American Journal of Obstetrics & Gynaecology

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To review all cases of maternal bacteremia, including associated pathogens and neonatal outcomes, in a Canadian tertiary center.
Author: R.C. Reimer, V. Paquette, A. Albert, E. McClymont, C. Elwood
Posted: December 1, 2020, 12:00 am
To evaluate the association between vaginal washing and relative abundances of vaginal bacterial taxa, measured by broad range 16S ribosomal RNA (rRNA) gene polymerase chain reaction (PCR) with deep sequencing of amplicons (Illumina sequencing).
Author: M.C. Sabo, J. Balkus, B.A. Richardson, S. Srinivasan, J. Kimani, O. Anzala, J.R. Schwebke, T.L. Fiedler, D. Fredricks, R.S. McClelland
Posted: December 1, 2020, 12:00 am
Maternal responses to bacterial chorioamnionitis (CAM) include production of matrix metalloproteases (MMPs), extracellular membrane-degrading enzymes thought to play a central role in the weakening of fetal membranes during CAM leading to preterm prelabor rupture of membranes (PPROM). Macrophages, the primary innate immune phagocyte of fetal membranes, secrete MMPs when provoked by microbes such as Group B Streptococcus (GBS). The objective of this project is to determine whether maternal cytotrophoblasts (CTBs) decrease macrophage expression of tissue-remodeling MMPs in the setting of GBS infection.
Author: E. Vrana, D. Aronoff, A. Eastman
Posted: December 1, 2020, 12:00 am
To examine the risk of recurrent spontaneous preterm birth (sPTB) among patients with a previous sPTB and with clinical chorioamnionitis (CC) in the first pregnancy.
Author: M.M. Sperling, L. Sie, A. Girsen, S.A. Leonard, R. Gibbs
Posted: December 1, 2020, 12:00 am
BV affects 15%–50% of women, frequently recurs after antibiotic treatment and is associated with an increased risk of acquiring sexually transmitted infections including HIV, and preterm birth. We recently completed a Phase 2B placebo-controlled trial of LACTIN-V (formulated vaginal Lactobacillus crispatus CTV-05) dosed over 11 weeks that demonstrated efficacy in the prevention of recurrent BV following use of vaginal metronidazole. In the intervention arm, 79% of participants were colonized with L.
Author: S.L. Hao, G.R. Castaneda, C.R. Cohen, A. Hemmerling, E.D. Crawford
Posted: December 1, 2020, 12:00 am
(1) Identify the risk of recurrent clinical chorioamnionitis (CC) and (2) determine whether gestational age (GA) at delivery of first pregnancy and interpregnancy interval (IPI) are risk factors for recurrent CC.
Author: M.M. Sperling, L. Sie, A. Girsen, S.A. Leonard, R. Gibbs
Posted: December 1, 2020, 12:00 am
Approved treatment options for vulvovaginal candidiasis (VVC) are currently azoles, including OTC topicals and one oral prescription, fluconazole. Ibrexafungerp is a novel oral triterpenoid antifungal with a new mechanism of action in development for the treatment of VVC. Ibrexafungerp is fungicidal with broad activity against Candida spp., including fluconazole-resistant strains. We present the first of two phase 3 studies evaluating the safety and efficacy of oral ibrexafungerp in VVC.
Author: J.R. Schwebke, V. Sorkin-Wells, N. Azie, D. Angulo, J. Sobel
Posted: December 1, 2020, 12:00 am
Low pre-pregnancy body mass index (BMI) and suboptimal gestational weight gain (GWG) are associated with an increased risk of neonatal morbidity including small for gestational age (SGA) infants. HIV infection is an independent risk factor for poor nutritional status. The effect of HIV infection on nutritional status during pregnancy and resulting neonatal outcomes is not well-studied particularly in low-and middle-income countries (LMIC). We sought to determine whether maternal HIV infection and low GWG are associated with an increased risk of SGA infants in a Zambian population.
Author: A.W. Honart, E.N. Reichert, A. Kumwenda, B. Vwalika, J. Stringer, J. Price, E. Stringer
Posted: December 1, 2020, 12:00 am
Many studies of placental, meconium or amniotic fluid microbiomes fail to account for the low-level contamination present in all sequencing experiments and do not implement adequate negative controls when interpreting results. We aimed to define and quantify the microbial content of meconium under properly controlled conditions.
Author: S.J. Dos Santos, Z. Pakzad, C. Elwood, A. Albert, J.E. Hill, D. Money, The Maternal Microbiome Legacy Project Team
Posted: December 1, 2020, 12:00 am
To describe baseline antimicrobial stewardship (AMS) metrics and apply AMS interventions tailored to an obstetrical population.
Author: J.M. Hay Wong, D.J. Wooding, S. Leung, V. Paquette, C. Elwood
Posted: December 1, 2020, 12:00 am
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