COPD Pubmed Results

CONCLUSION: These findings highlight rs17580 as a potential genetic biomarker for COPD susceptibility and provide insights for targeted therapeutic strategies.

CONCLUSIONS: Current evidence challenges the dogma that PH is an absolute contraindication to LVR. In selected emphysema patients with heterogeneous disease and mild-to-moderate PH, LVRS and BLVR can be performed safely and may reduce pulmonary artery pressures and improve right-ventricular function. Right heart catheterisation should be strongly considered for haemodynamic phenotyping before intervention and multidisciplinary selection protocols are recommended. Severe PH or decompensated...

CONCLUSION: FLI exhibits a dual association with COPD, serving as a risk factor for its prevalence in the general population yet being inversely associated with disease severity among diagnosed patients. These findings support FLI as a clinically relevant, non-invasive biomarker for stratifying COPD risk and assessing severity.

CONCLUSION: Swallowing impairment and aspiration are frequent after acute respiratory events, including in COPD. Recent bronchitis and pharyngeal residue represent clinically relevant markers of aspiration risk. Early, structured swallowing assessment may help identify vulnerable patients and guide targeted interventions to reduce aspiration-related respiratory morbidity.

Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a life-course disorder with origins rooted in early-life insults. However, the current diagnostic reliance on the FEV1/FVC < 0.7 threshold often fails to capture the early phases of disease evolution, particularly within the pulmonary "Silent Zone." This narrative review examines small airway disease (SAD) in pre-COPD and early COPD by integrating physiological, structural, molecular, and diagnostic evidence. Findings...

Emerging evidence suggests that metabolic dysregulation is a central driver in the pathogenesis of pulmonary disorders, extending beyond structural or immunological failures. This review synthesises current research on the specific alterations of glucose and lipid metabolism within the context of asthma, COPD, pulmonary fibrosis and lung cancer. We highlight how these metabolic alterations fuel disease progression and identify them as promising targets for novel biomarkers and therapeutic...

Respiratory diseases remain a leading health burden across Europe, yet national strategies are often fragmented or absent. The International Respiratory Coalition's Lung Facts platform offers a comprehensive, up-to-date resource for epidemiological and economic data for major respiratory conditions across 53 European countries. This viewpoint outlines the platform's development and the types of data available, including disease burden, societal costs and risk factor attribution. It also...

CONCLUSION: We developed and internally validated a practical nomogram that integrates clinical variables with immune-inflammation-nutrition indicators to predict 28-day mortality in sepsis patients with severe fungal pneumonia. This tool may help clinicians with early risk stratification and individualized treatment decisions.

CONCLUSIONS: H(2) therapy shows consistent antioxidative, anti-inflammatory, and anti-senescence effects across preclinical and clinical settings, suggesting potential as an adjunctive treatment for COPD in aging populations. Further large-scale, long-term trials are warranted to confirm efficacy, optimize dosage, and clarify mechanistic pathways.

While the health effects of ambient temperature have been widely studied, temperature variability (TV), which is a critical aspect of climate change, has received limited attention. This study investigated the associations and potential mediating effects of long-term TV and chronic obstructive pulmonary disease (COPD) on a national scale. COPD was identified based on lung function data from the China Pulmonary Health Study (N = 50,991). Long-term TV was defined as the standard deviation of daily...

CONCLUSION: This best practice implementation project significantly improved adherence to COPD self-management practices. The findings demonstrate that the JBI Evidence Implementation Framework is a feasible and effective approach for strengthening COPD self-management and has strong potential for wider implementation and sustainability in clinical practice.

CONCLUSIONS: Being more aerobically fit may prevent or delay the onset of COPD. Improving CRF has the potential to attenuate the increased risk of COPD associated with elevated genetic risk. Public health initiatives should prioritise making measurable improvements in cardiorespiratory fitness (beyond merely being active or exercising more) as a promising intervention target for reducing the risk of COPD.

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) - obstructive sleep apnea (OSA) overlap is prevalent in patients with either COPD or OSA. Patients with COPD-OSA overlap are likely to have different pathophysiological endotypes and thus different clinical phenotypes which are likely to lead to challenges in the management of this heterogenous population. This report examines current evidence for positive airway pressure therapy in COPD-OSA overlap, with an emphasis on outcomes and...

Acute fibrinous organizing pneumonia (AFOP) is a rare form of interstitial lung disease characterized histopathologically by intra-alveolar fibrin "balls" and organizing pneumonia. AFOP is associated with infections, malignancies, and immune dysregulation, posing diagnostic and therapeutic challenges. We present the case of a 66-year-old female with rectal adenocarcinoma, chronic obstructive pulmonary disease (COPD), and a posterior mediastinal mass who was admitted with sepsis and...

Chronic respiratory diseases such as Chronic Obstructive Pulmonary Disease, Asthma, Interstitial Lung Disease, Cystic Fibrosis, and Pulmonary Hypertension affect over 500 million people globally and pose significant challenges for diagnosis, management, and long-term care. Traditional approaches often rely on episodic clinical assessments and patient-reported symptoms, which fail to capture the dynamic nature of respiratory health. The integration of wearable technology offers a transformative...

CONCLUSIONS: In hypertensive AHF, multiple factors are associated with mortality, and intravenous nitroglycerine use appears to increase risk. Post-discharge adverse events are more frequent in patients with chronic pulmonary and ischaemic heart disease. No sex-based differences were observed for any of the outcomes analysed.

CONCLUSION: PREFUL MRI sensitively captured immediate SD T/O-induced improvements in V/Q parameters and dose-dependent PWV responses after sustained bronchodilation.

CONCLUSION: Peripheral blood inflammatory markers are increased in smokers, including those with preserved lung function, and in COPD. Differences in eosinophil patterns between COPD current smokers and ex-smokers suggest inflammatory heterogeneity and should be confirmed in larger, well-characterized cohorts. These findings support the move towards careful personalized medicine interventions, based on individual inflammatory profiles.

CONCLUSIONS: Application of a CART-based classification derived from real-life cohorts to a clinical trial population revealed subgroups with distinct baseline characteristics and differential treatment outcomes. These findings should be interpreted as exploratory and hypothesis-generating, and may inform future work on trial enrichment strategies and personalized approaches to COPD management.

CONCLUSION: Our findings reveal a high disease burden among patients with COPD in China despite stable triple therapy, reflecting the high-risk clinical profile of these patients and supporting an ongoing need for improved management strategies.

Chronic obstructive pulmonary disease (COPD) leads to high symptom burden, functional decline, and often disability. Combining rehabilitation and palliative care is recommended to address these challenges. However, the position of occupational therapists (OTs) in such interventions remains unclear. The objective of this scoping review was to map organizational roles and tasks of OTs in interventions combining rehabilitation and palliative care for people with COPD. Literature search was...

CONCLUSIONS: In the absence of single-inhaler triple therapy (SITT), statins were associated with a reduction in severe exacerbations and hospitalization rates of COPD. Given the limitations of the evidence we found, further large-scale, high-quality studies are needed to clarify the impact of statins on prognosis and the beneficiary population.

CONCLUSION: TCM-BDRT holds promise as a potential non-pharmacological intervention for enhancing lung function, exercise endurance, and gas exchange capacity in patients with COPD. This low-intensity, scalable therapeutic approach aligns with the integrated treatment paradigm of combining Traditional Chinese Medicine and Western Medicine. It may be particularly suitable for patients who are frail or have limited exercise capacity. Nevertheless, large-scale, multi-center, high-quality RCTs are...

CONCLUSION: Sarcopenia and nutritional risk independently increase AECOPD risk in stable COPD. Incorporating muscle mass parameters into risk stratification may improve predictive accuracy.

Tamil Nadu Kasanoi Erappila Thittam (TN-KET) is India's first state-wide differentiated TB care initiative to reduce TB deaths. Since April 2022, this involved triaging for severe illness at diagnosis and prioritisation of severely ill for inpatient care. In the third year (2024), TN-KET sustained its performance in comprehensive assessment of severely ill during inpatient care, possibly contributing to low deaths in 2024. The information on reasons for severe illness provided will guide...

Centrilobular emphysema has significantly worse remodelling of pulmonary arteries than panlobular emphysema, suggesting distinct pathological phenotypes in COPD, a concept that might improve the understanding of the disease https://bit.ly/4oZtm09.

The organisation and implementation of long-term home noninvasive ventilation treatment for COPD patients across Europe is complex and heterogeneous. Further research and experience sharing is required to optimise and align the patient pathway. https://bit.ly/3M3r566.

The Portuguese version of the PREM-C9 questionnaire is translated and culturally adapted for people with COPD, providing a tool to assess patient experiences, guide patient-centred care and support quality improvements in Portuguese healthcare https://bit.ly/48QhSFS.

CONCLUSIONS: Ensemble ML models provide calibrated 6-month risk estimates for revascularisation, CLTI, and mortality after nurse-led IC clinic assessment, which may support patient prioritization for surveillance and early escalation of care. External validation and prospective impact evaluation are warranted and represent our next steps.

COPD is a multifactorial and heterogeneous disorder, a leading cause of morbidity and mortality worldwide. Not only does its progression compromise lung function, but it is also associated to systemic complications, including skeletal muscle dysfunction. Skeletal muscle dysfunction affects up to 35% of individuals diagnosed with COPD and is marked by muscle atrophy and altered fibre composition, thus resulting in reduced strength, endurance and physical capacity with an increased mortality risk....

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CONCLUSION: Research on COPD complicated with sarcopenia has shifted from descriptive phenotypes to standardised assessment, functional outcomes, and clinical management. Future studies should strengthen multicentre longitudinal designs and multidisciplinary collaboration to better integrate mechanisms with clinical assessment and intervention.

ObjectivesChronic obstructive pulmonary disease (COPD) is a common respiratory disorder. Acute exacerbation of COPD (AECOPD) severely affects patients' quality of life and prognosis. This study aimed to identify novel risk factors and develop an effective predictive model for AECOPD using machine learning (ML) models.MethodsIn this retrospective single-center study, clinical data and biomarkers from 565 participants were analyzed using ML algorithms. Feature selection employed least absolute...

CONCLUSION: Triple therapy was not associated with improved outcomes in the overall cohort but may be associated with better outcomes in selected high-risk subgroups. These findings should be interpreted with caution given the observational design and potential residual confounding. Further studies are warranted to confirm these findings and refine patient selection for triple therapy.

CONCLUSIONS: Middle-aged patients with COPD initiating LAMA/LABA therapy exhibited distinct adherence trajectories. Understanding these patterns may help inform more targeted approaches to support adherence and improve patient outcomes.

CONCLUSION: This consensus underscores the role of NAC in chronic respiratory diseases beyond its mucolytic properties and reiterates that NAC's antioxidant, anti-inflammatory, immunomodulatory and anti-biofilm properties provide significant clinical utility. It is a proven adjunctive therapy for COPD, bronchiectasis, and cystic fibrosis. While promising for TB and respiratory infections, further evidence is required. Its efficacy in asthma and ILDs remains uncertain. These findings guide...

Chronic obstructive pulmonary disease (COPD) involves persistent airflow limitation and chronic inflammation. To define the clinical and mechanistic role of the miR-532-5p/CXCL1 axis in COPD, this study used bioinformatic analysis of the GEO dataset GSE70080 to identify miR-532-5p, which was significantly down-regulated in COPD. Multiple databases predicted CXCL1 as its potential target gene. The clinical study included 90 subjects (52 with COPD, 38 controls). We detected serum levels of...

CONCLUSION: Neurocognitive symptoms are independently associated with increased risk of opioid overdose among Veterans receiving LTOT. Incorporating cognitive screening into opioid safety assessments may help identify individuals at heightened risk and inform tailored risk mitigation strategies.

CONCLUSIONS: Comorbid respiratory complaints are present in a small, but significant, number of manual therapy patients. The CAT appears to be the most appropriate respiratory PROM for primary care manual therapy practice because of its brevity and responsiveness. Respiratory PROMS, such as the CAT, may assist manual therapists to assess the severity of chronic respiratory diseases and quantify patients' response to manual therapy. The protocol for the study was registered with Open Science...

CONCLUSION: High UCR is correlated with poor prognosis of patients with COPD.

CONCLUSION: Expiratory tracheal stenosis remains an underdiagnosed and underestimated condition. Primary etiopathogenetic factor is excessive intrathoracic pressure during exhalation. The gold standard for diagnosis is tracheobronchoscopy. Imaging techniques are useful only in dynamic formats. Conservative therapy (anti-inflammatory, mucolytic and bronchodilators), including positive end-expiratory pressure (PEEP) ventilation, is effective for most patients, but should be considered as a...

Anxiety and depression are highly prevalent among patients with chronic and progressive illnesses. At the terminal stage, these symptoms are closely linked with existential distress and can worsen quality of life. A scoping review of randomized controlled trials (RCTs) reporting on pharmacological interventions for anxiety and depression in terminal illnesses was conducted. MEDLINE, Embase, and CENTRAL databases were searched from inception to September 2024. Two reviewers independently...

CONCLUSION: Although suction level did not significantly influence postoperative recovery, the higher incidence of subcutaneous emphysema in the low suction group warrants further investigation. The presence of COPD and impaired baseline lung function should be considered when selecting suction levels after VATS lobectomy.

CONCLUSIONS: Lower grip strength is associated with an increased risk of a wide range of incident diabetes-related complications, and its predictive value is superior to that of muscle mass. Future studies should evaluate whether interventions aimed at improving muscle strength can reduce the incidence of these complications among individuals with T2D.

BACKGROUND: Bronchiectasis and diabetes commonly coexist and are associated with immune dysfunction and increased susceptibility to infection. Although diabetes is associated with worse prognosis in cystic fibrosis-related bronchiectasis, data are scarce for its impact on non-cystic fibrosis bronchiectasis. This study aimed to characterise the impact of diabetes on clinical outcomes and microbial and inflammatory profiles in patients with bronchiectasis.

CONCLUSION: One third of patients with AECOPD had unstable disease despite optimised management. Implementing structured clinical pathways is essential to systematically address modifiable treatment barriers and comorbidities contributing to recurrent exacerbations, and to identify candidates for advanced therapies.

CONCLUSION: Comorbidities, particularly hypothyroidism and cardiovascular diseases, significantly influence the development of TKI-related adverse effects in patients with CML. Careful assessment of comorbidities and concomitant medications is essential for optimal TKI selection and toxicity management in clinical practice.

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Parkinson's disease (PD) and chronic obstructive pulmonary disease (COPD) are prevalent conditions with substantial impact on quality of life and health care systems. Both disorders affect voice production through different physiological mechanisms, yet neither condition has a widely adopted objective biomarker for routine clinical use. Voice analysis has emerged as a non-invasive digital biomarker candidate, but existing studies have largely focused on binary classification within a single...

CONCLUSIONS: Advanced age and smoking history are risk factors for elevated sputum neutrophils in chronic cough patients. Neutrophil-mediated airway inflammation is associated with pulmonary lesions and declined lung functions in chronic cough patients.