Cardiac Disease – Pubmed

Home-based rehabilitation after stroke is increasingly important, as pressure on hospital services rise and recovery occurs mostly at home. Enriching the home (Environmental Enrichment, EE) represents a potential strategy to support rehabilitation by providing continuous task- and context-specific stimulation that promotes functional recovery through frequent and exploratory use of the affected arm. Exploratory behaviour - self-initiated, varied and adaptive movements - is an important driver of...

Venous leg ulcers (VLUs) are a chronic and often debilitating condition, affecting a significant number of individuals worldwide. One of the most distressing aspects of VLUs is the persistent pain they can cause, which impacts quality of life, mobility and overall wellbeing. Despite advances in wound care, VLU-related pain remains under-recognised and poorly managed. Pain in VLUs is complex and typically includes nociceptive pain from tissue damage, neuropathic pain due to nerve involvement, and...

CONCLUSIONS: This prospective observational study found that different ventilation strategies influenced catheter-tissue interaction and procedural metrics during pediatric RF ablation. Notably, HFLTV ventilation was linked to higher contact force metrics. Additional research is necessary to verify these results.

Glutamate transporters are essential for maintaining CNS homeostasis by clearing extracellular glutamate following synaptic transmission. Dysregulation of these transporters contributes to glutamate-mediated excitotoxicity across numerous neurological disorders, including ischemic stroke, underscoring their potential as therapeutic targets. However, the regulatory response of these transporters following ischemic insult remains poorly defined. In this study, using a model of oxygen-glucose...

Stroke occupies an important position in the global disease burden, but the combined effect of heavy metal exposure and the inflammatory marker C-reactive protein (CRP) on stroke remains unclear. Based on the National Health and Nutrition Examination Survey, this study explores the association between blood lead, blood cadmium, blood mercury, CRP, and the risk of stroke. A total of 8297 American adults aged 20 years and older were included in the National Health and Nutrition Examination Survey....

Background Cardiac gallium 68-labeled fibroblast activation protein inhibitor (FAPI)-4 (^(68)Ga-FAPI-4) PET/MRI allows simultaneous assessment of cardiac tissue characteristics, function, and molecular remodeling in myocardial diseases. An integrated workflow for nonischemic dilated cardiomyopathy (DCM) has yet to be developed. Purpose To evaluate the feasibility and performance of a time-efficient cardiac ^(68)Ga-FAPI-4 PET/MRI protocol in participants with DCM. Materials and Methods In this...

CONCLUSIONS: In this national in-home echocardiography study, VHD was common among older adults, with important age-related and valve-specific patterns. PREVUE-VALVE establishes the feasibility of large-scale decentralized cardiovascular imaging studies and provides a contemporary foundation for clinical and policy planning related to the burden of VHD. (Age- and Sex-Specific Prevalence of Acquired Valvular Heart Disease (PREVUE-VALVE; NCT05357404).

CONCLUSIONS: ANP was identified as an independent predictor of PAF detection in patients with ESUS, with strong ROC performance. Given its atrial origin and very short half-life, ANP may serve as an atrium-specific biomarker reflecting acute atrial load, potentially enabling earlier identification of latent PAF in the acute phase.

Cell signaling regulates cellular physiological functions, including the cell cycle, survival, immune response, gene expression, and protein-protein interactions. Within this complex system and its intrinsic mechanisms, non-receptor tyrosine kinases (NRTKs) play a crucial role in signaling in the cellular cytoplasmic compartments. Owing to the involvement of NRTKs in the signaling cascade, they have made a significant contribution to the manifestation of etiologically complex diseases such as...

Clopidogrel therapy is recommended to prevent recurrent ischemic stroke. However, clopidogrel resistance exists. This study examines which enzymes are involved in clopidogrel resistance. The study group includes 402 neurology patients who had experienced a recurrent ischemic stroke while receiving clopidogrel monotherapy. Patients were genotyped for CYP2C19, CYP2C9, CYP2B6, CYP3A4, CYP3A5, CYP1A2, ABCB1 and CES1A1. Phenotype frequencies were compared with those of a Global(G), European(E) and a...

Despite substantial therapeutic advances in multiple myeloma (MM), extramedullary disease (EMD) remains an aggressive subtype associated with poor prognosis, for which consensus on management is lacking and dedicated clinical trials are scarce. We conducted a retrospective single-center analysis of 86 patients with radiologically confirmed EMD, defined as soft-tissue involvement without bone contiguity (data cut-off September 30, 2024). The cohort included patients with de novo EMD (n = 19, 22%)...

Dysregulated intracellular lipid metabolism emerged as a driver of heart failure (HF), a leading cause of death worldwide that is frequently caused by dilated cardiomyopathy (DCM). Yet, how defective lipid signaling destabilizes failing cardiomyocytes (CMs) at the molecular level remains elusive. We utilized induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), patient-derived heart tissue, and living adult CMs to elucidate lipid-dependent endoplasmic reticulum (ER) dysregulation in...

The eye is a recognized source of biomarkers for cardiovascular and neurodegenerative disease risk. Here we characterize the breadth of these associations and identify biological axes that may mediate them. Using UK Biobank data, we developed a multi-omic analysis pipeline integrating physiological, radiomic, metabolomic and genomic information. We trained retinal adversarial autoencoders to represent optical coherence tomography images and color fundus photographs as 256-dimensional embeddings....

Titin, the largest human protein, forms the elastic sarcomeric backbone, providing passive stiffness and length-dependent activation in cardiomyocytes. Whereas titin mutations cause inherited cardiomyopathies, ischemic and chemotherapy-induced injury also provoke proteolytic cleavage of titin's elastic segment. However, the effects of acute titin stiffness loss remain unknown. Here we develop a knock-in mouse enabling in vivo cleavage of cardiac titin springs and use multimodal analysis (cardiac...

CONCLUSION: SREBP gene polymorphisms exhibited suggestive associations with ambulatory blood pressure in Chinese adolescents. Although the associations were not significant after multiple testing correction, these findings suggest potential genetic influences on blood pressure regulation in youth and may inform future research on genetically informed approaches to hypertension prevention.

CONCLUSION: Both 3D PASL-MRI and PC-MRI can noninvasively evaluate CBF changes in patients with MMD after surgery. The CBF of the cerebral was significantly improved after surgery. Moreover, the improvement of CBF was more obvious in patients with non-hemorrhagic rather than hemorrhagic MMD.

Electroacupuncture (EA) has been documented to exert therapeutic benefits in vascular dementia (VD). This study seeks to elucidate the therapeutic efficacy and underlying molecular mechanisms of EA in VD. A VD model was induced in rats, which received EA with or without an Shh pathway inhibitor. An in vitro VD model was generated by exposing BV2 microglial cells to oxygen-glucose deprivation (OGD). A battery of tests was employed: cognitive function (novel object recognition and morris water...

Acute hypoxaemic respiratory failure is frequently attributed to primary pulmonary pathology, particularly in the presence of radiographic abnormalities and inflammatory markers. Cardiac conditions, however, may present with similar features and lead to diagnostic error. We report the case of a man in his early 60s admitted with acute hypoxaemic respiratory failure, initially diagnosed with severe community-acquired pneumonia on the basis of unilateral chest opacity and an apparent inflammatory...

CONCLUSIONS: At the 10-year follow-up, TAVR in intermediate-risk patients with the SAPIEN XT prosthesis compared with surgery was associated with lower survival rates, with differences predominantly observed in the TA/TAo access cohort. TAVR with the XT valve was also associated with significantly higher rates of aortic valve reintervention. (PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - XT Intermediate and High Risk [PII A]; NCT01314313).

OBJECTIVES: To evaluate the prognostic value of carotid-femoral pulse wave velocity (cfPWV), a marker of aortic stiffness, for cardiovascular events (CVEs) in patients with autoimmune rheumatic diseases (ARDs) and to compare its performance with the Systematic Coronary Risk Evaluation 2 (SCORE2).

Pyroptosis, as an inflammatory type of regulated cell death, is associated with the pathogenesis of various inflammatory diseases. Targeted therapy for pyroptosis has shown promise in multiple preclinical models of neurological injury and disorders. Stroke is one of the leading causes of morbidity and mortality worldwide and the top cause of disease-related death in China. Although the pyroptosis signaling pathway has been studied in cerebral ischemic diseases, its pathophysiological mechanisms...

Vascular cognitive impairment (VCI) comprises cognitive dysfunction caused by vascular pathology and is associated with various forms of dementia. VCI is typically caused by chronic cerebral hypoperfusion (CCH), which is accompanied by oxidative stress, central nervous system inflammation, microglial activation, and white matter injury. Therapeutic targets for VCI remain largely unknown. Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in the brain, where it senses...

This study extracted radiomics features of blood clots from computed tomography pulmonary angiography (CTPA) images of acute pulmonary embolism (APE) patients, and constructs a predictive model for APE patient risk stratification by comparing multiple machine learning (ML) algorithms. This retrospective study analyzed patients with APE, documenting their clinical characteristics (clinical and hematological indicators), conventional CTPA imaging parameters. Patients are stratified into low-risk...

CONCLUSIONS: Dynamic exercise-derived physiologic markers provide prognostic information complementary to resting haemodynamic assessment in PH-COPD and may improve risk stratification across this heterogeneous population.

CONCLUSIONS: Perioperative psychological intervention combined with distraction therapy provides a potential strategy to alleviate preoperative anticipatory anxiety in patients with lower limb varicose veins undergoing combined minimally invasive treatment. By employing various intraoperative methods to divert patients' attention from pain, this approach may further alleviate overall discomfort. These findings suggest that this strategy is associated with favorable outcomes and may warrant...

CONCLUSIONS: PVC patients without structural heart disease had a favourable long-term survival, exceeding the expected survival of the general population. These results suggest that most PVC patients without structural heart disease may be given a reassuring message.

Pacemakers are implantable cardiac devices used in the treatment of bradycardia and heart failure. They monitor electrical signals in the heart and deliver electrical stimuli to cause contraction in the targeted heart chamber. Permanent pacemaker therapy is recommended in patients with symptomatic bradycardia or asymptomatic infranodal atrioventricular block to improve symptoms and quality of life. Biventricular pacemakers can also be used in cardiac resynchronization therapy, which corrects...

CONCLUSIONS: In adults without significant VHD, systolic murmurs were strongly associated with mean aortic valve gradient and occurred at lower gradients in women than in men. These findings support interpreting systolic murmurs as a probabilistic and context-dependent clinical finding rather than a binary marker of VHD.

CONCLUSIONS: Shifting to an integrated and digitalized model is essential to ensure continuity of care and therapeutic adherence, thereby reducing exacerbations and optimizing the use of public resources.

BACKGROUND: Antipsychotic use in people living with dementia has been linked to serious adverse outcomes. Guidelines recommend limiting antipsychotic treatment to short-term use (<12 weeks), followed by tapering and cessation. However, antipsychotic treatment in routine practice often exceeds the recommended duration. The effect of discontinuing antipsychotics on reducing adverse outcomes in practice remains unclear. We aimed to use linked primary and secondary care data in England to...

Ischemic stroke is a major cause of mortality globally, but single-target therapies often fail due to the complex "ischemic cascade". This study investigated the neuroprotective effects and multitarget mechanisms of Curcumae Rhizoma (CR) using an integrated network pharmacology approach and in vivo validation. The active compounds of CR were screened through ADME filtering, and their potential targets were identified using the TCMSP, TTD, and UniProt databases. Molecular docking was used to...

CONCLUSIONS AND CLINICAL IMPORTANCE: Measurement of uNa and diuretic concentration identifies dogs with low natriuresis, which is not predicted by diuretic dose or duration. Observation of uNa patterns generates hypotheses regarding potential causes of low DR that warrant confirmation in larger studies.

CONCLUSIONS: Mechanical CPR in prehospital blunt traumatic cardiac arrest was associated with improved survival to hospital arrival compared with manual CPR; however, in-hospital mortality remained extremely high. These findings suggest that mechanical CPR may facilitate transport of patients in traumatic cardiac arrest without substantially improving overall outcomes. While mechanical devices can provide continuous chest compressions during transport, their impact on meaningful survival in the...

CONCLUSION: Brief cognitive screening tools, used in isolation, may not be suitable for assessment in acute stroke settings.

A man in his early 60 s developed persistent hyponatremia following lumbar spine surgery complicated by traumatic brain injury with subarachnoid hemorrhage. Initial evaluation demonstrated hypotonic hyponatremia with inappropriately concentrated urine, consistent with the syndrome of inappropriate antidiuretic hormone secretio. Standard therapy including hypertonic saline and oral sodium supplementation resulted in only transient improvement. Given a history of secondary adrenal insufficiency...

CONCLUSIONS: This study will provide insight into the prevalence of MetS, ED, and accelerated aging, as well as potentially modifiable risk factors, including those that have not been previously examined, among survivors of HSCT for hematological malignancies in childhood. The findings will inform surveillance guidelines and support the development of health behavioral and anti-inflammatory interventions to mitigate the risk of these severe late effects.

Background Ischemic lesion net water uptake (NWU), a CT biomarker of cerebral edema, has been linked to poor outcomes in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Whether NWU outperforms other imaging markers in predicting futile recanalization (FR) (ie, poor functional outcome despite successful endovascular thrombectomy [EVT]) remains uncertain. Purpose To evaluate the association between NWU and FR and compare the predictive performance of NWU with Alberta...

CONCLUSIONS: Engagement with home telemonitoring technologies among older adults depends not only on usability but also on the relational context in which these technologies are embedded. Combining technofunctional and relational perspectives provides a more comprehensive understanding of how telemonitoring interventions are experienced and highlights the importance of personalized support, reliable technology, and sustained clinical engagement to promote meaningful adoption.

CONCLUSIONS: At 10 years, TAVR with the SAPIEN 3 valve and surgery resulted in similar rates of mortality and aortic valve reintervention, and similar hemodynamics in intermediate-risk patients with symptomatic severe aortic stenosis. This analysis highlights challenges associated with extended long-term follow-up of clinical trials, including differential loss to follow-up and the competing risk of mortality in elderly populations. (PARTNER 2A Trial; NCT01314313; PARTNER 2 SAPIEN 3...

CONCLUSIONS: While behaviour change strategies can enhance engagement in cardiac rehabilitation, their impact on measurable health outcomes remains unclear. Social support, professional oversight, and structured programming appear effective in maintaining physical activity levels, but future interventions should prioritise exercise confidence and education to promote sustained behaviour change.

CONCLUSIONS: Current evidence underscores substantial gaps in understanding the natural history and optimal management of diabetic foot disease in dialysis-dependent ESKD. Future research should prioritise well-designed prospective studies to delineate dialysis-specific risk pathways, incorporate robust stratification by dialysis modality, and evaluate interventions targeting ischaemia and limb preservation. Standardisation of outcome reporting, particularly for healing durability and...

CONCLUSIONS: This 13-year nationwide overview highlights the growing uptake of TAVR in France, likely driven by clinical practice and procedural innovation rather than guidelines. Further analyses will compare efficacy and safety between TAVR and SAVR.

The cardiovascular system is among the earliest functional systems in fetal development, playing a central role in maintaining circulation and ensuring oxygen and nutrient delivery. The fetal heart undergoes continuous maturation in anatomical configuration, hemodynamics, and biventricular coupling throughout gestation. Recent advances in ultrasound imaging-including Doppler, tissue doppler imaging (TDI), and two- and three-dimensional speckle tracking-have enabled comprehensive assessment of...

CONCLUSIONS: The study revealed that the rate of amputations was relatively high and highest survival rate was patients with cardiovascular disease. Receiving insulin therapy, staying in rural area, no-neuropathy, underweight and normal weight and no-hypertension showed more likely to amputation. Early detection of comorbidities is recommended to prevent amputation among patients with DFU.

CONCLUSION: The changes and improvements were relatively easy to implement and were highly impactful across measured outcomes. Empowering nurses to lead quality initiatives and using a structured change management framework benefits patients and fosters a more fulfilled, effective nursing team.

Sickle cell disease (SCD) is associated with substantial cardiovascular morbidity, but echocardiographic data from Latin American populations remain scarce. We aimed to characterise the structural, functional, and haemodynamic echocardiographic profile of adults with SCD attending a tertiary referral centre in Cali, Colombia. We conducted an observational, cross-sectional study based on systematic review of medical records and transthoracic echocardiography reports of consecutive adult patients...

Cardiovascular magnetic resonance (CMR) is a noninvasive, detailed imaging modality regarded as the gold standard for assessing cardiac structure, function, and tissue characteristics. Data on its impact in acute settings, particularly in regional centers, remain limited. We evaluated the clinical impact of CMR on diagnostic accuracy and management decisions in acute cardiovascular presentations at a single regional Australian hospital. This retrospective, single-center study included 111 adult...

Cardiovascular disease is frequently diagnosed in birds that are presented to veterinary hospitals, and atherosclerosis is a common cardiovascular condition identified in postmortem evaluations of pet psittacine birds. Atherosclerotic lesions are accumulations of lipids, smooth muscle cells, macrophages, and foam cells in the intimal layer of a blood vessel, narrowing the lumen. A reduced lumen diameter in a blood vessel typically results in physiological complications, such as ischemia,...

Short-video platforms are important sources of cerebral infarction-related health information, but the completeness, reliability, and platform differences of such content remain unclear. This study compared engagement, topic coverage, and information quality of cerebral infarction-related videos on TikTok and Bilibili. Using the keyword "cerebral infarction," we screened the top 150 search results from each platform. Of 300 retrieved videos, 289 were included (TikTok: n = 146; Bilibili: n =...

INTRODUCTION: Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD-relevant cerebrovascular phenotypes.