New England Journal of Medicine – Pediatrics News

Since 1922, insulin has been the sole effective treatment for type 1 diabetes, which is now known to be the result of T-cell–mediated autoimmune destruction of pancreatic beta cells. In 1982, the approval of synthetic recombinant human insulin by the Food and Drug Administration heralded an era of…
Posted: November 19, 2020, 12:00 am
Figure 1.
Posted: November 19, 2020, 12:00 am
Type 1 diabetes is an autoimmune disease characterized by progressive loss of pancreatic beta cells that leads to lifelong dependence on insulin therapy. More than 13 million people are affected by type 1 diabetes, and the incidence increases by 3 to 4% per year globally. Even with important…
Posted: November 19, 2020, 12:00 am
"Black people love their children with a kind of obsession. You are all we have, and you come to us endangered." So writes Ta-Nehisi Coates in Between the World and Me, and for all my clinical training, it’s narratives such as his that have provided me with a shadow curriculum of racial…
Posted: November 12, 2020, 12:00 am
Postlicensure studies of rotavirus vaccines have shown varying risks of intussusception in different settings worldwide. The association of intussusception with rotavirus vaccination was identified in 1998, when RotaShield (Wyeth–Lederle Vaccines), the first licensed rotavirus vaccine, was…
Posted: November 12, 2020, 12:00 am
Worldwide, 5.4 million children under 5 years of age died in 2017, with the highest childhood mortality occurring in sub-Saharan Africa. Mass distributions of oral azithromycin twice a year to children 1 to 59 months of age reduced childhood mortality by 18% over 2 years in Niger, which suggests…
Posted: November 12, 2020, 12:00 am
Figure 1.
Posted: November 5, 2020, 12:00 am
Migraine is a ubiquitous neurologic disorder that is estimated to affect approximately 1 billion people worldwide, predominantly females. According to the Global Burden of Disease Study 2016, migraine is the second leading cause of disability and accounts for more disability than all other…
Posted: November 5, 2020, 12:00 am
Tumors that occur in multiple sites usually represent metastatic disease originating from the same primary tumor. However, in some forms of childhood cancer, it has been proposed that synchronous lesions that are located in separate anatomical regions may represent independent tumors. The only…
Posted: November 5, 2020, 12:00 am
On October 5, 2020, the Center for Drug Evaluation and Research (CDER) of the Food and Drug Administration (FDA) proposed withdrawal of approval of Makena (hydroxyprogesterone caproate injection), the only drug approved for the prevention of recurrent preterm birth. Here we summarize our rationale…
Posted: November 3, 2020, 12:00 am
In the late 1990s, there was no drug approved by the Food and Drug Administration (FDA) with a labeled indication for preventing recurrent preterm birth in women with a previous preterm birth. The risk of such recurrence was and is known to vary widely by study population, but it was consistently…
Posted: November 3, 2020, 12:00 am
Figure 1.
Posted: October 29, 2020, 12:00 am
Preterm birth is a leading cause of death in infants and children younger than 5 years of age globally. Infants born preterm are also at increased risk for a wide range of short-term and long-term respiratory, infectious, metabolic, and neurologic conditions, with higher risks among those born…
Posted: October 23, 2020, 12:00 am
Some of the most challenging mitochondrial disorders arise from mutations in mitochondrial DNA (mtDNA), a high-copy-number genome that is maternally inherited. These disorders manifest with marked clinical heterogeneity, in part because tissues generally contain a mixture of both nonmutant and…
Posted: October 15, 2020, 12:00 am
"Philip’s labs are high again. We would like to schedule a biopsy for tomorrow morning. Come to the hospital this evening so we can monitor his blood sugar while he is NPO before the procedure. Afterward, we will need to monitor him overnight for bleeding. Hopefully it’s not rejection, and you can…
Posted: October 15, 2020, 12:00 am
Mitochondrial diseases are a heterogeneous group of disorders with varying clinical features caused by impaired function of the mitochondrial respiratory chain. The underlying cause can be gene mutations affecting either the nuclear DNA or the mitochondrial DNA (mtDNA), both of which contain genes…
Posted: October 8, 2020, 12:00 am
Figure 1.
Posted: October 8, 2020, 12:00 am
The ultimate goal of human papillomavirus (HPV) vaccination is to prevent invasive cervical cancer by preventing infection with major oncogenic types of HPV. As of December 2019, a total of 124 countries and territories had implemented national immunization programs for HPV vaccination. In Sweden,…
Posted: October 1, 2020, 12:00 am
Familial hypercholesterolemia is a genetic condition characterized by an elevated plasma concentration of low-density lipoprotein (LDL) cholesterol starting at birth and an increased risk of premature atherosclerotic cardiovascular disease. With an estimated prevalence of 1 in 250 in the general…
Posted: October 1, 2020, 12:00 am
Heterozygous familial hypercholesterolemia — in contrast to the more rare and more severe homozygous familial hypercholesterolemia — is a common genetic cholesterol disorder affecting approximately 1 in 250 persons and resulting in an increased risk of premature atherosclerotic cardiovascular…
Posted: October 1, 2020, 12:00 am
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BBC News- Health

Christmas could be a dangerous time to contract the virus - but precautions can be taken.
Three households will be allowed to meet indoors over a five-day period between 23-27 December.
Busting myths and explaining the facts around immunisation.
People arriving in England can end their self-isolation with a negative test taken after five days.
People have tendency to soldier on, potentially making colleagues sick, health secretary says.

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