Clinical Questions 2016 -17

Below are clinical questions received by meeting the staff at WMUH Queen Mary Maternity Unit and attending haematology/O&G MDT meetings from May 2016 – Mar 2017. Please contact us for more details. Last updated 07/12/17.

Celox in the obstetric and non-obstetric setting. Results1; Results 2

SSRIs and aspirin interaction in young/pregnant subjects

Genetic Mutation of Haemophilia B and development of inhibitory antibodies

Low BMI in pregnancy and effects on low birth weight/neonatal outcomes

Skull fractures and birth trauma (inc vacuum extraction/depressed/linear fractures)

Legal requirement to report foetal death prior to 24 weeks

Fetal intraventricualar haemorrhage associated with low molecular weight herparin

Tubo-ovarian abcesses

Metformin in Pregnancy

Inhalant abuse (lighter fluid) during pregnancy effects on fetus

Epirubicin/ cyclophosphamide chemotherapy in pregnancy (breast cancer)

BMI <18.5 cut off for underweight in pregnancy. What is the evidence for this?

POGL1 mutations in pregnancy

McArdle’s disease in pregnancy

Taxol in Pregnancy

Gonadotropin-releasing hormones and Psychosis

Subarachnoid haemorrhage/cerebral anneurysms in pregnancy/intrapartum period

Identfiable risk factors for MRSA carriage

Vasa praevia (diagnosis, management, classification)

Pregnancy outcomes and low PAPP-A Levels

Propess and uterine rupture in the unscarred uterus

Zika virus and pregnancy

Blood platelet testing in pregnancy standard vs optical/immunocounting

Toxoplasmosis in pregnancy and childbirth

effect of first trimester subchorionic haemorrhage on pregnancy/perinatal outcomes

Cervical length in the first trimester and prediction of preterm birth

Is the first morning void best test for women suspected of proteinurea

Repeating tests if the dipstick test is positive for proteinurea

Are PCR (protein creatinine ratio tests compromised by a small amount of mixed growth?

Timing of restarting biologic therapy (Infliximab or Adalimumab) after major surgery (particularly c section)

N-acetylcysteine use in liver failure/fatty liver disease (non-paracetamol poisoning)

Antipsychotic medication in pregnancy and risk of hypoglycaemia/gestational diabetes

Are progestogens contraindicated in coagulated patients with a history of venous thromboembolism?

When we suture post-delivery do we need to use surgical drapes/leggings?

Sclerosing Cholangitis in Pregnancy

myofibrillar myopathies (MFMs) and incidence of cardiomyopathy

Oral vs. intramuscular Dexamethasone for preterm labour

GDM screening at 34 weeks using OGTT in women with a BMI >35 who have previously had a negative result

Oramorph (oral morphine) in latent phase of labour

Diagnosis and Management of Pneumothorax in Pregnancy

kyphoscoliosis and pregnancy (maternal and neonatal outcomes)

Respiratory Failure and pregnancy neontal outcomes

Oxytocin dosing regime 50ml dilute vs 500ml

Arabin Pessaries – infection risk/timing of removal

Duration of the latent phase of labour according to parity

Higher dose methyldopa

Insulin Degludec (Tresiba) for type 1 diabetes in pregnancy

syringomyelia in pregnancy and delivery

Pudendal Block and Urinary Dysfunction/Retention

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