Vascular Medicine – Pubmed

This cross-sectional study aimed to examine the associations between total intake of 3 B vitamins (thiamin, riboflavin, niacin) and hypertension and increased pulse pressure in U.S. adults, and to explore potential nonlinear relationships.Data from the U.S. National Health and Nutrition Examination Survey (NHANES) 1999-2023 were analyzed. A total of 17,484 participants aged ≥ 20 years were included. Total vitamin intake (diet plus supplements) was categorized into quartiles. Hypertension was...

Stroke occupies an important position in the global disease burden, but the combined effect of heavy metal exposure and the inflammatory marker C-reactive protein (CRP) on stroke remains unclear. Based on the National Health and Nutrition Examination Survey, this study explores the association between blood lead, blood cadmium, blood mercury, CRP, and the risk of stroke. A total of 8297 American adults aged 20 years and older were included in the National Health and Nutrition Examination Survey....

CONCLUSION: Research on CES has progressed rapidly, and research development and collaboration frequently occur across countries, regions, and institutions. Further strengthening these partnerships may advance the field. The recent focus on ESUS, Mendelian randomization, and atrial cardiopathy highlights the need for refined etiological phenotyping and individualized secondary prevention.

Pyroptosis, as an inflammatory type of regulated cell death, is associated with the pathogenesis of various inflammatory diseases. Targeted therapy for pyroptosis has shown promise in multiple preclinical models of neurological injury and disorders. Stroke is one of the leading causes of morbidity and mortality worldwide and the top cause of disease-related death in China. Although the pyroptosis signaling pathway has been studied in cerebral ischemic diseases, its pathophysiological mechanisms...

CONCLUSION: The changes and improvements were relatively easy to implement and were highly impactful across measured outcomes. Empowering nurses to lead quality initiatives and using a structured change management framework benefits patients and fosters a more fulfilled, effective nursing team.

CONCLUSION: This study defines a genetically anchored plasma protein panel that mechanistically links CKD to CAD via a lipid-inflammation axis. The findings support the development of precision blood-based tools for early risk stratification and highlight potential targets for therapeutic intervention in cardiorenal disease.

BACKGROUND: Endovascular procedures using a mobile C-arm are commonly performed in patients with peripheral artery disease. During these procedures, digital subtraction angiography (DSA) requires intra-arterial administration of contrast agent and exposes both patients and staff to radiation from the C-arm. The Vascular Navigation PAD system (Brainlab, Germany) may reduce the number of DSAs performed and thereby decrease both contrast agent use and radiation exposure. The objective of this study...

CONCLUSIONS: Dynamic exercise-derived physiologic markers provide prognostic information complementary to resting haemodynamic assessment in PH-COPD and may improve risk stratification across this heterogeneous population.

BACKGROUND: Antipsychotic use in people living with dementia has been linked to serious adverse outcomes. Guidelines recommend limiting antipsychotic treatment to short-term use (<12 weeks), followed by tapering and cessation. However, antipsychotic treatment in routine practice often exceeds the recommended duration. The effect of discontinuing antipsychotics on reducing adverse outcomes in practice remains unclear. We aimed to use linked primary and secondary care data in England to...

CONCLUSION: Both 3D PASL-MRI and PC-MRI can noninvasively evaluate CBF changes in patients with MMD after surgery. The CBF of the cerebral was significantly improved after surgery. Moreover, the improvement of CBF was more obvious in patients with non-hemorrhagic rather than hemorrhagic MMD.

Vascular cognitive impairment (VCI) comprises cognitive dysfunction caused by vascular pathology and is associated with various forms of dementia. VCI is typically caused by chronic cerebral hypoperfusion (CCH), which is accompanied by oxidative stress, central nervous system inflammation, microglial activation, and white matter injury. Therapeutic targets for VCI remain largely unknown. Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in the brain, where it senses...

CONCLUSIONS: ANP was identified as an independent predictor of PAF detection in patients with ESUS, with strong ROC performance. Given its atrial origin and very short half-life, ANP may serve as an atrium-specific biomarker reflecting acute atrial load, potentially enabling earlier identification of latent PAF in the acute phase.

Despite substantial therapeutic advances in multiple myeloma (MM), extramedullary disease (EMD) remains an aggressive subtype associated with poor prognosis, for which consensus on management is lacking and dedicated clinical trials are scarce. We conducted a retrospective single-center analysis of 86 patients with radiologically confirmed EMD, defined as soft-tissue involvement without bone contiguity (data cut-off September 30, 2024). The cohort included patients with de novo EMD (n = 19, 22%)...

Clopidogrel therapy is recommended to prevent recurrent ischemic stroke. However, clopidogrel resistance exists. This study examines which enzymes are involved in clopidogrel resistance. The study group includes 402 neurology patients who had experienced a recurrent ischemic stroke while receiving clopidogrel monotherapy. Patients were genotyped for CYP2C19, CYP2C9, CYP2B6, CYP3A4, CYP3A5, CYP1A2, ABCB1 and CES1A1. Phenotype frequencies were compared with those of a Global(G), European(E) and a...

This study investigates the relationship between 25-hydroxyvitamin D (25(OH)D) levels and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Participants were divided into 3 groups based on their 25(OH)D status: normal (group A), insufficient (group B), and deficient (group C). The study analyzed the relationship between 25(OH)D and DR, as well as its association with various clinical parameters. In T2DM patients, 25(OH)D levels were significantly correlated with serum...

CONCLUSION: Brief cognitive screening tools, used in isolation, may not be suitable for assessment in acute stroke settings.

In patients with chronic total occlusion on coronary angiography, myocardial viability assessment is an essential tool in guiding treatment decisions, especially revascularization. Current non-invasive tests are often limited by the presence of myocardial fibrosis. This narrative review incorporates evidence from 76 studies and aims to provide an updated overview of non-invasive methods for myocardial viability assessment, with emphasis on the role of myocardial fibrosis. Every imaging modality...

CONCLUSIONS: This study will provide insight into the prevalence of MetS, ED, and accelerated aging, as well as potentially modifiable risk factors, including those that have not been previously examined, among survivors of HSCT for hematological malignancies in childhood. The findings will inform surveillance guidelines and support the development of health behavioral and anti-inflammatory interventions to mitigate the risk of these severe late effects.

CONCLUSION: EA remains a biologically plausible but clinically unconfirmed adjunctive approach for EH. Its clinical efficacy, optimal parameters, and target populations require confirmation in completed, adequately powered, sham-controlled multicenter randomized trials.

CONCLUSIONS: While behaviour change strategies can enhance engagement in cardiac rehabilitation, their impact on measurable health outcomes remains unclear. Social support, professional oversight, and structured programming appear effective in maintaining physical activity levels, but future interventions should prioritise exercise confidence and education to promote sustained behaviour change.

CONCLUSIONS: Current evidence underscores substantial gaps in understanding the natural history and optimal management of diabetic foot disease in dialysis-dependent ESKD. Future research should prioritise well-designed prospective studies to delineate dialysis-specific risk pathways, incorporate robust stratification by dialysis modality, and evaluate interventions targeting ischaemia and limb preservation. Standardisation of outcome reporting, particularly for healing durability and...

CONCLUSIONS: The study revealed that the rate of amputations was relatively high and highest survival rate was patients with cardiovascular disease. Receiving insulin therapy, staying in rural area, no-neuropathy, underweight and normal weight and no-hypertension showed more likely to amputation. Early detection of comorbidities is recommended to prevent amputation among patients with DFU.

Glutamate transporters are essential for maintaining CNS homeostasis by clearing extracellular glutamate following synaptic transmission. Dysregulation of these transporters contributes to glutamate-mediated excitotoxicity across numerous neurological disorders, including ischemic stroke, underscoring their potential as therapeutic targets. However, the regulatory response of these transporters following ischemic insult remains poorly defined. In this study, using a model of oxygen-glucose...

Cardiovascular disease is frequently diagnosed in birds that are presented to veterinary hospitals, and atherosclerosis is a common cardiovascular condition identified in postmortem evaluations of pet psittacine birds. Atherosclerotic lesions are accumulations of lipids, smooth muscle cells, macrophages, and foam cells in the intimal layer of a blood vessel, narrowing the lumen. A reduced lumen diameter in a blood vessel typically results in physiological complications, such as ischemia,...

CONCLUSIONS: Perioperative psychological intervention combined with distraction therapy provides a potential strategy to alleviate preoperative anticipatory anxiety in patients with lower limb varicose veins undergoing combined minimally invasive treatment. By employing various intraoperative methods to divert patients' attention from pain, this approach may further alleviate overall discomfort. These findings suggest that this strategy is associated with favorable outcomes and may warrant...

Venous leg ulcers (VLUs) are a chronic and often debilitating condition, affecting a significant number of individuals worldwide. One of the most distressing aspects of VLUs is the persistent pain they can cause, which impacts quality of life, mobility and overall wellbeing. Despite advances in wound care, VLU-related pain remains under-recognised and poorly managed. Pain in VLUs is complex and typically includes nociceptive pain from tissue damage, neuropathic pain due to nerve involvement, and...

Short-video platforms are important sources of cerebral infarction-related health information, but the completeness, reliability, and platform differences of such content remain unclear. This study compared engagement, topic coverage, and information quality of cerebral infarction-related videos on TikTok and Bilibili. Using the keyword "cerebral infarction," we screened the top 150 search results from each platform. Of 300 retrieved videos, 289 were included (TikTok: n = 146; Bilibili: n =...

Home-based rehabilitation after stroke is increasingly important, as pressure on hospital services rise and recovery occurs mostly at home. Enriching the home (Environmental Enrichment, EE) represents a potential strategy to support rehabilitation by providing continuous task- and context-specific stimulation that promotes functional recovery through frequent and exploratory use of the affected arm. Exploratory behaviour - self-initiated, varied and adaptive movements - is an important driver of...

Limited evidence links chronic inflammation to stroke prevalence, and the Dietary Inflammatory Index (DII) serves as a valid tool to quantify the inflammatory potential of diets. This cross-sectional study utilized data from the National Health and Nutrition Examination Survey 2007 to 2016, enrolling 27,250 adult participants. DII was calculated based on 24 dietary components and categorized into tertiles (Q1: anti-inflammatory diet, Q2: intermediate diet, Q3: pro-inflammatory diet). Stroke...

Ischemic stroke is a major cause of mortality globally, but single-target therapies often fail due to the complex "ischemic cascade". This study investigated the neuroprotective effects and multitarget mechanisms of Curcumae Rhizoma (CR) using an integrated network pharmacology approach and in vivo validation. The active compounds of CR were screened through ADME filtering, and their potential targets were identified using the TCMSP, TTD, and UniProt databases. Molecular docking was used to...

CONCLUSION: Current evidence shows that HPI-directed hemodynamic management effectively reduces IOH and decreases intraoperative fluid administration and phenylephrine utilization. However, these physiological improvements did not translate into clinical benefits for postoperative AKI.

CONCLUSION: SREBP gene polymorphisms exhibited suggestive associations with ambulatory blood pressure in Chinese adolescents. Although the associations were not significant after multiple testing correction, these findings suggest potential genetic influences on blood pressure regulation in youth and may inform future research on genetically informed approaches to hypertension prevention.

CONCLUSION: Elderly patients with non-valvular AF with SA ≤ 3.6 g/dL show a higher risk of MACE and non-cardiovascular mortality.

Electroacupuncture (EA) has been documented to exert therapeutic benefits in vascular dementia (VD). This study seeks to elucidate the therapeutic efficacy and underlying molecular mechanisms of EA in VD. A VD model was induced in rats, which received EA with or without an Shh pathway inhibitor. An in vitro VD model was generated by exposing BV2 microglial cells to oxygen-glucose deprivation (OGD). A battery of tests was employed: cognitive function (novel object recognition and morris water...

CONCLUSION: Long-term SBP trajectories and variability demonstrated sex-specific effects on AF risk. An elevated SBP trajectory and high variability conferred an increased risk of AF in men, but not in women. This novel finding may provide new insights into sex-specific differences in the pathogenesis of AF.

A man in his early 60 s developed persistent hyponatremia following lumbar spine surgery complicated by traumatic brain injury with subarachnoid hemorrhage. Initial evaluation demonstrated hypotonic hyponatremia with inappropriately concentrated urine, consistent with the syndrome of inappropriate antidiuretic hormone secretio. Standard therapy including hypertonic saline and oral sodium supplementation resulted in only transient improvement. Given a history of secondary adrenal insufficiency...

Vascular dementia (VaD) is the second most common age-related condition worldwide in aging populations. Neuroinflammation is a key contributor to the pathological process of VaD. Shrimp oil is a by-product of shrimp processing that is rich in astaxanthin and lipids. This study aimed to investigate the effect of shrimp oil on neuroinflammation and its underlying mechanisms in chronic cerebral hypoperfusion (CCH) rats. Male Wistar rats subjected to bilateral common carotid artery occlusion...

Background Ischemic lesion net water uptake (NWU), a CT biomarker of cerebral edema, has been linked to poor outcomes in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Whether NWU outperforms other imaging markers in predicting futile recanalization (FR) (ie, poor functional outcome despite successful endovascular thrombectomy [EVT]) remains uncertain. Purpose To evaluate the association between NWU and FR and compare the predictive performance of NWU with Alberta...

CONCLUSIONS: ICAS was independently associated with an increased risk of 1-year cognitive impairment after AIS/TIA, particularly in memory performance.

This study extracted radiomics features of blood clots from computed tomography pulmonary angiography (CTPA) images of acute pulmonary embolism (APE) patients, and constructs a predictive model for APE patient risk stratification by comparing multiple machine learning (ML) algorithms. This retrospective study analyzed patients with APE, documenting their clinical characteristics (clinical and hematological indicators), conventional CTPA imaging parameters. Patients are stratified into low-risk...

INTRODUCTION: Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD-relevant cerebrovascular phenotypes.

Compression therapy is the evidence-based treatment for healing venous leg ulcers. However, it is not routinely applied in many UK hospitals. This paper explores hospital staff's' perspectives of venous leg ulcer care provision where compression therapy is not routinely applied. A semi-structured interview study was conducted with 11 participants, drawn from a larger study, who confirmed that their respective hospitals did not apply compression therapy to inpatients with venous leg ulcers. The...

CONCLUSIONS: SMuRFs remain strong determinants of earlier ACS onset and shorter ACS-free survival. The apparent paradox of higher mortality in SMuRF-less patients likely reflects index-event and dilution bias. Prevention strategies targeting smoking, hypercholesterolemia, and diabetes remain crucial to extend ACS-free life expectancy.

Liver cirrhosis causes physiological and pharmacokinetic alterations that complicate antihypertensive therapy, in the presence of portal and arterial hypertension. This study evaluated the efficacy and safety of PBPK-guided dosing of carvedilol and nebivolol in cirrhotic patients. First, PBPK models were validated using clinical pharmacokinetic data from healthy volunteers and optimized for cirrhosis, then applied to simulate untested cirrhotic populations and estimate unbound plasma exposure...

To evaluate markers of cerebral small vessel disease (SVD), cerebral blood flow (CBF), and white matter integrity in patients with subcortical ischemic vascular dementia (SIVD) using multimodal magnetic resonance imaging (MRI), and to analyze the impact of total SVD load on cerebral perfusion and white matter injury. Fifty SIVD patients who visited the Cognitive Disorders Clinic of Tianjin Medical University General Hospital between October 2017 and October 2022 were enrolled and underwent 3.0 T...

Inflammatory bowel disease (IBD) is consistently associated with an increased risk of venous thromboembolism, particularly during active disease and hospitalization, yet thrombosis in this context extends beyond a transient inflammatory complication. Emerging evidence supports a unifying thromboinflammatory framework in which chronic intestinal inflammation promotes systemic vascular activation. Endothelial dysfunction represents a central interface in this process and is characterized by...

Diabetic Foot Ulcer (DFU), a prevalent and refractory diabetic complication, lacks clear pathological targets and effective therapeutic strategies. This study aimed to identify potential DFU biomarkers and preliminarily explore the mechanism of Badushengji San (BDS) in treating DFU. Transcriptome datasets (GSE199939, GSE134431) and single-cell RNA sequencing (scRNA-seq) data (GSE165816) were retrieved to screen differentially expressed genes (DEGs) and DFU-related cell subsets. Intersection...

CONCLUSIONS: In this large, real-world cohort of stroke patients, NCCT-based IGR was associated with functional outcomes, whereas CTP-based IGR was not. This highlights the need to refine and identify more accurate markers of infarct growth within perfusion imaging.

Isolated diastolic hypertension (IDH) is frequently considered a lower-risk phenotype due to preserved systolic pressure; however, sustained ambulatory diastolic load may promote early myocardial remodeling. Dynamic circadian variation, particularly diastolic morning surge (DMS), may impose additional hemodynamic stress not reflected by mean blood pressure values. We evaluated whether incorporation of DMS improves risk stratification for subclinical left ventricular diastolic dysfunction (LVDD)...

The association of atherogenic index of plasma (AIP) control level with hypertension onset in children was still unclear. This study aimed to investigate the association between AIP control levels and risk of childhood hypertension. We obtained data from 12,800 students participating in a national, multi-center, school-based health lifestyle intervention program aimed at combating obesity. AIP was calculated using the formula log(10)(TG/HDL-C), and was categorized into five clusters based on...