Treatment of the left main coronary artery with percutaneous coronary intervention (PCI) in the absence of previous surgical revascularization, also referred to as an unprotected left main coronary artery PCI, is one of the riskier tasks that interventional cardiologists are asked to perform. Stent implantation in the left main coronary...
Posted: June 11, 2026, 12:00 am
The use of intravascular ultrasound (IVUS) imaging for assessment of the coronary arteries has an almost 40-year history. In an editorial comment on an early ex vivo assessment of the accuracy of IVUS in evaluating human coronary arteries, Yock and Linker1 posed three questions that remain relevant today:...
Posted: June 11, 2026, 12:00 am
Despite recognition that racial and ethnic categories are poor proxies for genetic diversity, race is still used to guide pharmaceutical use, posing risks of ineffectively low or dangerously high dosing.
Posted: June 11, 2026, 12:00 am
A 14-year-old girl was admitted to the hospital because of hypertension and headache. She had hypokalemia, an elevated blood level of C-reactive protein, and an elevated erythrocyte sedimentation rate. A diagnosis was made.
Posted: June 11, 2026, 12:00 am
The authors review current strategies for anticoagulation reversal in major bleeding events or urgent surgery as well as specific antidotes, limits of available evidence, thrombotic risks, unmet therapeutic needs, and ongoing research.
Posted: June 11, 2026, 12:00 am
In a randomized trial involving patients undergoing complex high-risk PCI, the risk of target-vessel failure (a composite outcome) was not lower with intravascular ultrasound guidance than with angiography guidance.
Posted: June 11, 2026, 12:00 am
Among patients with unprotected left main coronary artery disease, intravascular ultrasound–guided PCI did not result in a lower risk of ischemic events or death than angiography-guided PCI.
Posted: June 11, 2026, 12:00 am
Every year, many millions of surgical patients worldwide are unnecessarily exposed to a higher-than-necessary risk of blood transfusion because they do not receive a single dose of tranexamic acid just before the surgery. This failing is due not to a lack of high-quality scientific evidence on the overall safety, efficacy,...
Posted: June 10, 2026, 12:00 am
In a cluster-randomized trial involving patients having major noncardiac surgery, tranexamic acid reduced the need for red-cell transfusion during hospitalization and was noninferior to placebo for venous thromboembolism within 90 days.
Posted: June 10, 2026, 12:00 am
Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy.
Posted: June 10, 2026, 12:00 am
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