The authors report reductions in PCSK9 and LDL cholesterol levels and no dose-limiting toxic effects in persons with hypercholesterolemia treated with VERVE-102, a base editor targeting PCSK9.
Posted: May 25, 2026, 12:00 am
This Double Take video outlines the five risk factors for cardiovascular disease and reviews strategies for blood-pressure control to reduce morbidity and mortality.
Posted: May 20, 2026, 12:00 am
One way to classify acute ischemic stroke is by the anatomy of vessel occlusion. Initial randomized trials of endovascular thrombectomy focused on large-vessel occlusions.1-5 These proximal occlusions of the intracranial carotid artery or the stem of the middle cerebral artery (MCA) represent the most severe form of anterior...
Posted: May 14, 2026, 12:00 am
A 65-year-old woman with cardiovascular risk factors presented with a 14-hour history of painless, worsening, blurry vision in the right eye (visual acuity, 20/400). Funduscopy showed diffuse retinal hemorrhages and venous dilatation.
Posted: May 14, 2026, 12:00 am
Among patients with stroke due to medium-vessel occlusion, thrombectomy led to functional independence at 90 days (in 58.6% of patients, vs. 46.6% with medical management) but also to a higher risk of intracranial hemorrhage.
Posted: May 14, 2026, 12:00 am
This patient-focused Double Take video describes heart failure with preserved ejection fraction and how it is managed.
Posted: May 7, 2026, 12:00 am
In the catheterization laboratory, the most consequential decisions are frequently not about whether to treat, but rather about how far to extend treatment. Nowhere is that tension more apparent than in high-risk percutaneous coronary intervention (PCI). In these cases, the margin between a good outcome and a catastrophic one is...
Posted: May 7, 2026, 12:00 am
Among patients undergoing complex PCI, elective unloading with a microaxial flow pump did not reduce the risk of major adverse clinical outcomes as compared with standard care.
Posted: May 7, 2026, 12:00 am
A physician offers to help in a medical emergency on a transatlantic flight. Though she faces limits of bureaucracy, equipment, and ultimately biology, she discovers her physicianhood is inescapable.
Posted: April 30, 2026, 12:00 am
This Double Take video reviews pharmacologic and nonpharmacologic interventions for heart failure with preserved ejection fraction.
Posted: April 30, 2026, 12:00 am
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