Hypertension – Pubmed Results

Hypertension is a major global health issue, and continuous, convenient blood pressure monitoring is of great significance for early screening and intervention. To address the insufficient exploitation of multi-scale temporal features and the high model complexity in existing radar-based non-contact blood pressure prediction methods, we propose a lightweight temporal multi-scale feature fusion network (LULMNet), for blood pressure prediction and waveform reconstruction. LULMNet adopts a...

CONCLUSION: This case highlights the early manifestation of metabolic syndrome and illustrates its underlying pathophysiological mechanisms. Effective management requires early diagnosis, lifestyle modification, weight reduction, and individualized pharmacological therapy to improve metabolic control and reduce long-term cardiovascular risk.

CONCLUSIONS: Smartphone-based interventions were associated with modest improvements in medication adherence over time, although between-group differences at follow-up were not statistically significant. As access to mobile technology expands across Africa, such interventions may provide scalable strategies to support chronic disease management.

CONCLUSION: In children with CKD, ambulatory hypertension is associated with elevated risk of LVH and increased LVMI. However, there was significant heterogeneity among the included studies with respect to study design and definition of outcomes. Timely detection of hypertensive target organ injury is imperative to mitigate future cardiovascular disease in pediatric CKD patients.Prospero Registration: CRD 42023426891.

PURPOSE OF REVIEW: To evaluate the emerging role of aldosterone synthase inhibitors (ASIs) in combination with sodium-glucose cotransporter 2 (SGLT2) inhibitors for the management of uncontrolled hypertension in patients with chronic kidney disease (CKD), and to assess their potential cardiorenal benefits.

BACKGROUND AND OBJECTIVES: The mechanisms underlying racial/ethnic differences in dementia incidence and pathology are multifactorial, and hypertension represents an actionable target for reducing these differences. We aimed to estimate the extent to which controlling for hypertension mediates racial/ethnic inequities in neuroimaging markers of brain aging.

Pulmonary arterial hypertension (PAH) is a chronic and progressive cardiopulmonary vascular disorder associated with poor clinical prognosis. Its hallmark pathological feature is sustained elevation of pulmonary vascular resistance resulting from extensive vascular remodeling. Endothelial-to-mesenchymal transition (EndMT), a critical event driving vascular remodeling, is increasingly recognized as central to PAH development and progression. This review systematically outlines the convergence of...

CONCLUSION: Our analysis underscores that factors such as the usability, design and relevance of social support profoundly influence the uptake and acceptance of DHIs in hypertension self-management among patients, caregivers and HCPs.

An initial presentation of severe chest or back pain with uncontrolled hypertension in the absence of cardiac etiology is synonymous with aortic dissection. For aortic dissections that do not involve the ascending aorta, malperfusion, or rupture, initial treatment with blood pressure management is favored to reduce short- and mid-term morbidity and mortality. Although medical management with surveillance remains broadly recommended for uncomplicated Type B aortic dissection, stent graft...

Congenital diaphragmatic hernia (CDH) is a complex neonatal condition characterized by pulmonary hypoplasia and pulmonary hypertension, requiring specialized ventilatory management from birth through postoperative care. This article synthesizes the current evidences and evolving strategies for optimizing respiratory support in CDH, emphasizing the importance of gentle ventilation to minimize lung injury and improve outcomes. We discuss delivery room resuscitation protocols, initial ventilator...

INTRODUCTION: We evaluated associations between phosphorylated au 217 (p-tau217), p-tau181, p-tau231, and vascular risk factors with cognitive outcomes across the Alzheimer's disease (AD) continuum.

CONCLUSION: In obese adults, METS-IR demonstrated a stronger association with comorbidity burden than HOMA-IR. However, because both indices showed limited discriminatory performance for T2DM and HT, they should not be used as standalone tools for treatment guidance or diagnostic classification. Rather, they should be interpreted alongside age, clinical, and biochemical findings, as isolated use may be misleading and fail to identify disease in specific patient subgroups.

PURPOSE OF REVIEW: This network meta-analysis (NMA) compares the efficacy of dietary interventions in improving flow mediated dilation (FMD) as a measure of endothelial function among individuals with cardiovascular diseases (CVDs) and hypertension. This work can be a basis for the design of future clinical trials and for the development of evidence-based nutritional guidelines to improve cardiovascular outcomes.

Right ventricular (RV) dysfunction in patients with coronary artery disease (CAD) and concomitant pulmonary hypertension (PH) is associated with poor outcomes, yet its short-term reversibility after percutaneous coronary intervention (PCI) remains unclear. Identifying echocardiographic predictors of RV functional improvement may inform tailored therapeutic strategies. This single-center retrospective cohort study enrolled 160 CAD patients with systolic pulmonary artery pressure (sPAP > 65 mm Hg)...

Cardiometabolic diseases (CMDs) have become the leading cause of mortality and disease burden in low- and middle-income regions, including ethnic minority areas in southwest China. However, population-based epidemiological data on CMDs and their socioeconomic impacts in karst rocky desertification areas remain scarce. This cross-sectional study aimed to investigate the prevalence, population distribution characteristics, and multilevel socioeconomic impacts of CMDs in Qianxinan Buyi and Miao...

Both hypertensive and breast diseases impose a significant societal burden. However, the correlation between antihypertensive drug use and breast cancer remains controversial. We aimed to determine their potential correlations and explore their possible mechanisms. We performed summary data-based Mendelian Randomization (SMR) analysis of expression quantitative trait loci (eQTL) data from the blood of patients with breast diseases. We then performed drug-targeting Mendelian Randomization (MR)...

Calcitonin gene-related peptide (CGRP)-targeted therapies are a recent addition to the migraine field. Monoclonal antibodies became available in 2018 and gepants in 2020, both now widely used for migraine prevention and acute treatment. CGRP is also a potent endogenous pulmonary vasodilator, and its blockade worsens pulmonary hypertension in experimental models. Yet the cardiopulmonary risks of CGRP pathway inhibition in humans have not been studied systematically. We report 3 patients with...

CONCLUSION: Lorundrostat effectively manages uncontrolled HTN but increases the risk of some AEs. More RCTs involving diverse populations are needed to improve clinical decision-making.

CONCLUSIONS: In this hospital-based hypertensive cohort, the post-pandemic period was associated with higher SUA levels and greater cardiorenal complication prevalence. Hyperuricemia and the post-pandemic period showed a significant multiplicative interaction on cardiorenal risk, with directionally consistent but statistically inconclusive additive synergism. These findings support routine SUA monitoring and proactive urate management in the post-pandemic care of hypertensive patients.

CONCLUSION: Lowering BP of below 130/80 mmHg in old and very old patients was associated with better cardiovascular and mortality outcomes without increased adverse events. These findings suggest that a lower BP target may be beneficial and safe for older patients with hypertension.

Diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) are significant contributors to pulmonary hypertension (PH) due to left heart disease. Standard in vivo evaluation of relaxation abnormalities in preclinical models includes two-dimensional (2D) echocardiography with Doppler assessment of transmitral flow and tissue relaxation, which is complex, expensive, and requires sophisticated echocardiographic equipment. Here, a valuable surrogate method to evaluate diastolic...

CONCLUSION: Among ED patients with intermediate hscTnI, blood pressure ≥ 140/90 mm Hg confers modestly higher short term risk of major adverse cardiovascular events, but incremental severity beyond this threshold does not add prognostic value. Elevated hscTnI in the context of severely elevated blood pressure likely reflects myocardial stress rather than additional ischemic risk. Clinicians should interpret intermediate troponin results in hypertensive patients cautiously, integrating clinical...

CONCLUSIONS: Our findings suggest a positive association between hypertension and tinnitus, with odds increasing alongside the severity and poor control of hypertension. Importantly, even controlled hypertension was associated with elevated odds, indicating that tinnitus screening may be warranted in all hypertensive patients, regardless of control status. These results underscore the need for heightened clinical awareness and further research into the pathophysiological mechanisms linking...

A woman in her 30s presented with acute flaccid paraparesis secondary to severe hypokalaemia. She had a known history of hypertension controlled on amlodipine and bisoprolol. Biochemical workup revealed metabolic alkalosis, renal potassium loss, suppressed plasma renin activity and markedly elevated aldosterone levels. CT imaging identified a left adrenal adenoma consistent with an aldosterone-producing adenoma. The patient underwent laparoscopic adrenalectomy, after which she no longer required...

CONCLUSIONS: Bridging with PH medical therapies to first BPA was associated with improved haemodynamic parameters in this real-world observational study. PDE5i and ERA dual therapy was associated with greater haemodynamic improvement than monotherapy with PDE5i or riociguat, without differences in complication rates.

Trisomy 21 (T21) results in Down syndrome (DS), a condition associated with a high prevalence of pulmonary complications. Pulmonary hypertension (PH) is a significant comorbidity in individuals with T21. Inflammation is a well-established driver of PH, and growing evidence implicates platelets as active contributors to inflammatory-mediated pulmonary vascular disease and PH. In T21, increased interferon (IFN) signaling resulting from an additional IFN receptor gene locus contributes to immune...

The role of proteins in cellular activity has received close attention. Proteome analysis can detect early enough changes in the cell before the appearance of pathological changes. Due to the increasing number of cardiovascular complications, more specifically hypertension in modern life, this experimental pilot study tries to detect early changes in the protein profile in cases with arterial hypertension. In this pilot study, animal models were used, specifically control rats and spontaneously...

CONCLUSIONS: Elevated serum IGFBP-1 and CHRDL1 levels in mid-pregnancy are independent risk factors for FGR in late pregnancy among women with GH. The combination of these two biomarkers demonstrates favorable predictive value, providing an actionable biomarker panel for early identification of high-risk populations in clinical practice, enabling intensified monitoring and intervention initiation at 20-24 weeks of gestation, and ultimately improving perinatal outcomes.

Carotid-femoral pulse-wave velocity (cfPWV) is a marker of central arterial stiffness and an established predictor of cardiovascular risk in hypertension. Although elevated lipoprotein(a) [Lp(a)] concentrations and peripheral arterial disease (PAD) are associated with atherosclerotic cardiovascular disease, their independent associations with central arterial stiffness and any potential interaction remain incompletely defined. We conducted a cross-sectional study of 366 adults with treated...

INTRODUCTION: Midlife hypertension is a well-established predictor of late-life cognitive decline; however, few population-representative estimates of this association exist among oldest-old cohorts.

CONCLUSIONS: Intensive BP lowering after EVT was associated with modestly worse HRQoL at 90 days. The observed differences were small in magnitude, particularly for EQ VAS relative to commonly reported thresholds for clinical importance. These findings are consistent with less intensive BP targets after EVT and highlight the importance of incorporating patient-reported outcomes in acute stroke trials.

Methamphetamine (MA) use is a recognized risk factor for drug-associated pulmonary arterial hypertension (PAH), yet mechanisms driving methamphetamine-associated PAH (MA-PAH) remain unclear due to the lack of reproducible animal models demonstrating hemodynamic changes. This study aimed to develop a rat model of MA-PAH that reflects human patterns of MA abuse. Male Wistar rats received methamphetamine (MA, 5 mg/kg, i.p.) for 8 weeks using either a chronic daily regimen or a binge-and-crash...

CONCLUSION: Upper arm NIBP measurements were the most accurate in the obese population. Alternative sites, such as the forearm and ankle, demonstrated inconsistent reliability, and require careful interpretation. Correction formulas can enhance the accuracy of NIBP readings but may be cumbersome for routine clinical use. Future studies should focus on refining measurement protocols and evaluating the efficacy of conically shaped cuffs for improved accuracy.

CONCLUSION: We observed strong associations between low RPM utilization and uncontrolled BP, with promising implications for patients with collectively high RPM use. These findings highlight the need to strengthen digital inclusion initiatives to improve RPM uptake and support existing efforts aimed at developing RPM clinical practice guidelines and expanding RPM reimbursement policies. Further research is warranted across diverse utilization components to better understand the linkages between...

CONCLUSION: The CHG index demonstrated the most independent association with incident hypertension, better than the AIP, TyG, and METS-IR indices in predictive accuracy.

CONCLUSION: Among Chinese adults aged 60 years and older, regular BP monitoring appears to be influenced more by operational capability than by conceptual awareness. Profile-guided, barrier-aware education may enhance the precision and scalability of hypertension self-management in similar community-based and outpatient care settings.

Chronic kidney disease (CKD) is a growing global health issue among ageing populations, driven by increasing diabetes and hypertension. Managing advanced stages of CKD with dialysis or transplants is costly. Early stages often have no symptoms, making early detection important for prevention. Primary care providers can help identify and manage CKD early by performing annual screening for high-risk patients, including blood pressure checks, urine tests for albuminuria or proteinuria and...

CONCLUSION: The study demonstrates that NPAR is a promising biomarker for assessing disease severity and predicting prognosis in PAH. Elevated NPAR levels may reflect systemic inflammation and contribute to the pathogenesis of PAH. Further research is needed to explore the potential therapeutic implications of targeting inflammation in PAH.

Abnormal LV geometrics implied higher cardiovascular risk for hypertensive patients. Ethnicity-specific cardiographic criteria classified more accurately the left ventricular (LV) geometric patterns for Chinese than international guideline. We hypothesized that the influences of achieved blood pressure on prognosis varied by different LV geometrics based on ethnicity-specific echocardiographic criteria. We enrolled participants from a nationwide public health research project in China and...

CONCLUSIONS: Impaired RA reservoir and conduit functions are hallmarks of CTEPH, with compensatory active contraction counteracting the reduction in passive filling. Given their noninvasive nature and high reliability, RAVmaxI and TAPSEra% are valuable indices for identifying patients with WHO-FC ≥ III and quantifying CTEPH severity, justifying their integration into standard echocardiographic protocols.

CONCLUSION: We found relatively high diabetes awareness and treatment. In contrast, for hypertension, reported diagnosis underestimated both prevalence and DLE compared to combined measures.

CONCLUSIONS: ASIs provide clinically meaningful BP reduction across both hypertension phenotypes; however, short-term use is associated with hypotension and electrolyte disturbances, necessitating careful monitoring. Phenotype-specific efficacy and long-term safety require validation in outcome-driven trials. Systematic Review Registration: PROSPERO CRD420251266257.

CONCLUSIONS: Nifedipine and labetalol were equivalent in effectiveness and safety. Methyldopa was associated with lower risks of adverse outcomes. Potential residual confounding and limited overlap between treatment groups warrant caution in interpretation of our findings. Future research is needed to clarify whether the apparent advantages of methyldopa reflect true therapeutic benefit or underlying biases.

PURPOSE: The Tianjin Health and Chronic Disease Study (THCDS) is a longitudinal dynamic cohort study established in 2022, aiming to investigate risk factors and intervention targets of common non-communicable diseases (NCDs) in Tianjin, China.

This study aimed to investigate the prevalence of previously undocumented suspected diagnoses identified during preventive health examinations in middle-aged adults, and to examine their associations with clinical and behavioral factors. In this cross-sectional study, 1,040 adults aged 45-59 years underwent preventive clinical examinations comprising self-reported medical histories, anamneses, previous medical records, and laboratory tests (LDL cholesterol, blood pressure, HbA1c, TSH). Suspected...

Hypertension is a major modifiable risk factor for chronic kidney disease (CKD), accelerating renal injury by promoting arterial stiffness. Estimated pulse wave velocity (ePWV), an indicator of arterial stiffness, is associated with CKD progression, but its relationship with urinary albumin-to-creatinine ratio (UACR) in non-diabetic hypertensive patients remains unclear. This retrospective study included 509 non-diabetic adults with essential hypertension. Participants were classified as having...

CONCLUSIONS: To improve FDC utilization, we propose: (1) integrating FDC exposure into early medical and pharmacy curricula; (2) embedding decision-support tools and SmartSets that prompt FDC consideration into electronic medical records; (3) expanding team-based care models to distribute responsibility for medication intensification; (4) securing leadership endorsements, novel incentive structures for providers, and data tracking mechanisms; and (5) fostering normative change through champions,...

Non-portal hypertension-related upper gastrointestinal bleeding (UGIB) remains one of the most common emergencies in gastroenterology, accounting for the majority of UGIB cases in Western countries.Its incidence is estimated at 50-150 cases per 100.000 population per year, with a mortality rate that remains between 5% and 10% despite advances in diagnostic and therapeutic strategies. Clinical presentation is often abrupt, typically as hematemesis or melena, requiring prompt and structured...

PURPOSE OF REVIEW: Resistant hypertension (RH) affects more than a tenth of adults and yet remains relatively underrecognized and undertreated. The electronic health record (EHR) now stands as a critical tool for overcoming barriers to the diagnosis and treatment of RH, specifically with respect to aiding in detection, excluding alternate diagnoses, and guiding clinical decision making. We review how the EHR has clarified the population level prevalence of RH and its impact on both quality of...

Hypertension affects approximately 47.7% of US adults, with higher rates observed in men (50.8%) compared with women (44.6%). Risk factors and characteristics such as age, family history, race, and ethnicity also can increase the risk of developing high blood pressure and can make treatment more difficult. Aprocitentan is the first dual endothelin receptor antagonist approved for the treatment of resistant hypertension. The PRECISION clinical trial resulted in a mean change in office systolic...