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Most clinical trials evaluating inhaler therapy in COPD have been conducted predominantly in smoking populations, and prognostic factors and therapeutic outcomes in COPD without any history of smoking were not well investigated. Therefore, this study was conducted to investigate the effect of inhaler prescription and comorbidities on the prognosis of COPD in never-smokers.
Chronic airway diseases (CAD) including Chronic obstructive pulmonary diseases (COPD), persistent asthma (≥2weekly episodes) and bronchiectasis, exhibit overlapping extrapulmonary manifestations potentially affecting health-related quality-of-life (HRQOL). The study objective was to quantify HRQOL of CAD patients and identify impact of associated pulmonary and extrapulmonary manifestations.
The ventilatory ratio (VR) has been proposed as a simple and accessible index to estimate ventilatory inefficiency and physiological dead space in critically ill patients with acute respiratory distress syndrome (ARDS). However, its association with mortality remains controversial, partly due to the methodological heterogeneity of the published studies.
This study aimed to investigate risk factors of prolonged length of hospital stay (LOHS) in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and to develop a predictive nomogram.
Diagnostic bronchoscopy has advanced rapidly over the last two decades with the adoption of novel technologies. Concurrently, social media platforms have proliferated, with some pulmonologists sharing and promoting these new technologies and diagnostic successes. The impact of this content on perceptions of diagnostic yield and utility remains unclear.
Recent literature has reported an association between diabetes and asthma, along with their contribution to increased disease burden. However, there is still limited knowledge on trends in diabetes-related asthma.
The CRQ is a valid and responsive measure of HRQoL in patients with ILD, including those with IPF, with an MCID of around 0.5 points per item. These findings support the use of the CRQ in ILD.
The healthcare sector significantly contributes to greenhouse gas emissions, with pharmaceuticals accounting for 20–35% of the total. Among these, pressurised metered-dose inhalers (pMDIs), commonly used in asthma management, contain hydrofluorocarbon (HFC) propellants with high global warming potential (GWP), representing the medications with the highest carbon footprint.
Primary Ciliary Dyskinesia (PCD) is a rare, genetically heterogeneous disorder. Despite the increasing number of identified causative genes, 20–30% of patients still lack a genetic diagnosis. To date, genetic analyses have primarily focused on single nucleotide variants (SNVs). In this study, we evaluated whether the detection of copy number variants (CNVs) improves the diagnostic yield in our large patient cohort.
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