Apnea/Sleep Disorders Pubmed Results

CONCLUSION: These findings suggest that PPG-based hypnodensities improve the characterisation of sleep quality and better predict patient-reported outcomes in SDB patients. Future uses may include tracking sleep quality with fingertip pulse oximeters outside of sleep centres, potentially over multiple nights due to their simplicity.

CONCLUSION: Patient-centered factors, particularly perceived benefit, practicality, and effective physician communication, are critical determinants of successful OSA management. Enhancing patient education and shared decision-making may significantly improve long-term adherence and real-world treatment outcomes.

INTRODUCTION: Asthma, chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea (OSA) are prevalent chronic respiratory diseases associated with increased comorbidity, mortality and healthcare costs. Physical activity and exercise are widely recommended as part of treatment for these conditions, yet the specific effects of Nordic walking (NW) remain underexplored. The aims of this randomised controlled trial (RCT) are to improve physical fitness, functional capacity and...

RATIONALE: Dexmedetomidine is extensively recognized as a sedative featuring a relatively mild respiratory depressant effect. Nevertheless, for patients who are on long-term sedative use and potentially suffer from co-morbid insomnia and sleep apnea (COMISA), the safety of this drug remains ambiguous. This case report uncovers a rare yet severe adverse reaction associated with this drug.

CONCLUSION: We developed a prediction model to identify individuals at high risk of SAS treated with CPAP and encourage them to undergo polysomnography or related tests.

Obstructive sleep apnoea (OSA) and spondyloarthritis (SpA) are chronic inflammatory disorders associated with substantial cardiometabolic morbidity and impaired quality of life. Increasing evidence suggests that these conditions frequently coexist and may share overlapping pathogenic mechanisms involving intermittent hypoxia, oxidative stress, endothelial dysfunction, autonomic dysregulation, and activation of TNF-α and the IL-17/IL-23 axis. This narrative review summarises current evidence on...

CONCLUSION: Short-term exposure to ambient air pollution is associated with minor reductions in CPAP usage; however, the effect size is small and unlikely to be clinically significant in a low-pollution settings. CPAP effectiveness, as measured by residual AHI and mask performance, appears unaffected. These findings suggest that CPAP therapy remains robust despite typical variations in environmental air quality, and the clinical relevance of pollution-driven adherence changes is limited.

CONCLUSIONS: These findings further support the association of OSA with post-hip arthroplasty VTE, with increased rates of the latter persisting even after extensive propensity matching for associated comorbidities. Further investigation to discern the underlying pathophysiology of this correlation is necessary.

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is characterized by recurrent upper airway obstruction and chronic intermittent hypoxia, which can promote oxidative stress, inflammation, and lung injury. Here, we established a rat model of OSAHS by exposing animals to chronic intermittent hypoxia in a plexiglass chamber with alternating cycles of nitrogen and compressed air for 8 h per day over 35 days, and used this model to evaluate the protective effects of Shenling Baizhu Powder (SLBZP)....

CONCLUSION: SA is highly prevalent in HCM, and HCM patients with comorbid SA exhibit distinct baseline characteristics, cardiac structure and drug application.

CONCLUSION: Visual epiglottis-related obstruction during DISE with PAP occurs in some individuals that limits increases in ventilation and mean inspiratory airflow normally seen with increases in PAP levels.

CONCLUSION: The findings suggest that combining Pilates and myofunctional therapy may be a useful non-pharmacological strategy to improve sleep and psychosocial outcomes in individuals with obesity-associated OSA.

CONCLUSION: In this Kuwaiti OSA cohort, age and BMI are the dominant determinants of sarcopenia, with no independent contribution from OSA severity. A modest association between OSA severity indices and CST time suggests that physical function may be more sensitive to OSA-related changes than muscle mass per se. The near-universal low STAR prevalence points to the need for population-specific normative data in high-obesity cohorts.

In patients with repaired open spina bifida, there are limited data on respiratory outcomes beyond the first year of life. We hypothesize that after 1 year of age there is 1) resolution of sleep-related breathing disorders (SRBD), 2) improvement of oxygenation and 3) no difference in SRBD between prenatally vs. postnatally repaired groups. We reviewed 67 patients with repaired open spina bifida and polysomnography (PSG) after age 1 year seen at Children's Hospital Los Angeles between 2015-2025....

CONCLUSIONS: In this nationwide sleep-clinic cohort, OAD was independently associated with COMISA. COMISA patients with OAD exhibited more adverse clinical and polysomnographic features. These findings highlight the multidimensional sleep burden in OAD and support integrated, personalized management strategies.

INTRODUCTION: Obstructive sleep apnea (OSA) is prevalent among patients with Parkinson's disease (PD), yet its contribution to neuroinflammation and disease progression remains poorly understood. This study investigated the association between OSA severity, sleep parameters, and systemic cytokine/chemokine profiles in PD.

CONCLUSION: Epoch-by-epoch sleep and wake can be effectively predicted by a model using CPAP flow and demographics. Such information may complement usage data from CPAP devices to better assess CPAP effectiveness.

Obstructive sleep apnea (OSA) is a highly prevalent disease worldwide and is closely associated with cardiovascular disease, metabolic disorders, and traffic accidents. Current OSA prevention and management face three major challenges: low public awareness, insufficient screening vigilance among non-specialist physicians, and a high proportion of asymptomatic patients who remain undiagnosed. Proactive intervention is crucial for reducing the public health burden and improving patient prognosis....

CONCLUSIONS: In obese adults, STOP-BANG-defined high OSA risk is associated with a phenotype characterized by greater epicardial adiposity, higher inflammatory burden, autonomic impairment, and a higher prevalence of LVDD. A parsimonious model integrating STOP-BANG, EAT thickness, and inflammatory indices may support screening-oriented phenotypic characterization of obese adults with a higher likelihood of LVDD; however, these findings should not be interpreted as establishing causal inference...

CONCLUSION: These novel hypoxia-related indices have demonstrated strong predictive power in identifying OSA and grading its severity, and can detect non-obese, non-severe hypoxic OSA patients at an early stage.

CONCLUSION: Tonsillar surgery alleviates OSA in most children irrespective of underlying comorbidities associated with OSA. In children with comorbidities, even operating on relatively small tonsils can lead to significant improvement in OSA. TT resulted in highly significant improvements in PSG parameters and the effectiveness of tonsillotomy seems equal to tonsillectomy.

CONCLUSIONS: Available evidence indicates that CSA syndromes during sleep are substantially more frequent in patients with ischemic stroke than in the general population and may be associated with increased cerebrovascular risk and subclinical brain injury. Heterogeneity in CSA definitions, diagnostic protocols, and outcome measures limits firm conclusions. Standardized criteria and adequately powered prospective studies are needed to clarify the mechanistic and prognostic role of CSA in stroke.

CONCLUSION: PBM alleviates systemic insulin resistance, restores eWAT insulin signaling, and limits hepatic oxidative stress induced by IH. By enhancing insulin sensitivity, PBM could be proposed as a new therapeutic strategy against OSA-associated metabolic comorbidities.

Prediabetes is a silent, common, and increasingly prevalent condition that carries a high risk of progressing to type 2 diabetes mellitus (T2DM). Obstructive sleep apnea (OSA) and prediabetes have been proposed to have a bidirectional relationship. We conducted a thorough literature search on PubMed, MEDLINE, Scopus, and Google Scholar using the keywords 'prediabetes,' 'impaired glucose tolerance,' 'OSA,' and 'sleep disordered breathing.' This narrative review aims to synthesize the...

CONCLUSIONS: OSA severity is linked to impaired autonomic capacity, while CPAP therapy selectively improves autonomic recovery dynamics. Sleepiness does not modify these adaptations, suggesting that CPAP enhances autonomic flexibility rather than reversing established autonomic impairment.

CONCLUSION: In newly diagnosed patients with OSA, the morning chronotype was primarily associated with cardiometabolic comorbidities, especially in young and middle-aged adults, but not in older individuals, suggesting that it may represent a potential adjunctive clinical marker.

Objective:To advance the precision diagnosis and treatment of obstructive sleep apnea-hypopnea syndrome（OSAHS）, this study aimed to identify phenotypes with distinct pathophysiological and clinical features based on multidimensional clinical data using unsupervised clustering methods. Methods:Polysomnography indicators （apnea-hypopnea index[AHI], lowest oxygen saturation, oxygen desaturation index, arousal index） and clinical symptom scale data（Epworth Sleepiness Scale[ESS], Insomnia Severity...

CONCLUSIONS: An anticipated six out of seven patients with COPD newly prescribed PAP therapy will be successful using therapy; however, heterogeneity was substantial among studies, and only partly explained by indication for use. Prospective studies to explore barriers to use and detailed reporting of acceptance and adherence in studies on PAP therapy in patients with COPD are needed.

Background and Objectives: Pregnancy causes various physiological and hormonal changes that disrupt sleep architecture and modify respiratory patterns, increasing the risk of sleep-related breathing disorders (SBDs) such as obstructive sleep apnea (OSA) and potentially exacerbating pre-existing conditions. These disorders have been linked to adverse maternal and fetal outcomes. However, current screening tools remain inadequate, and data, including from Portugal, remain limited. This study aimed...

Background and Objectives: Continuous positive airway pressure (CPAP) is the standard first-line treatment for patients with obstructive sleep apnea (OSA). Patients with OSA exhibit a higher prevalence of vitamin D deficiency, and CPAP treatment has been reported to improve vitamin D levels. Therefore, the aim of this study was to investigate the association between vitamin D deficiency and the risk of patients receiving a diagnosis of OSA or utilizing CPAP, using the TriNetX research network to...

Background and Objectives: Obstructive sleep apnea (OSA) is a common disorder associated with significant cardiovascular, metabolic, and neurocognitive consequences. The STOP and STOP-BANG questionnaires are widely used screening tools for identifying individuals at increased risk of OSA. However, their performance may vary across populations. This variability is due to demographic and anthropometric differences. We aimed to analyze the screening accuracy of the STOP and STOP-BANG questionnaires...

CONCLUSIONS: Sleep apnea is underdiagnosed and undertreated among ethnic minorities. Factors such as ancestry, comorbidities, social determinants, geography, and healthcare access drive global inequities. Further sleep apnea phenotyping may be of value in planning treatment strategies.

Sleep apnea is a prevalent sleep-related breathing disorder characterized by recurrent cessations or reductions in airflow during sleep. It significantly impacts the quality of life, yet current diagnostic methods like polysomnography (PSG) are expensive and uncomfortable, limiting accessibility and ease of use. We developed a novel non-contact biosensing system using secondary laser speckle pattern analysis and dedicated image processing algorithms for apnea-like breathing cessations. The...

CONCLUSIONS: SP-D demonstrates severity-associated alterations consistent with alveolar epithelial stress during IH, though high variability limits definitive biomarker validation in this sample. Gal-3 inhibition modulates surfactant homeostasis and attenuates cardiopulmonary injury in a context-dependent manner. These findings support further investigation into SP-D as a component of multimodal severity stratification in OSA and highlight Gal-3 inhibition as a context-dependent...

The role of m⁶A RNA methylation in obstructive sleep apnea (OSA)-related metabolic dysfunction and systemic inflammation is unknown. We aimed to identify the key m⁶A regulator involved in OSA-induced adipose tissue inflammation and explore the underlying mechanisms. The expression of m⁶A methylation regulators was measured and their associations with systemic inflammation indicators were analyzed in patients with OSA. A mouse model of OSA was established with high-fat diet feeding and chronic...

CONCLUSION: Our study confirms significant differences in collapse degree and pattern between awake and sedated assessments using the NOHL classification. These discrepancies influence surgical decision-making in OSA patients. Further research is needed to improve patient phenotyping and guide more accurate, personalized treatment strategies for optimal surgical outcomes.

The diagnostic armamentarium for sleep-disordered breathing (SDB) has undergone substantial expansion in recent years, alongside the heightened awareness of SDB, its systemic impact on health, and the proliferation of home sleep apnea testing (HSAT). Many contemporary diagnostic modalities incorporate physiological measurement techniques that draw upon concepts primarily investigated in research paradigms, but may not align with existing HSAT classification frameworks, particularly regarding...

CONCLUSIONS: This study provides long-term follow-up data on craniofacial, airway, and sleep-related changes in children with OSA treated with a monoblock appliance. Although partial recurrence of AHI was observed during adolescence, airway dimensions and skeletal parameters demonstrated relative stability over time. These findings suggest that structural adaptations may be maintained, while functional outcomes may vary during growth. Given the multifactorial nature of pediatric OSA, these...

AIM: To investigate the current status of discharge readiness in post-surgical patients with obstructive sleep apnoea hypopnoea syndrome (OSAHS) and analyse the influencing factors.

CONCLUSION: Since most patients with CSA also have some degree of obstructive type respiratory events, adding HARMS questions to the widely used STOP-BANG screening questionnaire for OSA may help identify patients at risk for CSA in the general population. This, in turn, would lead to prompt diagnostic testing and treatment for CSA.

Obstructive sleep apnea (OSA) is a sleeping disorder which can lead to severe health consequences. Information gaps in the patient's diagnostic path may result in duplicate examinations, while patients wait long for sleep diagnostics. We propose an architecture for standardized sleep data exchange along the OSA patient diagnostic path. Our system consists of extended and interconnected established components for biosignal storage and electronic patient data and is entirely based on open source...

BACKGROUND: Obstructive sleep apnea (OSA) is more common among Hispanic individuals and contributes to risk for cardiometabolic diseases, dementia and poor quality of life. Positive airway pressure (PAP) improves sleep and quality of life, and culturally adapted interventions are promising for increasing treatment engagement. The goal of this study is to test Nuestro Sueño, a culturally adapted couples-based intervention to promote positive airway pressure adherence and sleep health for Hispanic...

Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk and hypertension. While continuous positive airway pressure (CPAP) therapy reduces blood pressure (BP), its effect shows substantial interindividual variability. Hypoxic burden (HB) has been proposed as a potentially superior predictor of cardiovascular outcomes compared to the apnea-hypopnea index (AHI). In this retrospective study, 141 patients with OSA underwent in-laboratory polysomnography and initiated CPAP...

CONCLUSION: Children with AD are more likely to have OSA than children without AD, emphasizing the need for careful management, especially when surgical options are considered.

CONCLUSION: Evening-to-morning changes in respiratory muscle strength reflect acute overnight respiratory muscle loading in patients with OSA and provide physiological insight into short-term neuromuscular adaptations associated with recurrent apnea-hypopnea events.

CONCLUSIONS: Diagnosing sleep disordered breathing in children can be challenging in a laboratory setting. HSAT is cost-effective and better tolerated in the younger population compared to PSG. It is a reliable alternative to PSG when used with multiple channels, including EEG and capnography.

Obstructive sleep apnoea syndrome (OSAS) is a breathing disorder frequently associated with mild cognitive impairment (MCI), a potential prodromal stage of Alzheimer's disease (AD). However, the mechanisms underlying MCI in OSAS remain unclear, making the identification of early biomarkers crucial. This pilot study investigates biochemical parameters related to oxygen disturbance and AD in OSAS patients with and without MCI (OSAS + MCI and OSAS-MCI, respectively) and explores their interplay...

Obstructive sleep apnea (OSA) exhibits distinct features in women across the lifespan, largely driven by hormonally mediated changes in sleep and respiratory physiology. Women remain under-represented in research cohorts, and few studies are designed to investigate sex-specific differences. Because of atypical clinical presentations related to menstrual cycling and lower anthropometric indices, OSA in women is frequently underdiagnosed in clinical practice. Women with OSA have higher risks of...

Obstructive sleep apnea (OSA) is increasingly recognized as an important comorbidity during pregnancy, with implications for both maternal and fetal health. Pregnancy-related anatomical, hormonal, and physiological changes, including upper airway edema, reduced functional residual capacity, increased respiratory drive, sleep fragmentation, and weight gain, collectively heighten susceptibility to sleep-disordered breathing. Evidence indicates that OSA can emerge or worsen as gestation progresses,...

Obesity hypoventilation syndrome (OHS) is the most severe form of sleep-disordered breathing, and most patients also have concomitant obstructive sleep apnea. Postmenopausal women show a higher prevalence of OHS, likely influenced by hormonal changes. Awareness of OHS among health care providers remains limited; therefore, many patients, particularly women, are underdiagnosed until presenting with acute respiratory failure requiring hospital admission. In women, delayed diagnosis is often...