Respiratory Tract Infections Pubmed Results

BACKGROUND: The COVID-19 pandemic and related non-pharmaceutical interventions (NPIs) (e.g., lockdowns and contact restrictions) disrupted routine healthcare delivery. In Germany, these measures affected diagnostic and treatment services for people with cancer and cardiovascular diseases, potentially delaying diagnosis and adversely influencing outcomes. We assessed whether and to what extent diagnosis, health utilization and health outcome among patients with selected cancer and cardiovascular...

CONCLUSION: Post-crisis BC screening adherence declined significantly, particularly among women without prior institutional screening. Continued follow-up was associated with more stable BI-RADS outcomes and earlier-stage cancer detection. Sustained public health strategies are needed to mitigate the impact of national emergencies on cancer prevention.

Older adults are highly vulnerable to infectious diseases, and vaccines are often less effective in this population because of diminished B and T cell memory responses driven by impaired autophagy, immunosenescence, and chronic low-grade inflammation. Spermidine has been shown to counteract immunosenescence and induce autophagy in preclinical models, and its levels decline with age in humans. We conducted a double-blind, randomised, placebo-controlled pilot study in 40 adults over 65 years of...

While thoracic radiographic studies have described the broad thoracic findings of canine blastomycosis, thoracic computed tomographic (CT) findings have been minimally reported. This single-center, retrospective, descriptive case series study aimed to characterize thoracic CT features of canine blastomycosis. CT studies of dogs diagnosed with blastomycosis with confirmed or presumed pulmonary involvement were included and reviewed by board-certified radiologists. A total of 23 dogs met the...

CONCLUSIONS: In this dementia-specific cohort, recorded aspiration pneumonia was common and consistently associated with greater subsequent inpatient use. The findings support interpreting recorded aspiration pneumonia as a pragmatic clinical marker of heightened service dependence within a broader frailty and illness context and underscore the value of multidisciplinary review and anticipatory care planning after such events.

Long-term complications following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, known as long-COVID, present significant global health challenges. The factors associated with developing long-COVID remain poorly understood, especially in individuals with pre-existing comorbidities, including mental health conditions. Additionally, the relationship between persistent symptoms and incident depression and anxiety symptoms remains unclear. We analysed baseline data from 9637...

Understanding population immunity to emerging viruses is critical for risk assessment. We characterised antibody responses to avian influenza A(H9N2) viruses in 298 human sera from adults in New York City. We observed widespread cross-reactive H9-binding antibodies, albeit at lower levels (GMT = 371.3) than against seasonal H3 (GMT = 1,398.0), with low to undetectable haemagglutination inhibition and neutralising antibodies. In contrast, NA-binding and neuraminidase inhibition responses were...

CONCLUSION: By integrating statistical, seasonal, and nonlinear modeling approaches, Stacked-NNLS demonstrated robust predictive performance in capturing influenza trends, seasonal fluctuations, and complex interactions among multiple factors, suggesting its potential utility for infectious disease early warning and public health decision-making.

CONCLUSION: Substantial mental health challenges were observed in both pre- and post-vaccine phases of the pandemic, particularly among women, younger adults, and non-citizens. Protective coping strategies, especially faith-based and social support mechanisms, should thus be integrated into pandemic preparedness alongside biomedical responses.

Influenza A, an acute or subacute respiratory infectious disease caused by the influenza A virus (IAV), affects humans and animals, and poses a serious threat to public health. Currently, IAV prevention and treatment rely primarily on antiviral drugs and nebulization therapy. Although these methods offer rapid efficacy, prolonged or excessive use often induces drug resistance and sequelae, and has high costs. Throughout China's history, traditional Chinese medicine (TCM) has repeatedly resisted...

CONCLUSION: We developed and internally validated a practical nomogram that integrates clinical variables with immune-inflammation-nutrition indicators to predict 28-day mortality in sepsis patients with severe fungal pneumonia. This tool may help clinicians with early risk stratification and individualized treatment decisions.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has sparked a global pandemic with extensive spread, posing a severe threat to public health due to its high mortality rate in severe cases. The continuous emergence of variants with enhanced immune evasion capabilities, coupled with the prolonged and debilitating symptoms of Long Coronavirus Disease (Long COVID) such as intermittent dyspnea, persistent fatigue, and cognitive impairment (brain fog), has become a major global concern....

INTRODUCTION: The emergence of immune-evasive SARS-CoV-2 variants has exposed limitations in the breadth and durability of protection conferred by current Spike-based vaccines, highlighting the need for next-generation approaches targeting conserved viral regions. Here, we describe the design and preclinical evaluation of an optimized multi-epitope vaccine, CoV2-BMEPu.

Background and objectives Cancer is a leading cause of death in India, with delays in diagnosis and treatment contributing to poor outcomes. Although several studies document these delays, most focus on single cancer types or specific regions. This review aimed to synthesise evidence across cancers to identify barriers to help-seeking and their implications for cancer control in India. Methods A scoping review was conducted using Arksey and O'Malley and Levac frameworks, guided by the PRISMA-ScR...

CONCLUSIONS: Strategic solidarity better captures the empirical reality of pandemic policymaking than a strict solidarity/self‑interest dichotomy and can inform the design of future mechanisms for more equitable global health responses.

United States seeks to debar Ralph Baric for misleading NIAID on old coronavirus studies, which he disputes.

CONCLUSIONS: The study findings offer confirmation that the expansion of virtual nursing models into medical-surgical acute care settings is associated with improved patient experiences. Many patients reported that they appreciated the virtual nurse and were comfortable with the technology. Some patients voiced concerns about privacy, which eased over time. Others worried that virtual nurses might replace bedside nurses. These findings indicate a need for improvement in how virtual nursing...

CONCLUSIONS: An ML-based logistic regression model using admission data accurately predicted paediatric vRTIs, outperforming traditional syndromic surveillance definitions, especially among infants <1 year. By integrating ML models into hospital electronic medical records, healthcare systems can achieve enhanced respiratory virus surveillance, faster outbreak detection, greater diagnostic efficiency and improved pandemic preparedness.

CONCLUSION: COVID-19 pandemic health data contributed to significant ML drift. Although ML approaches allow for quick re-training to mitigate drift, health regulators should approach ML prediction with caution when using pandemic-times data.

The Somatic Symptom Scale (SSS-8) is a brief 8-item tool for screening common somatic symptoms. This study is the first to examine its temporal invariance and stability across three COVID-19 pandemic time points, while also analyzing changes in SSS-8 scores in the general population and across groups (sex, age, relationship status, poverty status), and testing temporal stability and measurement invariance. Longitudinal data from three pandemic time points in a large population-based sample were...

CONCLUSIONS: The lung interstitial-to-airway/alveolar cross-compartment sharing pattern of activated immune cells (Pattern 1a) provide a robust working hypothesis for clinical and translational research for severe pneumonia.

CONCLUSIONS: Penn State responded to the COVID-19 pandemic with an innovative course that developed students' real-time understanding of pandemic response. Students gained knowledge and skills relevant to the practice of public health. Based on the positive student feedback, the course will serve as a model for future classes on public health and emergency management.

CONCLUSIONS: This study successfully developed the first PopPK model for eravacycline in critically ill patients with CRAB pneumonia. The findings highlight substantial pharmacokinetic variability and demonstrate that weight-based dosing is crucial to ensure effective exposure, underscoring the necessity of PK/PD-guided personalized therapy.

Prolonged grief disorder (PGD), recently classified in ICD-11 and DSM-5-TR, is characterized by persistent and functionally impairing grief lasting beyond 6-12 months. The COVID-19 pandemic was accompanied by widespread mortality, social isolation, disrupted mourning rituals, and social disconnection, raising concerns about a potentially high burden of PGD during the pandemic period. We conducted a systematic review and meta-analysis, following PRISMA guidelines and PROSPERO registration...

CONCLUSION: The co-circulation of SARS-CoV-2, influenza, and RSV highlights Uganda's ongoing respiratory virus burden. Seasonal patterns and recurrent outbreaks underscore the need for sustained surveillance, targeted vaccination, and public health interventions to mitigate the impact of these pathogens, particularly in vulnerable populations.

Enterovirus D68 (EV-D68) is a re-emerging respiratory pathogen that is increasingly associated with severe respiratory disease and occasional neurological complications, yet its circulation in Portugal remains poorly documented. In the present study, we investigated the presence of EV-D68 in respiratory samples collected in southern Portugal (Algarve region) from October 2024 to February 2025. Screening of 150 respiratory samples from patients (115 from children and 35 from adults), all...

CONCLUSIONS: The level of illegitimate work varies across different occupations, with a higher prevalence in female-dominated, human service fields compared to male-dominated technical roles. Addressing the growing care needs with more human resources will be challenging. One possible solution is to increase available working time by reducing illegitimate and especially unnecessary tasks. Overall, this study contributes to a better understanding of how an important aspect of the work...

CONCLUSIONS: The clinical significance of detection of Pneumocystis jiroveci in immunocompetent children with LRTI should be further investigated, and specific therapy could be considered individually based on clinical symptoms, radiological features, and co-infection patterns.

BACKGROUND: Glucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that they may also develop de novo after SARS-CoV-2 infection. Neutrophil extracellular trap formation (NETosis) plays a central role in immunothrombosis, and because neutrophils rely predominantly on glycolysis, they are particularly sensitive to systemic metabolic disturbances. However, the impact of post-COVID-19 GMDs on NETosis remains poorly understood. This...

CONCLUSION: A symptom-based rehabilitation programme significantly improved HRQoL in individuals with PCC after 3 weeks, with some benefits persisting at 3 months.

CONCLUSIONS: The pathogenic diagnosis of mNGS in BALF of patients with lower respiratory tract infections is su-perior to conventional culture detection; it can detect more and a wider range of pathogens, helping to promote rational drug use and improve patient prognosis in clinical practice.

Amidst the abrupt school closure due to the COVID-19 pandemic, adolescents faced unexpected challenges. Drawing on data collected 1 week before, during, and 1 year after the first COVID-19 school closure in Belgium, this study investigated (1) changes in life satisfaction, (2) whether parent-child relationship quality served as a protective factor during school closures over and beyond COVID-19-related concerns; and (3) differences among early adolescents (N = 124, M(age) = 12.86, 40.3% girls,...

AIM: The current study aimed to explore the lived experiences of nurses providing care to patients with COVID-19.

» Virtual and hybrid mentorship models have transitioned from temporary coronavirus disease 2019 pandemic responses to durable, scalable components of the orthopaedic training curriculum. » Despite high trainee satisfaction, most orthopaedic virtual mentorship programs rely on short-term, self-reported metrics and lack the objective, longitudinal tracking of research productivity or career advancement seen in other specialties. » While virtual pipelines demonstrate the potential to broaden...

We report two singular cases of sudden death in which the cause was advanced tuberculosis infection. In the first case, a 24-year-old man died suddenly following massive hemoptysis due to erosion of the pulmonary vessels. The second case involved a 29-year-old man who died unexpectedly from asphyxia secondary to hemoptysis caused by fibrocavitatory tuberculosis. Toxicological screening and HIV testing were negative in both cases. Medico-legal autopsy, combined with detailed histological...

Invasive pulmonary mucormycosis (IPM) is a severe opportunistic mold infection whose outcome is predominantly host driven. Preclinical proof-of-concept studies and clinical case reports in salvage therapy settings suggested a benefit of immune checkpoint inhibitors (ICIs) in IPM management. However, the kinetics of infection-induced immune paralysis and optimal timing of ICI therapy remain poorly understood. Here, we performed sequential nCounter-based transcriptomics on lung tissue of...

The tripartite motif-containing (TRIM) 34 protein is an interferon (IFN)-induced protein whose expression is upregulated after influenza A virus (IAV) infection. Here, we identify a previously unknown function for TRIM34 as a negative regulator of innate immune responses following IFN treatment and IAV infection, even in mice, suggesting that this effect is broad and conserved. Complementary overexpression and silencing experiments in cultured cells show that TRIM34 expression positively...

Influenza virus A (H1N1) can lead to acute respiratory infection, while Guillain-Barré Syndrome (GBS) is an autoimmune peripheral neuropathy, which can work as a post-infectious disease. There are clinical observations showing the existence of a possible relationship between the presence of H1N1 infection and GBS disease, and therefore there could be common immunopathological pathways associated with H1N1 infection and GBS. The possible similarity between H1N1 infection and GBS was further...

Glomerulonephritis (GN), secondary to tuberculosis, is quite a rare condition. Here we report the case of membranous nephropathy, which completely resolved after the treatment of tuberculosis. A 42-year-old man presented to a nephrologist with burning micturition. His urine routine examination (RE) was suggestive of 2+ protein. His 24-hour urinary protein was 4.2 grams. Renal biopsy revealed membranous nephropathy. His autoimmune, hepatitis B, hepatitis C, and HIV workups were non-conclusive....

CONCLUSIONS: VCs offer an opportunity to improve digital inclusion in health care for people with intellectual disabilities. However, the quality and safety of VCs for this population are dependent on continuous review of patients' needs over time and ensuring that their choices and preferences are considered when planning and providing ongoing care.

Hyperbaric oxygen therapy (HBOT) demonstrates expanding applications in infectious diseases through its multimodal mechanisms. As an adjunctive treatment, HBOT directly exerts antimicrobial effects through oxygen toxicity and reactive oxygen species generation, while indirectly enhances host immunity by improving neutrophil function and promoting tissue repair. Clinical evidence supports its adjunctive use in complex infections including diabetic foot wounds, necrotizing soft tissue infections,...

GOAL: High turnover and turnover intention among nurses persists worldwide, necessitating a study of deterrents such as personal spiritual beliefs and posttraumatic growth (PTG). PTG refers to positive psychological changes that occur in response to struggle with highly stressful or traumatic experiences. This study aims to verify a hypothetical model that explains nurse turnover intention in South Korean hospitals since the start of the COVID-19 pandemic.

CONCLUSIONS: Post-COVID-19 HZ is associated with an increased risk of peripheral nervous system disorders, highlighting the need for symptom-based neurological awareness during both early and delayed post-infectious periods.

CONCLUSIONS: In multilayer urban contact networks with community structure, our results indicate that intensifying incidental encounters can change the main contributors to transmission even when overall contact opportunities and routine contacts are unchanged. We present an analysis framework under explicit daily-contact constraints to identify this contributor shift and its transition point, supporting comparisons of intervention priorities across social contact conditions.

Understanding the complex epidemiological and virological characteristics of influenza is critical for optimizing seasonal influenza control and prevention programs; to this end, we analyzed the influenza and influenza-like illness (ILI) cases reported in Zhejiang Province from 2010 to 2025. Annual average percentage (AAP) approach was used to estimate the influenza seasonal epidemic onset and duration. Generalized additive model (GAM) was used to explore the nonlinear relationship between age...

CONCLUSIONS: In this pilot randomized controlled trial, the resveratrol/β-glucan nasal spray was safe and well tolerated. Although the study did not show a statistically significant effect on the primary endpoint, the observed numerical differences consistently favored the intervention. These findings should be interpreted as exploratory and hypothesis-generating and require confirmation in larger adequately powered studies.

BACKGROUND Legionella pneumophila is a common and often severe cause of community-acquired pneumonia. Infection with this organism is also known to be associated with a wide range of extrapulmonary manifestations, such as neurologic deficits, hyponatremia, acute kidney injury, and elevated liver enzymes. Other complications, such as rhabdomyolysis and hypertriglyceridemia, are rare. CASE REPORT A rare presentation of Legionella infection was observed in a 34-year-old man, characterized by severe...

Background. Mycoplasma pneumoniae (MP) is a common causative pathogen of community-acquired pneumonia in children, with clinical presentations ranging in severity. Early stratification and timely intervention are essential for improving patient outcomes. However, a major clinical challenge lies in the limited ability to accurately distinguish between mild and severe cases based solely on early clinical indicators.Methods. This prospective real-world study investigated the differences in...

CONCLUSIONS: Early-life hospitalisation for HRV or RSV, particularly at 13-24 months of age, may be associated with increased risk of asthma and greater asthma morbidity. These findings suggest a potential role of infection timing in shaping long-term respiratory outcomes.

Post-COVID-19 syndrome (PCS) may vary across pandemic phases. We compared the prevalence of post-acute COVID-19 symptom clusters following SARS-CoV-2 infection in the early pandemic and during the Omicron era using a population-based approach. The EPILOC study enrolled individuals aged 18-65 years who tested PCR-positive for SARS-CoV-2 during the early pandemic, between October 2020 and April 2021, in defined geographic regions within Baden-Württemberg. EPILOC-Omicron used an identical design...