COPD Pubmed Results

CONCLUSION: Eight weeks of probiotic supplementation was associated with reduced systemic IL-6 levels and clinically meaningful improvement in patient-reported outcomes in mild-to-moderate COPD. These findings support a potential adjunctive role for probiotics and warrant larger mechanistic trials.

CONCLUSIONS: Exposure to wood smoke from incomplete wood log combustion suppressed nuclear translocation of transcription factors and the expected inflammatory response in endobronchial mucosal biopsies at 6 h post-exposure. This contrasts to the strong proinflammatory effects of other air pollutants such as ozone and diesel exhaust. Together with previous findings of increased cytotoxicity and impaired airway macrophage phagocytosis in humans, this response may be in line with compromised...

CONCLUSION: Rosavin ameliorates COPD-associated pathology through integrated mechanisms involving NF-κB inhibition, reduction of IL-17-enriched NET formation, and modulation of lung microbiota composition. These findings identify Rosavin as a promising multi-target therapeutic candidate for COPD.

CONCLUSION: The nonlinear relationship between age and COPD in pneumoconiosis in patients with pneumoconiosis is significantly modified by sociodemographic factors.

CONCLUSION: From 16.5 ℃ to 40.0 ℃, personal temperature exposure is associated with SpO(2) decline during sleep in COPD patients. There was a significant synergistic amplification between temperature and humidity, patients were more susceptible to damage under high temperature and high humidity conditions. Moreover, patients with poorer lung function are more significantly affected by temperature.

Background/Objectives: Frailty is highly prevalent among individuals with chronic obstructive pulmonary disease (COPD) and further elevates the risk of disability, hospitalization, and mortality. However, longitudinal evidence examining the combined impact of COPD and frailty on adverse events remains limited. This study aims to examine the longitudinal association of COPD and frailty with adverse events. Methods: This longitudinal study analyzed data from the Toledo Study for Healthy Aging,...

Background/Objectives: Chronic obstructive pulmonary disease (COPD) often coexists with heart failure (HF) and can complicate the interpretation of symptoms, biomarker profiles, and clinical deterioration. Its prognostic significance at the time of sodium-glucose cotransporter 2 inhibitor (SGLT2i) initiation remains incompletely defined. We therefore evaluated whether baseline COPD was associated with a greater biomarker burden and worse 12-month outcomes in a real-world HF cohort at the time of...

CONCLUSIONS: Our data provide further evidence for disease stability as an achievable COPD treatment target that predicts long-term clinical benefits in exacerbations and mortality.

Veno-venous extracorporeal membrane oxygenation (V-V ECMO) serves as an advanced extracorporeal life support modality capable of totally or partially substituting pulmonary gas exchange function. It is indicated for severe acute respiratory distress syndrome, chronic obstructive pulmonary disease, and bridging therapy prior to lung transplantation. Currently, the fixation of the internal jugular vein catheter for ECMO mainly relies on transparent dressings supplemented by secondary securing with...

CONCLUSION: Mechanical ventilation is independently associated with 28-day mortality in ICU sepsis patients, particularly in those with an elevated anion gap, lower serum creatinine, and without COPD. These findings highlight the importance of judicious MV use in sepsis patients and support individualized patient assessment and tailored respiratory management strategies in clinical practice.

Acute exacerbations of chronic obstructive pulmonary disease (COPD) frequently result in excessive empirical antibiotic use despite heterogeneous infectious triggers. Therefore, it is of interest to evaluate C-reactive protein (CRP) -guided antibiotic therapy and its prognostic significance in 50 hospitalized patients with acute infective exacerbation. Antibiotics were initiated when CRP ≥50 mg/L, while lower values were managed conservatively unless deterioration occurred. Patients with...

Air pollution remains a critical environmental health challenge in Thailand, yet evidence linking high-resolution exposure to short-term respiratory health and inequality at the national scale remains limited. This study presents the first nationwide, high-resolution, daily assessment of PM(2.5) and NO(2) in Thailand, jointly quantifies short-term respiratory impacts and spatial inequality from 2019 to 2023. Daily pollutant concentrations at 0.01° resolution were reconstructed using Light...

Cardiovascular disease is the leading cause of death in Greece, despite substantial reductions in age-standardized mortality over recent decades. These improvements have been largely confined to older populations, while the burden of cardiometabolic risk remains high. The Greek cardiovascular landscape has also evolved under the combined influence of population aging, the COVID-19 pandemic, persistent socioeconomic pressures, and increasingly stringent European Society of Cardiology targets for...

CONCLUSION: Within the same practice, patients from more deprived areas are less likely to receive recommended care for key quality of care indicators.

Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by persistent airflow limitation and chronic airway inflammation. Current therapeutic strategies primarily offer symptomatic relief and are often limited by systemic side effects, inadequate lung deposition, and poor patient compliance. Naringin (NAR), a natural flavonoid with strong antioxidant, anti-inflammatory, and anti-fibrotic activities, has demonstrated potential in mitigating COPD-associated...

CONCLUSIONS: This retrospective case series characterizes the clinical and laboratory features of LRTIs in patients with concomitant S. stercoralis infection. Pneumonia and COPD exacerbations were predominant presentations, often with marked laboratory abnormalities despite infrequent eosinophilia. Although hyperinfection was frequent and direct parasitological tests showed limited sensitivity, no inference can be made regarding the frequency or strength of this association due to the...

CONCLUSION: Research in this niche is increasingly oriented towards rehabilitation-focused integrative care and mechanism-informed perspectives (gut-lung axis). Future studies should prioritise a GI-inclusive core outcome set, standardised reporting of nursing-deliverable TCM modalities and pragmatic/hybrid effectiveness-implementation designs aligned with gut-lung-related hypotheses.

CONCLUSION: Results of this preliminary study showed improvements in both patient-reported and imaging respiratory outcomes, suggesting that targeted singing components in music-based interventions such as the EMPOWER intervention may support physiological lung function changes in COPD patients.

Glucocorticoid treatment for patients with rheumatoid arthritis (RA) is widely used as fast-acting bridging therapy to reduce disease activity. However, the safety is still discussed. This cohort study describes glucocorticoid dosage during the first year after treatment initiation in patients with RA and secondarily presents the one-year dosedependent infection risk. Hospital records were reviewed for 574 newly diagnosed RA cases treated at Department of Rheumatology Aalborg University Hospital...

CONCLUSION: In China, rural residence, larger household size, and prior exacerbation history were common determinants of hospitalized exacerbations and longer annual total LHS in patients with COPD, while biomass exposure and low BMI exerted stronger effects in non-smoking COPD.

Exposure to cigarette smoke (CS) is a potent and major risk factor for chronic obstructive pulmonary disease (COPD). Luteolin (Lut), a flavonoid found in many edible plants, has displayed therapeutic effects on COPD; however, the underlying mechanisms are not well comprehended. In this study, C57Bl/6 J mice were exposed to CS combined with lipopolysaccharide (LPS) to induce COPD. Examination of the levels of inflammatory markers, including TNF-α, IL-1β, IL-6, IL-18, NO, and LPS, revealed that CS...

CONCLUSIONS: Implementation of the targeted diaphragmatic function exercise bundle strategy based on ultrasound assessment can effectively improve nutritional status and diaphragmatic function, enhance muscle strength, and shorten the duration of mechanical ventilation and hospital stay in mechanically ventilated patients with AECOPD complicated by type II respiratory failure. It can serve as an effective adjunctive treatment for these patients.

CONCLUSIONS: pMDIs are vital inhalers for most patients in Europe and around the world. While transitioning to near-zero or low-GWP inhalers, it is essential to avoid unintended consequences from the proposed PFAS ban by safeguarding patient access to this essential device option.

The clinical management of nutrition in acute and chronic diseases requires an integrated understanding of the interactions between energy intake, dietary protein, and amino acids (AAs). Many conditions (including sepsis, major trauma, cancer cachexia, chronic heart failure, chronic obstructive pulmonary disease, renal and liver failure, autoimmune diseases, and aging) share a common pathophysiological feature: the hypercatabolic state (HCS). HCS is characterized by systemic inflammation and...

CONCLUSIONS: Rising absolute counts of NCDs are largely explained by demographic change and diagnostic expansion, while age-standardised trends suggest stable or declining risk for several major conditions. These findings support a more nuanced interpretation of global chronic disease trends, integrating demographic, diagnostic, and risk-factor perspectives. Careful use of age-standardised measures alongside absolute counts is essential for accurate monitoring and for informing public health...

Chronic obstructive pulmonary disease remains a leading cause of death worldwide, with emphysema contributing significantly to dyspnea, exercise limitation, and mortality. Bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBVs) has emerged as a minimally invasive, reversible alternative to lung volume reduction surgery for carefully selected patients with severe emphysema who remain symptomatic despite optimal medical therapy. EBVs are one-way valves placed bronchoscopically...

Bronchoscopic procedures are increasingly performed with shape-sensing robotic-assisted bronchoscopy under general anaesthesia, allowing biopsy of small and distal pulmonary lesions. We performed a retrospective cohort study at a single centre of patients undergoing robotic bronchoscopy to describe the peri-operative care. The primary outcome measure was post-procedural length of hospital stay, with secondary outcomes including complication rates and diagnostic success of biopsy. A total of 200...

Background: Sepsis-associated cardiac dysfunction has historically been characterized as predominantly systolic, yet the burden of heart failure with the preserved ejection fraction (HFpEF) phenotype among patients with heart failure (HF) first documented during sepsis remains poorly defined. Methods: In a single-center retrospective cohort of adults (≥18 years) admitted to a tertiary-care hospital between 1 January 2022 and 31 December 2024, we identified patients whose first sepsis diagnosis...

INTRODUCTION: Sex differences strongly influence immune responses and susceptibility to inflammatory diseases, yet how biological sex shapes immune regulatory mechanisms in chronic obstructive pulmonary disease (COPD) remains poorly understood. Neutrophils are key drivers of COPD pathogenesis, but whether biological sex shapes their inflammatory programming has not been systematically investigated.

Background/Objectives: Clostridioides difficile infection (CDI) is the leading cause of colitis and hospital-acquired diarrhea. Patients with Chronic Obstructive Pulmonary Disease (COPD) frequently have infectious exacerbations requiring treatment with antibiotics, which may be predisposing them to CDI. This study examines the prevalence and in-hospital outcomes of CDI in patients with COPD. Methods: Data for hospitalized patients with CDI was extracted from the National Inpatient Sample...

Whereas cellular stress responses are well defined, tissue-level stress remains poorly understood. Proteases are among the most widespread enzymes, and excessive proteolytic activity drives diseases such as arthritis and chronic obstructive pulmonary disease, yet unifying features of this stress are unclear. Here, using the lung and diverse proteases, we identify a conserved injury signature of proteolytic stress marked by vascular disruption, red blood cell extravasation, and heme release that...

CONCLUSIONS: AS and LVDD share both clinical and genomic associations, with overlapping genetic drivers that are enriched in pathways related to inflammation, extracellular matrix remodeling, and vascular stress responses. This work supports the potential of blood-based multi-omics profiling to uncover early, systemic molecular signals of cardiac dysfunction and lays the groundwork for future tissue-specific studies to guide precision diagnosis, risk stratification, and targeted therapeutics in...

Chronic Obstructive Pulmonary Disease (COPD) often leads to anxiety and depression, adversely impacting patients' quality of life. Therefore, it is of interest to evaluate the prevalence and correlation of anxiety and depression among COPD patients categorized by the GOLD guidelines. Hence, a total of 160 clinically stable COPD patients were assessed for anxiety and depression using the Hindi translations of PHQ-9 and GAD-7 questionnaires. Spirometry was used for classifying COPD severity as per...

Background/Objectives: Skeletal muscle depletion is an important extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD) and is associated with adverse clinical outcomes. Chest computed tomography (CT), which is frequently performed in patients with COPD, provides an opportunity for opportunistic assessment of thoracic muscle mass. However, the prognostic relevance of CT-derived pectoralis muscle measurements for long-term survival in COPD remains incompletely defined. This...

CONCLUSION: This computational discovery framework introduces an oxeiptosis-specific molecular taxonomy of COPD. The results underscore oxidative stress and the interaction between immune regulation and matrix remodeling as pivotal elements linked to disease heterogeneity, presenting potential pathways for precise diagnosis and treatment.

CONCLUSION: Influenza vaccination appears to be a safe and clinically meaningful preventive strategy in populations at high risk of cardiopulmonary complications. The strongest current evidence supports selected cardiovascular endpoints and influenza-related outcomes. This umbrella review provides an integrated synthesis of cardiovascular, respiratory, and safety outcomes while explicitly addressing review quality, overlap of primary studies, and certainty of evidence.

CONCLUSION: In this single-centre retrospective observational study, there is a rise in HMV setups for ORRF following hospital admission for AHRF. Further multicentre work is needed to assess the significance of this trend and the impact of associated comorbidities on survival.

CONCLUSIONS: In adults with asthma or COPD exacerbations receiving high-dose albuterol, the JN and VMN protocols resulted in similar need for repeat bronchodilator therapy. VMN therapy led to greater heart rate increases. These findings suggest that for delivery of high-dose albuterol, rapid VMN delivery does not provide benefit over traditional JN but may increase side effects. Additional prospective randomized trials are needed to further clarify the role of VMN for high-dose albuterol...

CONCLUSIONS: The Danish Breathe-VQ demonstrates content equivalence and face validity, offering a suitable tool for measuring breathing vigilance in Danish-speaking populations.

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction is increasingly recognized as a key contributor to a broad spectrum of human diseases beyond classical cystic fibrosis (CF). CFTR is a cAMP-regulated chloride and bicarbonate ion channel expressed in both epithelial and non-epithelial tissues, where it regulates ion homeostasis, mucosal hydration, and cellular signaling. Both inherited CFTR mutations and acquired dysfunction resulting from environmental or inflammatory...

CONCLUSIONS: This pilot study suggests that a brief educational intervention may improve general practitioners' knowledge and intended prescribing of lower-carbon inhaler alternatives, particularly in asthma scenarios. However, the outcomes were based on theoretical clinical vignettes rather than real-world prescribing data, and the study was not designed to assess the safety or clinical effectiveness of changing inhaler prescriptions. Future studies should evaluate sustained changes in...

Chronic respiratory diseases pose a major global public health challenge, and the role of metabolic reprogramming in their pathogenesis has attracted increasing attention. Mitochondrial fatty acid oxidation (FAO) is a core energy metabolic pathway that not only fuels pulmonary tissues but also participates in essential physiological processes such as alveolar surfactant synthesis. This review outlines the molecular mechanisms of mitochondrial FAO and focuses on its complex regulatory roles in...

CONCLUSION: A higher simplified GDMT score was associated with reduced 30-day and 6-month readmissions, particularly among patients with ischemic heart failure, supporting its potential utility as a pragmatic measure of GDMT optimization.

CONCLUSION: Occupational exposure to airborne MNP is associated with lower lung function and a higher prevalence of respiratory symptoms in this cohort. These findings warrant further investigation with complete occupational histories.

CONCLUSION: The hospital-acquired RAM developed and validated in this study for patients with cancer performed better than a non-cancer specific model. This tool will support individualized risk-assessment in medical inpatients with cancer.

CONCLUSION: These findings highlight PRISm as a potentially relevant pattern within chronic airway disease. Within the context of Sustainable Development Goal 3 on non-communicable diseases, they underscore the importance of identifying this subgroup for closer clinical attention. Further longitudinal and multicentre studies are needed to better understand the clinical significance of PRISm and its relationship to chronic airway diseases.

CONCLUSIONS: AWEs significantly impact daily life but vary widely in recognition and thresholds for seeking care. Limited awareness of daily disease variations may contribute to both under-reporting of worsening events to healthcare providers and suboptimal self-management in COPD.

CONCLUSION: In patients with COPD and pre-COPD, mucus plugs are associated with reduced muscle and fat mass and a heightened sarcopenia risk.

Fine particulate matter 2.5 (PM(2.5)) is linked to rising cases of respiratory, cardiovascular, and immune-mediated diseases and increased hospitalizations in non-respiratory patients. Chiang Mai Province in Northern Thailand, faces seasonal severe PM(2.5) pollution, but its impact on immune responses in human remains poorly characterized. This study aimed to investigate the association between air pollution and non-communicable diseases in Chiang Mai and to assess how PM(2.5) collected in...

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