Dermalogical Onclogy -Pumed

Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and typically involves the head and neck. Systemic therapy is often required for patients with advanced CSCC to achieve optimal disease control. Immune checkpoint inhibitors (ICIs) are now the standard of care for these patients, with a 50%-60% response rate and sustainable remission for at least 30% of patients. Given the activity of ICIs in advanced head and neck CSCC, ICIs are being studied in early-stage...

Malignant melanoma (MM) is a highly aggressive skin cancer known for its rapid progression, potential for metastasis, and resistance to treatment. Despite advances in targeted therapies and immunotherapy, the prognosis for metastatic melanoma remains unfavorable. Recent research has shed light on the significance of epigenetic modifications in the pathogenesis of melanoma, revealing critical mechanisms of melanoma development and progression. Epigenetic modifications, including DNA and RNA...

CONCLUSION: These findings establish a CDC42-PAK-STAT nuclear transport axis wherein IQDMA simultaneously inhibits PAK2 kinase activity and depletes its CDC42 scaffold, creating cytoplasmic pY-STAT5 retention that uncouples phosphorylation from transcriptional execution-a dual mechanism distinct from selective JAK inhibitors that warrants clinical evaluation.

A white Bengal hybrid tiger (Panthera tigris cross) was presented for a tumor subjacent to the right inferior eyelid. Surgical excision under general anesthesia followed by photodynamic therapy (PDT) with infracyanine green (EmunDo^(w)) was performed. Two months after surgery, a new tumor involving the concave left pinna was noted, and surgical excision followed by PDT was again performed. Healing of both surgical sites was achieved by 37 d postoperatively. Histopathologic review of both masses...

BACKGROUND Lymphangioma circumscriptum (LC) is a rare condition characterized by a lymphatic malformation primarily affecting the cutaneous region. Although surgical excision has historically been the first-line treatment, it may be associated with substantial complications and recurrence. This case report presents the first documented use of a simultaneous combination of erbium glass (1540 nm) and CO₂ (10 600 nm) lasers as a targeted therapeutic strategy for LC in a patient with a dark...

Mucosal melanoma (MM), an aggressive melanoma subtype arising in mucosal tissues, displays resistance to therapies effective in cutaneous melanoma. To understand how mucosal microenvironment contributes to treatment nonresponsiveness, we performed integrative analysis of single-cell and bulk messenger RNA sequencing data derived from oral mucosa-originated melanoma and revealed that mucosa-specific inflammation induces enrichment of low-pigmented neural crest-like cancer cell, mediated by...

The high nominal accuracy achieved by deep learning models in predicting malignant skin lesions is frequently undermined by their susceptibility to operational uncertainty. Image acquisition conditions, such as lighting, device settings, and skin characteristics, introduce variations in optical parameters that compromise the model's reliability in real-world clinical settings. This instability produces an unquantified diagnostic risk, which makes the safe clinical implementation of these...

CONCLUSION: This targeted nanoplatform offers a promising strategy to integrate localized PTT/CDT with systemic immune modulation, addressing key limitations of current melanoma therapies.

Basal cell carcinoma (BCC) is the most common cutaneous malignancy worldwide. The face is the most frequent site and presents reconstructive and functional challenges after excision. This study describes the clinical profile, surgical strategies and reconstructive outcomes of facial BCC cases managed in a tertiary hospital in Bangladesh. Retrospective analysis of 62 consecutive patients with histologically confirmed facial BCC treated surgically between January 2021 and December 2024 at the Burn...

CONCLUSIONS: Results highlight the potential of the obtained dual-molecule-loaded thin films based on hyaluronic acid as topical and safe antitumor therapy systems for local administration for the melanoma treatment. Moreover, due to the intrinsic properties of usnic acid and curcumin, and the biological activity of native hyaluronic acid, it is supposed that the obtained matrices possess the anti-inflammatory, antioxidant, antibacterial, and wound-healing activities, which are planned to be...

CONCLUSIONS: Elevated nestin expression was statistically associated with nodular melanoma and a deeper Clark level of invasion. In addition, it was significantly linked to an increased risk of histological ulceration.

CONCLUSIONS: Celebrity health announcements can trigger immediate spikes in public information seeking, but the effect is brief and geographically limited. However, heightened awareness may not necessarily lead to sustained engagement or preventive behavior.

CONCLUSIONS: Our findings validate the combination of CXCL11- and vXCL1-armed SVA as a potent immunovirotherapy strategy and propose a design principle for multistage, multigene intervention: concurrently targeting leukocyte recruitment, antigen presentation, and effector activation provides complementary mechanisms that synergistically amplify therapeutic efficacy.

The emergence of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of metastatic melanoma. However, despite its success, reliable biomarkers for predicting primary resistance are not available in clinical practice. This study seeks to identify predictors of primary resistance based on novel gene expression signatures. The transcriptomic profile of the tumor microenvironment was analyzed using tissue samples from 46 metastatic cutaneous melanoma patients collected prior...

ImportanceThe currently recommended postoperative adjuvant treatment for sinonasal mucosal melanoma (SNMM) (chemotherapy, optionally accompanied by local radiotherapy) has limited efficacy.ObjectiveWe aimed to provide a potentially optimal adjuvant therapeutic strategy for patients with SNMM.DesignRetrospective cohort study.SettingOur hospital's cancer center.ParticipantsSeventy-nine patients with stage III/IV SNMM who underwent complete resection and received adjuvant radiotherapy between April...

CONCLUSION: Sunburn prevalence was high despite good sun protection. Only few at heightened risk for skin cancer due to their treatment history attend PSEs as recommended by the Children's Oncology Group. Health care practitioners should systematically integrate yearly PSE after radiotherapy or HSCT and encourage consistent sun protection, particularly among younger generations and adolescents.

INTRODUCTION: Extramedullary leukaemia, also known as myeloid sarcoma, is a rare manifestation of acute myeloid leukaemia (AML) that typically occurs in conjunction with bone marrow involvement. It is characterized by infiltration of leukemic cells into extramedullary tissues, including the skin, soft tissues, and lymph nodes, where it may present as mass-like or nodular lesions. When associated with high-risk cytogenetic abnormalities, extramedullary disease may exhibit particularly aggressive...

CONCLUSION: Eccrine porocarcinoma is a rare cutaneous neoplasm but has aggressive potential. Its diagnosis requires a comprehensive approach based on clinical evaluation, histopathology, and immunohistochemistry. Complete excision with free margins is the treatment of choice, although other therapies may be considered in advanced cases. Periodic follow-up is essential for early detection of recurrences and metastases.

Sebaceous carcinoma (SC) typically arises in the periocular region but on rare occasions can present within the oral cavity, posing diagnostic and therapeutic challenges. This report describes a 50-year-old male who developed a progressively enlarging ulcero-proliferative lesion in the right buccal mucosa, initially misdiagnosed as squamous cell carcinoma. Histopathological re-evaluation, supported by immunohistochemistry (CK5/6, p63, and epithelial membrane antigen positivity), established the...

Malignant melanoma is the most aggressive and lethal type of skin cancer associated with increased mortality rates. Moreover, beyond the genetic background, the altered epigenetic landscape (e.g., abnormal patterns of DNA methylation, aberrant histone modifications and de-regulated expression levels of ncRNAs) further contributes to the pathophysiology of the disease. In addition, despite the improvement of current anti-melanoma strategies and the development of new therapeutic approaches, the...

Skin cancer risk prediction plays a critical role in early diagnosis and personalized healthcare. However, existing approaches often struggle to achieve both rich feature representation and computational efficiency. To address these issues, this study proposes Bicom, a brain-inspired framework for skin cancer risk prediction that integrates efficient attention mechanisms, multi-scale feature fusion, and confidence-aware refinement. Specifically, we develop F-ResNeSt, a multi-scale...

Given the challenges in treating metastatic melanomas, there is a growing need for novel and effective therapeutic strategies. This study aimed to understand molecular mechanisms underlying synergistic effects of a Tempol and ML210 combination in B16F10 murine melanoma cells and to evaluate its therapeutic potential. We hypothesized that this combination would synergistically induce cell death by increasing oxidative stress and triggering ER stress. B16F10 melanoma cells were treated with Tempol...

Melanoma is a highly malignant neoplasm of the skin with early metastatic spread and increasing incidence worldwide. Although there are significant therapeutic advances in immunotherapy, especially with the checkpoint inhibitors targeting PD-1 and CTLA-4, challenges such as treatment-related toxicities, a heterogeneous response to therapy, and drug resistance continue to exist. There are unmet needs for novel therapeutic strategies and/or approaches to complement the existing treatment options....

Melanoma is an aggressive skin cancer with high metastatic potential and poor long-term survival, highlighting the need for new therapeutic targets. Although microRNAs are critical regulators of tumor progression, the function of miR-374b-5p in melanoma remains poorly understood. Here, we identify miR-374b-5p as a tumor suppressor in melanoma cells. We show that miR-374b-5p directly targets vascular endothelial growth factor C (Vegfc) and is associated with changes in mitogen-activated protein...

Neurofibromatosis type 1 (NF1) and NF2-related schwannomatosis (NF2-SWN) are major genetic tumor predisposition syndromes characterized by progressive, often debilitating neoplasms of the peripheral and central nervous systems. Over the past five years, substantial advances in molecular genetics, signaling biology, and targeted therapeutic development have reshaped diagnostic and management paradigms for both disorders. This Perspective synthesizes recent developments, including gene-based...

Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent skin cancer diagnosed worldwide after basal cell carcinoma. CSCC represents a growing global public health challenge due to its higher potential of local invasion, recurrence, and metastasis. Incidence rates of cSCC are projected to increase due to rising exposures to risks factors. Ultraviolet light exposure is the primary cause, and lighter skin pigmentation, immunosuppressive conditions and skin phototype are the primary...

CONCLUSIONS: In conclusion, the present study did not identify statistically significant associations between the IRF5 single-nucleotide variants rs3807135, rs3757385, and rs3778754 and melanoma risk in the analyzed population from western Mexico. Likewise, no significant differences in allele or genotype distributions were observed between melanoma patients and control individuals. These findings suggest that the evaluated IRF5 genetic variants do not constitute major susceptibility factors for...

Background/Objective: Although most melanocytic lesions are diagnosed as benign or malignant by histopathologic evaluation, with or without the aid of immunohistochemistry, diagnosis may remain uncertain in a minority of cases. Assessment of copy number abnormalities (CNAs) may provide sufficient additional evidence to favor either a benign or malignant diagnosis in both pediatric and adult cases and in melanocytic lesions of various subtypes, including Spitzoid, mucosal, and acral. CNAs are...

Enhancer of Zeste Homolog 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), mediates histone H3 lysine 27 trimethylation (H3K27me3), an epigenetic modification associated with transcriptional repression. EZH2 inhibitors (EZH2is) gained attention after the first-in-class drug Tazemetostat received FDA approval for treating epithelioid sarcoma. Preclinical studies suggest that EZH2is could be effective against melanoma, but their general inability to cross the blood-brain...

Background and Objectives: Melanoma is the leading cause of skin cancer-related mortality due to its high propensity for early metastasis, although survival rates have improved with the advent of targeted and immune-based therapies. Accurate detection of targetable mutations and assessment of tumor mutational burden are essential for informed therapeutic decision-making. Mutation profiling is routinely performed using next-generation sequencing (NGS). The Oncomine Focus Assay (OFA) detects...

Avian reovirus (ARV) is a major poultry pathogen recently recognized for its potential as an oncolytic virus that selectively infects and kills cancer cells without harming healthy human cells. However, the receptors mediating ARV entry into cancer cells remain unclear. Using mouse melanoma B16-F10 cells as a model, this study identified ARV-binding receptor candidates through viral overlay protein binding assay (VOPBA), SDS-PAGE, and LC-MS/MS analysis. Plaque-forming assays (PFAs) evaluated...

Quercetin, a plant-derived dietary flavonoid, has multifunctional biological activities, including anticancer action; however, its applications may be restricted due to limited bioavailability. Thus, novel synthetic quercetin derivatives (QDs) with improved properties and/or drug combinations should be designed and tested. In the present study, anticancer activity of fourteen newly synthesized QDs was investigated using four cellular models of melanoma, namely A375, MM370, G-361, and SH-4 cells....

Historically, the standard of care for melanoma has been surgical resection followed by consideration of adjuvant therapy based on clinical staging, however, there is mounting evidence for a neoadjuvant approach. Administering immunotherapy prior to surgery ensures the maximal antigen stimulus and thus a more robust anti-tumor response. A neoadjuvant approach to therapy also allows for an early readout to assess treatment efficacy, as assessment of pathologic treatment response after neoadjuvant...

Background and Objectives: Melanoma is an aggressive cutaneous malignancy with a high recurrence rate even after complete resection. Circulating tumour DNA (ctDNA) has emerged as a promising biomarker for detecting minimal residual disease (MRD), assessing tumour burden, and predicting recurrence. This study aims to evaluate the clinical utility of ctDNA analysis in determining completeness of melanoma resection and disease staging. Materials and Methods: A systematic review was conducted in...

Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma, a disease characterized by malignant T cells that home to the skin. In early stages, clinical presentation is often indistinguishable from benign chronic inflammatory skin diseases such as atopic dermatitis (AD), posing a challenge for proper diagnosis and treatment. Previous studies have established that MF is characterized by the expansion of a single T-cell clone, whereas benign skin conditions are polyclonal...

Malignant melanoma is skin cancer arising from genetically altered melanocytes. Recently, a complex relationship between melanoma and chronic inflammation has been highlighted, representing an excellent condition for tumor development. Microalgae have been shown to be a promising source of bioactive compounds for drug discovery. In this study, we investigated Halamphora sp. (BEA0050) to identify possible compounds with immunomodulatory activity. The most active fraction (fraction D) showed...

As primary producers in aquatic ecosystems, microalgae function not only as a natural source of nourishment for several economically important aquatic species but also as reservoirs of bioactive molecules. Microalgae can secrete exosome-like nanoparticles that transport functional biomolecules, such as proteins and nucleic acids, into the extracellular milieu, thereby mediating intercellular signaling and eliciting ecological or biomedical responses. Although plant-derived exosome-like...

CONCLUSIONS: These findings demonstrate that pharmacologic modulation of D2R impacts the efficacy of immune checkpoint blockade in murine melanoma and raise the possibility of using FDA-approved D2R targeting therapies as cotherapeutics to overcome ICI resistance in patients with advanced melanoma.

CONCLUSIONS: AI chatbots can provide moderately accurate and supportive responses to needs of AYA patients with melanoma, but outputs are inconsistent, written above the recommended reading level for health information, and limited in empathy. Question framing strongly influenced chatbot performance, with more emotional prompts drawing greater empathy, and readability aligning with both quality and empathy. Chatbot use in this population should remain adjunctive, with further research needed to...

Propolis is a complex natural product used in functional foods and nutraceuticals, and its bioactivity depends on its botanical origin and processing. In this study, we employed a cold-ethanol extraction method on Polish propolis to produce wax-free polyphenol-rich extracts while preserving heat-sensitive compounds. UHPLC-DAD-ESI-IT-MS profiling identified 72 compounds in the extracts, predominantly flavonoids and caffeic acid esters (e.g., CAPE), which is consistent with a poplar-type propolis...

In this study, we investigated the anticancer activity of cedrol, a sesquiterpene alcohol, in the human epidermoid carcinoma cell A431 and in epidermal carcinoma 3D skin. Although various physiological activities of cedrol have been reported, the anticancer effect of cedrol in epidermal carcinoma and its molecular mechanisms still remain unclear. Cedrol exhibited significant cytotoxicity in A431 cells in a concentration-dependent manner and reduced the expression of minichromosome maintenance...

Monocyte-derived macrophages are usually recruited and play pivotal roles in establishing an immunosuppressive tumor microenvironment, and the interplay between tumor cells and tumor-associated macrophages (TAMs) is crucial for tumor development. However, the detailed mechanisms remain largely unelucidated in certain aggressive human cancers, such as melanoma. Here, through miRNA sequencing analysis, we found the microRNA miR-708-5p was highly enriched in melanoma exosomes, which was dependent...

Melanoma accounts for over 85% of all skin cancer deaths. Current therapies including drugs targeting BRAF and MEK significantly improve the prognosis of metastatic melanoma patients, yet innate or acquired resistance challenges long-term responses. We have shown previously that fatty acid beta-oxidation (FAO) is up-regulated during the acquisition of BRAF-inhibitor (BRAFi) resistance and that the FDA approved drug ranolazine, by targeting FAO attenuates the development of acquired resistance....

Hemorrhagic central nervous system (CNS) metastases are well recognized in melanoma yet seldom represent the initial manifestation, and fulminant, steroid-refractory hepatitis from immune checkpoint inhibitors (ICIs) remains exceedingly rare. Here, we present a 54-year-old man with no prior medical history who was brought to the emergency department with acute confusion and aphasia and was found to have a large right frontal hemorrhagic mass with midline shift. Urgent craniotomy and hematoma...

CONCLUSIONS: The Ann Arbor staging was not suitable for SPTCL. Radiotherapy represents an appropriate therapeutic option for patients with single or localized skin lesions. No statistically significant differences in prognosis were observed between patients who received no chemotherapy or radiation and those who received either chemotherapy alone or radiochemotherapy. This finding suggests that immunomodulatory agents may be preferable to cytotoxic therapy as initial treatment for SPTCL, an...

Melanoma is a global health issue, with an increasing incidence in recent years. Immune checkpoint inhibitors (ICIs, e.g., antiprogrammed cell death protein 1 [PD-1]) and targeted therapies (e.g., BRAF/MEK inhibitors) have revolutionized treatment for melanoma patients (MPs), but prognostic markers of drug response and disease progression remain elusive. We conducted a prospective baseline and follow-up study to investigate peripheral blood neutrophils and monocytes as immune biomarkers in stage...

Cancer cachexia is a complex syndrome associated with chronic inflammation, catabolic dysregulation, and sympathetic nervous system hyperactivity contribute to energy imbalance and skeletal muscle and adipose tissue wasting. This study investigates the therapeutic potential of pindolol in a murine model of cancer cachexia. In vitro study evaluated the cachexia-inducing potential of B16F10 melanoma cells and the therapeutic effects of pindolol on 3T3-L1 adipocytes. In vivo, cachexia was induced...

Background: T-LAK cell-originated protein kinase (TOPK), a serine/threonine kinase, is aberrantly overexpressed in human tumors and promotes malignant proliferation. Melanoma is a highly immunogenic tumor in which CD8^(+) T cell-mediated cytotoxicity is usually less effective in tumor control and responsive to immune checkpoint blockade. It is unclear whether the expression and functional characterization of TOPK within the immune cells affect the tumor microenvironment (TME) in patients with...

CONCLUSION: CVD increases the risk of developing NMSC, and obesity and inflammation partially mediate the relationship. Weight loss and control of inflammation may be beneficial in reducing the prevalence of CVD and NMSC.

Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are melanoma subtypes associated with chronic photoexposure, often located on areas such as the face and neck. Early diagnosis of these lesions is challenging due to their similarity to other benign conditions. Non-invasive methods, such as visual inspection, dermoscopy (DMT), and reflectance confocal microscopy (RCM), have been employed to improve diagnostic accuracy and surgical margin definition. However, evidence on which technique is...