New England Journal Of Medicine – Search Results for Gastroenterology

Figure 1.
Posted: January 23, 2020, 12:00 am
Presentation of Case. Dr. Jacqueline N. Chu: A 44-year-old man was evaluated at this hospital because of diarrhea, weight loss, and abdominal pain. Approximately 6 months before admission, the patient began to have early satiety, nausea approximately 30 minutes after eating small amounts of food,…
Posted: January 23, 2020, 12:00 am
We had just completed a dramatic 3 hours in the emergency department: one patient in shock, another in status epilepticus, and a third with multiple traumas after having been hit by a car. I took one self-congratulatory moment before checking the board. Fortunately, there was only one new patient,…
Posted: January 23, 2020, 12:00 am
To the Editor: Combined therapy with an immune checkpoint inhibitor containing antibodies against both CTLA4 (cytotoxic T-lymphocyte–associated protein) and PD-1 (programmed cell death 1) is an efficient first-line treatment for malignant melanoma. However, in about half the patients who receive…
Posted: January 16, 2020, 12:00 am
Presentation of Case. Dr. Jenna R. Lillemoe (Pediatrics): An 11-year-old boy was seen in the emergency department of this hospital because of ongoing vomiting and weight loss. One month before this presentation, the patient was evaluated by his primary care pediatrician because of nausea, vomiting,…
Posted: January 9, 2020, 12:00 am
Schistosomiasis is an ancient, neglected parasitic disease caused by blood flukes (trematode worms) of the genus schistosoma. Affecting an estimated 200 million persons in 78 countries, the disease is intimately associated with poverty and is grossly debilitating, leading to chronic ill health. The…
Posted: December 26, 2019, 12:00 am
According to Weindruch and Sohal in a 1997 article in the Journal, reducing food availability over a lifetime (caloric restriction) has remarkable effects on aging and the life span in animals. The authors proposed that the health benefits of caloric restriction result from a passive reduction in…
Posted: December 26, 2019, 12:00 am
Schistosomiasis is a parasitic neglected tropical disease that is estimated to currently infect more than 140 million persons. Ninety percent of the disease burden is in sub-Saharan Africa, where the main species that cause schistosomiasis in humans are Schistosoma mansoni (intestinal…
Posted: December 26, 2019, 12:00 am
Although the growing obesity epidemic in the United States has been well documented, less is known about long-term trends and the future of obesity prevalence. Although national projections of obesity have been made previously, state-specific analyses are limited. State-specific projections of the…
Posted: December 19, 2019, 12:00 am
Achalasia is an esophageal motor disorder consisting of defective relaxation of the lower esophageal sphincter and disturbed esophageal peristalsis. The clinical symptoms associated with the condition include dysphagia, regurgitation, chest pain, and weight loss. Current treatment options include…
Posted: December 5, 2019, 12:00 am
An altered intestinal microbiome has been implicated in the pathogenesis of many disorders. Fecal microbiota transplantation (FMT) refers to the administration of intestinal microbes from a healthy donor into a recipient with the intent of modifying the recipient’s intestinal microbiome. FMT is an…
Posted: November 21, 2019, 12:00 am
The term "dysbiosis" usually refers to a change in the human microbiome from a healthy pattern toward a pattern associated with disease. Although the term is increasingly being used, the definition, not surprisingly, is vague. Yet dysbiosis has become an area of great interest in medical science.…
Posted: November 21, 2019, 12:00 am
To the Editor: Fecal microbiota transplantation (FMT) has emerged as a treatment for recurrent Clostridioides difficile infection. Procurement of safe donors for FMT and for biologically sourced microbiome therapies is complex, particularly given recent concerns over antibiotic-resistant bacteria…
Posted: November 21, 2019, 12:00 am
Presentation of Case. Dr. Pierre O. Ankomah (Medicine): A 34-year-old man with asthma was admitted to this hospital during the winter because of dyspnea. Three months before admission, odynophagia developed, and the patient noted white plaques in his mouth. He presented to an urgent care clinic,…
Posted: November 21, 2019, 12:00 am
Figure 1.
Posted: November 7, 2019, 12:00 am
Insulin resistance is present in most, but not all, obese and elderly patients and even in some young and lean persons. It is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and probably obesity-associated cancers.…
Posted: November 7, 2019, 12:00 am
Presentation of Case. Dr. Akash Gupta (Pediatrics): A 16-year-old boy was admitted to this hospital in autumn because of jaundice and abnormal results on liver-function tests. The patient had been well until 4 days before admission, when he noted pruritus around his ankles. That night, malaise and…
Posted: October 31, 2019, 12:00 am
The BRAF V600E mutation occurs in approximately 10% of patients with metastatic colorectal cancer, with recent estimates ranging from as low as 5% to as high as 21%. This mutation identifies a distinct subtype of colorectal cancer that has a poor prognosis. Initial standard chemotherapy for BRAF…
Posted: October 24, 2019, 12:00 am
In the United States, approximately 20% of adults regularly have symptoms of gastroesophageal reflux disease (GERD), and annual costs for managing GERD exceed $12 billion. Patients with heartburn, the cardinal symptom of GERD, report reduced work productivity and significant impairments in…
Posted: October 17, 2019, 12:00 am
Conceptualizing gastroesophageal reflux disease (GERD) as a single disease process that will respond to higher and higher doses of acid suppression is a mistake. The underlying mechanisms that can lead to reflux of stomach contents into the esophagus and subsequent symptoms or esophagitis are…
Posted: October 17, 2019, 12:00 am
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