Arthritis/Rheumatology Pubmed Results

This research focuses on exploring the modulation of pyroptosis and its underlying mechanisms via the "Tianyu" formulation (TY), a traditional Chinese medicine, in human rheumatoid arthritis fibroblast-like synovial cells (RA-HFLS) and a collagen-induced arthritis (CIA) rat model. In vitro, RA-HFLS cells were induced with tumor necrosis factor α (TNF-α). Cell viability, proliferation, migration, and invasion were assessed using CCK-8, EdU, and Transwell assays, respectively. Pyroptosis was...

CONCLUSIONS: Our findings suggest that achieving CliDR is associated with significantly higher sustained remission rates in RA and that the safety of treatment tapering is contingent on prior achievement of CliDR.

CONCLUSION: In this case, iNO may have served as a bridging therapy, improving oxygenation until immunosuppressive treatment was effective. iNO may serve as a useful interim measure for avoiding ECMO in collagen vascular disease-associated respiratory failure, particularly when pulmonary hypertension is suspected. J. Med. Invest. 73 : 270-273, February, 2026.

Rheumatoid arthritis (RA) is one of the most prevalent systemic autoimmune inflammatory diseases worldwide, causing chronic, progressively worsening arthritis that may ultimately lead to disability. Despite the availability of numerous therapeutic agents, limitations exhibit, including poor aqueous solubility, suboptimal stability, inadequate permeability, short half-lives, and multi-organ toxicity during long-term or high-dose administration. Nanoparticle-based drug delivery offers a robust...

INTRODUCTION: Individuals with Sjögren's syndrome (SjD) experience notable health challenges, including chronic pain, fatigue, and depression; however, the potential benefits of physical activity in alleviating these issues remain unclear. We aim to systematically assess the comprehensive effects of physical activity on individuals with SjD.

A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared...

CONCLUSIONS: Moxibustion at BL23 and ST36 can ameliorate mitochondrial structural damage and reduce the level of mitochondrial autophagy in RA model rats, which may be related to its function in inhibiting the abnormal activation of PINK1/Parkin pathway.

CONCLUSION: S024 demonstrated favorable preclinical PK/ADME properties, characterized by robust oral absorption, moderate PPB, extensive distribution, and a low predicted clinical DDI risk. These findings strongly support its further development as a promising clinical candidate for RA therapy.

Objective To investigate the correlation between anemia and rheumatoid arthritis (RA), and to analyze the potential impact and causal relationship between them. Methods Using data from the National Health and Nutrition Examination Survey (NHANES) database, a logistic regression model was constructed to assess the association between anemia and RA; subgroup analysis was performed to verify the stability of the results. Subsequently, a two-sample mendelian randomization (MR) analysis was conducted...

CONCLUSION: Tofacitinib effectiveness and persistence/adherence were generally similar to TNFi in this real-world analysis in Taiwanese patients with RA. Safety outcomes were consistent with the known safety profiles of tofacitinib and TNFi.

CONCLUSIONS: Achieving and maintaining LDA is challenging for patients with RA but leads to better functional outcomes and reduced DME use. Patients who achieve remission have further improvements.

Rheumatoid arthritis (RA) is a systemic autoimmune disease whose pathogenic drivers and initiating immune events remain incompletely understood. Increasing evidence implicates the gut-joint axis in RA, yet the mechanisms by which intestinal microbiota contribute to disease development still require integrative clarification. This review summarizes current experimental and clinical evidence on the role of gut dysbiosis in promoting autoimmunity in RA. We discuss alterations in microbial...

CONCLUSIONS: Cannabis use was associated with prolonged RA flares but not increased flare frequency. As cannabis becomes more accessible, further research is needed to clarify its immunologic effects. Clinicians should counsel patients regarding the potential risks of cannabis use in autoimmune disease management.

CONCLUSIONS: In this cross-sectional study, AIT was associated with prevalent RA, and selected metabolic and endocrine biomarkers were statistically related to this association. Although causal inference is precluded by the study design, these findings suggest the presence of shared metabolic and endocrine contexts underlying thyroid and joint autoimmunity and support further longitudinal investigation.

Previous studies to date have demonstrated a significant relationship between spontaneous abortion (SA) and rheumatoid arthritis (RA). Moreover, positive links between gut microbiota and SA, RA have been discussed in observational studies. However, observational studies are prone to bias and result in the causality between gut microbiota and the comorbidity of SA and RA remaining unclear. We therefore aimed to investigate this using a two-sample Mendelian randomization study. A total gut...

CONCLUSIONS: The SjD-ASyS overlap seem characterized by a coherent clinical-serological phenotype, defined by anti-Ro52-positive sicca presentation, non-Jo1 anti-ARS autoantibodies and early interstitial lung disease. Pulmonary involvement represents the main driver of disease course and outcomes in this subset. Recognition of this pattern may improve early identification of ASyS in Ro52-positive SjD presentations. Further prospective studies are warranted to clarify whether this subset reflects...

CONCLUSION: Analysis based on a multivariate adjusted model showed that high NLR is an important predictor of poor prognosis in RA patients. As an economical and readily available inflammatory marker, it holds promise for use in RA risk stratification and personalized treatment decision support, but further prospective studies are required to clarify the causal relationship and optimize the clinical cutoff value.

CONCLUSION: Zhuang medicine heat-sensitive acupuncture method can effectively alleviate joint swelling in RA model rats. The underlying mechanism may be related to modulation of tryptophan metabolism, vitamin digestion and absorption, and steroid biosynthesis pathways.

CONCLUSION: This case highlights the effectiveness of rituximab in managing secondary membranous nephropathy associated with pSS. Further studies are needed to clarify the underlying mechanisms and optimize treatment strategies for this condition.

CONCLUSIONS: AOSD patients with fungal infections exhibit distinct immune activation patterns involving neutrophils and CD8^(+) T cells, reflecting dynamic immune changes during infection episodes. These immunological features may support integrated immune assessment and inform therapeutic considerations under immunosuppressive treatment.

CONCLUSIONS: Visual inspection of photos and videos to detect MCP and PIP joint effusions was poor at both the joint and person levels. Patients and rheumatologists should be aware of these limitations when conducting remote telehealth assessments.

CONCLUSIONS: Long-term follow-up did not demonstrate statistically significant alterations in the immunological profile of RA patients with SARS-CoV-2 infection. Nevertheless, further prospective studies are required to elucidate potential long-term immunological effects in this population.

Anti-citrullinated protein autoantibodies promote inflammation and joint tissue injury and define a poor prognostic group of patients with rheumatoid arthritis (RA). Citrullinated autoantigens that drive this autoimmune response are generated by peptidylarginine deiminase (PAD) enzymes, which are predominately expressed and released by neutrophils and monocytes. Accordingly, blocking the enzymatic activity of PADs to curb the generation of citrullinated autoantigens that drive autoimmunity and...

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. The underlying molecular mechanisms remain incompletely defined. Transcriptomic data of RA and normal synovial samples (GSE89408) were analyzed to identify the differentially expressed genes (DEGs). WGCNA, GO/KEGG enrichment, and PPI analysis were performed on the DEGs to screen for hub genes involved in RA progression. The proliferation, apoptosis,...

Innate immune cell death is critical for host defense but drives inflammatory disease when dysregulated. In this issue of Immunity, Huang et al. report that the complement protein C1q activates macrophage mitochondrial SARM1 to deplete NAD^(+) and produce cADPR, triggering NLRC5/NLRP12-PANoptosome formation, PANoptosis, and synovial inflammation in rheumatoid arthritis; targeting this pathway reduces inflammation.

Environmental factors are suspected of triggering rheumatoid arthritis (RA). One such factor is oxidative stress (OS), which is a step in ecotoxin detoxification and a damaging factor. The linkage of ecotoxin-triggered OS with clinical and laboratory RA indices in patients and individuals at the pre-RA stage was studied in patients with early (e) (n = 35) and advanced (a) stages of RA (n = 25) and individuals at pre-RA stages (FDR-First-Degree Relative(s), pre-RA, n = 72) in comparison with 52...

Background: The Mediterranean diet (MedDiet) has been associated with anti-inflammatory effects and potential benefits in several chronic conditions. However, adherence to the MedDiet and its relationship with lifestyle factors and disease severity across different rheumatological diseases remain poorly characterized. Objectives: This study aimed to evaluate differences in MedDiet adherence among patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and fibromyalgia (FM), and to...

CONCLUSION: RA patients with ACD had more severe joint involvement, higher inflammatory indicators, and more active conditions, making them more prone to pleural effusion and venous thrombosis. High disease activity, high inflammatory status, and venous thrombosis were risk factors for RA with ACD.

CONCLUSION: The integration of nanotechnology with TCM pharmacology provides mechanistic synergy by coupling material-based targeting with pathway-specific regulation. This dual modulation represents a key advantage over conventional therapies and supports the rational design of mechanism-guided TCM-based nanomedicines for RA.

Wuweiganlu (WGL) is a traditional formulation widely applied in the treatment of rheumatoid arthritis (RA), yet the identity of its bioactive constituents remains inadequately defined. In this study, ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and untargeted serum metabolomics were employed to characterize the active components of WGL. Fraxin was identified as a principal compound from WGL. To investigate its therapeutic...

CONCLUSIONS: High-titer RF simultaneously interferes with PCT and CK-MB immunoassays. Dilution tests, alternative platforms, and RF blocking are essential to mitigate misdiagnosis. Laboratories should implement RF interference protocols for discordant results.

Tuft cells (TCs) are rare chemosensory epithelial cells that regulate mucosal homeostasis in multiple organs, but their role in salivary gland (SG) biology remains poorly defined. This study aimed to define TC structure in mice submandibular glands (SMGs), determine how TC loss affects gland organization and function, and evaluate whether TC abundance in human minor SGs is associated with Sjögren's disease (SjD) features. Specifically, TC ultrastructure and ductal localization were characterized...

CONCLUSION: SjD shows strong familial aggregation and shared genetic susceptibility with multiple autoimmune diseases. These findings support a hierarchical model in which broad HLA-driven polygenic sharing coexists with selective non-HLA convergence.

CONCLUSIONS: Biomarkers of intestinal integrity, especially serum occludin, are altered in patients with RA and were associated with response to anti-TNF. Disruption of the intestinal barrier, as reflected by these indirect markers, is associated with systemic inflammation, thus reinforcing the gut-joint axis as a potential therapeutic target.

This study aimed to examine the regulatory effects of moxibustion on macrophage polarization and migration in a rat model of rheumatoid arthritis, as well as the role of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) in this process. On day 0 of the experiment, Sprague-Dawley (SD) rats were divided into five groups. Complete Freund's adjuvant (CFA) was injected into the hind footpads to establish the rheumatoid arthritis model. Additionally, lentivirus-mediated Havcr2 RNA...

CONCLUSIONS: MTX-related GIAE are frequently and largely driven by metabolic comorbidities, lifestyle exposures, sex and baseline ALT. These routinely available parameters allow early identification of high-risk patients and may guide personalized MTX initiation and monitoring strategies.

INTRODUCTION: Pulmonary rheumatoid nodules are a relatively uncommon extra-articular manifestation of rheumatoid arthritis. We report a case occurring after therapy with golimumab.

Rheumatoid arthritis (RA) is a progressive autoimmune disorder driven by immune cell and cytokine interactions. This case-control study investigated microRNA-146a (miRNA-146a) and tumor necrosis factor-alpha (TNF-α) as prognostic markers in RA patients. Fifty RA patients from Marjan Hospital (Babylon) and 50 controls were enrolled. Serum TNF-α was measured by ELISA, and miRNA-146a expression was assessed by RT-qPCR. TNF-α levels were significantly elevated in RA patients compared to controls...

CONCLUSIONS: Seropositive RA, especially ACPA-positive, is frequently associated with reduced microbial diversity and distinct compositional shifts compared with seronegative RA and healthy controls. Larger standardized studies are required to validate these associations and assess their biomarker potential.

The pathogenesis of rheumatoid arthritis (RA) involves complex interactions among genetic predisposition, environmental factors, and immune dysregulation. Emerging evidence indicates that mitochondrial dysfunction plays a central role in RA pathology and its systemic complications, including rheumatoid arthritis-associated interstitial lung disease. This review systematically examines the synergistic effects of mitochondrial DNA mutations, oxidative stress, and metabolic reprogramming in...

CONCLUSION: IP-MS revealed a diverse spectrum of autoantigens in patients with ANA-positive RA, including previously unreported targets. These findings expand our knowledge of RA-associated autoimmunity and highlight antibodies to NatC and BCS1 as potential novel biomarkers. Further studies are needed to assess their clinical relevance.

CONCLUSIONS: Women with primary SS exhibit lower 2D:4D digit ratios compared with healthy controls, suggesting that a shifted prenatal estrogen-to-androgen balance may prime the immune system toward the glandular autoimmunity and exocrine dysfunction that define this disease. These findings implicate the prenatal hormonal milieu as a potential contributor to the immunological processes underlying SS pathogenesis.

Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by synovial inflammation and joint deformity. Anti-citrullinated protein antibodies is one of the key biomarkers for RA, produced against citrullinated peptides and contribute to inflammation by forming immune complexes. While current RA treatments may help in managing the symptoms, they may compromise the immune system by increasing vulnerability to infections. In this study, an immunoinformatics approach was used to design a...

A 51-year-old woman with rheumatoid arthritis treated with rituximab and leflunomide presented with a 5-month history of malodorous vaginal discharge. Initial examination revealed vulvovaginitis and cervicitis, and she was treated with metronidazole and topical corticosteroids. Pelvic ultrasound showed free fluid in the pouch of Douglas, raising suspicion of ovarian malignancy. Shortly thereafter, she was hospitalized with fever, abdominal pain, and elevated C-reactive protein. Despite...

Macrophage polarization imbalance is closely implicated in the pathogenesis of rheumatoid arthritis (RA). Triptolide (TP) can effectively regulate macrophage polarization but is severely limited by its high toxicity and narrow therapeutic window. Calycosin (CAL) not only alleviates TP-induced toxicity but also exhibits anti-inflammatory and chondroprotective effects, making their combination a promising strategy for safer and more effective RA therapy. However, this free combined therapy suffers...

CONCLUSION: The CBD-MTX combination exerts superior antiarthritic effects by inhibiting STAT3/NF-κB-mediated M1 macrophage polarization and protecting against MTX-induced reproductive toxicity. This study provides a preclinical rationale for this novel combination strategy in RA management.

CONCLUSIONS: In this large prospective cohort, most perinatal factors were not associated with RA risk in adulthood. A signal related to larger birth length emerged only in selected analyses based on more precise exposure assessment and should be interpreted cautiously. These findings are hypothesis-generating and warrant replication in independent cohorts using prospectively measured perinatal data.

CONCLUSION: PR often begins in the hands and shoulders, and joint inflammation during PR usually precedes PIA in the same joints. Despite lower pain and disability, RA patients with PR show greater inflammatory joint burden at progression.

Musculoskeletal ultrasound has become an essential tool in the management of rheumatoid arthritis (RA), particularly for early diagnosis, assessment of disease activity, treatment monitoring, and decision-making during remission. It also contributes to improving the accuracy of interventional procedures. In Maghreb countries, its use has expanded significantly through local and international training initiatives. In this article, the Maghreb Committee of Experts in Rheumatologic Imaging (CEMIR)...

CONCLUSION: the study highlighted the frequent risk of falls in patients with RA. Factors associated with fall occurrence involved the number of falls, and a history of vertigo.