Sarcoidosis, Pumonary Pubmed Results

Pulmonary sarcoidosis and asthma can present identical symptoms, making clinical evaluation difficult if the two diseases overlap. Diagnostic challenges often lead to either overdiagnosis of asthma in patients with confirmed sarcoidosis or withholding appropriate asthma treatment. The true prevalence of patients with bronchial hyperresponsiveness, the hallmark of asthma, among sarcoidosis patients remains unknown, although it is suspected to be significantly higher compared to the general...

Pulmonary sarcoidosis is typically treated with prednisone, but its side effects are prompting the search for alternatives. The PREDMETH study compared methotrexate and prednisone, demonstrating similar efficacy on lung function at 24 weeks. Methotrexate causes fewer metabolic effects but more gastrointestinal and liver disturbances. These results support an alternative approach in sarcoidosis. Non-cystic fibrosis bronchiectasis (NCFBE) has long been limited to repeating what works in cystic...

Sarcoidosis is a systemic, granulomatous disorder commonly affecting the lungs that has the potential to cause numerous thoracic complications. We present a novel case of a 44-year-old woman with pulmonary sarcoidosis who demonstrated a large pulmonary infarction. The disease presentation ultimately was attributed to arterial stenosis resulting from sarcoidosis-associated fibrosing mediastinitis and compressive mediastinal adenopathy. The patient was treated with an extended course of prednisone...

CONCLUSIONS: Volume-based biomarkers derived from 18F-FDG PET/CT were associated with disease progression in pulmonary sarcoidosis, whereas SUVmax showed no prognostic implications.

CONCLUSION: We identified that βc cytokines are critical regulators in driving inflammatory and metabolic processes that lead to granuloma formation in sarcoidosis. Precisely targeting the βc receptor effectively disrupts these pathogenic networks and offers a promising new strategy for mitigating sarcoidosis immunopathology.

Sarcoidosis is a chronic, idiopathic, multisystemic inflammatory disease characterized by non-caseating granulomas, most commonly affecting the lungs and mediastinal lymph nodes. Radiological imaging plays a fundamental role in the diagnosis, assessment of disease extent, and differentiation from other pulmonary conditions. This narrative review offers a comprehensive overview of the imaging features of pulmonary sarcoidosis, focusing on both typical patterns-such as bilateral hilar...

CONCLUSION: Age over 50 years and a CPI greater than 35 were identified as independent predictors of 5-year all-cause mortality in our Spanish pulmonary sarcoidosis cohort.

Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating epithelioid granulomata, most commonly involving the lungs and thoracic lymph nodes. Although definitive diagnosis relies on tissue biopsy, characteristic findings detected on computed tomography (CT) often allow a confident diagnosis. Atypical imaging patterns, however, can complicate differentiation from other diseases. Different high-resolution CT phenotypes of pulmonary sarcoidosis have been recently defined by...

CONCLUSIONS: The addition of TBLC significantly enhances the diagnostic yield in the workup of sarcoidosis and CBD, particularly in cases without radiologically detected parenchymal involvement. This underscores the added value of TBLC in improving diagnostic accuracy in challenging clinical scenarios.

CONCLUSION: The septated appearance of lymph nodes on EBUS can be helpful to predict sarcoidosis, while heterogeneous echotexture and coagulation necrosis in the lymph nodes on EBUS are suggestive of TB.

CONCLUSIONS: Our study demonstrated Th cells imbalance in patients with sarcoidosis and COVID-19 history. These findings suggest possible clinical and visual progression of chronic lung sarcoidosis in COVID-19 convalescent patients.

In sarcoidosis, pulmonary manifestations are almost universal; however, their severity ranges from asymptomatic to respiratory failure and death. Approximately 20% of patients progress to advanced pulmonary sarcoidosis (APS), a disease phenotype that is driven mostly by pulmonary fibrosis and associated complications, including bronchiectasis, chronic pulmonary aspergillosis, and pulmonary hypertension, which may result from multiple mechanisms. APS may be burnt out but is often active as...

CONCLUSIONS: SIRPα is robustly expressed in monocyte/macrophage lineages within human sarcoidosis tissues, and inhibition of SIRPs (ELA026) suppresses sarcoidosis granuloma formation by preventing macrophage adhesion/aggregation.

CONCLUSIONS: This study demonstrates that TCTSS significantly correlates with most functional parameters, exhibiting stronger correlations for key measures (FVC%, FEV1%, DLCO, and 6MWT%) compared to the Scadding staging system. TCTSS is a valuable tool that warrants consideration in the follow-up of sarcoidosis patients. Our findings suggest that TCTSS could serve as a potential alternative or complementary system to the Scadding classification, potentially informing the development of a...

A female in her early 40s with a history of acute decompensated congestive heart failure was admitted following a farming accident and received a contrast-enhanced CT trauma scan of the whole body which subsequently revealed extensive lung fibrosis, cavitations, granulomas and hilar lymphadenopathy. Subsequent whole body 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) showed no evidence of metabolic activity within the myocardium or skeletal muscles,...

CONCLUSION: In this large multicenter cohort, ocular involvement in sarcoidosis was associated with elevated cardiopulmonary risk, underscoring the need for vigilant systemic monitoring in this population.

CONCLUSIONS: In this UK cohort, treatment decisions were more influenced by sex and ethnicity than by lung function or imaging. Male and non-white patients received immunosuppression more frequently, suggesting possible biological, socioeconomic or practice-related differences.

INTRODUCTION: There is an increased risk of chronic obstructive pulmonary disease (COPD) in heterozygotes for the alpha-1 antitrypsin (AAT) Z allele (PI*MZ), but there is significant variation in outcomes. Matrix metalloproteinases (MMPs) contribute to worse airway disease and emphysema. Given that the AAT protein is an antiprotease, we hypothesised that MMPs play a modifying role among AAT-deficient individuals.

BACKGROUND: The landscape of sarcoidosis in the United States is unclear, which makes it difficult to optimize the allocation of health care resources, clinical care programs, and research activities for sites that specialize in sarcoidosis.

CONCLUSION: Pulmonary sarcoidosis predominantly affects middle-aged and young women and can be differentiated from intrathoracic lymph node TB by the presence of uveitis and myocardial sarcoidosis, although these manifestations are rare. A significant proportion of pulmonary sarcoidosis patients experience a reduction in their peripheral blood lymphocyte count. Chest CT scans often reveal symmetric bilateral enlargement of hilar lymph nodes, and in some cases, multiple nodules in the tracheal or...

Background: Sarcoidosis is a multisystem granulomatous disease that often impacts the lungs with mucosal inflammation, cobblestoning of the central airways, obstruction, and small airway disease. Airway involvement is often under-reported and not well understood, despite likely having implications for the work of breathing and particle dosimetry. Methods: To shed light on sarcoidosis disease with airway involvement, we performed patient-specific computational fluid dynamics and particle...

Established fibrosis in pulmonary sarcoidosis is typically not progressive. However, progressive fibrosis similar to interstitial pneumonia occasionally occurs. We herein report a 49-year-old woman who was histologically diagnosed with sarcoidosis. She also had honeycomb-like manifestations in the lower lobes that resembled idiopathic pulmonary fibrosis on computed tomography, whereas pathological findings of a surgical lung biopsy suggested interstitial lung disease associated with rheumatoid...

BACKGROUND: Individuals with sarcoidosis face many sources of illness uncertainty, including diagnostic delays, unpredictable therapeutic efficacy and toxicity, and disease-associated morbidity and mortality. Patient perspectives on illness uncertainty in sarcoidosis have not been evaluated critically and offer an opportunity for providers to contextualize and prioritize gaps in care and patient support.

Recent reports suggest that a transbronchial mediastinal cryobiopsy (TMC) offers a better diagnostic performance for benign diseases than endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) because it can obtain larger specimens. We herein report the utility of TMC in three patients with sarcoidosis at our institution. EBUS-TBNA failed to diagnose sarcoidosis in all three patients, whereas TMC provided a definitive diagnosis. Although no significant differences in either...

New ultrathin bronchoscopes (UTBs) enable the inspection and biopsy of small airways, potentially offering diagnostic advantages in sarcoidosis. In this prospective study, patients with suspected sarcoidosis underwent airway inspection with a UTB. Observed airway abnormalities were categorised into six predefined patterns. UTB-directed small airway biopsies (SABs) were collected from the upper lobes following a standardised procedure. We evaluated the prevalence and patterns of SAAs, as well as...

sarcoidosis is a rare granulomatous disease of unknown aetiology belonging to the wide group of interstitial lung diseases.). Although the limitlessness of BAL fluid is debated, it remains one of the best matrices for studying the pathogenesis of sarcoidosis. Natural killer (NK) cells have been described in BAL fluid from sarcoidosis patients. Elevated NK cells in BAL fluid from sarcoidosis patients have been found to be associated with poor outcomes. in this study, NK cells were evaluated in...