New England Journal of Medicine – Pulmonary/Critical care articles

Chronic obstructive pulmonary disease (COPD) affects 174 million people worldwide, a number expected to rise over the next several decades as a result of the increased prevalence of smoking in developing countries and markedly aging populations in higher-income nations. Approximately 1.13 billion…
Posted: January 23, 2020, 12:00 am
Presentation of Case. Dr. Blake A. Niccum (Medicine): A 64-year-old man was admitted to this hospital in the spring because of acute renal failure. The patient had been generally well until 4.5 months before this admission, when fevers, malaise, mild cough, and pain in the left flank developed. He…
Posted: January 16, 2020, 12:00 am
Figure 1.
Posted: January 16, 2020, 12:00 am
Production of natural gas has grown by nearly 400% in the United States since 1950, and gas is now the country’s second-largest energy source. The main driver of this increase has been the wide-scale adoption of hydraulic fracturing ("fracking"). During the fracking process, large volumes of water,…
Posted: January 9, 2020, 12:00 am
Figure 1.
Posted: January 2, 2020, 12:00 am
To the Editor: We would like to clarify a statement in the letter by Mudan et al. (Sept. 12 issue) suggesting the lack of a national pharmacovigilance database for reporting adverse events associated with products containing cannabis. Consumers and health care professionals can directly report to…
Posted: January 2, 2020, 12:00 am
Vitamin D may improve outcomes in critically ill patients. Preclinical data suggest that vitamin D is a potent immunomodulatory agent that is essential for lung development and function. Observational data and initial clinical trial data indicate that vitamin D deficiency is common among critically…
Posted: December 26, 2019, 12:00 am
Figure 1.
Posted: December 26, 2019, 12:00 am
As of December 12, 2019, the ongoing national outbreak of electronic-cigarette, or vaping, product use–associated lung injury (EVALI) has affected more than 2400 hospitalized patients across all 50 states, the District of Columbia, the U.S. Virgin Islands, and Puerto Rico. In addition, 52 deaths…
Posted: December 20, 2019, 12:00 am
Cardiovascular disease, which is common in patients with chronic obstructive pulmonary disease (COPD), has a profound effect on morbidity and mortality, yet the condition is often unrecognized and as a result is undertreated. Systematic reviews have recognized the underuse of beta-blockers in…
Posted: December 12, 2019, 12:00 am
In accordance with the 2015 guidelines of the International Liaison Committee on Resuscitation (ILCOR), targeted temperature management with a target of 32°C to 36°C (moderate therapeutic hypothermia) is currently advocated for all patients with coma after successful resuscitation from cardiac…
Posted: December 12, 2019, 12:00 am
Presentation of Case. Dr. Michael B. Feldman: A 20-year-old man with a history of electronic-cigarette (e-cigarette) use, also known as vaping, was evaluated in the pulmonary clinic of this hospital because of progressive dyspnea and abnormal findings on chest imaging. The patient had been well…
Posted: December 12, 2019, 12:00 am
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Most of COPD-related morbidity, mortality, and health care costs are driven by exacerbations, particularly those leading to hospitalization. Since many patients have such exacerbations despite maintenance…
Posted: December 12, 2019, 12:00 am
Evidence supports the use of benzodiazepines as the initial treatment for status epilepticus; however, seizures do not respond to benzodiazepines in up to a third of patients. The treatment for this type of benzodiazepine-refractory status epilepticus has not been well studied. Of the three…
Posted: November 28, 2019, 12:00 am
The primary goal of diagnostic testing for pulmonary embolism is to identify which patients should be treated with anticoagulant agents and which should not. The patients who should be treated are those who have pulmonary embolism that has a substantial risk of recurrence or progression. The…
Posted: November 28, 2019, 12:00 am
Status epilepticus is a medical emergency characterized either by continued seizures or by a lack of full recovery between seizures. It is relatively common, with a reported annual incidence of between 10 and 41 cases per 100,000 population (the variation partly reflects differing diagnostic…
Posted: November 28, 2019, 12:00 am
Acute upper airway obstruction is a life-threatening emergency and requires immediate assessment and intervention with little margin for error, making it a constant challenge for clinicians. Substantial advances have been made in preventive medicine, our understanding of the pathophysiology of…
Posted: November 14, 2019, 12:00 am
Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 58-year-old…
Posted: November 7, 2019, 12:00 am
Despite improved management, overall survival rates at hospital discharge among patients with out-of-hospital cardiac arrests do not exceed 20%, and neurologic outcomes remain poor. Even though controversies persist, targeted temperature management at 32 to 36°C remains recommended in patients with…
Posted: November 7, 2019, 12:00 am
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 51-year-old man…
Posted: November 7, 2019, 12:00 am
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