COPD Pubmed Results

CONCLUSION: The palliative care needs of patients with advanced COPD must be addressed, as they directly impact quality of life and dignity during the final stages of life. Efforts should focus on developing systematic interventions that are culturally appropriate and policy-driven.

Chronic obstructive pulmonary disease (COPD) is a heterogeneous chronic respiratory disorder characterized by persistent airflow obstruction. Its high morbidity and mortality have posed a substantial public health burden, with current symptomatic treatments exhibiting inadequate control and potential adverse effects. With advances in microecological research techniques, the critical role of microbial homeostasis in the oral cavity, lungs, and gut in respiratory health has become increasingly...

CONCLUSIONS: Current evidence positions MOTS-c as a promising biomarker and potential therapeutic candidate in respiratory medicine. Well-designed translational and multicenter clinical studies are needed to determine whether modulation or supplementation of MOTS-c can influence disease progression and clinical outcomes in inflammatory lung diseases.

BACKGROUND: Digital inhaler therapy management can help patients promote adherence and correct inhaler techniques. Poor inhaler technique and suboptimal adherence contribute to COPD exacerbations, uncontrolled symptoms, and a progressive decline in pulmonary function. Digital Inhaled Therapy Management (DITM) platforms can provide standardized technique training, objective adherence monitoring, and real-time feedback. Respiratory Muscle Training is a recommended component of pulmonary...

INTRODUCTION: Effective feedback can enhance integrated knowledge translation (iKT); it can lead to more successful implementation efforts and support other key implementation mechanisms (such as provider empowerment and readiness to implement). However, there is limited consensus in the literature on how to deliver feedback effectively within iKT contexts specifically, highlighting the need to better understand these practices in real-world implementation settings.

CONCLUSION: In elderly patients with AECOPD, terbutaline sulfate combined with ambroxol hydrochloride was associated with greater improvements in pulmonary function, inflammatory and airway remodeling-related biomarkers, symptom relief, and length of hospital stay than terbutaline sulfate alone.

CONCLUSION: Tirzepatide use was associated with a potentially reduced risk of COPD exacerbations, lower mortality, and a decreased incidence of pneumonia and acute respiratory failure. These findings should be interpreted with caution, given the inherent limitations of observational study designs, including the possibility of residual confounding and selection bias. The observed associations do not establish causality, and the clinical generalizability of these results remains uncertain....

CONCLUSIONS: These findings add rigorous evidence to support the continuation of the current annual PM(2.5) standard, which was lowered to 9 μg/m³ in 2024. Our novel contribution is documenting the dose-response relationship between chronic PM(2.5) and multiple respiratory outcomes in a longitudinal cohort with patients followed for up to 10 years.

Purpose To investigate the association between impaired lung function and pulmonary perfusion defect percentage (QDP) using phase-resolved functional lung (PREFUL) MRI. Materials and Methods In this prospective study (March 2023-July 2024), participants underwent spirometry to assess lung function, including forced expiratory volume in 1 second (FEV(1)) and forced vital capacity (FVC). Lung function was classified as either normal or impaired, with the impaired category including airflow...

CONCLUSIONS: In this nationwide sleep-clinic cohort, OAD was independently associated with COMISA. COMISA patients with OAD exhibited more adverse clinical and polysomnographic features. These findings highlight the multidimensional sleep burden in OAD and support integrated, personalized management strategies.

CONCLUSIONS: The present simulations show that breathing pattern influences intranasal airflow, air conditioning, rebreathed gas clearance, and sinus ventilation. Lower respiratory rates improved gas clearance by reducing the relative effect of anatomical dead space, while waveform differences also affected heat exchange and sinus transport. The findings should be interpreted as a mechanistic, case specific assessment of waveform effects rather than a population level comparison between healthy...

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CONCLUSION: The increase and severity of post-COVID respiratory infections in Pakistan is due to a combination of factors including lack of immune compromise, socio-environmental and behavioral factors, and irrational antibiotics prescriptions fueling the rising antimicrobial resistance (AMR) perceived by Physicians. It is crucial to integrate public health measures, vaccination, and antimicrobial stewardship to strengthen diagnostics and mitigate the long-term respiratory morbidity and...

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by alveolar destruction, impaired epithelial regeneration and chronic inflammation. While circadian disruption has been linked to COPD pathogenesis, the cellular mechanisms remain unclear. Here, we identify the core clock components Cryptochrome 1 and 2 ( Cry1/2 ) as essential regulators of alveolar epithelial cell proliferation and pulmonary immune homeostasis. Cry1/2 double knockout (dKO) mice exhibit...

This study investigates the interfacial interactions between the selected methylxanthines, theophylline (Theo) and its derivative theophylline-7-acetic acid (TheoAcid), and model pulmonary surfactants. Chronic obstructive pulmonary disease (COPD) and asthma treatments utilizing these drugs are often limited by a narrow therapeutic window and systemic toxicity. We explore the biophysical feasibility of localized inhalation delivery by analyzing physicochemical drug effects on two-dimensional (2D)...

CONCLUSION: Elevated EqCO(2)@AT is associated with impaired ventilatory efficiency, reduced exercise capacity, and increased AE risk in COPD. A model incorporating EqCO(2)@AT, age, BMI, and FEV(1)% predicted showed good predictive performance and may support individualized AE risk stratification. These findings suggest that CPET-derived ventilatory efficiency parameters may provide clinically useful information beyond conventional pulmonary function assessment, although validation in larger...

CONCLUSIONS: Gut microbiota and metabolites in participants with a smoking history differ according to the presence of emphysema and its severity, and can affect emphysema development. This suggests a role for gut microbiota in lung disease and provides a foundation for exploring gut microbiota as a potential therapeutic target for chronic obstructive pulmonary disease.

One-dimensional (1D) magnetism offers unidirectional spin interactions that allow unique tunable properties and unconventional spin phenomena. However, it often suffers from poor stability, limiting practical applications. In this regard, integrating 1D magnetism into two-dimensional (2D) materials enables a promising route to stabilize these systems while preserving their anisotropic magnetic characteristics. Here, we focus on the 2D ferromagnet FePd(2)Te(2) (T(C) = 183 K), which hosts 1D spin...

CONCLUSIONS: Longitudinal PRO data effectively capture the dynamic changes in health status among COPD patients and can serve as important time-varying predictors for adverse outcomes. Among the three dynamic prediction approaches evaluated, the SREM model demonstrated the best predictive performance. These findings provide a scientific basis for risk stratification and individualized management strategies in COPD patients after hospital discharge.

CONCLUSIONS: These findings support the notion that infection-related COPD (COPD-I) represents a clinically distinct phenotype.

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This paper discusses temporal effects on the initial Pearson correlation analysis of the climate and mortality data for Kazakhstan (2000-2021), revealing deceptively negative associations, such as Ischemic Heart Disease (IHD) with Carbon Dioxide (CO(2)) (r = -0.876) and Stroke with Particulate Matter (PM(2).(5)) (r = -0.396). However, the transformed findings indicate the true positive associations between some of the contaminants and disease by undertaking partial correlation, accounting for...

CONCLUSION: This study presented a comprehensive comparative analysis of the global burden of LC and COPD, offering descriptive and comparative epidemiological evidence to inform tailored, disease-specific and region-specific prevention and control efforts.

CONCLUSIONS: The VOF-CFD model developed in this study enables quantitative analysis of mucus transport dynamics across diverse pathophysiological conditions and can be further refined to support personalized therapeutic assessment through predictions of mucus clearance efficacy.

CONCLUSIONS: It was indicated that a pro-inflammatory diet is associated with reduced lung function in AECOPD patients, with lung function showing a significant negative correlation with inflammatory markers. WBC serves as a key mediator between the DII and FEV1.

CONCLUSION: The HAVOC score appears to be a useful tool for predicting NOAF in patients with STEMI. Identifying individuals with high HAVOC scores may enable early recognition and prevention of AF-related complications.

INTRODUCTION: Exacerbations, impaired health-related quality of life (HRQoL) and reduced exercise capacity increase the risk of hospitalisations and death in chronic obstructive pulmonary disease (COPD). However, their monitoring relies on in-person assessments, potentially delaying early care. While smart sensing technologies can enable remote monitoring, their use in predicting disease worsening remains limited. The TOLIFE Clinical Study A (CSA) aims to develop an artificial intelligence (AI)...

miRNAs play critical roles in regulating inflammatory responses in chronic obstructive pulmonary disease (COPD). This study investigated the expression patterns of miR-146a/b and miR-181a, along with associated inflammatory mediators, in COPD patients. This cross-sectional study included 40 patients with acute exacerbation of COPD (AECOPD), 40 patients with stable COPD, and 40 healthy controls. Expression levels of miR-146a, miR-146b, and miR-181a in peripheral blood mononuclear cells (PBMCs)...

CONCLUSION: It remains unclear whether changes in phenotype reflects the biological variability of the measure or disease progression. The instability of adult spirometry classifications across serial spirometry measurements suggests this approach does not adequately capture the complexity of prematurity-associated lung disease during the growth period.

CONCLUSION: Recognising the risk factors for POAF helps us to identify high-risk patients to provide better preventive measures and management strategies for POAF after CABG.

CONCLUSIONS: COPD and exacerbations were associated with increased risks of overall and multiple site-specific cancers beyond the lungs. These findings support the systemic nature of COPD.

CONCLUSION: This study demonstrated improved access and improved guideline directed therapy outcomes for rural Veterans seen by a CPP. Integration of the CPP with a focus on the management of COPD can increase access to CMM and increase overall quality.

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CONCLUSION: A generic, 8-week telewellness program designed for individuals with mobility limitations was acceptable and beneficial for individuals with COPD.

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Inflammatory biomarkers reflecting acute immune responses may aid prognostic stratification in patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease (COPD). The eosinophil-neutrophil ratio (ENR) integrates two key inflammatory cell populations; however, its prognostic value in the acute exacerbation of COPD has not been fully established. We conducted a retrospective cohort study of patients hospitalized for acute exacerbation of COPD between 2016 and 2021. ENR...

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Rare coding variants can have large effects on disease risk and provide direct routes from human genetics to disease mechanisms and therapeutic targets, but their discovery is constrained by sample size, particularly for low-prevalence diseases. Here we establish the Biobank Rare Variant Analysis (BRaVa) consortium, a global rare variant association resource that integrates sequencing and linked health-record data from ten biobanks and cohorts comprising over 1.2 million individuals across...

One of the most prevalent and impactful symptoms in COPD is persistent dyspnea, occurring in the majority of patient with advanced COPD. Opioids, mostly morphine, have been investigated and suggested as treatment in palliative care guidelines. However, in recent years multiple trials on morphine for persistent dyspnea have shown no clinical benefit, and there are concerns regarding adverse events. Transdermal fentanyl has not yet been investigated for this indication.We performed a multicenter,...

CONCLUSION: Triple therapy was associated with improvements in some outcomes, particularly lung function, but did not show consistent statistically significant superiority over dual therapy across all endpoints in this network meta-analysis. Given the small number of included trials and limited power for some comparisons, these findings should be interpreted cautiously and should not be taken as evidence of equivalence. Dual regimens remained effective options, while triple therapy may still be...

BACKGROUND: The trade-offs between regulatory preferences, trial success probability, and patient exclusion by eligibility criteria in randomised controlled trials (RCTs) of biologics for severe asthma remain poorly understood. We assessed biologic effectiveness and effect modification by nine RCT-derived criteria in a large real-world cohort of subspecialist-treated patients with severe asthma.

BACKGROUND: The six-minute stepper test (6MST) is increasingly used to assess functional exercise capacity in people with chronic obstructive pulmonary disease (COPD). However, the physiological responses elicited during the 6MST and their relationship to those obtained during cardiopulmonary exercise testing (CPET) remain incompletely characterised.

CONCLUSIONS: In this real-world cohort of exacerbating patients with COPD, once-daily single-inhaler FF/UMEC/VI was associated with improved lung function, reduced hyperinflation, better symptom control, enhanced quality of life, and a significant reduction in exacerbation frequency. These findings suggest that FF/UMEC/VI may be a useful therapeutic option for supporting multidimensional disease stability in high-risk patients with COPD, although prospective controlled studies are needed to...

CONCLUSION: Handgrip strength was associated with serum albumin and selected nutritional parameters. It reflects functional status influenced by both nutritional and clinical factors and may complement conventional nutritional assessment in critically ill patients with acute COPD exacerbation.

Menopause is accompanied by loss of ovarian estrogen and progesterone production and by age-related changes in circulating androgens, with implications for respiratory physiology and chronic pulmonary disease. Sex steroids influence lung development, immune responses, airway tone, vascular remodeling and pathways involved in lung carcinogenesis. Epidemiological evidence linking menopausal hormone therapy (MHT) to asthma is heterogeneous; some cohorts show increased incident asthma or...

CONCLUSIONS: The plausible AI-driven future of remote chronic care is a nuanced one. The FW method indicated that a bespoke, co-designed AI tool can positively support virtual care delivery and remote interactions while indicating potential risks. These insights can inform strategies related to early planning, governance, and implementation considerations.

CONCLUSIONS: The MPT test showed good diagnostic accuracy as a simple screening tool for detecting exercise-induced DH in COPD. An absolute IC decrease ≥ 0.27 L after MPT may represent a potentially useful cross-sectional screening threshold, although further validation is needed before it can be interpreted as a definitive longitudinal threshold.

CONCLUSIONS: HAP contributes substantially to the respiratory and economic burden in Morocco. These estimates should be interpreted considering the regional source of exposure data and the application of pooled international relative risks to the Moroccan context.

Chronic obstructive pulmonary disease (COPD) is a major global health burden. However, it remains widely under-recognized despite its substantial impact on morbidity and mortality rates. Most cases remain undiagnosed because the early symptoms are often subtle, thus hindering timely intervention. Globally, the World Health Organization (WHO), within its noncommunicable disease framework, advocates a multifaceted approach to COPD, including prevention, early diagnosis, and long-term management....

CONCLUSION: Age, diffusing capacity of the lung for carbon monoxide, and total lung capacity were identified as significant associated factors for RP after lung SBRT. Incorporating clinical, dosimetric, and functional respiratory parameters into a multifactorial predictive model could optimize patient selection and risk stratification.