Respiratory Medicine Journal

Survival in cystic fibrosis (CF) has improved markedly in high-income countries over recent decades; however, important disparities persist across regions. Long-term data describing survival patterns and their determinants in middle-income settings remain limited. The aim of this study was to estimate survival in Mexican patients with CF over three decades and to explore the clinical and health-system factors associated with mortality.

Cystic Fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CFTR gene. The genetic spectrum of CF in Iran is highly heterogeneous due to ethnic diversity and consanguinity, particularly in the Khorasan province. Data regarding the Torbat Jam region is scarce.

Despite improvements seen with elexacaftor/tezacaftor/ivacaftor (ETI), many people with CF (PWCF) still experience symptom burden. This study aimed to evaluate current perceived symptom burden and contrast it with PWCF’s recollection of symptoms before starting ETI.

Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently coexist and share common risk factors. However, the mortality burden associated with their co-occurrence has not been fully characterized at the population level, particularly with respect to cause-specific and absolute risks.

Airway mucus plugging is an underrecognized feature of COPD that is increasingly associated with adverse outcomes, including higher mortality rates. Computed tomography studies demonstrate that mucus plugs are prevalent, variable, and frequently persistent or dynamic over time. The presence of mucus plugs is independently linked to a worse prognosis, even after adjusting for cardiovascular and respiratory risk factors. Patients with mild COPD appear to be at particularly high risk, suggesting that mucus plugging may represent an early and potentially modifiable disease trait.

Chronic obstructive pulmonary disease (COPD) is a common and debilitating respiratory disease. Acute exacerbations of COPD (AECOPD), characterized by a sudden worsening of symptoms, are associated with cardiovascular (CV) morbidity and mortality. However, their impact on cardiopulmonary outcomes (CP) has not been evaluated in Israel.

This manuscript covers guidance proposed by The European Cystic Fibrosis Society Clinical Trials Network (ECFS-CTN) for the use of chest computed tomography (CT) scans in special situations such as haemoptysis, aspergillus-related lung disease, non-tuberculous mycobacterial (NTM) infection and pneumothorax in people with CF. Guidance development followed a three-step process.The most important questions were first identified via anonymous online survey, then a comprehensive literature search was made to support a first set of statements.

The association between acute-phase corticosteroid therapy and subsequent Long COVID symptoms remains uncertain. Therefore, we aimed to evaluate the association between systemic corticosteroid therapy during hospitalization and patient-reported Long COVID symptoms during follow-up.

Asthma and neurodevelopmental and mental disorders (NMD) are associated. It is important to understand how having both asthma and a NMD is associated with health outcomes. We sought to determine if having both asthma and a NMD was associated with poorer health outcomes in children.