Clinical Questions 2016 -17

Below are clinical questions received by meeting the staff at WMUH Queen Mary Maternity Unit and attending haematology/O&G MDT meetings from May 2016 – Mar 2017. Please contact us for more details.  Last updated 07/12/17.
Are Troponin levels effected by pregnancy/delivery?
CADASIL syndrome and pregnancy
Maternal bradycardia (causes and frequency)
Immunoplatelet counting
Differences between intravenous immunogloblins (Privigen/Vigam/Sandogobulin)
Multivitamins in pregnancy
Frequency of Clindamycin Resistance in Group B Strep
Incidence of facial palsy/Bell Palsy associated with Methyldopa in Pregnancy
Vitamin B12 deficiency in pregnancy/normal reference ranges
Ankyloglossia
Superovulation and intrauterine stimulation
Onset of action/onset of side effects (depression/hepatitis) in use of Methyldopa
Celox in the obstetric and non-obstetric setting. Results1Results 2
SSRIs and aspirin interaction in young/pregnant subjects
Genetic Mutation of Haemophilia B and development of inhibitory antibodies
Low BMI in pregnancy and effects on low birth weight/neonatal outcomes
Skull fractures and birth trauma (inc vacuum extraction/depressed/linear fractures)
Legal requirement to report foetal death prior to 24 weeks
Fetal intraventricualar haemorrhage associated with low molecular weight herparin
Tubo-ovarian abcesses
Metformin in Pregnancy
Inhalant abuse (lighter fluid) during pregnancy effects on fetus
Epirubicin/ cyclophosphamide chemotherapy in pregnancy (breast cancer)
BMI <18.5 cut off for underweight in pregnancy. What is the evidence for this?
POGL1 mutations in pregnancy
McArdle’s disease in pregnancy
Taxol in Pregnancy
Gonadotropin-releasing hormones and Psychosis
Subarachnoid haemorrhage/cerebral anneurysms in pregnancy/intrapartum period
Identfiable risk factors for MRSA carriage
Vasa praevia (diagnosis, management, classification)
Pregnancy outcomes and low PAPP-A Levels
Propess and uterine rupture in the unscarred uterus
Zika virus and pregnancy
Blood platelet testing in pregnancy standard vs optical/immunocounting
Toxoplasmosis in pregnancy and childbirth
effect of first trimester subchorionic haemorrhage on pregnancy/perinatal outcomes
Cervical length in the first trimester and prediction of preterm birth
Is the first morning void best test for women suspected of proteinurea
Repeating tests if the dipstick test is positive for proteinurea
Are PCR (protein creatinine ratio tests compromised by a small amount of mixed growth?
Timing of restarting biologic therapy (Infliximab or Adalimumab) after major surgery (particularly c section)
N-acetylcysteine use in liver failure/fatty liver disease (non-paracetamol poisoning)
Antipsychotic medication in pregnancy and risk of hypoglycaemia/gestational diabetes
Are progestogens contraindicated in coagulated patients with a history of venous thromboembolism?
 When we suture post-delivery do we need to use surgical drapes/leggings?
 Sclerosing Cholangitis in Pregnancy
 myofibrillar myopathies (MFMs) and incidence of cardiomyopathy
 Oral vs. intramuscular Dexamethasone for preterm labour
GDM screening at 34 weeks using OGTT in women with a BMI >35 who have previously had a negative result
Oramorph (oral morphine) in latent phase of labour
Diagnosis and Management of Pneumothorax in Pregnancy
kyphoscoliosis and pregnancy (maternal and neonatal outcomes)
Respiratory Failure and pregnancy neontal outcomes
Oxytocin dosing regime 50ml dilute vs 500ml
Arabin Pessaries – infection risk/timing of removal
Duration of the latent phase of labour according to parity
 Higher dose methyldopa
 Insulin Degludec (Tresiba) for type 1 diabetes in pregnancy
 syringomyelia in pregnancy and delivery
 Pudendal Block and Urinary Dysfunction/Retention
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