A 44-year-old man presented with a 4-year history of choking episodes while eating. Endoscopy revealed narrowing of the upper esophagus by a pulsating, cordlike structure in the posterior wall (shown in a video).
Author: Ishita Dubey, Neha Wadhwa
Posted: June 4, 2026, 12:00 am
The prevalence of wasting among children in Gaza tracks with Israeli blockades on aid, but war may lead to famine even without such policies. How should starvation be prevented and treated in wartime?
Author: Kevin Stephenson, Christa Lolley, Mark Manary
Posted: June 4, 2026, 12:00 am
Vaccine hesitancy is often driven by safety concerns. Clinician recommendations, presumptive communication, and empathy improve uptake; maintaining trust supports future acceptance and community protection.
Author: Sean T. O’Leary, Margie Danchin
Posted: June 4, 2026, 12:00 am
A neuroepithelial tumor occurred in a child who had previously received AAV gene therapy for mucopolysaccharidosis type I. Analysis of tumor tissue showed the integration of rearranged AAV vector elements in the gene PLAG1.
Author: Rebecca C. Ahrens-Nicklas, Chelsea Kotch, Aoife M. Roche, John K. Everett, Shantan Reddy, Mariarita Santi, Peter J. Madsen, Cristina Martos-Rus, Carolyn M. Yrigollen, Juliana C. Small, Sarah McCague, Beverly L. Davidson, Benjamin J. Samelson-Jones, Lea F. Surrey, Marilyn Li, Can Ficicioglu, Raymond Wang, Frederic D. Bushman, Lindsey A. George
Posted: June 4, 2026, 12:00 am
In an African study of severe malaria in children with partially artemisinin-resistant parasites with PfK13 mutations, artesunate did not lead to worse outcomes, which suggests that parenteral artesunate may still be used.
Author: Kathryn Maitland, Maurice Okao, Melissa D. Conrad, Tonny Etwop, Modester Akite, Emmanuel Oguda, Florence Alaroker, Denis Aromut, Rita Muhindo, Sophie Uyoga, Peter Olupot-Olupot, Christabel Mogaka, Roisin Connon, Thomas Katairo, Martin Okitwi, Jessica Briggs, Diana M. Gibb, Nicholas P.J. Day, Nicholas J. White, Thomas N. Williams, Arjen M. Dondorp, A. Sarah Walker, Elizabeth C. George, Philip J. Rosenthal, for the SMAART-CHARISMA group†
Posted: June 3, 2026, 12:00 am
Ugandan children with sickle cell anemia who received 10 years of hydroxyurea therapy had sustained laboratory and clinical benefits, improved growth, and few toxic effects.
Author: Russell E. Ware, Robert O. Opoka, Teresa Latham, Phillip Kasirye, Priscilla Kasembo, Heather Hume, Isaac Birungi, Norah Kadde, Bill Wambaka, Maria Nakafeero, Andrea L. Conroy, George Tomlinson, Adam Lane, Chandy John
Posted: May 28, 2026, 12:00 am
After a physician pronounces his 15-year-old patient dead over the phone, he respects her parents’ silence, though it leaves him isolated in his grief and craving some form of closure.
Author: James A. Feinstein
Posted: May 28, 2026, 12:00 am
The new Dietary Guidelines for Americans represent progress in some areas but raise concerns about transparency, internal consistency, practical implementation, and ignoring of key scientific evidence.
Author: Deirdre K. Tobias, Frank B. Hu
Posted: May 28, 2026, 12:00 am
In a trial involving children with Chiari type I malformation and syringomyelia, the percentage with surgical complications did not differ significantly between posterior fossa decompression with duraplasty and decompression alone.
Author: David D. Limbrick Jr., Chevis N. Shannon, Emine O. Bayman, Thanda Meehan, Marisa Kallem, Laurie L. Ackerman, P. David Adelson, Raheel Ahmed, Gregory Albert, Philipp R. Aldana, Tord D. Alden, Richard C.E. Anderson, Lissa C. Baird, David Bauer, Tammy Bethel-Anderson, Karin Bierbrauer, Douglas L. Brockmeyer, Joshua J. Chern, Daniel E. Couture, David J. Daniels, Robert C. Dauser, Brian J. Dlouhy, Susan R. Durham, Richard G. Ellenbogen, Ramin Eskandari, Stephen R. Gannon, Gerald A. Grant, Patrick C. Graupman, Jacob K. Greenberg, Stephanie Greene, Jeffrey P. Greenfield, Naina L. Gross, Daniel J. Guillaume, Todd C. Hankinson, Gregory Heuer, Mark Iantosca, Bermans J. Iskandar, Eric M. Jackson, George I. Jallo, James M. Johnston, Robert F. Keating, Michael P. Kelly, Elaine Kennedy, Mark D. Krieger, Abhaya V. Kulkarni, Rick Labuda, Jeffrey R. Leonard, Cormac O. Maher, Francesco T. Mangano, J. Gordon McComb, Sean D. McEvoy, Robert C. McKinstry, Arnold H. Menezes, Toba N. Niazi, Jerry Oakes, Greg Olavarria, Brent R. O’Neill, Dorothy Poppe, John Ragheb, Samuel Reeves, Lisa Reynolds, Nathan R. Selden, Manish N. Shah, Joshua S. Shimony, Matthew D. Smyth, Sandy Spears, Scellig S.D. Stone, Jennifer M. Strahle, Mandeep Tamber, Gina Tramelli, Gerald F. Tuite, Elizabeth C. Tyler-Kabara, Haley Vance, Scott D. Wait, John C. Wellons III, William E. Whitehead, Alexander T. Yahanda, Yan Yan, Ralph G. Dacey Jr., Tae Sung Park, James C. Torner, the Park-Reeves Syringomyelia Research Consortium Investigators
Posted: May 28, 2026, 12:00 am
Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the emergency department with wheezing, regardless of whether they tested positive for pathogenic bacteria.
Author: Kurt R. Denninghoff, T. Charles Casper, Joseph J. Zorc, Richard M. Ruddy, Sarah Satola, Wendi-Jo Wendt, Claudia R. Morris, Melissa M. Tavarez, Matthew J. Lipshaw, Maria Y. Kwok, Jo-Ann O. Nesiama, Kyle A. Nelson, Michael Webb, Fernando D. Martinez, the PECARN AZ-SWED Trial Study Group*
Posted: May 18, 2026, 12:00 am
An analysis of current causes of deaths among U.S. children and adolescents underscores the need for sustained investment in prevention, research on injury and overdose treatments, and readiness in emergency settings.
Author: Caroline Raymond-King, Molly M. Jeffery, Edward R. Melnick
Posted: May 14, 2026, 12:00 am
In a study involving 180 blood bags, use of a double-knot closure rather than the usual single knot prevented bacterial contamination. This strategy may reduce the risk of blood-product contamination in resource-limited settings.
Author: Kathleen Selleng, Halima Ismail, Christian Kohler, Jan Wesche, Jessica Fuhrmann, Anne Kohler, Claudia Wiede, Vivien Huj, Yazid Ibrahim, Evgeny A. Idelevich, Dalhat Gwarzo, Andreas Greinacher
Posted: May 7, 2026, 12:00 am
A 22-year-old man presented with a 5-day history of painful lesions on his hands, feet, lips, and tongue. Physical examination showed erosions on the tongue and target lesions on the palms.
Author: Inês Pereira Amaral, Joana Antunes
Posted: May 7, 2026, 12:00 am
In this study involving persons with sickle cell disease, adenine base editing was used to target the promoters of HBG1 and HBG2 in autologous hematopoietic stem cells to increase fetal hemoglobin expression.
Author: Ashish O. Gupta, Akshay Sharma, Haydar Frangoul, Julie Kanter, Markus Y. Mapara, Jignesh Dalal, Asif Alavi, Jennifer J. Jaroscak, Ernesto Ayala, John F. DiPersio, Edward D. Ziga, Mary Eapen, Stacey Rifkin-Zenenberg, Alex C. Minella, Yinzhong Chen, Sarah Chesler, Srikanth Ambati, Thomas S. Bowman, Bahru Habtemariam, Marcelyne Joseney-Antoine, Priya S. Chockalingam, Ling Lin, Sunita Goyal, Amy Simon, Alexis A. Thompson, Matthew M. Heeney, the BEACON Investigators*
Posted: May 7, 2026, 12:00 am
There has been substantial interest in the development of GLP-1 drugs and optimism about their public health effects. But some worrisome signals related to disordered eating have emerged.
Author: Amanda Banks
Posted: April 30, 2026, 12:00 am
The author describes the scientific foundations and implications of the results of a randomized, controlled trial of Mim8, a new mimetic of factor VIIIa, to treat hemophilia A.
Author: Alok Srivastava
Posted: April 30, 2026, 12:00 am
Among patients with hemophilia A, the annualized rate of treated bleeding events with Mim8 was more than 96% lower than with on-demand therapy and more than 42% lower than with clotting factor prophylaxis.
Author: Maria Elisa Mancuso, Anthony K.C. Chan, Chandrakala Shanmukhaiah, Chuhl Joo Lyu, Joanna Zdziarska, Johnny Mahlangu, Lize F.D. van Vulpen, Pratima Chowdary, Renchi Yang, Steven R. Lentz, Tadashi Matsushita, Wan Hui Ong Clausen, Ilgiz Rakhmatullin, Johannes Oldenburg, the FRONTIER2 Investigators*
Posted: April 30, 2026, 12:00 am
In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation.
Author: Fran Balamuth, Scott L. Weiss, Elliot Long, Graham C. Thompson, Amanda S. Artis, Atzael B. Campos, Meredith L. Borland, Stuart R. Dalziel, Adriana Yock-Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz, Christopher P. Hickey, Julie C. Fitzgerald, Benjamin L. Laskin, Robert W. Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D. Clukies, Simon Craig, Sarah J. Curtis, Adrienne L. Davis, Susan Duffy, Matthew A. Eisenberg, Jason G. Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E. Gripp, Priya G. Jain, Shefali Jani, Gary I. Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y. Kwok, Roni D. Lane, Anna Lithgow, Julia Lloyd, Karim Mansour, Julie K. McManemy, Claudia Morris, Natalie Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G. Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B. Freedman, Franz E. Babl, Nathan Kuppermann, the PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks*
Posted: April 24, 2026, 12:00 am
The Pediatric Research Equity Act was intended to promote the development and testing of prescription drugs for children. But its implementation has been constrained.
Author: Ian T.T. Liu, Florence Bourgeois
Posted: April 23, 2026, 12:00 am
In a randomized trial involving 3208 children with Kawasaki disease, adding prednisolone to standard primary therapy did not reduce the incidence of coronary-artery lesions at 1 month.
Author: Siyuan Lin, Yuanchen He, Lan He, Yiling Liu, Fangjie Wang, Zhenyu Xiong, Yixiang Lin, Lan Ye, Chen Chu, Feng Wang, Lu Zhao, Yinyin Cao, Yuanzheng Zheng, Qin Huang, Jie Wang, Xuecun Liang, Quming Zhao, Shuna Sun, Yalan Dou, Wennan He, Xiaobi Huang, Jingwei Sun, Xianmei Huang, Yan Li, Yanling Liao, Haitao Lv, Silin Pan, Hua Zhu, Xinjiang An, Xuehua He, Cuifen Zhao, Xiaoyan Liu, Yaofei Hu, Jinhua Piao, Lijun Qin, Xiangyu Dong, Qian Peng, Ce Wang, Shubin Lin, Ping Huang, Rongzhou Wu, Hua Peng, Zipu Li, Duolao Wang, Xiaohui Liu, Weili Yan, Fang Liu, Guoying Huang, the Chinese Kawasaki Disease Collaboration Network*
Posted: April 16, 2026, 12:00 am
- Check what you can access with your account
![qrcode.14118297[1]](http://www.library.wmuh.nhs.uk/wp/wp-content/uploads/2013/06/qrcode.141182971.png)