Heart Failure- Pubmed Results

CONCLUSION: HRR1 and VE/VCO(2) slope can serve as independent predictors for the incidence of MACCE in patients with CHF.

Heart failure (HF) remains a major global health challenge, necessitating accurate yet accessible diagnostic tools. While the left ventricular ejection fraction (LVEF) is the primary metric for classifying HF into preserved (HFpEF), mid-range (HFmrEF), and reduced (HFrEF) phenotypes, conventional imaging modalities such as echocardiography are resource intensive. In contrast, the electrocardiogram (ECG) offers a low-cost, non-invasive alternative for continuous cardiac assessment. This paper...

CONCLUSIONS: In patients with heart failure, parameters like mean E/e' ratio, LAVi, E wave DT are useful indices to estimate LVEDP; however, peak LAS-r (cut-off ≤17) provides a better prediction of LVEDP and could be considered a promising noninvasive index to assess LVEDP in patients of heart failure.

The timing of obesity onset may influence long-term cardiovascular risk. Whether obesity beginning in early adulthood differs from obesity acquired later in life with respect to cardiometabolic and cardiovascular outcomes remains uncertain. We analysed adults with obesity (BMI ≥ 30 kg/m²) from the National Health and Nutrition Examination Survey (NHANES) 2017-2020. Participants were classified as having early-onset obesity (with obesity at approximately age 25) or adult-onset obesity (with...

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is common in older multimorbid patients and is associated with substantial morbidity and mortality. Pacemaker (PM) patients may be particularly vulnerable given the clustering of conventional HFpEF risk factors and the hemodynamic effects of long-term right ventricular pacing. Nevertheless, HFpEF is rarely systematically assessed in device clinics.

Chronic heart failure is a major public health issue that requires a multidisciplinary approach based on a coordinated care pathway. The emergence of new nursing specialties, the development of patient education, and the rise of telemedicine are helping to strengthen follow-up and continuity of care in the outpatient setting, improve quality of life, and prevent decompensation and rehospitalisations. In this context, the interuniversity diploma in heart failure management offers a shared...

Heart failure is most often diagnosed in a hospital setting following cardiac decompensation. The delivery of the diagnosis does not occur within a specific framework designed to help patients come to terms with their condition. The study presented here highlights these patients' feelings and needs, with a view to further exploring the possibility of specific nursing interventions.

Heart failure is a common condition that leads to a large number of hospitalizations, a high mortality rate, and significant costs for the healthcare system. The symptoms and chronic nature of the disease severely impair patients' quality of life, forcing them to adapt their daily routines by following various lifestyle and dietary recommendations, including salt restriction. This diet, often presented as essential, can have mixed effects: while it may sometimes reduce the risk of...

Heart failure is a chronic condition whose course can be affected by extended travel. This prospective, open-label study evaluated the impact of stays abroad lasting more than two months on a population of outpatients with heart failure receiving care in a cardiology clinic. Of the 14 patients included, 12 (86%) met the composite endpoint combining a disruption in cardiac follow-up (64%), a disruption in medication adherence (64%), or cardiac decompensation (57%) upon return from their trip....

Heart failure is a public health issue affecting more than 1 million people in France in 2022, according to Santé publique France. The healthcare teams in the cardiology department at the University Hospital of Réunion care for these patients, from the onset of the disease through to the end of their lives. While they strive to provide personalized care, they face constraints and are seeking solutions to overcome them.

The various educational options offered to patients upon discharge following cardiac decompensation were assessed using a questionnaire as part of this retrospective study. Respondents indicated that they found these options to be more complementary than redundant, with a preference for those that occur as soon as possible after discharge and in their own environment (such as the return-home program and therapeutic support through telemonitoring of heart failure). The therapeutic education...

Heart failure (HF) remains associated with high morbidity and mortality, with heart failure with preserved ejection fraction (HFpEF) becoming increasingly prevalent and therapeutically challenging despite advances in pharmacological and rehabilitative care. Beyond their glucose-lowering effects, glucagon-like peptide-1 receptor agonists (GLP-1RAs) confer cardiometabolic benefits and may serve as effective adjuncts to cardiac rehabilitation (CR), particularly in obese patients with HFpEF. Obesity...

Heart failure (HF) affects 2.6 % of adults in France. Against a backdrop of increasingly complex care, the cross-sectional survey presented here-conducted between May and June 2023-analyzes the roles of three specialized profiles: nurses working under the heart failure cooperation protocol, advanced practice nurses, and telehealth nurses. The results highlight the complementary nature of their skills within the care pathways for HF patients.

Myocardial fibrosis is a common pathological feature of multiple cardiovascular diseases, including heart failure, hypertension, and myocardial infarction, and is associated with poor prognosis. Despite extensive research, clinically validated molecular biomarkers for early diagnosis and reliable therapeutic targets for myocardial fibrosis remain limited. Post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, SUMOylation, and glycosylation, are critical...

CONCLUSION: Our results show that a longer baseline LVAT is associated with a lower risk of heart failure hospitalization and all-cause mortality. This relationship was of borderline significance in multivariable analysis. Prospective trials would be useful to further explore the potential role of pre-implant LVAT in patient selection for CRT.

Psoriasis has been associated with cardiovascular risk, but the combined association of psoriasis and cardiovascular-kidney-metabolic (CKM) syndrome with mortality remains unclear. This study examined the individual and joint associations of CKM syndrome and self-reported psoriasis with allcause and cardio-cerebrovascular disease (CCD) mortality among 9,598 U.S. adults aged ≥20 years from NHANES 2003-2006 and 2009-2014. CKM syndrome stages were defined according to the 2023 American Heart...

CONCLUSIONS: Despite being low-intensity, dressing was associated with measurable physiological and subjective HF responses. R-HF trended toward slower HR recovery; NO-HF demonstrated consistently higher HR levels and perceived exertion. Monitoring recovery responses and supporting pacing and symptom self-monitoring during daily activities may be important in HF nursing care.

AIM: The "2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome" retires, replaces, and expands upon the "2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults." The primary intended audience for this guideline is clinicians who care for patients across the spectrum of cardiovascular-kidney-metabolic syndrome, an interrelated condition characterized by the interconnections among metabolic...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to cardiovascular morbidity, yet it remains unclear which anthropometric indices most effectively capture the burden of prevalent heart failure (HF) in this population. This cross-sectional study utilized data from the National Health and Nutrition Examination Survey conducted from 2017 to March 2020 (pre-pandemic). MASLD was defined according to the 2023 Delphi consensus as hepatic steatosis plus ≥ 1...

Impaired activities of daily living (ADL) significantly affect the prognosis and quality of life in patients with heart failure (HF). We aimed to identify the key clinical and self-management predictors of ADL 12 months after hospital discharge. This prospective cohort study enrolled 162 hospitalized patients with HF stratified into low-ADL (ADL < 100, n = 66) and high-ADL (ADL = 100, n = 96) groups based on 12 months of follow-up. The baseline characteristics, comorbidities, biomarkers (B-type...

The digoxin drug has a narrow therapeutic window that requires regular blood concentration monitoring in a tertiary hospital. The concentration of a drug varies due to several factors. The factors may include physiological and biochemical factors, comorbidities, and concomitant medications. The purpose of this study was to analyze the monitoring data of serum digoxin concentration (SDC) using logistic regression and to find the SDC correlated factors. SDC with a cutoff value of 0.9 ng/mL, which...

CONCLUSION: Among HF patients with LBBB undergoing LBBaP implantation, treatment with sacubitril/valsartan was associated with greater short-term improvements in QRS duration, cardiac function and exercise capacity compared with enalapril. Larger prospective studies with longer follow-up are required to further evaluate long-term clinical outcomes.

CONCLUSIONS: Inhibition of S100A8/A9-mediated inflammation improved diastolic function and reversed the pathological changes of the heart in mice with HFpEF. The observed effects were potentially mediated via inhibition of the TLR4/NF-κB pathway. The present study identified S100A8/A9 as a possible therapeutic target in HFpEF.

Despite major advances in guideline-directed medical therapy (GDMT), many patients with heart failure with reduced ejection fraction (HFrEF) remain symptomatic, with persistent limitations in functional capacity and health status, underscoring the need for adjunctive therapeutic strategies. Direct cardiac microcurrent (C-MIC) therapy is a non-excitatory bioelectrical intervention device to modulate myocardial remodeling rather than rhythm or acute contractility. C-MIC therapy influence...

CONCLUSION: The proposed virtual Forrester profiling integrating BIA and PWA provides a practical, quantitative and reproducible framework for non-invasive haemodynamic assessment.

The association between the timing of coffee consumption and mortality risk among individuals with cardiovascular-kidney-metabolic (CKM) syndrome remains unclear. This study aims to identify patterns of coffee intake timing and assess their links to all-cause and cause-specific mortality. This prospective cohort study included 21 553 adults with CKM syndrome from the 1999-2018 National Health and Nutrition Examination Survey. Two-step cluster analysis was used to identify temporal patterns of...

CONCLUSION: The comparison revealed that while patients focused on practical habituation, physical effort, and maintaining interpersonal harmony, experts prioritized nutritional knowledge and broader socioeconomic or clinical risks. To bridge these differing perspectives, future research should focus on developing a brief self-assessment tool that encompasses both patients' lived experiences and expert-identified risks, enabling personalized dietary management tailored to patients' daily...

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are recommended for multiple populations-type 2 diabetes (T2D), chronic kidney disease, and heart failure-but their role after heart transplant (HTX) remains unclear. We searched PubMed, Cochrane, and Embase for studies of HTX recipients with T2D comparing outcomes in SGLT2i users vs. non-users. Outcomes of interest were all-cause mortality, urinary tract infection (UTI), and estimated glomerular filtration rate (eGFR) change from baseline. Odds...

CONCLUSION: When treating heart failure, atrial resynchronization should be considered along with ventricular resynchronization. Crucially, convenient pacing sites have been outmoded by active-fixation leads that can be placed at stimulation sites approximating normal conduction, including the atria; achievement hinges on understanding atrial anatomy and activation. Atrial resynchronization may significantly improve cardiac function where dyssynchrony relates to atrial disease/conduction delay,...

Heart failure with preserved ejection fraction (HFpEF) is associated with skeletal muscle dysfunction that contributes to exercise intolerance and disease progression. Altered Ca^(2+) homeostasis and increased oxidative stress have been proposed as mechanisms underlying muscle weakness in HFpEF; however, the effects of aerobic exercise on skeletal muscle physiology in this condition remain unclear. This study evaluated the impact of moderate-intensity aerobic exercise on skeletal muscle...

Heart failure (HF) remains one of the leading health problems globally. It is often characterized by unresolved inflammation, adverse cardiac remodeling, and tissue damage. Efferocytosis, the process by which phagocytes clear apoptotic cells, is a key process that helps to resolve inflammation and maintain tissue homeostasis. In the healthy heart, efferocytosis ensures the proper removal of apoptotic cardiac cells (e.g., cardiac fibroblasts and cardiomyocytes) and promotes inflammation...

Heart failure with preserved ejection fraction (HFpEF) is a common cardiovascular disorder characterized by a left ventricular ejection fraction of ≥45%, which is typically accompanied by diastolic dysfunction and symptoms of heart failure. Although dapagliflozin treatment may relieve symptoms in patients with HFpEF, the precise biological mechanisms underlying its therapeutic effects remain incompletely understood. Pyroptosis can induce inflammatory amplification and contribute to the...

Cardiorenal syndrome (CRS) encompasses the bidirectional and complex interaction between cardiac and renal dysfunction. The present review focuses on CRS types 3 and 4, highlighting the negative effects of acute kidney injury and chronic kidney disease, respectively, on cardiac function. The present review focuses on pathophysiological mechanisms, associating renal impairment with cardiovascular events, paying particular attention to systemic inflammation, oxidative stress, endothelial damage...

CONCLUSIONS: The review shows that it is useful to group the studies into outcomes of readmission, mortality and phenotyping. This made it possible to highlight the relevant variables in each group. In addition, the different predictive capabilities of each outcome were identified. This research was conducted within the scope of the project KardioInterakt, which is supported by the German Federal Ministry of Research, Technology and Space (BMFTR) (grant number 16SV8906).

Heart failure with preserved ejection fraction (HFpEF) is frequently complicated by atrial fibrillation (AF), yet the mechanisms underlying AF vulnerability prior to or independent of extensive structural remodeling remain incompletely understood. In this study, we investigated atrial electrophysiological remodeling in a murine HFpEF model induced by combined high-fat diet and L-NAME administration. The model reproduced key HFpEF features, including obesity, hypertension, preserved systolic...

Background Cardiac sarcoidosis (CS) may present with conduction abnormalities, ventricular arrhythmias, and heart failure. The delay in recognizing cardiac involvement in systemic sarcoidosis leads to disease progression, resulting in major morbidity and mortality. We studied the clinical, electrocardiographic, and imaging features of cardiac sarcoidosis and its mortality predictors. Methods The clinical data of patients with CS who presented to the Sree Chitra Tirunal Institute for Medical...

Although studied for decades, metabolic therapies that target cardiac lipid metabolism are underdeveloped, and most approaches have thus far failed as a heart failure treatment. In contrast, new therapies for diabetes and obesity are widely used for the prevention and treatment of heart failure. The heart depends heavily on lipid uptake and utilization for proper function. Too much or too little cardiac lipid catabolism becomes detrimental and causes heart failure, either due to lipotoxicity or...

CONCLUSIONS: The digital platform was easily integrated into patients' daily routines. CHWs played a key role in making the platform more approachable for participant use. Further research is needed to better understand the impact of this intervention in larger HF populations over more extended time intervals.

This retrospective study analyzed 10,934 hyperkalemia episodes to compare outcomes between the hyperkalemia routine group and the hyperkalemia standardized group, the latter managed with a strategy supported by the 'Serum Potassium Management Center System' in a real-world implementation setting. The study compared process and outcome metrics between this system-level intervention cohort and the routine care cohort. The hyperkalemia standardized group exhibited significantly higher rates of...

PURPOSE OF REVIEW: Advanced heart failure (HF) is characterized by high symptom burden, poor quality of life (QoL), and recurrent hospitalizations. As survival improves, an increasing proportion of patients progresses to advanced stages, leading to a growing population of individuals with end-stage HF, many of whom are ineligible for heart transplantation or mechanical circulatory support due to age, comorbidities, frailty, or limited social support. This review aims to synthesize current...

Heart failure is a chronic disease that leads to disabling symptoms and recurrent hospitalizations, mainly for acute heart failure episodes, having a major impact on patients' quality of life. An effective treatment is available but not always accessible, for miscellaneous reasons including difficulties in understanding the prescription and in reaching guideline-directed medical therapies to the optimal tolerated dose.Patient education is a key component of heart failure management, enabling...

Obesity is a major and potentially modifiable risk factor for heart failure (HF); however, the biological mediators linking excess adiposity to adverse cardiac remodeling and HF progression remain incompletely defined. Among adipose-derived factors, leptin has emerged as a candidate mediator because of its associations with neurohormonal activation, vascular dysfunction, inflammation, oxidative stress, and myocardial remodeling. This review synthesizes contemporary evidence regarding the role of...

CONCLUSIONS: Smartphone ownership accounted for just over 50% of the patients in this population. It was less common among older adults, patients with comorbidities, and those with markers of lower socioeconomic status. This needs to be considered when delivering mHealth interventions.

CONCLUSIONS: Psychological well-being is associated with determinants of SR acceptability in patients with HF, while psychological distress and personality traits are not associated with these determinants. These patient-level factors ought to be examined more closely before SR implementation.

CONCLUSION: This audit provides the first concrete evidence of widespread potential inequity in access to AHF therapies across the UK and Ireland. These findings have important implications for national healthcare planning, including workforce development and allocation of public health resources. Further work is required to investigate barriers to referral, enhance clinician awareness and optimise care pathways for patients in need of both life-prolonging and supportive therapies.

Symptomatic heart failure (HF) with reduced ejection fraction is traditionally drawn as 2 stages. Most stage C patients report manageable symptoms on guideline-directed medical therapy (GDMT), whereas stage D therapies are transplant or durable circulatory support, if eligible, and otherwise palliation with inotropic infusions or hospice considered for most. However, advanced HF includes not only end-stage D patients but also a large ambulatory population progressing beyond sustained response to...

CONCLUSIONS: This study identified proteomic biomarkers for HF, highlighted potential pathways that inform biological mechanisms, and demonstrated that proteomic data enhanced HF risk prediction in individuals with T2D.

CONCLUSION: The HALP and PNI scores, which reflect nutritional status, were associated with mortality and may provide supportive prognostic information in ICU patients with decompensated HF; however, they were not independent predictors in multivariate analysis.

ObjectiveSodium-glucose cotransporter 2 inhibitors are widely used in the management of diabetes mellitus and have demonstrated substantial cardiovascular and renal protective effects, particularly in patients with heart failure. However, their impact on cardiovascular outcomes in patients with chronic obstructive pulmonary disease remains insufficiently characterized.MethodsWe conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy and safety of...

INTRODUCTION: Persistent psychological distress including symptoms of depression, anxiety, and posttraumatic stress disorder (PTSD) occur in as many as 70% of intensive care unit (ICU) survivors. However, few therapies exist that target this population's unique symptoms and needs. To address this, we developed the Blueprint adaptive coping skills mobile app, which was found to be feasible and reduce psychological distress symptoms in a recent single-center pilot randomized control trial (RCT).