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Gastroenterology

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Clinical Knowledge Summaries- Gastrointestinal Topics

COVID-19 – PubMed search results

Longitudinal stability of cognitive impairments in post-COVID-19 syndrome assessed with the tablet-based Oxford Cognitive Screen-Plus
In a previous cross-sectional study using the tablet-based Oxford Cognitive Screen-Plus (OCS-Plus), deficits in delayed memory, attention, and executive functioning were identified in working-age patients with post-COVID-19 syndrome (PCS) following infection in 2020 or early 2021. Initial assessment occurred approximately five months after infection. To examine short-term longitudinal trajectories, patients were reassessed several months later. Eighty-one patients with PCS (mean age 46.6 years,...
Clinical Characteristics at the Diagnosis of New Primary Melanoma in Italy: A Multicenter Retrospective Study Before and After the COVID-19 Pandemic
Background/Objectives: During the pandemic, access to healthcare was severely disrupted, inevitably affecting melanoma diagnosis. While this was clearly evident during the pandemic itself, it is less clear whether clinical presentation has returned to baseline levels in subsequent years. Our study aimed to compare the current clinical presentation of melanoma with that in the pre-pandemic setting. Methods: We conducted a retrospective multicenter study involving Italian melanoma referral centers...
Ten-Year Trends in Serum 25-Hydroxyvitamin D in Slovenia (2014-2023): Laboratory-Based Data from Tested Individuals and COVID-19-Period Changes
CONCLUSIONS: This laboratory-based analysis of tested patients showed higher 25(OH)D concentrations during and after the COVID-19 period, superimposed on persistent seasonal and age-related gradients. These observations identify older adults and winter testing periods as important contexts for vitamin D optimization, but they should be interpreted as descriptive trends among tested individuals rather than as evidence of causal pandemic effects or population-wide prevalence changes.
Influence of the COVID-19 Pandemic on the Prevalence of Depression Among US Adults
CONCLUSIONS: The persistence of mental health disparities highlights the need for sustained efforts from the government, mental healthcare organizations, and healthcare providers to support vulnerable groups even beyond the pandemic.
Malaria: 11-Year Experience With Imported Cases at a German University Hospital and Epidemiological Trends Amid the COVID-19 Pandemic
CONCLUSION: Imported malaria remains rare in Europe. However, severe cases still occur, often requiring intensive care and resulting in high morbidity or even death. The diagnosis and management of malaria in nonendemic settings present a clinical challenge, and the delayed diagnosis is responsible for preventable deaths.
Leveraging an Electronic Consultation Program for a High-Volume Hepatology Clinic
CONCLUSION: Hepatology E-consults can effectively manage many low-complexity cases within primary care, preserve specialty clinic capacity, and reduce patient travel burden. These findings highlight the role of E-consults in addressing the growing demand for hepatology expertise.
Trends in Blood Pressure Control During the COVID-19 Pandemic: A Study of 17 US Health Systems in the National Patient-Centered Clinical Research Network Blood Pressure Control Laboratory
CONCLUSIONS: BP control was disrupted during the COVID-19 pandemic and had not fully rebounded to prepandemic levels by the end of 2022. Continued surveillance is needed to determine whether the decline in BP control will persist and will result in future adverse cardiovascular events.
Dual Antiplatelet Therapy and Arteriovenous Malformations Increase 30-Day Readmission Rates for Patients Who Undergo Endoscopic Procedures for Gastrointestinal Bleeding
CONCLUSIONS: DAPT use and AVMs were independently associated with increased risk of 30-day readmissions following inpatient endoscopy for GIB. These findings highlight the importance of targeted discharge planning and closer follow-up in high-risk populations to reduce readmissions and improve outcomes.
The 516th case: hyperinflammatory state, acute renal dysfunction, hepatosplenomegaly with lymphadenopathy, and recurrent cerebral infarctions
A 25-year-old male patient presented with diarrhea, elevated serum creatinine, and thrombocytopenia for six months, with a recurrence for one month. He developed a systemic hyperinflammatory state following SARS-CoV-2 infection, involving the renal, gastrointestinal, and hematologic systems. Although glucocorticoid therapy initially demonstrated efficacy, the patient experienced disease relapse post-gastrointestinal infection, complicated by recurrent cerebral infarctions. Through...
mRNA Vaccines: Development, Mechanisms and Advances in Delivery Systems
For more than over two decades, mRNA vaccines have been successfully administered and continues to be a promising platform for preventive and therapeutic uses. A key advantage of mRNA-based therapies over DNA-based approaches is that the mRNA molecule only needs to reach the cytoplasm for translation, bypassing the need for nuclear entry. Unlike pre-designed peptide vaccines, which may be restricted to specific MHC haplotypes, mRNA vaccines encode full-length antigens, allowing the host's cells...

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