Heart Failure- Pubmed Results

Pacemakers are implantable cardiac devices used in the treatment of bradycardia and heart failure. They monitor electrical signals in the heart and deliver electrical stimuli to cause contraction in the targeted heart chamber. Permanent pacemaker therapy is recommended in patients with symptomatic bradycardia or asymptomatic infranodal atrioventricular block to improve symptoms and quality of life. Biventricular pacemakers can also be used in cardiac resynchronization therapy, which corrects...

Renal dysfunction in heart failure (HF) involves congestion-associated injury, tubular damage, and inflammatory remodeling. Although SGLT2 inhibitors improve renal outcomes in HF, associated renal structural changes in nondiabetic HF remain incompletely characterized. Kidney samples from a previously published cohort of nondiabetic male Wistar rats with myocardial infarction-induced HF treated with empagliflozin (10 mg/kg/day) or vehicle for 4 weeks were analyzed histologically and by...

CONCLUSIONS: In HFpEF, sex-related differences in circulating NO-related metabolites were limited and metabolite-specific, with SDMA showing the most consistent sex-associated difference with higher concentrations in men. The substantial overlap of metabolic profiles between women and men showed no distinct patterns of circulating metabolites linked to endothelial function in patients with HFpEF.

Endothelial dysfunction plays a central role in the pathophysiology of cardiovascular, renal, and metabolic diseases. The Endothelial Activation Stress Index (EASIX) has emerged as a promising prognostic marker in endothelial-related disorders. This study aimed to evaluate the association between EASIX and the risks of all-cause and cardiovascular mortality in individuals with cardio-renal-metabolic (CKM) syndrome stages 0 to 3. Data were obtained from the National Health and Nutrition...

CONCLUSIONS: Shifting to an integrated and digitalized model is essential to ensure continuity of care and therapeutic adherence, thereby reducing exacerbations and optimizing the use of public resources.

CONCLUSIONS: Engagement with home telemonitoring technologies among older adults depends not only on usability but also on the relational context in which these technologies are embedded. Combining technofunctional and relational perspectives provides a more comprehensive understanding of how telemonitoring interventions are experienced and highlights the importance of personalized support, reliable technology, and sustained clinical engagement to promote meaningful adoption.

CONCLUSION: Neuromuscular electrical stimulation was noted to be effective for improving physical capacity and quality of life in patients with acute heart failure. It offers a promising option for patients unable to engage in conventional rehabilitation. Further large-scale, multicenter Randomized Controlled Trials (RCTs) are needed to confirm these findings.

CONCLUSION: This cohort demonstrates improved adoption of evidence-based heart failure therapies compared with regional data, but highlights a persistent mineralocorticoid receptor antagonists (MRA) treatment gap. Cardiology-led inpatient management is associated with superior GDMT implementation and clinical outcomes, underscoring the importance of specialist-driven care pathways.

CONCLUSIONS: IgG3-β(1)AR-AAb positivity was associated with adverse outcomes in acute HF, particularly among patients not treated with β-blockers. These findings suggest a potential role of IgG3-β(1)AR-AAb as a treatment-responsive biomarker, although prospective studies are needed.

CONCLUSION: In HFrEF patients, LASr tracks SV-associated reverse remodeling and is independently associated with subsequent therapy-associated changes in LVESV.

PURPOSE OF REVIEW: This review synthesizes recent progress in applications of artificial intelligence to heart failure care, including phenotyping, risk stratification, imaging interpretation, and point-of-care decision support, and delineates barriers that currently limit safe and equitable clinical translation.

CONCLUSIONS: The current literature highlights significant conceptual and methodological gaps in understanding social frailty in heart failure. Standardised definitions, validated assessment tools and deeper exploration of underlying mechanisms are needed to guide effective interventions and improve holistic care for people living with heart failure.

Cardiovascular-Kidney-Metabolic (CKM) syndrome represents a complex, interconnected cluster of cardiovascular disease, chronic kidney disease, and metabolic disorders such as obesity and type 2 diabetes. These conditions share overlapping metabolic, inflammatory, and vascular pathways, with the gut microbiome increasingly recognised as a key contributor and common underlying risk factor. Uremic toxins, traditionally considered waste products of host and microbial metabolism, are now recognised...

CONCLUSION: The coexistence of social frailty and sarcopenia is associated with adverse outcomes in outpatients with stage B HF. Early identification and multidisciplinary interventions for social frailty may help improve long-term prognosis.

CONCLUSION: Lipid-lowering agents have divergent effects; Atorvastatin and Fenofibrate best reduce CVER despite variable renal effects, supporting a phenotype-driven CRM strategy prioritizing residual cardiovascular risk reduction.

CONCLUSIONS: A reduction in the mLAP during M-TEER is independently associated with improved clinical outcomes in patients with DMR but not in those with FMR. These findings underscore the importance of real-time haemodynamic assessment - especially in DMR - as a valuable procedural endpoint that may aid in optimising long-term outcomes beyond anatomical MR reduction alone.

To identify and describe components of the home-based palliative care model for patients with heart failure, re-conceptualize the process, and update the existing model to inform nursing research and clinical practice. Heart failure, as a chronic progressive disease, has a continuously increasing incidence and medical burden, and requires multidimensional clinical management strategies. Although palliative care is recommended for improving the quality of life of heart failure patients, its...

Shengxian Quyu decoction (SXQY) has been suggested as a potential therapeutic strategy for heart failure (HF), but its therapeutic mechanisms remain unclear. This study investigated the therapeutic effects and underlying mechanisms of SXQY in HF. A rat model of HF was induced by transverse aortic constriction (TAC) and treated with SXQY. Cardiac function was assessed by transthoracic echocardiography, and myocardial structure and fibrosis were evaluated using hematoxylin and eosin and Masson's...

HeartMate 3 (HM3) has demonstrated excellent outcomes in adults, and its use in pediatric patients has recently increased. In small pediatric patients, previous studies have mainly focused on whether the device can be accommodated within the thoracic cavity. However, the physiological suitability of pump flow relative to body size and the potential mechanical effects of the device have not been well investigated. A 12-year-old girl (height 138 cm, weight 28.9 kg, body surface area 1.07 m²) with...

CONCLUSION: HRR1 and VE/VCO(2) slope can serve as independent predictors for the incidence of MACCE in patients with CHF.

This consensus paper, jointly developed by the Austrian Society of Laboratory Medicine and Clinical Chemistry (ÖGLMKC), the Austrian Society for Quality Assurance and Standardization of Medicinal Diagnostics (ÖQUASTA), and the Austrian Society of Nephrology (ÖGN), outlines standardized approaches to the laboratory diagnosis of chronic kidney disease (CKD) within the framework of cardiovascular-renal-metabolic health. CKD represents a major public health burden, with low awareness among affected...

The timing of obesity onset may influence long-term cardiovascular risk. Whether obesity beginning in early adulthood differs from obesity acquired later in life with respect to cardiometabolic and cardiovascular outcomes remains uncertain. We analysed adults with obesity (BMI ≥ 30 kg/m²) from the National Health and Nutrition Examination Survey (NHANES) 2017-2020. Participants were classified as having early-onset obesity (with obesity at approximately age 25) or adult-onset obesity (with...

Normal heart contraction requires synchronized calcium ion (Ca^(2+)) release from the sarcoplasmic reticulum (SR), traditionally attributed to ryanodine receptor 2 (RyR2). Here, we identify vacuole membrane protein 1 (VMP1) as a previously unrecognized SR Ca^(2+) release channel essential for postnatal cardiac function. VMP1 expression is up-regulated in cardiomyocytes after birth, and its genetic deletion causes severe arrhythmias, dilated cardiomyopathy, and sudden cardiac death....

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is common in older multimorbid patients and is associated with substantial morbidity and mortality. Pacemaker (PM) patients may be particularly vulnerable given the clustering of conventional HFpEF risk factors and the hemodynamic effects of long-term right ventricular pacing. Nevertheless, HFpEF is rarely systematically assessed in device clinics.

Heart failure (HF) is a complex and heterogeneous clinical syndrome defined by progressive structural, functional, and molecular alterations in the myocardium, representing a significant global health challenge. Beyond haemodynamic compromise, HF arises from intricate interactions among neurohormonal activation, chronic inflammation, oxidative stress, mitochondrial dysfunction, impaired calcium handling, and extracellular matrix remodelling. These processes drive maladaptive cardiac remodelling...

Chronic heart failure is a major public health issue that requires a multidisciplinary approach based on a coordinated care pathway. The emergence of new nursing specialties, the development of patient education, and the rise of telemedicine are helping to strengthen follow-up and continuity of care in the outpatient setting, improve quality of life, and prevent decompensation and rehospitalisations. In this context, the interuniversity diploma in heart failure management offers a shared...

Heart failure is most often diagnosed in a hospital setting following cardiac decompensation. The delivery of the diagnosis does not occur within a specific framework designed to help patients come to terms with their condition. The study presented here highlights these patients' feelings and needs, with a view to further exploring the possibility of specific nursing interventions.

Heart failure (HF) remains a major global health challenge, necessitating accurate yet accessible diagnostic tools. While the left ventricular ejection fraction (LVEF) is the primary metric for classifying HF into preserved (HFpEF), mid-range (HFmrEF), and reduced (HFrEF) phenotypes, conventional imaging modalities such as echocardiography are resource intensive. In contrast, the electrocardiogram (ECG) offers a low-cost, non-invasive alternative for continuous cardiac assessment. This paper...

Heart failure (HF) remains associated with high morbidity and mortality, with heart failure with preserved ejection fraction (HFpEF) becoming increasingly prevalent and therapeutically challenging despite advances in pharmacological and rehabilitative care. Beyond their glucose-lowering effects, glucagon-like peptide-1 receptor agonists (GLP-1RAs) confer cardiometabolic benefits and may serve as effective adjuncts to cardiac rehabilitation (CR), particularly in obese patients with HFpEF. Obesity...

This article describes the implementation of a program that incorporates therapeutic education into the care of patients with heart failure and reduced left ventricular ejection fraction who are admitted to a hospital-based cardiovascular rehabilitation program. This approach aims to empower patients to take an active role in managing their health.

Heart failure is a chronic condition whose course can be affected by extended travel. This prospective, open-label study evaluated the impact of stays abroad lasting more than two months on a population of outpatients with heart failure receiving care in a cardiology clinic. Of the 14 patients included, 12 (86%) met the composite endpoint combining a disruption in cardiac follow-up (64%), a disruption in medication adherence (64%), or cardiac decompensation (57%) upon return from their trip....

Frailty syndrome is frequently associated with heart failure (HF). It is a progressive condition associated with a poor prognosis but is potentially reversible. The study presented here aims to evaluate the feasibility of telephone-based frailty screening conducted by a registered nurse among individuals with HF who are being monitored via telemedicine. The goal is to enable early intervention in order to reduce the burden of frailty and improve patients' quality of life.

Heart failure is a public health issue affecting more than 1 million people in France in 2022, according to Santé publique France. The healthcare teams in the cardiology department at the University Hospital of Réunion care for these patients, from the onset of the disease through to the end of their lives. While they strive to provide personalized care, they face constraints and are seeking solutions to overcome them.

Total hip arthroplasty (THA) is the preferred treatment for femoral neck fracture when functional longevity is expected, but congestive heart failure (CHF) is a risk factor for mortality. The hypothesis of this study is that mortality risk increases with disease severity, influencing the choice between total and hemiarthroplasty. This study queried the National Surgical Quality Improvement database for patients treated for an acute, closed, intracapsular femoral neck fracture, identifying 4486...

This article presents a single-center, cross-sectional, descriptive epidemiological field study evaluating the screening for iron deficiency and pneumococcal prevention by community cardiologists in patients with heart failure. In total, 90% of the practitioners surveyed reported being familiar with the European Society of Cardiology's recommendations regarding iron deficiency screening, but only 60% perform it at least once a year. In contrast, 90% do not assess the patient's pneumococcal...

CONCLUSIONS: In patients with heart failure, parameters like mean E/e' ratio, LAVi, E wave DT are useful indices to estimate LVEDP; however, peak LAS-r (cut-off ≤17) provides a better prediction of LVEDP and could be considered a promising noninvasive index to assess LVEDP in patients of heart failure.

Given the high prevalence of heart failure in Réunion, it is necessary to optimize patient care. This requires the development of a coordinated, multidisciplinary, and multiprofessional care pathway; the establishment of a tailored, well-defined, and visible care network across the region; and efforts to address diagnostic uncertainty. Screening and coordination tools have been developed to encourage healthcare professionals to actively engage with patients with heart failure and to improve...

Heart failure with preserved ejection fraction (HFpEF) is a major healthcare problem affecting approximately 1-2% of the adult population in highly developed countries. It is a heterogeneous condition with cardiometabolic disorders such as obesity, insulin resistance, diabetes mellitus, and hypertension. Pathophysiologically, HFpEF is currently recognized as a systemic disease characterized not only by impaired left ventricular relaxation and increased ventricular stiffness but also by chronic...

Myocardial fibrosis is a common pathological feature of multiple cardiovascular diseases, including heart failure, hypertension, and myocardial infarction, and is associated with poor prognosis. Despite extensive research, clinically validated molecular biomarkers for early diagnosis and reliable therapeutic targets for myocardial fibrosis remain limited. Post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, SUMOylation, and glycosylation, are critical...

Pregnancy-associated hemodynamic overload and hormonal changes induce hypertrophy and metabolic remodeling of the maternal heart. Mitochondrial motility, mediated by ras homolog family member T (RHOT) 1 and RHOT2, is essential for cardiac adaptation to increased workload, cardiomyocyte hypertrophy, and sarcomere maturation. To test the hypothesis that Rhot1/2 expression is required for pregnancy- and postpartum-associated adaptations of the maternal heart, female mice with tamoxifen-inducible,...

Heart failure (HF) affects 2.6 % of adults in France. Against a backdrop of increasingly complex care, the cross-sectional survey presented here-conducted between May and June 2023-analyzes the roles of three specialized profiles: nurses working under the heart failure cooperation protocol, advanced practice nurses, and telehealth nurses. The results highlight the complementary nature of their skills within the care pathways for HF patients.

Acute heart failure (AHF) causes abrupt hemodynamic disturbances, including reduced forward flow and venous congestion, which may extend beyond the heart and contribute to peripheral organ stress. Skeletal muscle may be particularly vulnerable to these changes, but the relationship between acute hemodynamic status and circulating markers of skeletal muscle stress and regulation remains unclear. We prospectively enrolled 35 men hospitalized with AHF and non-invasively assessed their cardiac index...

The various educational options offered to patients upon discharge following cardiac decompensation were assessed using a questionnaire as part of this retrospective study. Respondents indicated that they found these options to be more complementary than redundant, with a preference for those that occur as soon as possible after discharge and in their own environment (such as the return-home program and therapeutic support through telemonitoring of heart failure). The therapeutic education...

Heart failure is a common condition that leads to a large number of hospitalizations, a high mortality rate, and significant costs for the healthcare system. The symptoms and chronic nature of the disease severely impair patients' quality of life, forcing them to adapt their daily routines by following various lifestyle and dietary recommendations, including salt restriction. This diet, often presented as essential, can have mixed effects: while it may sometimes reduce the risk of...

CONCLUSION: Our results show that a longer baseline LVAT is associated with a lower risk of heart failure hospitalization and all-cause mortality. This relationship was of borderline significance in multivariable analysis. Prospective trials would be useful to further explore the potential role of pre-implant LVAT in patient selection for CRT.

Psoriasis has been associated with cardiovascular risk, but the combined association of psoriasis and cardiovascular-kidney-metabolic (CKM) syndrome with mortality remains unclear. This study examined the individual and joint associations of CKM syndrome and self-reported psoriasis with allcause and cardio-cerebrovascular disease (CCD) mortality among 9,598 U.S. adults aged ≥20 years from NHANES 2003-2006 and 2009-2014. CKM syndrome stages were defined according to the 2023 American Heart...

CONCLUSIONS: Despite being low-intensity, dressing was associated with measurable physiological and subjective HF responses. R-HF trended toward slower HR recovery; NO-HF demonstrated consistently higher HR levels and perceived exertion. Monitoring recovery responses and supporting pacing and symptom self-monitoring during daily activities may be important in HF nursing care.

Extracorporeal membrane oxygenation (ECMO) has revolutionized neonatal care, providing lifesaving support for cardiorespiratory failure. Miniaturized circuits and improved cannulae expanded ECMO eligibility to smaller and more complex infants. Indications now extend beyond respiratory failure to include structural and acquired heart disease and extracorporeal cardiopulmonary resuscitation. Contemporary anticoagulation strategies, incorporating multimodal monitoring and alternative agents, seek...

AIM: The "2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome" retires, replaces, and expands upon the "2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults." The primary intended audience for this guideline is clinicians who care for patients across the spectrum of cardiovascular-kidney-metabolic syndrome, an interrelated condition characterized by the interconnections among metabolic...

CONCLUSIONS: In this national database analysis of patients with inflammatory bowel disease, infliximab was associated with a higher observed risk of incident heart failure compared with adalimumab.