Arthritis/Rheumatology Pubmed Results

RATIONALE: Organizing pneumonia (OP) rarely occurs in patients with rheumatoid arthritis (RA). We report a case of concurrent onset of OP and RA, in which OP relapsed after 9 years, while RA remained in a state of low disease activity.

CONCLUSION: TCM decoctions as adjunctive RA treatment significantly enhance efficacy. However, due to study limitations, further large-scale, multicenter RCTs are needed to confirm these findings.

Background and Objectives: Sjögren's disease (SjD) is a chronic autoimmune disorder in which the immune system attacks the glands that produce tears and saliva, leading to symptoms such as dry eyes and dry mouth. If left untreated, SjD can also cause inflammation and damage to other parts of the body, including the skin, lungs, kidneys, and nervous system, and increase the risk of developing lymphoma. The human leukocyte antigen (HLA) class II molecule HLA-DR3 is strongly associated with SjD....

CONCLUSIONS: Higher UPF consumption is associated with an increased risk of self-reported diagnosed psoriasis and rheumatoid arthritis, whereas MUPF intake appears to be inversely associated with self-reported diagnosed psoriasis risk. These findings contribute to the ongoing evidence regarding the degree of food processing as a potential factor in the epidemiological profile of specific autoimmune conditions. However, given the observational design of the study, these findings reflect...

The global prevalence of autoimmune diseases ranges from 3% to 8%, with women at a significantly higher risk than men. The core mechanisms underlying these diseases include impaired T-cell and B-cell immune tolerance, abnormal cytokine production, and aberrant activation of related signaling pathways. Conventional treatments primarily focus on suppressing immune responses, but their efficacy remains limited and they are often associated with substantial side effects. Nanomedicine leverages...

CONCLUSIONS: Higher oral microbiome alpha diversity is significantly associated with lower prevalence of RA. Oral microbial diversity may serve as a potential indicator associated with RA status. However, given the cross-sectional nature of this study, longitudinal and interventional studies are warranted to further elucidate causal relationships.

CONCLUSION: Research on PCD in RA has expanded continuously and evolved from an apoptosis-centered framework toward a broader and more differentiated mechanistic landscape. These findings provide a systematic reference for future mechanistic and translational research, while the roles of emerging PCD pathways require further disease-specific validation.

CONCLUSION: The drug retention rates and effectiveness of bDMARDs with different modes of action were comparable in patients with RA and reduced kidney function.

CONCLUSION: These updated recommendations complement previous APLAR guidelines and aim to support best practice management of RA across the Asia-Pacific region. They provide a practical framework for national rheumatology associations to develop local guidelines adapted to their specific needs and clinical practice.

Mesenchymal progenitor cells (MPCs) play a significant role in articular cartilage homeostasis and regeneration. Yet, the functional dynamics and molecular characteristics of MPCs may differ significantly across various pathological conditions. Hence, this study comprehensively investigates the biological and molecular characteristics of MPCs isolated from articular cartilage of patients with osteoarthritis (OA) and rheumatoid arthritis (RA), aiming to uncover disease-specific differences that...

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cell populations with potent immunosuppressive activity. MDSCs accumulate during states of chronic inflammation in response to inflammatory cytokine signaling that triggers emergency myelopoiesis in the bone marrow. In rheumatoid arthritis and experimental models of inflammatory arthritis, MDSCs were initially thought to serve as a regulatory checkpoint that limits excessive inflammation. However, subsequent...

CONCLUSIONS: In the present study, an immune-based derivation-stage classifier showed potential for distinguishing TN-RA from UA at initial presentation. The IL-2-Treg axis perturbation represents a potential pathophysiological distinction, with sIL-2R as a candidate biomarker. These findings suggest that objective immune profiling may inform clinical decision-making when conventional criteria are inconclusive.

Autoantibodies against Ro52 are not only detected in Sjögren's disease (SjD), but also in idiopathic inflammatory myopathies, where they correlate with the incidence and severity of interstitial lung disease (ILD). It is still unclear whether antibodies against Ro52 are associated with further clinical manifestations in idiopathic inflammatory myopathies, as reduced tear and saliva production as a sign of associated SjD. Thus, this study aimed to determine the prevalence of objective SjD signs...

CONCLUSION: Salivary SP appears to be elevated in patients with SjD compared to those with NSS in this preliminary study, suggesting a potential diagnostic signal that warrants further investigation. Although the observed differences hint at possible utility as a non-invasive biomarker related to neuroimmune dysregulation, the diagnostic accuracy observed should be interpreted with caution due to the limited sample size and the exploratory nature of the findings. Larger, prospective, and...

Rheumatoid arthritis (RA) is an autoimmune disease primarily characterized by chronic, erosive polyarthritis. It is associated with a high rate of disability, and its pathogenesis remains incompletely understood. Uncontrolled chronic inflammation, synovial hyperplasia, Pannus formation, and bone destruction in RA patients remain the core challenges facing current clinical treatment, and the inflammatory response is generally considered the initiating factor for this series of pathological...

ObjectiveArthritis, including rheumatoid arthritis, gonarthrosis, and gouty arthritis, poses a substantial public health challenge. Regulatory T cells are critical for immune homeostasis, and their dysfunction contributes to arthritis pathogenesis; however, the specific gene regulatory programs causally influencing disease susceptibility remain elusive. We aimed to identify regulatory T cell-specific therapeutic targets using single-cell cis-expression quantitative trait locus and Mendelian...

Objectives: To evaluate associations between social vulnerability and rheumatoid arthritis (RA)-related mortality in the United States, with emphasis on domain-specific effects of the Social Vulnerability Index (SVI). Methods: We conducted a county-level ecological study of RA-related mortality from 2010 to 2019 using age-adjusted mortality rates and the Centers for Disease Control and Prevention SVI. Gamma regression models examined associations between RA mortality and overall SVI and four...

This study investigated the synergistic anti-arthritic effects of Wenyang Yishen Tongluo Prescription (TLP) combined with bone marrow mesenchymal stem cells (BMSCs) in rheumatoid arthritis (RA). A collagen-induced arthritis (CIA) rat model was established, and animals were divided into groups receiving TLP, BMSCs, or combination therapy. Network pharmacology identified IL-6 as a core target of TLP, which was further validated by molecular docking and cellular thermal shift assay (CETSA). The...

CONCLUSIONS: In this selected cohort of repeatedly hospitalized patients with RA or AS, treatment adherence, psychosocial factors, and supportive care indicators were associated with clinically relevant longitudinal outcomes. The findings support a multidisciplinary, patient-centered approach to inflammatory rheumatic disease care. However, because of the retrospective design, modest sample size, selected inpatient population, non-standardized assessment of several variables, and possible...

CONCLUSION: CD19 CAR-T therapy induced profound, durable responses in extremely severe patients with seropositive PIRRA. Despite significant acute toxicities, recovery was complete and long-term safety was favourable. These findings suggest that CAR-T may provide a transformative benefit in severe RA, warranting controlled clinical trials.

In chronic inflammatory diseases, maladaptive tissue remodeling is driven by a complex interplay of resident cells, immune infiltrates, and the extracellular matrix. In the autoimmune disorder rheumatoid arthritis (RA), synovial tissue undergoes massive expansion to form an invasive pannus that drives the erosion of cartilage and bone. The mechanisms mediating this aggressive growth are incompletely defined. Using spatial transcriptomic profiling of patient tissue, we detected an abundance of...

Rheumatoid arthritis (RA) is a chronic inflammatory disease in which symptoms such as pain and functional limitations can persist despite pharmacological control. Balneotherapy and pelotherapy are widely used as complementary, non-pharmacological interventions, although clinical evidence remains heterogeneous. To evaluate the clinical effects of a combined balneotherapy protocol consisting of local application of low-temperature sulphurous peloids followed by partial baths in natural sulphurous...

CONCLUSIONS: Despite heterogeneity, the results of this study may help rheumatologists guide selection of b/tsDMARDs, taking into account PROs that are important to the patient or reflect their primary symptoms. Future research should investigate within-class differences between specific b/tsDMARDs and emphasise individualised, PRO-based augmentation within treat-to-target strategies.

Sjögren's disease (SjD) is a chronic, multisystem autoimmune disorder characterised by lymphocytic infiltration of exocrine glands, leading to dryness, fatigue and variable extraglandular involvement. Despite its significant clinical and socioeconomic burden, no disease-modifying therapies have yet been approved. Current management remains largely symptomatic, reflecting the complexity and heterogeneity of the disease and the limitations of past clinical trials. Recent advances in the...

CONCLUSIONS: Disease activity may better discriminate inflammation-driven cardiovascular risk in seronegative and double seropositive than single RF-positive or ACPA-positive patients. Risk protection through lowering disease activity may be serostatus dependent.

CONCLUSION: The safety profile of upadacitinib remained consistent with previous analyses, with no new safety concerns through 7 years. Upadacitinib and adalimumab (continuous or rescue treatment) maintained disease activity targets throughout the 7-year treatment period. Upadacitinib exhibited an acceptable benefit-risk profile for long-term RA treatment.

Rheumatoid arthritis is characterized by chronic synovial inflammation and recurrent flares, which are thought to involve joint-specific inflammatory memory. Synovial fibroblasts (SFs) contribute to this process through altered responses to repeated inflammatory stimulation. However, pharmacological targeting of these state-dependent responses remains limited, partly due to the lack of screening systems that distinguish responses under initial and repeated stimulation conditions. Here, we...

CONCLUSION: Targeting LRRC15+ fibroblasts and fibrotic microenvironment may offer a new therapeutic opportunity to reduce inflammation in RA, SSc and other autoimmune disorders where activated fibroblasts play a role in disease pathogenesis.

CONCLUSION: QFZTP synergistically regulates the PI3K/AKT, NF-κB, and MAPK pathways to inhibit synovial cell proliferation and migration, induce apoptosis, and attenuate inflammation. This study provides a robust theoretical and experimental basis for its clinical application in RA.

The increasing age of patients with rheumatoid arthritis (RA) has heightened concern regarding osteoporosis and bone fragility. While bone loss in RA has been well studied, less is known about long-term changes in bone quality-related markers under different disease activity states and antirheumatic treatments. In this retrospective observational study, 25 patients with RA aged ≥ 50 years were followed for up to 2 years, during which serum bone matrix and turnover markers, including pentosidine,...

The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a potential composite biomarker that integrates nutritional and immune-inflammatory profiles. However, its association with rheumatoid arthritis (RA) prevalence remains undefined. In this large-scale cross-sectional study, we investigated the relationship between HALP and RA, explored the cross-sectional association between HALP score and RA prevalence, and evaluated HALP as a concurrent composite biomarker reflecting...

CONCLUSIONS: The wrist, MCP2 and MCP3 joints resolve more slowly than other joints following treatment with b/tsDMARDs, indicating that a longer evaluation period of treatment response and/or bridging intra-articular steroid injections may be required when these joints are affected.

BACKGROUND Congenital myasthenic syndrome (CMS) is a clinically and genetically heterogeneous disorder of neuromuscular transmission, with more than 35 associated genes. Although CMS typically presents at birth or in early childhood, adult-onset forms are increasingly recognized and frequently mimic seronegative autoimmune myasthenia gravis, causing diagnostic delay. Its prevalence (2.8-14.8 per million) is probably underestimated, particularly for mild, late-onset, or atypical phenotypes. CASE...

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation, pannus formation, and progressive joint destruction. Despite their established clinical benefits, conventional antirheumatic drugs remain hampered by poor targeting precision, systemic toxicity, and inadequate immunomodulation of the dysregulated microenvironment. The recent development of nanomedicine technology offers transformative potential to address these therapeutic challenges. This review...

Immune-mediated inflammatory arthritides (IMIA), including rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, and juvenile idiopathic arthritis, are chronic immune-driven disorders in which long-term malignancy safety has become a key determinant of therapeutic decision-making. Patients with IMIA are not oncologically neutral at baseline; persistent inflammatory burden, smoking exposure, age, and cumulative immunosuppressive treatment all modify cancer susceptibility. Against...

CONCLUSIONS: This case demonstrates that rituximab monotherapy can achieve clinical remission in iMCD-NOS with concurrent autoimmune manifestations when anti-IL-6 therapy is unavailable. The delayed response pattern-with biomarker improvement preceding clinical recovery-highlights the importance of serial VEGF monitoring and persistence with B-cell-directed therapy before concluding treatment failure.

CONCLUSION: The findings suggest significant metabolic and lipidomic alterations in RA, and indicate that these candidate biomarkers may serve as preliminary indicators of treatment response.

Lutein is a bioactive carotenoid best known for its role in retinal protection, but emerging evidence suggests that it may also exert anti-inflammatory activity in chronic inflammatory disorders. In this study, we investigated the anti-inflammatory and joint-protective effects of lutein in rheumatoid arthritis (RA)-related experimental models. Transcriptomic profiling was performed in MH7A fibroblast-like synovial cells treated with lutein, followed by Gene Ontology (GO), Kyoto Encyclopedia of...

Structured claims or EMR datasets have limitations, such as lacking important clinical variables, upcoding, or potential coding errors. Unstructured data powered with natural language processing (NLP) might bridge these gaps. We assessed the integration of NLP with unstructured data in advancing care for rheumatoid arthritis (RA). We conducted a scoping literature review search in PubMed, Embase, Web of Science and Directory of Open Access Journal to identify full-text studies published through...

CONCLUSIONS: This study demonstrated that SOL-116 has a favourable safety and PK profile. Combined with effective reduction of free BSSL in the circulation, findings in this study support ongoing clinical development of SOL-116, with a focus on elucidating the efficacy and mechanism of action of BSSL in the treatment of chronic inflammation, primarily RA.

This Health Policy compares the current recommendations from the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for new treatments in rheumatoid arthritis, highlighting where they align, where they differ, and how harmonisation could make drug development more efficient. We examined the EMA's Guidelines on Clinical Trials of Medicinal Products for the Treatment of rheumatoid arthritis and the FDA's draft guidance rheumatoid arthritis Development of Drugs for...

CONCLUSION: The findings suggest that patients with RA frequently experience moderate stigma, and that self-esteem and coping modes may serve as chain mediators between social support and stigma. Nurses may consider assisting patients in building positive social support networks, enhancing their self-esteem and promoting positive coping modes as potential strategies to reduce stigma.

Anti-TNF-α therapies, though known for their anti-inflammatory effects, have been associated with paradoxical inflammatory reactions, of which anterior uveitis is the most common. We report a case of recurrent bilateral cicatricial conjunctivitis linked to systemic adalimumab (ADA) treatment in a 66-year-old man with rheumatoid arthritis (RA). The patient experienced worsening bilateral red eyes, blurry vision, and discomfort following each ADA injection. Examination revealed signs of...

CONCLUSION: Automated assays (CLIA and MBI) demonstrate high specificity and analytical accuracy for anti-Ro/La antibody detection in pSS. MBI achieved the highest accuracy, whereas LIA showed superior sensitivity for anti-Ro60/52 detection. CLIA provided reliable specificity but failed to detect anti-Ro52 in this study. Collectively, these findings indicate that CLIA and MBI may represent reliable alternatives to LIA, although validation in disease-controlled cohorts is required before clinical...

Receptor activator of nuclear factor-κB ligand (RANKL) is a key mediator linking inflammation to osteoclast activation and bone erosion in rheumatoid arthritis (RA). Evidence on circulating RANKL levels and RANKL (TNFSF11) polymorphisms in RA has been inconsistent. Web of Science, Scopus, and PubMed were searched from inception to December 2025 for clinical studies comparing patients with RA and healthy controls and reporting either serum/plasma RANKL concentrations and/or RANKL genotype/allele...

CONCLUSION: HCV was for long considered a poor prognosis factor in CryoVas, and now those secondary to autoimmune conditions seem to evolve with a more severe course, notably carrying a higher lymphoma risk.

CONCLUSION: High direct medical costs were observed among patients with IA and OA both before and after diagnosis. The varying cost drivers over time and across different arthritis could provide a foundation for future healthcare resource planning.

CONCLUSIONS: The existing evidence suggests that RA may be associated with the risk of thyroid cancer. Given the limitations of this study, well-designed prospective studies with appropriate confounding controls are needed to further verify this association.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition that causes patients pain and seriously affects their quality of life. Therefore, finding a diagnostic marker is of great significance for the prediction and early diagnosis of RA. This study included 105 patients with RA and 90 healthy volunteers. miR-383-5p was quantified by RT-qPCR. The diagnostic potential of miR-383-5p for RA was evaluated by the ROC curve. Chi-square analysis was performed to evaluate correlations...

We report the case of a man in his 30s who presented with exertional dyspnoea and dry cough for 18 months, along with fever and generalised lymphadenopathy (cervical and axillary) for 3 months. He had no feature indicating a connective tissue disorder. High-resolution CT of the chest revealed bilateral and diffuse thin-walled cysts with multiple mediastinal lymph nodes, consistent with a cystic interstitial lung disease. His pulmonary function test showed a severe restrictive disease and an...