Treatment decisions should be guided by careful cardiovascular risk assessment and targeted to symptom relief and osteoporosis prevention.

CONCLUSION: Preoperative evaluation of cataract patients revealed that a substantial proportion exhibited signs of ocular surface disease, despite not reporting ocular discomfort. This highlights the importance of integrating ocular surface evaluation into routine preoperative assessment and considering targeted preoperative optimization, particularly in high-risk populations.

CONCLUSION: The majority of post-menopausal women do not report distress while taking AET; however, one in six reports high distress that did not dissipate with time. This work adds to the understanding of distress in breast cancer survivors and supports the use of the DT in providing actionable information on distress and its causes.

CONCLUSION: The Frauenherzen study provides a comprehensive design framework for evaluating cardiovascular health in middle-aged women using digital biomarkers. By describing the study design and methods in detail, we aim to enhance transparency, enable replication, and inform future research on sex-specific cardiovascular risk stratification and preventive strategies.

CONCLUSION: Mammographic microcalcifications are strong independent predictors of breast cancer, particularly among peri- and postmenopausal women, highlighting their clinical value in risk stratification and diagnostic evaluation.

Background: Inhibitory processes in the nervous system are traditionally conceptualized as suppressive mechanisms; however, their fundamental role is the refinement and optimization of sensory information. In nociception, this function is mediated by the descending pain inhibitory system (DPIS), which modulates nociceptive transmission at multiple hierarchical levels. Biological sex and gender-related factors significantly influence these inhibitory pathways, yet they are often overlooked in...

CONCLUSIONS: MSE appears effective in reducing systemic inflammation and improving QoL among postmenopausal breast cancer survivors with metabolic syndrome. However, evidence for specific biomarkers remains limited. Further high-quality, standardized RCTs are needed, especially in underrepresented regions such as sub-Saharan Africa, to guide global implementation of MSE in cancer rehabilitation.

CONCLUSION: In a high-risk colposcopy-referred cohort, HR-HPV infection, non-NILM TCT results, and positive PAX1/JAM3 gene methylation are independently associated with the presence of high-grade cervical lesions. These biomarkers have the potential to enhance clinical risk stratification and inform decision-making in cervical cancer screening. However, their clinical utility and cost-effectiveness need to be further evaluated through larger, prospective studies to validate their role in routine...