Apnea/Sleep Disorders Pubmed Results

CONCLUSION: Obesity is a key risk factor for OSA combined with hypertension. VAI demonstrates the best predictive performance for the risk of OSA combined with hypertension and can be used as a priority indicator for hypertension screening in OSA patients in Southwest China. Age and obesity indicators exhibit a cumulative risk effect, which highlights the need to strengthen obesity management in middle-aged and older populations with OSA.

CONCLUSION: Integrating AI into clinical practice will likely continue to evolve, enhancing treatment planning in selective cases. The best applications were over TMJ osteoarthritis, skeletal maturation, and classification, OSA, and the need for orthognathic surgery.

CONCLUSIONS: OSA is an independent, dose-dependent risk factor for accelerated AMD progression. Screening and treating OSA in patients with intermediate AMD may represent a novel strategy to preserve vision.

CONCLUSION: Careful history-taking and understanding of the underlying biomechanical pathophysiology can orient physicians to consider OSA. Personalized and interdisciplinary approaches should be considered when prescribing OSA treatment and during follow-up assessments.

CONCLUSION: Une anamnèse rigoureuse et la compréhension de la pathologie biomécanique sous-jacente de l’AOS peuvent inciter les médecins à envisager un diagnostic d’AOS. Des approches individualisées et interdisciplinaires devraient être prises en compte dans la prescription d’un traitement pour l’AOS et durant les évaluations de suivi.

CONCLUSION: Expanded NHI coverage positively affected OSA detection and patient management, providing valuable insights into the potential for policy-driven improvements in the management of sleep disorders. The expanded PSG coverage effectively improved OSA detection in the underserved and high-risk populations.

Nocturnal yawning may represent a subtle clinical marker of arousal instability in patients with sleep-disordered breathing (SDB), potentially unveiling latent comorbid insomnia and sleep apnea (COMISA) phenotypes, and expanding the interpretative scope of sleep-related behaviors.

CONCLUSION: We developed an explainable nomogram that integrates upper airway anatomy, allergic, sex, and specific inflammatory cytokines. This tool provides clinicians with a practical, non-invasive method for individualized risk assessment, facilitating the identification of children with moderate-to-severe OSA who may benefit from prioritized diagnosis and intervention.

Obesity-hypoventilation syndrome is characterized by daytime hypercapnia (arterial partial pressure of carbon dioxide of 45 mm Hg or more) in a patient with a body mass index of 30 kg/m2 or more, in the absence of alternative causes of hypoventilation. It should be suspected in patients with obesity who have daytime somnolence, dyspnea, fatigue, snoring, apnea, and sleep-related and daytime hypoxemia. The diagnosis is confirmed with overnight polysomnography. Additional tests such as measurement...

CONCLUSIONS: CBCT measurements can predict OSA severity. The newly introduced DISE-Sum is highly correlated with polysomnography and CBCT findings. Individual DISE scores may be associated with AHI and CBCT only at one or two airway levels. BMI is associated with OSA. Age and neck circumference are associated with OSA only before controlling for BMI.

CONCLUSION: Combined treatment with Hyrax + Up-Locker vacuum activator yielded superior outcomes in sleep architecture and sleep behavior.

Obstructive sleep apnea syndrome (OSAS) presents with various cues and symptoms such as witnessed apneas, excessive daytime sleepiness, and snoring. However, these symptoms are not exclusive to OSAS and can be indicative of a spectrum of sleep disorders. Despite its global prevalence, there lacks a clinical predictor for determining OSAS incidence and severity. This study aims to explore the correlation between the monocyte-to-HDL cholesterol ratio (MHR) and obstructive sleep disorders, thereby...

Sleep disordered breathing can cause serious health issues, yet current diagnostic methods are cumbersome and prone to error. Thoracic electrical bio-impedance (BioZ) is a promising alternative, but it remains unclear whether the measured BioZ variations reflect lung volume changes. We leverage linear reductions in lung volume during central sleep apnea (CSA) events to assess whether BioZ measurements capture changes in lungs. BioZ signals from 92 sleep studies were analyzed using linear...

CONCLUSION: Obesity, neck circumference >40 cm, severe BA, rhinitis, and GERD independently predict OSAS in BA. LEP, IL-6, and NLR correlate with OSAS severity, and their combined use provides superior diagnostic value for identifying BA-OSAS comorbidity and may aid targeted screening and referral. (≈240 words).

Adenoid hypertrophy (AH) and combined adenotonsillar hypertrophy (ATH) are primary causes of childhood sleep-disordered breathing (SDB), and they are strongly correlated with atopic diseases affecting the respiratory mucosa. Allergen sensitization, class-switching of B cells, and IgE production in the adenotonsillar tissue, namely local atopy, are crucial steps in the pathogenesis of allergic rhinitis (AR) and asthma. The adenotonsillar tissue is also responsible for a considerable part in...

Obstructive sleep apnea (OSA) is one of the most common sleep disorders, affecting 1-10 % of children. A key risk factor is elevated body mass index (BMI). This exploratory study aimed to assess OSA prevalence and severity in adolescents living with obesity and explore associations with clinical and metabolic parameters. Adolescents with obesity aged 10-15 years hospitalized for weight management were enrolled. Participants underwent examination including anthropometry, blood pressure, and lipid...

A woman in her early 40s presented with a 7-year history of recurrent choking episodes affecting solids and liquids, nocturnal choking episodes occurring 3-4 times weekly, and chronic occipital headaches spanning 14 years. Home monitoring during the COVID-19 pandemic incidentally revealed episodes of severe oxygen desaturation (70%-80%) without respiratory distress. Multiple laryngoscopies and endoscopies performed to investigate the choking episodes were normal. Review of a 14-year-old CT scan...

CONCLUSIONS: Accordingly, our model can help automatically detect pediatric OSA and offers clinicians an explainable approach that enhances credibility and usability, thus providing a path toward clinical translation in early diagnosis.

The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), known as overlap syndrome (OS), presents unique diagnostic and therapeutic challenges. Patients with overlap syndrome exhibit more severe hypoxemia, higher cardiovascular risk, and increased COPD exacerbations compared to those with either condition alone. While treatment with positive airway pressure (PAP) remains the cornerstone of OSA management, its role in patients with OS requires more...

CONCLUSIONS: RPM solutions for OSA should expand beyond AHI, ensure accuracy and interpretability, and provide actionable insights to support comprehensive patient-centric management.

CONCLUSION: These findings suggest that a moderate increase in indoor environmental oxygen can significantly improve nocturnal blood-oxygen saturation. This simple, non-invasive method may complement existing therapies, offering benefits to individuals with mild-to-moderate OSA, sleep disturbances at high altitudes, and nocturnal hypoxemia from chronic respiratory diseases such as COPD.

CONCLUSIONS AND PRACTICAL IMPLICATIONS: Dentists can contribute to multidisciplinary sleep care through established therapies, selective use of emerging interventions, and early recognition of airway growth issues. Adoption of new therapies should follow expert consensus and robust evidence until stronger data are available.

This study investigated the potential causal relationship between gut microbiota (GM) and sleep apnoea using Mendelian randomisation (MR) analysis. Summary-level genome-wide association (GWAS) data for 473 GM and sleep apnoea were obtained from the IEU Open GWAS database. A two-sample MR framework was applied to assess the potential causal effects of GM on sleep apnoea. The primary analysis was conducted using the inverse variance-weighted (IVW) method, complemented by MR-Egger regression,...

CONCLUSIONS: CAO and EDS emerged as independent predictors of mortality, while the coexistence of CAO and snoring conferred synergistic risk. These findings highlight the need to recognize OSA symptoms in patients with obstructive lung disease, as they may identify a vulnerable subgroup at heightened risk. Future studies using objective sleep assessments are warranted to clarify mechanisms and guide preventive strategies.

CONCLUSION: This study observed that serum asprosin levels were higher in OSAS patients than in the control group and increased with disease severity. In addition, asprosin levels were determined to be related to body fat tissue distribution. These findings suggest that asprosin can be used as a potential biomarker in diagnosing OSAS and assessing disease severity.

PURPOSE OF REVIEW: Obstructive sleep apnea (OSA) is common and strongly linked with systemic hypertension, including resistant and nocturnal forms. Traditional OSA therapies lead to modest blood pressure (BP) reductions, but optimal antihypertensive strategies in this population remain unclear. This review examines OSA driven hypertension mechanisms, differential responses to standard OSA therapies, and evaluates evidence for mineralocorticoid-targeted treatment - including blockade of...

CONCLUSION: The immune regulation mediated by CD4^(+) T cells demonstrates significant temporal dynamics and cell type specificity in OSA pathogenesis. Key genes including TUFM, MAST3, FNBP4, SGF29, and SH3YL1 participate in the pathological process by regulating mitochondrial function, cell migration, transcriptional regulation, and inflammatory responses. These findings provide a novel theoretical foundation and reveal potential targets for personalized therapeutic strategies and biomarker...

Background and Objectives: Obstructive sleep apnea (OSA) is a clinically relevant comorbidity in both alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD). However, whether its impact differs between these etiologies remains unclear. This study directly compared OSA risk in patients with AFLD and NAFLD to elucidate its role in disease progression. Materials and Methods: We conducted a retrospective cohort study using the TriNetX research network. Adults aged ≥ 20...

Background and Objectives: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is associated with increased cardiovascular risk, particularly in hypertensive patients. Heart rate variability (HRV) and QTc interval are noninvasive markers of autonomic function and ventricular repolarization, respectively, but their relationship with OSAHS severity remains unclear. To investigate whether the severity of OSAHS influences standard HRV and QTc parameters in hypertensive patients with moderate or severe...

CONCLUSIONS: A nocturnal burden of GERD was detected and related to sleep disruption, including PLMs, and to daytime complaints. SDB/OSA, of a severity known to have significant health consequences, was common; it was adversely related to pulmonary diffusion and exercise capacity. These findings call for comprehensive, early evaluation of GERD and OSA for improved IPF outcomes.

CONCLUSIONS: This study established DUSP9 as a pivotal shared biomarker and central regulator linking OSA and IC/BPS through integrated bioinformatics analysis.

In mice, intermittent hypoxia is associated with an increase in microvessels in the hippocampus, whereas in humans with obstructive sleep apnoea (OSA), microvessels are lost from the heart and retina. The present study investigated microvascular changes in the hippocampus of patients with OSA, and whether patient age or use of continuous positive airway pressure (CPAP) influence microvascularisation. Using autopsy samples from 31 people with confirmed OSA, microvessels were immunolabelled and...

Obstructive sleep apnea (OSA) is a common disorder in the general population and individuals with hypertension. We reviewed the literature on the prevalence of OSA in hypertension and hypertension subgroups. The current literature shows a high prevalence of OSA in patients with nocturnal and resistant hypertension, up to more than 90% in patients with refractory hypertension. The prevalence of OSA in patients with primary aldosteronism is greater than 45%. We also conducted an Italian national...

CONCLUSION: The MMP-1-1607 2G/G and 2G/2G genotypes are significant risk factors for OSA, while the MMP-9 - 1562 C/T polymorphism is not.

CONCLUSION: FSTL1 demonstrates potential as a valuable biomarker that can aid current diagnostic tools for OSA and help evaluate treatment efficacy; however, additional research is warranted to confirm its clinical applicability and explore its therapeutic potential.

Objective:To investigate the role of the body roundness index（BRI） and a body shape index（ABSI） in the assessment of Obstructive Sleep Apnea-Hypopnea Syndrome（OSAHS）. Methods:A retrospective analysis was performed on the medical records of 256 adult patients with suspected OSAHS who underwent polysomnography（PSG） in the Department of Otorhinolaryngology, Peking University Third Hospital, from March 2024 to February 2025. The collected data included gender, age, Body Mass Index（BMI）, waist...

Objective:This study cvaluates the application value of tonsillar ultrasound measurement in pediatric obstructive sleep apnea （OSA） by analyzing its correlation with key indicators of pediatric OSA. Methods:Fifty-nine children diagnosed at Chongqing Peoples Hospital from July 2023 to July 2024 were included. Preoperative measurements included height, weight, BMI, tonsil grading, ultrasonic tonsil measurements, Obstructive Apnea Hypopnea Index（OAHI）, Lowest Pulse Oximetry（LSpO2）, and A/N ratio...

Objective:To identify risk factors for retinopathy in patients with obstructive sleep apnea（OSA） and hypertension, and develop a machine learning-based risk prediction model by integrating optical coherence tomography angiography（OCTA） -derived retinal microvascular parameters. Methods:This study enrolled 98 adult patients diagnosed with OSA and hypertension at China-Japan Friendship Hospital and Capital Medical University afflicted Beijing Tiantan Hospital, from June to December 2024. Clinical...

Objective:This study aims to systematically explore the clinical characteristics of rapid eye movement（REM） -related obstructive sleep apnea（OSA） and objective polysomnography（PSG） indicators, and conduct an in-depth investigation into the specific manifestations of REM-OSA at different disease severity levels, and clarify the differences in clinical characteristics and PSG parameters between REM-OSA and non-rapid eye movement OSA（NREM-OSA）. It provides a scientific basis for optimizing the...

Objective:To analyze individual differences and influencing factors of upper airway collapse in patients with moderate to severe obstructive sleep apnea（OSA） with different genioglossus negative pressure reflex patterns. Methods:This prospective cohort study started from January 2021 to September 2023, recruited male patients with moderate to severe OSA who were treated at Tsinghua Chang Gung Hospital in Beijing. After completing upper airway CT, each subject underwent drug-induced sleep...

Objective:To analyze the surgical efficacy of drug-induced sleep endoscopy（DISE） localization-assisted treatment for obstructive sleep apnea-hypopnea syndrome（OSAHS）, and to explore the guiding role of DISE in multi-plane surgery for OSAHS. Methods:A retrospective analysis was conducted on patients with OSAHS who underwent surgical treatment in the Department of Otorhinolaryngology Head and Neck Surgery of the Second Hospital of Jilin University from January 2020 to October 2023. All patients...

CONCLUSION: Our findings indicate that depressive symptoms, subclinical affective instability, and respiratory arousals are independently associated with EDS in OSA patients, with clear dose-response relationships. These results suggest that a multifactorial framework encompassing both psychological and physiological domains may be a valuable direction for understanding EDS, and warrant future investigation into the clinical value of integrated assessments.

Objective: To evaluate the effect of targeted therapy for primary aldosteronism (PA) on the clinical outcome of coexisting obstructive sleep apnea (OSA). Methods: A prospective study was conducted on patients diagnosed with both PA and OSA in the Sun Yat-sen Memorial Hospital between June 2023 and January 2025. All patients received PA targeted treatment. Full-night portable sleep monitoring was performed before and 3-12 months after treatment. Participants were divided into the OSA improvement...

Surgical treatments are important options for adult obstructive sleep apnea, especially when the treatment compliance of continuous positive airway pressure, the first-line treatment, is poor. Currently, there are several surgical procedures that had been used in treating this disease in clinical work, including nasal surgery, velopharyngeal surgery, glossopharyngeal surgery, maxillofacial surgery, bariatric surgery, and nerve stimulation surgery. These procedures involve different specialties...

Objective:To investigate the therapeutic effect of upper airway surgery on patients with obstructive sleep apnea hypopnea syndrome（OSAHS）, observing changes in their cardiopulmonary function, and comparing the improvement of cardiopulmonary function between patients with different therapeutic effects. Methods:A total of 70 patients with moderate to severe OSAHS admitted to our hospital from July 2021 to February 2024 were selected. All patients underwent nasal cavity expansion surgery combined...

Objective: To investigate the characteristics of event-related potential (ERP) in adult males with obstructive sleep apnea (OSA) comorbid with depressive state and their correlation with polysomnography (PSG) parameters. Methods: Cross-sectional study. A total of 77 adult male OSA patients aged 18 to 60 from the Sleep Center of the Second Affiliated Hospital of Soochow University were prospectively enrolled between August 2023 and June 2024. General clinical data, Epworth sleepiness scale (ESS),...

Objective:To investigate the effects of postoperative management based on health promotion strategies on weight control and symptom improvement in patients with obstructive sleep apnea-hypopnea syndrome（OSAHS）. Methods:A total of 120 OSAHS patients who underwent uvulopalatopharyngoplasty（UPPP） between January 2024 and May 2025 were selected and randomly divided into a control group and an intervention group, with 60 patients in each group. The control group received routine postoperative...

Objective:To investigate the risk factors for delayed discharge inchildren with mild to moderate obstructive sleep apnea（OSA） undergoing day surgery. Methods:The electronic medical records of 374 children with OSA who underwent day surgery at Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2021 to December 2022 were retrospectively analyzed. The patients were divided into a delayed discharge group（38 cases） and a normal discharge group（336 cases） based on their...

CONCLUSIONS: These findings suggest a possible link between OSA-related hypoxia and carcinogenesis in urinary tract tissues and support increased clinical surveillance and further research to determine potential protective effects of C-PAP therapy.

CONCLUSIONS: OSA was independently associated with self-reported previous non-traumatic fractures in the general population. The association was age-dependent and more meaningful in the elderly population.