Paediatric Dermatology – Pubmed Results

CONCLUSIONS: We propose a clinically based clustering framework to refine pediatric AD phenotypes and support individualized care across diverse ancestries.

Dermatology is one of the most interdisciplinary specialties in medicine, yet the pathways through which physicians may enter dermatologic practice are not always clearly defined for trainees. Although dermatology residency remains the primary route to board certification, alternative pathways allow physicians from other specialties to participate in dermatologic care. These include fellowships and training opportunities in dermatopathology, pediatric dermatology, cosmetic dermatologic surgery,...

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Crohn disease (CD), a subtype of inflammatory bowel disease, may be complicated by extraintestinal manifestations. Although cutaneous findings are among the most frequent, metastatic Crohn disease (MCD), defined as mucocutaneous CD at sites noncontiguous with the gastrointestinal tract, is rare. Children with MCD are more likely than adults to develop genital inflammation. Case reports describe the vulva, scrotum, and penis as common locations of involvement in children with genital MCD. We...

CONCLUSIONS: Children and adolescents with moderate-to-severe AD in TREATkids exhibit distinct anthropometric patterns, characterized by height deficits but normal weight distribution, independent of systemic glucocorticoid treatment.

CONCLUSIONS: The underutilization of PROMs in AD and CU is strongly driven by physicians' perceptions that patients dislike them and that they constrain the doctor-patient relationship. This suggests physicians may have deeper insights into the practical shortcomings of current instruments. Therefore, rather than solely focusing on physician education, existing AD and CU PROMs urgently require re-evaluation and co-development with direct patient involvement (eg, Core Outcome Sets) to ensure they...

CONCLUSION: ANA-positive DLE-only patients warrant close monitoring for progression SLE, especially within the first year. Severe end-organ disease in DLE patients who progress to SLE is uncommon. Future studies should test whether early recognition and intervention in DLE-only slows progression to SLE.

Exercise-induced vasculitis (EIV), colloquially known as "Disney rash," is a benign, self-limited leukocytoclastic vasculitis of the lower extremities triggered by prolonged exertion in warm weather, well-recognized in adults but underappreciated in children. We report a 12-year-old immunocompromised boy who developed purpuric lower-extremity thin plaques with sharp sock-line sparing following a full day at a theme park. Although this initially prompted concern for a systemic vasculitis,...

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Cutis tricolor (CT) is a rare pigmentary mosaicism characterized by the coexistence of hyperpigmented and hypopigmented areas on a background of normal skin; its syndromic form, Ruggieri-Happle syndrome (RHS), is associated with neurodevelopmental delay, facial dysmorphism, skeletal abnormalities, and other systemic defects. We report a 16-year-old girl with molecularly confirmed Mowat-Wilson syndrome caused by a de novo pathogenic ZEB2 frameshift variant, who presented with extensive CT-like...

Preoperative imaging methods in hidradenitis suppurativa (HS) surgery are beneficial for determining the surgical margins and significantly reducing postoperative recurrence rates. We present an adolescent HS patient who underwent excision of an inguinal lesion utilizing both preoperative and intraoperative ultrasonography. We aim to emphasize that in patients with complex subcutaneous fistulas, particularly in the inguinal-gluteal regions, the combination of preoperative and intraoperative...

The medical care of the pediatric population is disproportionately affected compared to adult medical care during periods of social and political unrest. No-show and late cancellation rates (NSLCR) were collected across pediatric and adult dermatology clinics in Minneapolis, Minnesota during recent periods of social unrest and the year prior. Pediatric dermatologic appointments, specifically those in metropolitan areas, were found to have a statistically significant increase (p < 0.001) in NSLCR...

CONCLUSIONS: Orthonyxia is an effective treatment option for pediatric ingrown toenails. Its practical value in children includes avoidance of surgery and immediate return to daily activities.

Erythroderma in the pediatric population is an uncommon yet challenging condition. The etiologies encompass a wide variety of illnesses, including seborrheic dermatitis, infections, inborn errors of immunity, ichthyosiform disorders and metabolic abnormalities. Hyper-immunoglobulin E syndrome (HIES) occurs due to various known genetic variants, e.g., STAT3 (signal transducer and activator of transcription-3), IL6R (Interleukin-6 receptor) deficiency and others, with an extensive list of features...

Polypodium leucotomos extract (PLE) has been widely studied for its antioxidant, photoprotective, and anti-inflammatory properties, but limited data exist regarding its use in children. This retrospective study evaluated the safety of a gummy-based PLE supplement (Inner Glow Sol Defense, 280 mg) in 77 pediatric patients across three dermatology clinics. Patients took the supplement for a median of 4 months with no documented adverse effects, including in cases of prolonged use and accidental...

CONCLUSION: There are a variety of skin manifestations on the hand in Proteus syndrome. Palmar CTN are often progressive whereas other lesions progress slowly or remain stable over time.

CONCLUSION: In recent decades, the dire need for pediatric dermatologists has exceeded the available workforce, with numerous fellowship programs remaining unfilled.

Reactive infectious mucocutaneous eruption (RIME) is a post-infectious mucositis which primarily affects pediatric patients. We report a 14-year-old girl with recent intensive sun exposure who developed RIME in a photodistributed pattern. Treatment with etanercept yielded clinical improvement. Potential mechanisms underlying photodistributed RIME syndrome are discussed, with comparison to photodistributed instances of Stevens-Johnson syndrome.

Alopecia areata is an immune-mediated disease resulting in non-scarring hair loss and is associated with significant burden on mental health and quality of life. Mindfulness-based stress-reduction therapies have emerged as a potential intervention and have shown promising results, though studies of efficacy in adolescent populations are lacking. Thus, this pilot study aimed to determine if the daily use of the Breathr mindfulness app would improve anxiety in adolescent patients with AA over a...

CONCLUSIONS: In our cohort, narrow excision of AST was commonly employed and associated with excellent short- to mid-term oncologic outcomes and low surgical morbidity. These findings provide supportive clinical outcome data aligning with current consensus recommendations favoring more narrow surgical management of AST in children.

The pediatric dermatology workforce shortage threatens equitable access to specialized care for children. We conducted a national survey of dermatology residents (n = 202) to examine the relative influence of mentorship, educational exposure, training satisfaction, and financial considerations on fellowship decision-making. In multivariable analysis, mentorship emerged as the primary predictor of fellowship pursuit (OR: 6.034, 95% CI: 2.315-19.648, p = 0.013), while structural program features...

CONCLUSIONS: AD seemed to be associated with comparable or slightly higher vocabulary and reading scores. Increased sedentary activities, such as reading and watching television, among children with AD may confer benefits that counterbalance or even slightly outweigh any inherent negative effects of AD on standardized testing performance.

CONCLUSIONS: Overall, available pediatric data supports topical JAK inhibitors as effective and well-tolerated nonsteroidal options for AD, providing rapid symptom relief and disease control that may help expand steroid-sparing treatment options for children.

A single-center retrospective study evaluated tofacitinib in 48 Chinese children and adolescents (aged 2-18 years) with alopecia areata. At Week 12, the median relative improvement rate in SALT score from baseline was 50.0% (IQR: 27.2%-70.2%). By Week 24, the improvement increased to 84.3% (IQR: 52.2%-100.0%), and 20 patients (41.7%) achieved SALT(100) complete response and 11 patients (22.9%) attained SALT(75). During extended follow-up, 24 patients experienced relapse. Recurrence rates were...

CONCLUSION: Primary care pediatricians provide an important perspective concerning the subspecialty care needs of their patients, and they report shortages for many subspecialty areas. The shortages are more pronounced in rural areas.

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Eruptive disseminated porokeratosis (EDP) is a rare subtype of porokeratosis with the rapid onset of numerous pruritic papules and plaques on sun-exposed and sun-protected skin. We report a 73-year-old man with a one-year history of a progressively spreading pruritic eruption involving the lower extremities and forearms. Examination revealed brown verrucous papules coalescing into plaques. Histopathology demonstrated cornoid lamella, confirming porokeratosis. Paired exome sequencing identified a...

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CONCLUSIONS: Published ELISA accuracy-especially sensitivity-may be overestimated; in practice, a negative ELISA should not be used to rule out BP when clinical suspicion is high.

CONCLUSION: Anaphylaxis occurring in educational settings can be severe, with frequent known allergy to the culprit food, peanut as the most frequent elicitor, and adrenaline underuse. Action at the national policy level and cross-country collaborations are required to implement a common approach to protect children in educational settings.

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CONCLUSION: Pediatric lichen is a rare and heterogeneous condition in which non-classical forms may predominate. Clinicodermoscopic evaluation appears to be a valuable non-invasive tool to improve diagnostic accuracy and guide management in children.

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CONCLUSIONS: Maternal T2DM was not found as a protective factor of AD in offspring. The observed protective trend may reflect confounding by sociodemographic or diagnostic factors. Prospective studies incorporating metabolic, immunological, and environmental data are warranted.

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CONCLUSION: While there was a modest numerical trend favoring crisaborole, its efficacy was not statistically superior to placebo in this small pilot study. Larger studies are needed to further validate the efficacy of crisaborole for the treatment for POD.

Congenital hemangioma with thrombocytopenia is rare and is often mistaken for Kasabach-Merritt phenomenon seen in kaposiform hemangioendothelioma. We present three neonatal cases with severe but transient thrombocytopenia that resolved without intervention. Accurate diagnosis, cardiac evaluation, and cautious management are essential, as most patients recover spontaneously, avoiding unnecessary interventions.

Paradoxical inflammatory reactions, also referred to as flip-flop phenomena, are increasingly recognized complications of biologic therapies targeting specific immune pathways. These reactions are characterized by the emergence of a new inflammatory phenotype with opposing immunologic polarization or by unexpected exacerbation of the underlying disease despite prior therapeutic response. Although numerous case reports have been published, a unified mechanistic framework and a practical clinical...

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CONCLUSION: Families affected by XP experience significant and enduring psychosocial burden. Findings highlight the urgent need for coordinated, interdisciplinary support that extends beyond medical care. This study contributes to the growing call within the rare disease community for integrated care models that centre patient and family wellbeing.

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CONCLUSION: In this retrospective case series, progressive re-epithelialization was documented during follow-up in pediatric patients with complex cutaneous wounds receiving adjunctive topical MSC-derived secretome-enriched biological dressings alongside standard care. However, given the observational design, small sample size, heterogeneous diagnoses, and absence of a control group, these findings should be interpreted as descriptive and hypothesis-generating. Prospective, controlled studies...

PURPOSE OF REVIEW: To review the current literature for updates on pediatric nonsteroidal topical therapies (NSTT) for the treatment of atopic dermatitis (AD), psoriasis, alopecia areata (AA), vitiligo, and seborrheic dermatitis (SD).

Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant rare disease characterized by progressive episodic multi-focal heterotopic ossification of skeletal muscle, ligaments, tendons, and fascia, associated with congenital malformation of the great toes. Progressive thoracic deformity with scoliosis is present in approximately 65% of patients, causing restrictive lung disease, respiratory failure, and premature death. We report 3 children who developed severe scoliosis and...

Atopic dermatitis (AD) is the most common inflammatory skin disease and carries the highest disability-adjusted life-years burden, ranking 15th among all non-fatal diseases globally. It is characterized by intensely itchy skin and is associated with multiple comorbidities, such as food allergy, asthma, allergic rhinitis and eosinophilic oesophagitis, which are mainly driven by type 2 immune responses. Other comorbidities include mental health disorders, disordered bone health, and cutaneous and...

CONCLUSION: Dupilumab provides sustained clinical benefit and, in this cross-sectional assessment of a small pilot cohort, is associated with lower S. aureus colonization and the presence of commensal staphylococci in pediatric atopic dermatitis.

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