Menopause Pubmed Results

CONCLUSIONS: In conclusion, the Menopause Comfort Scale developed in this study is a valid and reliable measurement tool, and it can be administered to assess the comfort levels of menopausal women in psychological, environmental, physical, and social dimensions.

CONCLUSIONS: These findings suggest a reproductive life-stage-specific sex difference, likely attributable to estrogen-associated reduction in CYP2C19 and CYP1A2 activity in premenopausal women. Our results indicate that sex and reproductive life-stage substantially influence (es)citalopram pharmacokinetics, potentially affecting tolerability, safety, and therapeutic response.

CONCLUSION: The review emphasizes the substantial adverse impacts of climate change, whether manifested through winter cold or rising temperatures, on women's reproductive and sexual health. Enhanced public health strategies and more longitudinal studies are needed to establish causality and address women's vulnerabilities in the face of escalating climate impact.

CONCLUSION: The implementation of evidence-based programs focusing on woman-centered care has the potential to improve the quality of childbirth care in Iran and enhance maternal satisfaction. This approach promotes a sense of security and comfort for women during labor, while empowering them to make informed decisions about their care.

CONCLUSIONS: As with genitally-stimulated orgasms, increases in prolactin accompany NGSOs induced by specific pelvic floor movements and occur in women regardless of their reproductive status. The induction of NGSOs represents a new vista in the study of women's orgasms and a potential therapeutic intervention for women with orgasm difficulties.

CONCLUSION: The mendelian randomization analysis reveals the potential causal mechanisms underlying the association between education and the risk of endometrial cancer and ovarian cancer. Interventions targeting obesity (body mass index and body fat percentage), age at menopause, fasting insulin, testosterone, and SHBG may reduce the incidence of endometrial cancer associated with lower educational levels. For ovarian cancer, intervention strategies targeting body mass index and age at...

CONCLUSIONS: The combination of a multi-ingredient nutraceutical and lifestyle modifications was associated with favourable changes in cardiometabolic, inflammatory and body composition parameters in women in perimenopause and postmenopause. These results support the role of early, non-pharmacological interventions in mitigating cardiometabolic risk during menopause. Further randomized controlled trials are needed to confirm efficacy and long-term outcomes.

Lichen sclerosus (LS) is a chronic inflammatory condition of the vulva. Although LS is thought to arise from autoimmune mechanisms, it is unclear whether disease drivers differ by menopausal status-an important distinction given its potential progression to differentiated vulvar intraepithelial neoplasia (dVIN) and vulvar squamous cell carcinoma (VSCC). We performed a retrospective review of 182 biopsy-proven LS cases (2020-2025), stratified by menopause status. In addition, we examined 27 VSCC...

CONCLUSION: This study represents one of the first applications of a structured participatory co-design approach to digital health intervention development within the Saudi Arabian context. The co-design process proved feasible and acceptable and generated culturally grounded insights for a population that remains underrepresented in health research. The findings provide a foundation and practical direction for intervention content, design features, and implementation strategies aligned with...

INTRODUCTION: Acute coronary syndrome (ACS) is a serious clinical condition linked to considerable morbidity and mortality. While percutaneous coronary intervention (PCI) is the mainstay of treatment, the occurrence of adverse cardiovascular events (MACE) following the procedure remains a significant challenge. Although numerous studies have explored risk factors for MACE in female ACS patients after PCI, inconsistent results exist due to sample size and regional variations. The purpose of this...

CONCLUSIONS: These findings highlight a higher prevalence of reproductive-related challenges in females with ADHD, underscoring the need for further research in this area and more in-depth analysis. They emphasise the importance of integrating ADHD considerations into female health research and clinical practice.

CONCLUSIONS: In conclusion, this preliminary, pilot registry on Menotrack in post-menopausal women indicated that this natural product may contribute safely to improve the quality of life of women who go through the MT, a difficult transitional period of their life and in the post-menopausal women with persisting, residual symptoms. A more prolonged study may better indicate the quality of this product and more potential positive effects on long-term problems, including osteoporosis.

CONCLUSION: Individuals with self-reported BRCA1/2 PVs preferred streamlined care through a single clinician/center, with expertise in cancer screening, risk-reducing surgery, and menopause management. A dedicated hereditary cancer program integrating clinical management, psychosocial support, and streamlined logistics may help improve care satisfaction, adherence, and confidence. These findings provide patient-centered guidance for optimizing care delivery in this high-risk population.

CONCLUSION: HRT use and older age were significantly associated with breast cancer history in this Lebanese screening population. Higher-risk groups may benefit from complementary imaging techniques. Larger multicenter studies are warranted to confirm these findings and identify additional risk factors.

CONCLUSIONS: Our findings show complex, menopause-dependent relationships between BLL and body composition parameters in middle-aged women. These results highlight the critical importance of considering menopausal status in future Pb toxicity studies.

CONCLUSION: Younger and better-educated postmenopausal women showed a better overall sexual quality of life. No meaningful association was found between sleep parameters and sexual outcomes.

Women are twice as likely to suffer from major depressive disorder (MDD). The underlying mechanism between estrogen and depression is still unknown. We used ovariectomized rats to simulate menopausal status and established a depression model of chronic and acute stress. The therapeutic effects of estrogen were systematically studied through behavioral testing, Western blotting, ELISA, LC-MS, and cell experiments. In chronic stress, OVX rats showed depressive-like behaviors, and elevated...

Background/Objectives: This study aimed to examine whether psychological resilience mediates the relationship between religious coping behaviors and menopausal symptoms among postmenopausal women. Methods: A cross-sectional study was conducted in Türkiye between July 2024 and July 2025 with women aged 45-60 years in the natural menopausal period (n = 190). Data were collected using a sociodemographic questionnaire, the Menopause Rating Scale (MRS), the Religious Coping Styles Scale (RCSS), and...

Background/Objectives: Lower circulating testosterone concentrations in postmenopausal women have been associated with adverse sexual, skeletal, and metabolic outcomes, yet population-level prevalence estimates remain inconsistent. In the absence of universally accepted diagnostic thresholds for androgen deficiency in women, interpretation of serum testosterone concentrations remains variable. This study aimed to describe the distribution of serum total testosterone and to evaluate demographic...

Osteoporosis in women is strongly influenced by menopause, a major physiological transition that reshapes bone metabolism. Although low bone mineral density (BMD) in premenopausal women and osteoporosis in postmenopausal women share the clinical outcome of skeletal fragility, it remains unclear whether they reflect a shared molecular program or distinct regulatory mechanisms. Here, we compared genetic signals associated with premenopausal and postmenopausal low BMD in Korean women using two...

CONCLUSIONS: Findings suggest that PMB appraisal and anticipated care-seeking vary by nativity and language among Black women. Nativity- and language-tailored community education and navigation strategies may improve symptom recognition and support timely evaluation, but future quantitative studies are needed to test whether these approaches reduce pre-diagnostic intervals for endometrial cancer.

Background/Objectives: Evidence-based nutritional recommendations for obesity management require understanding of sex-specific and age-specific body composition patterns and their associations with metabolic biomarkers, habitual dietary intake and chronic low-grade inflammation. This study aimed to characterize body composition phenotypes in a large clinical cohort of adults with obesity, to evaluate associated metabolic and inflammatory biomarker patterns, to contextualise these patterns...

CONCLUSIONS: The risk assessment model for CHD in Chinese postmenopausal women established in this study demonstrates good accuracy and applicability to allow early identification of high-risk patients.

HIV is primarily acquired in women at the female genital mucosa through heterosexual contact. Mucosal immune cells reside adjacent to, within, below, and distant from the epithelium that lines the surface of the female genital tract (FGT) mucosa. Innate immune cells play dual roles in HIV acquisition, both poised to rapidly recognize and respond to HIV, but are also capable of promoting HIV infection locally and distantly in the lymph nodes. In this review we emphasize recent human research on...

No abstract

Maintaining hormonal equilibrium is a key determinant of women's health, particularly during the menopausal transition and postmenopause. The decline in ovarian estrogen and progesterone production influences multiple physiological systems, affecting many aspects like vasomotor stability, bone and cardiovascular health, cognitive function, mood, and metabolic regulation. As a result, many women may experience symptoms that impair daily functioning and increase long-term morbidity. Recent...

CONCLUSION: PE may permit acceptable long-term global QoL in selected women; however, this is frequently achieved at the cost of sustained sexual, body image and psychological morbidity. Multidimensional QoL assessment should be integral to patient selection, counselling and survivorship care. There is an imminent need for future prospective studies with standardised longitudinal QoL.

Background/Objectives: Blood iron biomarkers are commonly interpreted using fixed clinical reference intervals, although iron metabolism varies by age, sex, menopausal status, and race. This study aimed to characterize the distribution of iron biomarkers across demographic subgroups and to examine their distribution relative to commonly used reference intervals. Methods: In this cross-sectional study, 7990 adults (≥18 years) from the All of Us Research Program were classified as premenopausal...

CONCLUSION: Recognition of analytical interference is essential to prevent misdiagnosis and avoid unnecessary or potentially harmful interventions. We propose a practical diagnostic workflow to support the identification and management of discordant estradiol results in routine laboratory practice.

Metabolic changes in saliva are known to be closely associated with the presence of non-oral cancers, particularly breast cancer. The diagnostic and prognostic potential of salivary biomarkers in breast cancer has been demonstrated, but their applicability for assessing therapy response has not yet been established. The aim of this study was to comprehensively analyze clinical, pathological, molecular, and salivary characteristics when assessing the response to neoadjuvant chemotherapy for...

CONCLUSION: Repeated intravaginal CO2 laser therapy does not consistently alter the histologic degree of atrophy but is associated with significant subjective improvement in GSM-related symptoms. No histologic evidence of mucosal injury or scarring was observed, supporting the safety of this therapy.

As stem cell therapy in regenerative medicine becomes more socially accepted, human perinatal tissue is attracting attention as a source because it can be harvested non-invasively. Human placental extracts (HPEs), which are prepared using acid hydrolysis and autoclaving, have been approved for treating menopausal disorders and liver dysfunction. This study investigated a new HPE formulation prepared under milder conditions by omitting acid hydrolysis and autoclaving to improve its effectiveness....

A key concern with menopausal hormone therapy is the potential duration-dependent increase in breast cancer risk. Despite using progestogens (micronized progesterone and dydrogesterone), associated with the lowest risk, a slight increase in risk is still observed over 6 years of treatment. This increase in breast cancer concerns estradiol receptor-positive breast cancers and is consistent with a promoter effect on preexisting lesions. It is thus recommended to select patients according to their...

Background/Objectives: The menopausal transition involves bodily, emotional, and sexual changes that may be relevant to body image. This study examined whether intrapersonal and relational dimensions of perceived self-attractiveness were associated with multidimensional body image among partnered women during the menopausal transition, after adjustment for BMI and sociodemographic factors. Methods: This cross-sectional study was conducted in 2024-2025 in primary health care clinics in Lublin...

Obesity is a global health concern linked to prediabetes, hypertension, sarcopenia, osteoporosis, and cardiovascular disease. However, body mass index (BMI) has limited sensitivity, misclassifying over half of individuals with excess adiposity as having normal weight. Growing evidence identifies a subgroup with normal BMI (18.5-24.9 kg/m²) but elevated body fat (>25% in men, >30% in women), termed normal weight obesity (NWO). Women are at a two-to six-fold higher risk of developing NWO compared...

CONCLUSIONS: Estrogen modulates endothelial-associated characteristics and angiogenesis-related responses of ADSCs via ER-associated signaling, and may contribute to improved functional outcomes in ischemic conditions. E2 preconditioning may represent a potential strategy for stem cell-based therapy in estrogen-deficient settings.

CONCLUSIONS: Hot flushes, sweats, sleeping problems, and loss of sexual desire were both common and severe among full-time working untreated women. In addition, symptoms were more troublesome among women in high-strain than low-strain jobs. Therefore, healthcare professionals should pay special attention to the above symptoms and to women in high-strain jobs.

Much of the interoception literature assumes that people can accurately detect their heart rate, stomach contractility, muscle tension, and other biological cues. This is not true. Instead, interoception is an active integrative psychological process where the feeling of one's internal state emerges from physiological signals, contextual cues, and the social and cultural experiences of living in a body. Thinking of interoception this way shifts the focus from measuring accuracy at detecting...

CONCLUSIONS: Tension and anxiety may play a role in increased bloating severity, whereas testosterone levels and age are associated with decreased bloating severity. The MT stage may contribute to bloating through several mechanisms. More research is needed to fully elucidate these relationships.

CONCLUSION: This study suggests that menopausal attitudes in postmenopausal women may be associated with sexual quality of life and depression levels. However, causal inferences cannot be made due to the cross-sectional design.

CONCLUSION: Postmenopausal status was associated with increased risk of catheter thrombosis in this hypothesis-generating analysis. These findings highlight the need for prospective studies investigating hormonal influences on catheter-related complications.

Background: Postmenopausal women are at high risk of Alzheimer's disease (AD) incidence and progression. Irisin, an exercise-induced myokine, has neuroprotective and antiaging effects against AD, especially in menopausal women suffering from insulin resistance (IR). For the first time, the novel role of irisin induced by melatonin (MTN) or/and physical exercise (PHE) was investigated in the current ovariectomized (OVX)/AD rat model by modulating brain neuroinflammation and IR-related markers....

CONCLUSIONS: Unhealthy lifestyle behaviours may exacerbate cognitive decline in women with adverse reproductive factors.

CONCLUSION: A high DI-GM score is significantly associated with a lower prevalence of osteoporosis in Chinese postmenopausal women, particularly when comparing the highest versus the lowest score categories.

CONCLUSIONS: Compared to other histotypes, seromucinous borderline ovarian tumors appeared more commonly as left unilateral unilocular or multilocular solid cysts, with ground-glass content, showing moderate vascularization of papillary projections/solid component. Moreover, they showed a higher increase in serum carbohydrate antigen 19.9 and were associated with endometriosis in most cases.

CONCLUSIONS: The association of EMSELLA electromagnetic stimulation with a structured Kegel exercise program was associated with greater symptom improvement than electromagnetic stimulation alone, suggesting an additive therapeutic effect of voluntary pelvic floor muscle training. This combined conservative approach was well tolerated and may represent a useful management strategy for postmenopausal urinary incontinence.

Background/Objectives: Health outcome determinants affecting Human Papillomavirus (HPV) vaccination among the adult female population are scarce in Spain. This study aimed to describe the health outcomes and determinants of HPV vaccination in women 18-65 years attending lower genital tract outpatient clinics across regions of Spain. Methods: This was a cross-sectional, multicenter, non-interventional, descriptive, and comparative nationwide study. Sociodemographic characteristics and health...

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PURPOSE OF REVIEW: Globally, cardiovascular disease (CVD) is the leading cause of mortality in women. Traditional risk calculators underestimate atherosclerotic cardiovascular disease risk (ASCVD), particularly in women classified as low or intermediate risk. While coronary artery calcium scoring improves risk stratification, it remains underutilized in practice. Extra-coronary calcification (ECC), including breast arterial calcification, valvular calcification, and thoracic aortic calcification...

CONCLUSION: EXD represents a holistic TCM approach with synergistic multi-target actions. Future research should focus on identifying active constituents, developing integrated quality control systems, elucidating pharmacokinetic and combination therapy mechanisms, and conducting evidence-based clinical trials to optimize personalized treatments. This will advance EXD from empirical use to precision medicine.