Respiratory Medicine Journal

In 2023, the European Academy of Allergy and Clinical Immunology (EAACI) proposed an immune response–based classification that integrates molecular, endotypic, and clinical characteristics to define predominant and co-occurring immune response groups in asthma. Applying this framework may clarify disease heterogeneity and support personalized treatment.

Our understanding of chronic obstructive pulmonary disease (COPD) has evolved over years to account for its wide biological and clinical heterogeneity. The identification of phenotypes as treatable traits has been crucial for advancing personalized therapies. Unfortunately, profiling validated phenotypes which associate endotypes and biomarkers to clinical outcomes has proved to be challenging1. After years of disappointment in the search for novel broadly-targeted pharmacotherapies, it has become evident that the selection of clinical trial participants based on phenotypic characteristics is most often crucial for a successful trial.

COVID-19–associated pulmonary aspergillosis (CAPA) has emerged as a severe and potentially underrecognised complication in patients with SARS-CoV-2 infection, particularly in intensive care units (ICUs). Existing reviews show substantial heterogeneity in diagnostic criteria, incidence estimates, and reported risk factors, limiting reliable interpretation of the overall evidence base.

Obese patients with acute respiratory distress syndrome (ARDS) may require higher positive end-expiratory pressure (PEEP), but the dose-response relationship between body mass index (BMI) and PEEP remained undetermined. This study aimed to investigate the relationship between BMI and the optimal PEEP titrated by electrical impedance tomography (EIT) in ARDS patients.

To investigate efficacy of standardized treatment for post-infectious bronchiolitis obliterans (PIBO) in infants and young children by evaluating changes in pulmonary function, and high-resolution computed tomography (HRCT) before and after treatment.

Lung cancer screening (LCS) has been shown to reduce both lung cancer related and all-cause mortality [1] and is recommended by United States Preventive Services Task Force (USPSTF) guidelines for those 50 – 80 years old with a 20-pack year or greater smoking history who currently smoke or have quit in the past 15 years [2].

Inhaled levofloxacin is widely used in cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa infection and is generally well tolerated. The most commonly reported adverse effects are bronchospasm and dysgeusia, with limited evidence of systemic toxicity.We report a case of a 26-year-old woman with CF who developed recurrent diffuse musculoskeletal pain temporally associated with inhaled levofloxacin therapy. Symptoms occurred exclusively during treatment cycles, resolved upon discontinuation, and have not recurred since cessation.

Chronic obstructive pulmonary disease (COPD) is a global disease characterized by persistent airflow limitation. Its pathogenesis is complex and there is currently no effective treatment. Although mitochondrial dysfunction and oxidative stress are closely related to the pathological process of COPD, the specific role of succinylation in pulmonary mitochondria of COPD is not clear.

Prolonged time to pregnancy, increased need for fertility treatment, and increased pregnancy loss have been reported in women with asthma. However, it is unknown whether uterine inflammatory cells negatively affects fertility in this group. We explored whether women with asthma undergoing fertility treatment have increased inflammatory cells in the endometrium compared to women without asthma.Thirty women with and without asthma (1:1) undergoing fertility treatment were included in this explorative observational study.